3,803 research outputs found
Phase statistics of seismic coda waves
We report the analysis of the statistics of the phase fluctuations in the
coda of earthquakes recorded during a temporary experiment deployed at Pinyon
Flats Observatory, California. The practical measurement of the phase is
discussed and the main pitfalls are underlined. For large values, the
experimental distributions of the phase first, second and third derivatives
obey universal power-law decays whose exponents are remarkably well predicted
by circular Gaussian statistics. For small values, these distributions are
flat. The details of the transition between the plateau and the power-law
behavior are governed by the wavelength. The correlation function of the first
phase derivative along the array shows a simple algebro-exponential decay with
the mean free path as the only length scale. Although only loose bounds are
provided in this study, our work suggests a new method to estimate the degree
of heterogeneity of the crComment: 4 figures, submitted to Physical Review Letter
Optical Coronagraphic Spectroscopy of AU Mic: Evidence of Time Variable Colors?
We present coronagraphic long slit spectra of AU Mic's debris disk taken with
the STIS instrument aboard the Hubble Space Telescope (HST). Our spectra are
the first spatially resolved, scattered light spectra of the system's disk,
which we detect at projected distances between approximately 10 and 45 AU. Our
spectra cover a wavelength range between 5200 and 10200 angstroms. We find that
the color of AU Mic's debris disk is bluest at small (12-35 AU) projected
separations. These results both confirm and quantify the findings qualitatively
noted by Krist et al. (2005), and are different than IR observations that
suggested a uniform blue or gray color as a function of projected separation in
this region of the disk. Unlike previous literature that reported the color of
AU Mic's disk became increasingly more blue as a function of projected
separation beyond approximately 30 AU, we find the disk's optical color between
35-45 AU to be uniformly blue on the southeast side of the disk and
decreasingly blue on the northwest side. We note that this apparent change in
disk color at larger projected separations coincides with several fast, outward
moving "features" that are passing through this region of the southeast side of
the disk. We speculate that these phenomenon might be related, and that the
fast moving features could be changing the localized distribution of sub-micron
sized grains as they pass by, thereby reducing the blue color of the disk in
the process. We encourage follow-up optical spectroscopic observations of the
AU Mic to both confirm this result, and search for further modifications of the
disk color caused by additional fast moving features propagating through the
disk.Comment: Accepted by AJ, 13 pages, 8 figures, 1 tabl
Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo)
Abstract
Background
Pregnancy-associated plasma protein A2 (PAPPA2) is an insulin-like growth factor-binding protein (IGFBP) protease expressed at high levels in the placenta and upregulated in pregnancies complicated by preeclampsia and HELLP (Hemolytic anemia, Elevated Liver enzymes, and Low Platelet count) syndrome. However, it is unclear whether elevated PAPPA2 expression causes abnormal placental development, or whether upregulation compensates for placental pathology. In the present study, we investigate whether PAPPA2 expression is affected by hypoxia, oxidative stress, syncytialization factors or substances known to affect the expression of PAPPA2's paralogue, PAPPA.
Methods
BeWo cells, a model of placental trophoblasts, were treated with one of the following: hypoxia (2% O2), oxidative stress (20 microM hydrogen peroxide), forskolin (10 microM and 100 microM), TGF-beta (10 and 50 ng/mL), TNF-alpha (100 ng/mL), IL-1beta (100 ng/mL) or PGE2 (1 microM). We used quantitative RT-PCR (qRT-PCR) to quantify the mRNA levels of PAPPA2, as well as those of PAPPA and ADAM12 since these proteases have similar substrates and are also highly expressed in the placenta. Where we observed significant effects on PAPPA2 mRNA levels, we tested for effects at the protein level using an in-cell Western assay.
Results
Hypoxia, but not oxidative stress, caused a 47-fold increase in PAPPA2 mRNA expression, while TNF-alpha resulted in a 6-fold increase, and both of these effects were confirmed at the protein level. PGE2 resulted in a 14-fold upregulation of PAPPA2 mRNA but this was not reflected at the protein level. Forskolin, TGF-beta and IL-1beta had no significant effect on PAPPA2 mRNA expression. We observed no effects of any treatment on PAPPA or ADAM12 expression.
Conclusion
Our study demonstrates that factors previously known to be highly expressed in preeclamptic placentae (PGE2 and TNF-alpha), contribute to the upregulation of PAPPA2. Hypoxia, known to occur in preeclamptic placentae, also increased PAPPA2 expression. These results are consistent with the hypothesis that PAPPA2 is upregulated as a consequence of placental pathology, rather than elevated PAPPA2 levels being a cause of preeclampsia.
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Quasinormal ringing of acoustic black holes in Laval nozzles: Numerical simulations
Quasinormal ringing of acoustic black holes in Laval nozzles is discussed.
