1,295 research outputs found
Emergence of noise-induced barren plateaus in arbitrary layered noise models
In variational quantum algorithms the parameters of a parameterized quantum
circuit are optimized in order to minimize a cost function that encodes the
solution of the problem. The barren plateau phenomenon manifests as an
exponentially vanishing dependence of the cost function with respect to the
variational parameters, and thus hampers the optimization process. We discuss
how, and in which sense, the phenomenon of noise-induced barren plateaus
emerges in parameterized quantum circuits with a layered noise model. Previous
results have shown the existence of noise-induced barren plateaus in the
presence of local Pauli noise [arXiv:2007.14384]. We extend these results
analytically to arbitrary completely-positive trace preserving maps in two
cases: 1) when a parameter-shift rule holds, 2) when the parameterized quantum
circuit at each layer forms a unitary -design. The second example shows how
highly expressive unitaries give rise not only to standard barren plateaus
[arXiv:1803.11173], but also to noise-induced ones. In the second part of the
paper, we study numerically the emergence of noise-induced barren plateaus in
QAOA circuits focusing on the case of MaxCut problems on -regular graphs and
amplitude damping noise.Comment: 34 pages, 9 Figures, added Refs. [31,32] and fixed typo in Eq (B.30
Meta-analyses of randomized controlled trials show suboptimal validity of surrogate outcomes for overall survival in advanced colorectal cancer
Comparative StudyMeta-AnalysisReviewValidation StudiesThis is the final version of the article. Available from Elsevier via the DOI in this record.OBJECTIVES: To quantify and compare the treatment effects on three surrogate end points, progression-free survival (PFS), time to progression (TTP), and tumor response rate (TR) vs. overall survival (OS) based on a meta-analysis of randomized controlled trials (RCTs) of drug interventions in advanced colorectal cancer (aCRC). STUDY DESIGN AND SETTING: We systematically searched for RCTs of pharmacologic therapies in aCRC between 2003 and 2013. Trial characteristics, risk of bias, and outcomes were recorded based on a predefined form. Univariate and multivariate random-effects meta-analyses were used to estimate pooled summary treatment effects. The ratio of hazard ratios (HRs)/odds ratios (ORs) and difference in medians were used to quantify the degree of difference in treatment effects on the surrogate end points and OS. Spearman ρ, surrogate threshold effect (STE), and R(2) were also estimated across predefined trial-level covariates. RESULTS: We included 101 RCTs. In univariate and multivariate meta-analyses, we found larger treatment effects for the surrogates than for OS. Compared with OS, treatment effects were on average 13% higher when HRs were measured and 3% to 45% higher when ORs were considered; differences in median PFS/TTP were higher than on OS by an average of 0.5 month. Spearman ρ ranged from 0.39 to 0.80, mean R(2) from 0.06 to 0.65, and STE was 0.8 for HRPFS, 0.64 for HRTTP, or 0.28 for ORTR. The stratified analyses revealed high variability across all strata. CONCLUSION: None of the end points in this study were found to achieve the level of evidence (ie, mean R(2)trial > 0.60) that has been set to select high or excellent correlation levels by common surrogate evaluation tools. Previous surrogacy relationships observed between PFS and TTP vs. OS in selected settings may not apply across other classes or lines of therapy
Microwave-activated gates between a fluxonium and a transmon qubit
We propose and analyze two types of microwave-activated gates between a
fluxonium and a transmon qubit, namely a cross-resonance (CR) and a CPHASE
gate. The large frequency difference between a transmon and a fluxonium makes
the realization of a two-qubit gate challenging. For a medium-frequency
fluxonium qubit, the transmon-fluxonium system allows for a cross-resonance
effect mediated by the higher levels of the fluxonium over a wide range of
transmon frequencies. This allows one to realize the cross-resonance gate by
driving the fluxonium at the transmon frequency, mitigating typical problems of
the cross-resonance gate in transmon-transmon chips related to frequency
targeting and residual ZZ coupling. However, when the fundamental frequency of
the fluxonium enters the low-frequency regime below 100 MHz, the
