Nonlinear spectral image fusion

In this paper we demonstrate that the framework of nonlinear spectral decompositions based on total variation (TV) regularization is very well suited for image fusion as well as more general image manipulation tasks. The well-localized and edge-preserving spectral TV decomposition allows to select frequencies of a certain image to transfer particular features, such as wrinkles in a face, from one image to another. We illustrate the effectiveness of the proposed approach in several numerical experiments, including a comparison to the competing techniques of Poisson image editing, linear osmosis, wavelet fusion and Laplacian pyramid fusion. We conclude that the proposed spectral TV image decomposition framework is a valuable tool for semi- and fully-automatic image editing and fusion

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

A yeast-based small molecule screen identifies a novel activator of human HSF1 and protein chaperone expression and which appears to alleviate the toxicity of protein misfolding diseases

A review of applying second-generation wavelets for noise removal from remote sensing data.

The processing of remotely sensed data includes compression, noise reduction, classification, feature extraction, change detection and any improvement associated with the problems at hand. In the literature, wavelet methods have been widely used for analysing remote sensing images and signals. The second-generation of wavelets, which is designed based on a method called the lifting scheme, is almost a new version of wavelets, and its application in the remote sensing field is fresh. Although first-generation wavelets have been proven to offer effective techniques for processing remotely sensed data, second-generation wavelets are more efficient in some respects, as will be discussed later. The aim of this review paper is to examine all existing studies in the literature related to applying second-generation wavelets for denoising remote sensing data. However, to make a better understanding of the application of wavelet-based denoising methods for remote sensing data, some studies that apply first-generation wavelets are also presented. In the part of hyperspectral data, there is a focus on noise removal from vegetation spectrum

Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics

Deciphering functional mechanisms of the Hsp90 chaperone machinery is an important objective in cancer biology aiming to facilitate discovery of targeted anti-cancer therapies. Despite significant advances in understanding structure and function of molecular chaperones, organizing molecular principles that control the relationship between conformational diversity and functional mechanisms of the Hsp90 activity lack a sufficient quantitative characterization. We combined molecular dynamics simulations, principal component analysis, the energy landscape model and structure-functional analysis of Hsp90 regulatory interactions to systematically investigate functional dynamics of the molecular chaperone. This approach has identified a network of conserved regions common to the Hsp90 chaperones that could play a universal role in coordinating functional dynamics, principal collective motions and allosteric signaling of Hsp90. We have found that these functional motifs may be utilized by the molecular chaperone machinery to act collectively as central regulators of Hsp90 dynamics and activity, including the inter-domain communications, control of ATP hydrolysis, and protein client binding. These findings have provided support to a long-standing assertion that allosteric regulation and catalysis may have emerged via common evolutionary routes. The interaction networks regulating functional motions of Hsp90 may be determined by the inherent structural architecture of the molecular chaperone. At the same time, the thermodynamics-based “conformational selection” of functional states is likely to be activated based on the nature of the binding partner. This mechanistic model of Hsp90 dynamics and function is consistent with the notion that allosteric networks orchestrating cooperative protein motions can be formed by evolutionary conserved and sparsely connected residue clusters. Hence, allosteric signaling through a small network of distantly connected residue clusters may be a rather general functional requirement encoded across molecular chaperones. The obtained insights may be useful in guiding discovery of allosteric Hsp90 inhibitors targeting protein interfaces with co-chaperones and protein binding clients