The equation for sounds in a transonic flow is written into a
Schr\"{o}dinger-type equation with a potential barrier, and the quasinormal
frequencies are calculated semianalytically. From the results of numerical
simulations, it is shown that the quasinormal modes are actually excited when
the transonic flow is formed or slightly perturbed, as well as in the real
black hole case. In an actual experiment, however, the purely-outgoing boundary
condition will not be satisfied at late times due to the wave reflection at the
end of the apparatus, and a late-time ringing will be expressed as a
superposition of "boxed" quasinormal modes. It is shown that the late-time
ringing damps more slowly than the ordinary quasinormal ringing, while its
central frequency is not greatly different from that of the ordinary one. Using
this fact, an efficient way for experimentally detecting the quasinormal
ringing of an acoustic black hole is discussed.Comment: 9 pages, 8 figures, accepted for publication in Physical Review
A Two-Threshold Model for Scaling Laws of Non-Interacting Snow Avalanches
The sizes of snow slab failure that trigger snow avalanches are power-law
distributed. Such a power-law probability distribution function has also been
proposed to characterize different landslide types. In order to understand this
scaling for gravity driven systems, we introduce a two-threshold 2-d cellular
automaton, in which failure occurs irreversibly. Taking snow slab avalanches as
a model system, we find that the sizes of the largest avalanches just
preceeding the lattice system breakdown are power law distributed. By tuning
the maximum value of the ratio of the two failure thresholds our model
reproduces the range of power law exponents observed for land-, rock- or snow
avalanches. We suggest this control parameter represents the material cohesion
anisotropy.Comment: accepted PR
Torsional nodeless vibrations of quaking neutron star restored by combined forces of shear elastic and magnetic field stresses
Within the framework of Newtonian magneto-solid-mechanics, relying on
equations appropriate for a perfectly conducting elastic continuous medium
threaded by a uniform magnetic field, the asteroseismic model of a neutron star
undergoing axisymmetric global torsional nodeless vibrations under the combined
action of Hooke's elastic and Lorentz magnetic forces is considered with
emphasis on a toroidal Alfv\'en mode of differentially rotational vibrations
about the dipole magnetic moment axis of the star. The obtained spectral
equation for frequency is applied to -pole identification of
quasi-periodic oscillations (QPOs) of X-ray flux during the giant flares of SGR
1806-20 and SGR 1900+14. Our calculations suggest that detected QPOs can be
consistently interpreted, within the framework of this model, as produced by
global torsional nodeless vibrations of quaking magnetar if they are considered
to be restored by the joint action of bulk forces of shear elastic and magnetic
field stresses.Comment: 18 pages, 5 figures; accepted in Ap
Attenuation of dispersed waves
A measure of the absorption of elastic waves is the specific absorption coefficient 1/Q. In dispersive mediums, whether the dispersion is due to geometry, inhomogeneity, or both, measurements are often made outside the body and the measurements must be interpreted as to the distribution of values of 1/Q within the body.
Two definitive experiments of this type are those performed using standing waves set up in a confined sample of the body and with waves that propagate through or on the surface of the body. Typical examples of these experiments involve the measurement of the damping coefficient of the free modes of vibration of the earth and the measurement of the attenuation factor of propagating surface waves on the earth. These two types of experiments can themselves be interpreted in terms of dimensionless attenuation factors. We call the dimensionless attenuation factors in the standing wave and propagating wave experiments 1/Q_T and 1/Q_x, defined as the logarithmic decrements π/QT and π/Q_x in each experiment. Then in a damped standing wave the amplitude will diminish with time t at a fixed point as exp (−πt/TQ_T), where T is the period. In a propagating monochromatic wave the amplitude will diminish with distance x as exp (−πx/cTQ_x), where c is the phase velocity
R-Process Nucleosynthesis in MHD Jet Explosions of Core-Collapse Supernovae
We investigate -process nucleosynthesis during the magnetohydrodynamical
(MHD) explosion of supernova in a massive star of 13 . Contrary to
the case of the spherical explosion, jet-like explosion due to the combined
effects of the rotation and magnetic field lowers the electron fraction
significantly inside the layers above the iron core. We find that the ejected
material of low electron fraction responsible for the -process comes out
from the silicon rich layer of the presupernova model. This leads to the
production up to the third peak in the solar -process elements. We examine
whether the fission affects the -process paths by using the full nuclear
reaction network with both the spontaneous and -delayed fission
included. Moreover, we pay particular attention how the mass formula affects
the -process peaks with use of two mass formulae. It is found that both
formulae can reproduce the global abundance pattern up to the third peak though
detailed distributions are rather different. We point out that there are
variations in the -process nucleosynthesis if the MHD effects play an
important role in the supernova explosion.Comment: 19 pages with 7 figures, submitted to Ap
Seismic imaging of hydraulically-stimulated fractures: A numerical study of the effect of the source mechanism
We present a numerical study of seismic imaging of hydraulically stimulated fractures using a single source from an adjacent fracturing-process. The source is either a point force generated from the perforation of the casing of the well or a double-couple as is typically observed from the induced microseismicity. We assume that the fracture is sufficiently stimulated to be imaged by reflected seismic energy. We show for a specific monitoring geometry of hydrofracturing that not only different waves (P and S) but also different source mechanisms from the same region form an image of different parts of the target fracture and thus add complementary information. The strategy presented here might be used as an additional monitoring tool of the hydrofracturing process
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