Investigation of Known Genetic Mutations of Arabian Horses in Egyptian Arabian Foals with Juvenile Idiopathic Epilepsy.

BackgroundThe carrier status of lavender foal syndrome (LFS), cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID), and occipitoatlantoaxial malformation (OAAM1) in foals with juvenile idiopathic epilepsy (JIE) is unknown.Hypothesis/objectivesTo determine the carrier status of LFS, CA, SCID, and OAAM1 in foals with JIE.AnimalsTen foals with JIE.Materials and methodsArchived DNA samples were tested for known genetic mutations causing LFS, CA, SCID, and OAAM1. The inclusion criteria consisted of having been diagnosed with JIE by ruling out other causes of seizures in foals and supported by electroencephalographic examination.ResultsTen Egyptian Arabian horses (5 females and 5 males) were phenotyped as foals with JIE by electroencephalography (EEG). All foals were negative for the genetic mutations that cause LFS, CA, SCID, and OAAM1 except for 1 foal that was a carrier of CA.Conclusions and clinical importanceJuvenile idiopathic epilepsy of Egyptian Arabian foals and LFS appear to be phenotypically and genetically distinct disorders. There was no apparent association between JIE and LFS, CA, SCID, and OAAM1

Functional Imaging of Stimulus Convergence in Amygdalar Neurons during Pavlovian Fear Conditioning

Background: Associative conditioning is a ubiquitous form of learning throughout the animal kingdom and fear conditioning is one of the most widely researched models for studying its neurobiological basis. Fear conditioning is also considered a model system for understanding phobias and anxiety disorders. A fundamental issue in fear conditioning regards the existence and location of neurons in the brain that receive convergent information about the conditioned stimulus (CS) and unconditioned stimulus (US) during the acquisition of conditioned fear memory. Convergent activation of neurons is generally viewed as a key event for fear learning, yet there has been almost no direct evidence of this critical event in the mammalian brain. Methodology/Principal Findings: Here, we used Arc cellular compartmental analysis of temporal gene transcription by fluorescence in situ hybridization (catFISH) to identify neurons activated during single trial contextual fear conditioning in rats. To conform to temporal requirements of catFISH analysis we used a novel delayed contextual fear conditioning protocol which yields significant single- trial fear conditioning with temporal parameters amenable to catFISH analysis. Analysis yielded clear evidence that a population of BLA neurons receives convergent CS and US information at the time of the learning, that this only occurs when the CS-US arrangement is supportive of the learning, and that this process requires N-methyl-D-aspartate receptor activation. In contrast, CS-US convergence was not observed in dorsal hippocampus

Gravitational waveforms from a point particle orbiting a Schwarzschild black hole

We numerically solve the inhomogeneous Zerilli-Moncrief and Regge-Wheeler equations in the time domain. We obtain the gravitational waveforms produced by a point-particle of mass $\mu$ traveling around a Schwarzschild black hole of mass M on arbitrary bound and unbound orbits. Fluxes of energy and angular momentum at infinity and the event horizon are also calculated. Results for circular orbits, selected cases of eccentric orbits, and parabolic orbits are presented. The numerical results from the time-domain code indicate that, for all three types of orbital motion, black hole absorption contributes less than 1% of the total flux, so long as the orbital radius r_p(t) satisfies r_p(t)> 5M at all times.Comment: revtex4, 24 pages, 23 figures, 3 tables, submitted to PR

The influence of semantic top-down processing in auditory verbal hallucinations

AbstractBackgroundAuditory verbal hallucinations (AVH) are one of the most prominent symptoms of schizophrenia but have also been reported in the general population. Several cognitive models have tried to elucidate the mechanism behind auditory verbal hallucinations, among which a top-down model. According to this model, perception is biased towards top-down information (e.g., expectations), reducing the influence of bottom-up information coming from the sense organs. This bias predisposes to false perceptions, i.e., hallucinations.MethodsThe current study investigated this hypothesis in non-psychotic individuals with frequent AVH, psychotic patients with AVH and healthy control subjects by applying a semantic top-down task. In this task, top-down processes are manipulated through the semantic context of a sentence. In addition, the association between hallucination proneness and semantic top-down errors was investigated.ResultsNon-psychotic individuals with AVH made significantly more top-down errors compared to healthy controls, while overall accuracy was similar. The number of top-down errors, corrected for overall accuracy, in the patient group was in between those of the other two groups and did not differ significantly from either the non-psychotic individuals with AVH or the healthy controls. The severity of hallucination proneness correlated with the number of top-down errors.DiscussionThese findings confirm that non-psychotic individuals with AVH are stronger influenced by top-down processing (i.e., perceptual expectations) than healthy controls. In contrast, our data suggest that in psychotic patients semantic expectations do not play a role in the etiology of AVH. This finding may point towards different cognitive mechanisms for pathological and nonpathological hallucinations

