In flight performance and first results of FREGATE

The gamma-ray detector of HETE-2, called FREGATE, has been designed to detect gamma-ray bursts in the energy range [6-400] keV. Its main task is to alert the other instruments of the occurrence of a gamma-ray burst (GRB) and to provide the spectral coverage of the GRB prompt emission in hard X-rays and soft gamma-rays. FREGATE was switched on on October 16, 2000, one week after the successful launch of HETE-2, and has been continuously working since then. We describe here the main characteristics of the instrument, its in-flight performance and we briefly discuss the first GRB observations.Comment: Invited lecture at the Woods Hole 2001 GRB Conference, 8 pages, 15 figure

HETE-II and the Interplanetary Network

The FREGATE experiment aboard HETE-II has been successfully integrated into the Third Interplanetary Network (IPN) of gamma-ray burst detectors. We show how HETE's timing has been verified in flight, and discuss what HETE can do for the IPN and vice-versa.Comment: To appear in the proceedings of the conference on Gamma-Ray Burst and Afterglow Astronomy 2001: A Workshop Celebrating the First Year of the HETE Mission, to be published by AIP. Figures must be downloaded and printed separatel

Scientific Highlights of the HETE-2 Mission

The HETE-2 mission has been highly productive. It has observed more than 250 GRBs so far. It is currently localizing 25 - 30 GRBs per year, and has localized 43 GRBs to date. Twenty-one of these localizations have led to the detection of X-ray, optical, or radio afterglows, and as of now, 11 of the bursts with afterglows have known redshifts. HETE-2 has confirmed the connection between GRBs and Type Ic supernovae, a singular achievement and certainly one of the scientific highlights of the mission so far. It has provided evidence that the isotropic-equivalent energies and luminosities of GRBs are correlated with redshift, implying that GRBs and their progenitors evolve strongly with redshift. Both of these results have profound implications for the nature of GRB progenitors and for the use of GRBs as a probe of cosmology and the early universe. HETE-2 has placed severe constraints on any X-ray or optical afterglow of a short GRB. It is also solving the mystery of "optically dark' GRBs, and revealing the nature of X-ray flashes.Comment: 10 pages, 9 figures, to appear in proc. "The Restless High-Energy Universe", Royal Tropical Institute, Amsterdam; revised text, added ref

Time-resolved X-ray spectral modeling of an intermediate burst from SGR1900+14 observed by HETE-2/FREGATE and WXM

We present a detailed analysis of a 3.5 s long burst from SGR 1900+14 that occurred on 2001 July 2. The 2-150 keV time-integrated energy spectrum is well described by the sum of two blackbodies whose temperatures are approximately 4.3 and 9.8 keV. The time-resolved energy spectra are similarly well fitted by the sum of two blackbodies. The higher temperature blackbody evolves with time in a manner consistent with a shrinking emitting surface. The interpretation of these results in the context of the magnetar model suggests that the two-blackbody fit is an approximation of an absorbed, multitemperature spectrum expected on theoretical grounds rather than a physical description of the emission. If this is indeed the case, our data provide further evidence for a strong magnetic field and indicate that the entire neutron star was radiating during most of the burst duration

Total hemoglobin reduction in the tumor volume correlates with response to breast cancer neoadjuvant chemotherapy within two weeks of treatment

Optical imaging techniques have emerged as a possible alternative to predict pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Our team developed a so-called diffuse optical tomographic breast imaging system (DOTBIS) which does not require the use of contrast agents or compression, and enables imaging of the whole breast volume using low intensity near infrared light capable to measure tissue concentration of oxy-hemoglobin (ctO2Hb), deoxy-hemoglobin (ctHHb) and water percentage. In this retrospective study, ctTHb changes in the tumor region of 16 breast cancer patients were analyzed across NAC. Both breasts of all patients have been scanned simultaneously with our DOTBIS system, Figure 1, which employs four wavelengths and gathers data from a total of 64 sources and 128 detectors per breast. A PDE-constrained multispectral image reconstruction code creates 3D image maps of total hemoglobin (ctHbT = ctO2Hb+ ctHHb). Tumor volume is selected by entering radiologic information such as tumor side, clock position and distance from the nipple (FN). An automated code was designed to select the highest value from the distance FN and the quadrant referent to the clock position. Subsequently, a region-based image segmentation method is implemented to examine neighboring pixels of the highest value point considering a mask of 90%. After tumor volume segmentation, we calculate the mean ctHbT extracted from the region of interest. An independent-samples t-test was run to determine if there were differences in ctTHb reduction in the tumor region before the third cycle of taxane between responders (n=4) and non-responders (n=12). ctTHb reduction was greater to pCR (45.71 ± 25.16 mM) than non-pCR tumors (-9.67 ± 25.65 mM), a statistically significant difference of 55.38 mM (95% CI, 23.74 to 87), t(14) = 3.755, p = .002, in Figure 2 we can see an example. From the ROC plot results, we can observe that ctTHb reduction in the tumor region after 2 cycles of Taxane is a good indicator to anticipate pCR status. With an area under the curve of 0.958, the best cut-off that maximizes sensitivity and specificity is 16.86mM. At this reduction level, the sensitivity is 100% and specificity is 91.7%. In conclusion, our findings indicate that DOTBIS-measured total hemoglobin in the tumor region may be a strong and independent predictor of treatment response to NAC. Please click Additional Files below to see the full abstract

Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. This was an open-labelled, nonrandomised dose-escalation phase I study. In all, 12 patients with a history of recurrent superficial bladder cancer were grouped into four dose levels (10–150 mg ml−1 in 60 ml saline). Six catheter instillations at weekly intervals were used. Cystoscopy and biopsy were performed before and 3 months after the start of treatment. Suramin was assayed using high-performance liquid chromatography, vascular endothelial growth factor (VEGF) using ELISA (enzyme-linked immunosorbent assay), and urinary protein profile using surface-enhanced laser desorption ionisation mass spectroscopy (SELDI). Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml−1. Urinary VEGF was affected by Suramin at doses above 50 mg ml−1, corresponding to the estimated threshold of saturation of Suramin binding to urine albumin. SELDI showed a specific disappearance of urinary protein peaks during treatment. Intravesical Suramin shows lack of toxicity and low systemic absorption. The results of this phase I trial support expanded clinical trials of efficacy at a dose of 100 mg ml−1 intravesically

Multi-Species Test of Ion Cyclotron Resonance Heating at High Altitudes

Observations of ion distributions and plasma waves obtained by the Dynamics Explorer 1 satellite in the high-altitude, nightside auroral zone are used to study ion energization for three ion species. A number of theoretical models have been proposed to account for the transverse heating of these ion populations. One of these, the ion cyclotron resonance heating (ICRH) mechanism, explains ion conic formation through ion cyclotron resonance with broadband electromagnetic wave turbulence in the vicinity of the characteristic ion cyclotron frequency. The cyclotron resonant heating of the ions by low- frequency electromagnetic waves is an important energy source for the transport of ions from the ionosphere to the magnetosphere. In this paper we test the applicability of the ICRH mechanism to three simultaneously heated and accelerated ion species by modelling the ion conic formation in terms of a resonant wave-particle interaction in which the ions extract energy from the portion of the broadband electromagnetic wave spectrum which includes the ion cyclotron frequency. Using a Monte Carlo technique we evaluate the ion heating produced by the electromagnetic turbulence at low frequencies and find that the wave amplitudes near the ion cyclotron frequencies are sufficient to explain the observed ion energies

Multi-Species Test of Ion Cyclotron Resonance Heating at High Altitudes

Observations of ion distributions and plasma waves obtained by the Dynamics Explorer 1 satellite in the high-altitude, nightside auroral zone are used to study ion energization for three ion species. A number of theoretical models have been proposed to account for the transverse heating of these ion populations. One of these, the ion cyclotron resonance heating (ICRH) mechanism, explains ion conic formation through ion cyclotron resonance with broadband electromagnetic wave turbulence in the vicinity of the characteristic ion cyclotron frequency. The cyclotron resonant heating of the ions by low-frequency electromagnetic waves is an important energy source for the transport of ions from the ionosphere to the magnetosphere. In this paper we test the applicability of the ICRH mechanism to three simultaneously heated and accelerated ion species by modelling the ion conic formation in terms of a resonant wave-particle interaction in which the ions extract energy from the portion of the broadband electromagnetic wave spectrum which includes the ion cyclotron frequency. Using a Monte Carlo technique we evaluate the ion heating produced by the electromagnetic turbulence at low frequencies and find that the wave amplitudes near the ion cyclotron frequencies are sufficient to explain the observed ion energies

HETE Observations of the Gamma-Ray Burst GRB030329: Evidence for an Underlying Soft X-ray Component

An exceptionally intense gamma-ray burst, GRB030329, was detected and localized by the instruments on board the High Energy Transient Explorer satellite (HETE) at 11:37:14 UT on 29 March 2003. The burst consisted of two \~10s pulses of roughly equal brightness and an X-ray tail lasting >100s. The energy fluence in the 30-400 keV energy band was 1.08e-4 erg/cm2, making GRB030329 one of the brightest GRBs ever detected. Communication of a 2 arcmin error box 73 minutes after the burst allowed the rapid detection of a counterpart in the optical, X-ray, radio and the ensuing discovery of a supernova with most unusual characteristics. Analyses of the burst lightcurves reveal the presence of a distinct, bright, soft X-ray component underlying the main GRB: the 2-10 keV fluence of this component is ~7e-6 erg/cm2. The main pulses of GRB030329 were preceded by two soft, faint, non-thermal bumps. We present details of the HETE observations of GRB030329.Comment: 22 pages, 5 figures, to be published in ApJ 617, no. 2 (10 December 2004). Referee comments have been incorporated; results of improved spectral analysis are include