6,639 research outputs found
PySINDy: A comprehensive Python package for robust sparse system identification
Automated data-driven modeling, the process of directly discovering the governing equations of a system from data, is increasingly being used across the scientific community. PySINDy is a Python package that provides tools for applying the sparse identification of nonlinear dynamics (SINDy) approach to data-driven model discovery. In this major update to PySINDy, we implement several advanced features that enable the discovery of more general differential equations from noisy and limited data. The library of candidate terms is extended for the identification of actuated systems, partial differential equations (PDEs), and implicit differential equations. Robust formulations, including the integral form of SINDy and ensembling techniques, are also implemented to improve performance for real-world data. Finally, we provide a range of new optimization algorithms, including several sparse regression techniques and algorithms to enforce and promote inequality constraints and stability. Together, these updates enable entirely new SINDy model discovery capabilities that have not been reported in the literature, such as constrained PDE identification and ensembling with different sparse regression optimizers
Photochemical Methods for Peptide Macrocylization
Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field
Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed
A characteristic lengthscale causes anomalous size effects and boundary programmability in mechanical metamaterials
The architecture of mechanical metamaterialsis designed to harness geometry,
non-linearity and topology to obtain advanced functionalities such as shape
morphing, programmability and one-way propagation. While a purely geometric
framework successfully captures the physics of small systems under idealized
conditions, large systems or heterogeneous driving conditions remain
essentially unexplored. Here we uncover strong anomalies in the mechanics of a
broad class of metamaterials, such as auxetics, shape-changers or topological
insulators: a non-monotonic variation of their stiffness with system size, and
the ability of textured boundaries to completely alter their properties. These
striking features stem from the competition between rotation-based
deformations---relevant for small systems---and ordinary elasticity, and are
controlled by a characteristic length scale which is entirely tunable by the
architectural details. Our study provides new vistas for designing, controlling
and programming the mechanics of metamaterials in the thermodynamic limit.Comment: Main text has 4 pages, 4 figures + Methods and Supplementary
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A Versatile cascade of intramolecular vilsmeier-haack and azomethine ylide 1,3-dipolar cycloaddition toward tricyclic cores of alkaloids
Abstract: In the pursuit of synthetic efficiency, we developed an innovative one-pot transformation of linear substrates into bi- and tricyclic adducts using a
cascade of amide activation, nucleophilic cyclization, azomethine ylide generation, and subsequent inter- or intramolecular 1,3-dipolar cycloaddition.
Despite the high density and variety of functional groups on the substrates, the sequence occurred with perfect chemoselectivity with good to
excellent yields
Probing Electron-Phonon Interactions Away from the Fermi Level with Resonant Inelastic X-Ray Scattering
Interactions between electrons and lattice vibrations are responsible for a wide range of material properties and applications. Recently, there has been considerable interest in the development of resonant inelastic x-ray scattering (RIXS) as a tool for measuring electron-phonon (e-ph) interactions. Here, we demonstrate the ability of RIXS to probe the interaction between phonons and specific electronic states both near to, and away from, the Fermi level. We perform carbon K-edge RIXS measurements on graphite, tuning the incident x-ray energy to separately probe the interactions of the Ïâ and Ïâ electronic states. Our high-resolution data reveal detailed structure in the multiphonon RIXS features that directly encodes the momentum dependence of the e-ph interaction strength. We develop a Greenâs-function method to model this structure, which naturally accounts for the phonon and interaction-strength dispersions, as well as the mixing of phonon momenta in the intermediate state. This model shows that the differences between the spectra can be fully explained by contrasting trends of the e-ph interaction through the Brillouin zone, being concentrated at the Î and K points for the Ïâ states while being significant at all momenta for the Ïâ states. Our results advance the interpretation of phonon excitations in RIXS and extend its applicability as a probe of e-ph interactions to a new range of out-of-equilibrium situations
Social and cultural factors underlying generational differences in overweight: a cross-sectional study among ethnic minorities in the Netherlands
<p>Abstract</p> <p>Background</p> <p>The prevalence of overweight appears to vary in people of first and second generation ethnic minority groups. Insight into the factors that underlie these weight differences might help in understanding the health transition that is taking place across generations following migration. We studied the role of social and cultural factors associated with generational differences in overweight among young Turkish and Moroccan men and women in the Netherlands.</p> <p>Methods</p> <p>Cross-sectional data were derived from the LASER-study in which information on health-related behaviour and socio-demographic factors, level of education, occupational status, acculturation (cultural orientation and social contacts), religious and migration-related factors was gathered among Turkish and Moroccan men (n = 334) and women (n = 339) aged 15-30 years. Participants were interviewed during a home visit. Overweight was defined as a Body Mass Index â„ 25 kg/m<sup>2</sup>. Using logistic regression analyses, we tested whether the measured social and cultural factors could explain differences in overweight between first and second generation ethnic groups.</p> <p>Results</p> <p>Second generation women were less often overweight than first generation women (21.8% and 45.0% respectively), but this association was no longer significant when adjusting for the socioeconomic position (i.e. higher level of education) of second generation women (Odds Ratio (OR) = 0.77, 95%, Confidence Interval (CI) 0.40-1.46). In men, we observed a reversed pattern: second generation men were more often overweight than first generation men (32.7% and 27.8%). This association (OR = 1.89, 95% CI 1.09-3.24) could not be explained by the social and cultural factors because none of these factors were associated with overweight among men.</p> <p>Conclusions</p> <p>The higher socio-economic position of second generation Turkish and Moroccan women may partly account for the lower prevalence of overweight in this group compared to first generation women. Further research is necessary to elucidate whether any postulated socio-biological or other processes are relevant to the opposite pattern of overweight among men.</p
A short sequence for the iterative synthesis of fused polyethers
A simple and efficient fourâstep sequence for the synthesis of fused polyether arrays has been developed. Cyclic ethers are installed by sequential alkynyl ether formation, carbocupration, ringâclosing metathesis and hydroboration with acidic workup. Crucially, the alkene required for the subsequent ring formation by ringâclosing metathesis is present in the substrate but is masked in the form of a vinylic silane, which prevents competitive metathesis of the side chain. Generation of the reactive alkene from the unreactive vinylic silane is accomplished by hydroboration and subsequent acidâmediated Peterson elimination of the intermediate hydroxysilane
Characteristics of patients receiving allergy vaccination: to which extent do socio-economic factors play a role?
Background: Little is known about characteristics of patients receiving allergen-specific immunotherapy. Identifying obstacles to appropriate treatment according to guidelines may facilitate the development of strategies aiming at improved treatment of patients with allergic respiratory diseases. The objective of this study was to investigate differences in disease severity, demographic and socioeconomic status between allergic rhinitis patients receiving allergen-specific immunotherapy and allergic rhinitis patients not receiving allergen-specific immunotherapy. Methods: A total of 366 patients were studied of whom 210 were going to receive subcutaneously administrated immunotherapy (SIT) against grass pollen and/or house dust mite allergy. The severity of rhino-conjunctivitis (hay fever) and/or asthma was classified according to international guidelines. The questionnaires included an EQ-5D visual analogue scale instrument and some socio-economic questions. Results: Severity of disease, young age, high level of education as well as greater perceived impairment of health-related quality of life due to allergic symptoms were significantly associated with use of SIT. Somewhat unexpectedly, household income was not associated with use of SIT. Conclusion: Use of SIT was associated with both disease severity measures and educational level, but not income level. These results suggest social inequality as reflected by lower use of SIT among patients with lower educational level may represent an obstacle to treatment with SIT
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