The Cesàro operator in growth Banach spaces of analytic functions

[EN] The CesA ro operator C, when acting in the classical growth Banach spaces and , for , of analytic functions on , is investigated. Based on a detailed knowledge of their spectra (due to A. Aleman and A.-M. Persson) we are able to determine the norms of these operators precisely. It is then possible to characterize the mean ergodic and related properties of C acting in these spaces. In addition, we determine the largest Banach space of analytic functions on which C maps into (resp. into ); this optimal domain space always contains (resp. ) as a proper subspace.The research of the first two authors was partially supported by the projects MTM2013-43540-P and GVA Prometeo II/2013/013.Albanese, A.; Bonet Solves, JA.; Ricker, WJ. (2016). The Cesàro operator in growth Banach spaces of analytic functions. Integral Equations and Operator Theory. 86(1):97-112. https://doi.org/10.1007/s00020-016-2316-zS97112861Albanese A.A., Bonet J., Ricker W.J.: Convergence of arithmetic means of operators in Fréchet spaces. J. Math. Anal. Appl. 401, 160–173 (2013)Albanese, A.A., Bonet, J.,Ricker, W.J.: The Cesàro operator on power series spaces. Preprint (2016)Albrecht E., Miller T.L., Neumann M.M.: Spectral properties of generalized Cesàro operators on Hardy and weighted Bergman spaces. Archiv Math. 85, 446–459 (2005)Aleman A.: A class of integral operators on spaces of analytic functions. In: Proc. of the Winter School in Operator Theory and Complex Analysis, Univ. Málaga Secr. Publ., Málaga, pp. 3–30 (2007)Aleman A., Constantin O.: Spectra of integration operators on weighted Bergman spaces. J. Anal. Math. 109, 199–231 (2009)Aleman A., Persson A.-M.: Resolvent estimates and decomposable extensions of generalized Cesàro operators. J. Funct. Anal. 258, 67–98 (2010)Aleman A., Siskakis A.G.: An integral operator on H p . Complex Var. Theory Appl. 28, 149–158 (1995)Aleman A., Siskakis A.G.: Integration operators on Bergman spaces. Indiana Univ. Math. J. 46, 337–356 (1997)Bayart F., Matheron E.: Dynamics of Linear Operators. Cambridge University Press, Cambridge (2009)Bierstedt K.D., Bonet J., Galbis A.: Weighted spaces of holomorphic functions on balanced domains. Michigan Math. J. 40, 271–297 (1993)Bierstedt K.D., Bonet J., Taskinen J.: Associated weights and spaces of holomorphic functions. Studia Math. 127, 137–168 (1998)Bierstedt, K.D., Summers, W.H.: Biduals of weighted Banach spaces of analytic functions. J. Aust. Math. Soc. 54, 70–79 (1993)Bonet J., Domanski P., Lindström M.: Essential norm and weak compactness on weighted Banach spaces of analytic functions. Can. Math. Bull. 42, 139–148 (1999)Curbera G.P., Ricker W.J.: Extensions of the classical Cesàro operator on Hardy spaces. Math. Scand. 108, 279–290 (2011)Danikas N., Siskakis A.: The Cesàro operator on bounded analytic functions. Analysis 13, 295–299 (1993)Duren P.: Theory of H p Spaces. Academic Press, New York (1970)Dunford N., Schwartz J.T.:Linear Operators I: General Theory, 2nd Printing. Wiley Interscience Publ., New York (1964)Grosse-Erdmann K., Peris A.: Linear Chaos. Springer, London (2011)Harutyunyan A., Lusky W.: On the boundedness of the differentiation operator between weighted spaces of holomorphic functions. Studia Math. 184, 233–247 (2008)Hedenmalm H., Korenblum B., Zhu K.: Theory of Bergman Spaces. Grad. Texts in Math., vol. 199. Springer, New York (2000)Katzelson Y., Tzafriri L.: On power bounded operators. J. Funct. Anal. 68, 313–328 (1968)Krengel U.: Ergodic Theorems. de Gruyter Studies in Mathematics, vol. 6. Walter de Gruyter Co., Berlin (1985)Lin M.: On the uniform ergodic theorem. Proc. Am. Math. Soc. 43, 337–340 (1974)Lusky W.: On the isomorphism classes of weighted spaces of harmonic and holomorphic functions. Studia Math. 175(1), 19–40 (2006)Megginson R.E.: An Introduction to Banach Space Theory. Springer, New York (1998)Meise R., Vogt D.: Introduction to Functional Analysis. Clarendon Press, Oxford (1997)Persson A.-M.: On the spectrum of the Cesàro operator on spaces of analytic functions. J. Math. Anal. Appl. 340, 1180–1203 (2008)Rubel L.A., Shields A.L.: The second dual of certain spaces of analytic functions. J. Aust. Math. Soc. 11, 276–280 (1970)Shields A.L., Williams D.L.: Bounded projections, duality and multipliers in spaces of analytic functions. Trans. Am. Math. Soc. 162, 287–302 (1971)Siskakis A.: Volterra operators on spaces of analytic functions—a survey. In: Proc. of the First Advanced Course in Operator Theory and Complex Analysis, Univ. Sevilla Serc. Publ., Seville, pp. 51–68 (2006