cross-resonance effect decreases leading to long gate times. For this range of
parameters, a fast microwave CPHASE gate can be implemented using the higher
levels of the fluxonium. In both cases, we perform numerical simulations of the
gate showing that a gate fidelity above 99% can be obtained with gate times
between 100 and 300 ns. Next to a detailed gate analysis, we perform a study of
chip yield for a surface code lattice of fluxonia and transmons interacting via
the proposed cross-resonance gate. We find a much better yield as compared to a
transmon-only architecture with the cross-resonance gate as native two-qubit
gate
The Dusty Starburst Nucleus of M33
We have thoroughly characterized the ultraviolet to near-infrared (0.15 - 2.2
micron) spectral energy distribution (SED) of the central parsec of the M33
nucleus through new infrared photometry and optical/near-infrared spectroscopy,
combined with ultraviolet/optical observations from the literature and the HST
archive. The SED shows evidence for a significant level of attenuation, which
we model through a Monte Carlo radiative transfer code as a shell of clumpy
Milky Way-type dust (tau_V ~ 2 +/- 1). The discovery of Milky Way-type dust
(with a strong 2175 A bump) internal to the M33 nucleus is different from
previous work which has found SMC-like dust (no bump) near starburst regions.
The amount by which dust can be processed may be related to the mass and age of
the starburst as well as the extent to which the dust can shield itself. Our
starburst models include the effects of this dust and can fit the SED if the
nucleus was the site of a moderate (~10^8 L_sun at 10 Myrs) episode of coeval
star formation about 70 Myrs ago. This result is quite different from previous
studies which resorted to multiple stellar populations (between 2 and 7)
attenuated by either no or very little internal dust. The M33 nuclear starburst
is remarkably similar to an older version (70 Myr versus 10 Myr) of the
ultra-compact starburst in the center of the Milky Way.Comment: 29 pages, 9 embedded figures, ApJ, in pres
Emergence of a non trivial fluctuating phase in the XY model on regular networks
We study an XY-rotor model on regular one dimensional lattices by varying the
number of neighbours. The parameter is defined.
corresponds to mean field and to nearest neighbours coupling. We
find that for the system does not exhibit a phase transition,
while for the mean field second order transition is recovered.
For the critical value , the systems can be in a non
trivial fluctuating phase for whichthe magnetisation shows important
fluctuations in a given temperature range, implying an infinite susceptibility.
For all values of the magnetisation is computed analytically in the
low temperatures range and the magnetised versus non-magnetised state which
depends on the value of is recovered, confirming the critical value
Fifteen shades of grey: combined analysis of genome-wide SNP data in steppe and mediterranean grey cattle sheds new light on the molecular basis of coat color
Coat color is among the most distinctive phenotypes in cattle. Worldwide, several breeds share peculiar coat color features such as the presence of a fawn pigmentation of the calf at birth, turning over time to grey, and sexual dichromatism. The aim of this study was to search for polymorphisms under differential selection by contrasting grey cattle breeds displaying the above phenotype with non-grey cattle breeds, and to identify the underlying genes. Using medium-density SNP array genotype data, a multi-cohort FST-outlier approach was adopted for a total of 60 pair-wise comparisons of the 15 grey with 4 non-grey cattle breeds (Angus, Limousin, Charolais, and Holstein), with the latter selected as representative of solid and piebald phenotypes, respectively. Overall, more than 50 candidate genes were detected; almost all were either directly or indirectly involved in pigmentation, and some of them were already known for their role in phenotypes related with hair graying in mammals. Notably, 17 relevant genes, including SDR16C5, MOS, SDCBP, and NSMAF, were located in a signal on BTA14 convergently observed in all the four considered scenarios. Overall, the key stages of pigmentation (melanocyte development, melanogenesis, and pigment trafficking/transfer) were all represented among the pleiotropic functions of the candidate genes, suggesting the complex nature of the grey phenotype in cattle
Sexually Antagonistic Selection in Human Male Homosexuality
Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling ‘Darwinian paradox’. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness), accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait
A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are unknown. Here we report that a long NAT (Mm-antiNos1 RNA) complementary to mRNA encoding the neuronal isoform of nitric oxide synthase (Nos1) is expressed in the mouse brain and is transcribed from the non-template strand of the Nos1 locus. Nos1 produces nitric oxide (NO), a major signaling molecule in the CNS implicated in many important functions including neuronal differentiation and memory formation. We show that the newly discovered NAT negatively regulates Nos1 gene expression. Moreover, our quantitative studies of the temporal expression profiles of Mm-antiNos1 RNA in the mouse brain during embryonic development and postnatal life indicate that it may be involved in the regulation of NO-dependent neurogenesis
Intralocus Sexual Conflict Diminishes the Benefits of Sexual Selection
Evolution based on the benefits of acquiring “good genes” in sexual selection is only plausible with the reliable transmission of genetic quality from one generation to the next. Accumulating evidence suggests that sexually antagonistic (SA) genes with opposite effects on Darwinian fitness when expressed in the two different sexes may be common in animals and plants. These SA genes should weaken the potential indirect genetic benefits of sexual selection by reducing the fitness of opposite-sex progeny from high-fitness parents. Here we use hemiclonal analysis in the fruit fly, Drosophila melanogaster, to directly measure the inheritance of fitness across generations, over the entire genome. We show that any potential genetic benefits of sexual selection in this system are not merely weakened, but completely reversed over one generation because high-fitness males produce low-fitness daughters and high-fitness mothers produce low-fitness sons. Moreover, male fitness was not inherited by sons, consistent with both theory and recent evidence connecting this form of SA variation with the X chromosome. This inheritance pattern may help to explain how genetic variation for fitness is sustained despite strong sexual selection, and why the ZW sex chromosome system found in birds and butterflies appears to foster the evolution of extreme secondary sexual characters in males
Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation:an individual-patient data meta-analysis of randomised trials
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordAIMS: To undertake an individual patient data (IPD) meta-analysis to assess the impact of exercise-based cardiac rehabilitation (ExCR) in patients with heart failure (HF) on mortality and hospitalisation, and differential effects of ExCR according to patient characteristics: age, sex, ethnicity, New York Heart Association functional class, ischaemic aetiology, ejection fraction, and exercise capacity. METHODS AND RESULTS: Randomised trials of exercise training for at least 3 weeks compared with no exercise control with 6-month follow-up or longer, providing IPD time to event on mortality or hospitalisation (all-cause or HF-specific). IPD were combined into a single dataset. We used Cox proportional hazards models to investigate the effect of ExCR and the interactions between ExCR and participant characteristics. We used both two-stage random effects and one-stage fixed effect models. IPD were obtained from 18 trials including 3912 patients with HF with reduced ejection fraction. Compared to control, there was no statistically significant difference in pooled time to event estimates in favour of ExCR although confidence intervals (CIs) were wide [all-cause mortality: hazard ratio (HR) 0.83, 95% CI 0.67-1.04; HF-specific mortality: HR 0.84, 95% CI 0.49-1.46; all-cause hospitalisation: HR 0.90, 95% CI 0.76-1.06; and HF-specific hospitalisation: HR 0.98, 95% CI 0.72-1.35]. No strong evidence was found of differential intervention effects across patient characteristics. CONCLUSION: Exercise-based cardiac rehabilitation did not have a significant effect on the risk of mortality and hospitalisation in HF with reduced ejection fraction. However, uncertainty around effect estimates precludes drawing definitive conclusions.This work is supported by UK National Institute for Health Research funding (HTA 15/80/30)
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