Photoelectron angular distributions in photodetachment from P-

The angular distributions of electrons ejected in laser photodetachment of the P- ion have been studied in the photon energy range of 0.95-3.28 eV using a photoelectron spectrometer designed to accommodate a source consisting of collinearly overlapping photon and negative ion beams. We observe the value of the asymmetry parameter β starting at zero near the threshold, falling to almost -1 about 0.5 eV above the threshold and eventually rising to a positive value. The experimental data has been fitted to a simplified model of the Cooper-Zare formula which yields a qualitative understanding of the quantum interference between the outgoing s and d waves representing the free electron. The present results are also compared with previous results for other elements involving p-electron photodetachment

Systematic profiling of Caenorhabditis elegans locomotive behaviors reveals additional components in G-protein Gαq signaling

Genetic screens have been widely applied to uncover genetic mechanisms of movement disorders. However, most screens rely on human observations of qualitative differences. Here we demonstrate the application of an automatic imaging system to conduct a quantitative screen for genes regulating the locomotive behavior in Caenorhabditis elegans. Two hundred twenty-seven neuronal signaling genes with viable homozygous mutants were selected for this study. We tracked and recorded each animal for 4 min and analyzed over 4,400 animals of 239 genotypes to obtain a quantitative, 10-parameter behavioral profile for each genotype. We discovered 87 genes whose inactivation causes movement defects, including 50 genes that had never been associated with locomotive defects. Computational analysis of the high-content behavioral profiles predicted 370 genetic interactions among these genes. Network partition revealed several functional modules regulating locomotive behaviors, including sensory genes that detect environmental conditions, genes that function in multiple types of excitable cells, and genes in the signaling pathway of the G protein Gαq, a protein that is essential for animal life and behavior. We developed quantitative epistasis analysis methods to analyze the locomotive profiles and validated the prediction of the γ isoform of phospholipase C as a component in the Gαq pathway. These results provided a system-level understanding of how neuronal signaling genes coordinate locomotive behaviors. This study also demonstrated the power of quantitative approaches in genetic studies

Extreme Mass Ratio Inspirals: LISA's unique probe of black hole gravity

In this review article I attempt to summarise past and present-ongoing-work on the problem of the inspiral of a small body in the gravitational field of a much more massive Kerr black hole. Such extreme mass ratio systems, expected to occur in galactic nuclei, will constitute prime sources of gravitational radiation for the future LISA gravitational radiation detector. The article's main goal is to provide a survey of basic celestial mechanics in Kerr spacetime and calculations of gravitational waveforms and backreaction on the small body's orbital motion, based on the traditional `flux-balance' method and the Teukolsky black hole perturbation formalism.Comment: Invited review article, 45 pages, 23 figure

Herschel Planetary Nebula Survey (HerPlaNS) - First Detection of OH+ in Planetary Nebulae

We report the first detections of OH$^+$ emission in planetary nebulae (PNe). As part of an imaging and spectroscopy survey of 11 PNe in the far-IR using the PACS and SPIRE instruments aboard the Herschel Space Observatory, we performed a line survey in these PNe over the entire spectral range between 51 and 672$\mu$m to look for new detections. OH$^+$ rotational emission lines at 152.99, 290.20, 308.48, and 329.77$\mu$m were detected in the spectra of three planetary nebulae: NGC 6445, NGC 6720, and NGC 6781. Excitation temperatures and column densities derived from these lines are in the range of 27 to 47 K and 2$\times$10$^{10}$ to 4 $\times$10$^{11}$ cm$^{-2}$, respectively. In PNe, the OH+ rotational line emission appears to be produced in the photodissociation region (PDR) in these objects. The emission of OH+ is observed only in PNe with hot central stars (T$_{eff}$ > 100000 K), suggesting that high-energy photons may play a role in the OH+ formation and its line excitation in these objects, as it seems to be the case for ultraluminous galaxies.Comment: 9 pages, 7 figures; accepted for publication in A&

A Statistical Inference Method for Interpreting the CLASP Observations

On 3rd September 2015, the Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) successfully measured the linear polarization produced by scattering processes in the hydrogen Lyman-$\alpha$ line of the solar disk radiation, revealing conspicuous spatial variations in the $Q/I$ and $U/I$ signals. Via the Hanle effect the line-center $Q/I$ and $U/I$ amplitudes encode information on the magnetic field of the chromosphere-corona transition region (TR), but they are also sensitive to the three-dimensional structure of this corrugated interface region. With the help of a simple line formation model, here we propose a statistical inference method for interpreting the Lyman-$\alpha$ line-center polarization observed by CLASP.Comment: Accepted for publication in The Astrophysical Journa