57 research outputs found
Mathematics and Medicine: How mathematics, modelling and simulations can lead to better diagnosis and treatments
Starting with the discovery of X-rays by Röntgen in 1895, the progress in medical imaging has been extraordinary and immensely beneficial to diagnosis and therapy. Parallel to the increase of imaging accuracy, there is the quest of moving from qualitative to quantitative analysis and patient-tailored therapy. Mathematics, modelling and simulations are increasing their importance as tools in this quest. In this paper we give an overview of relations between mathematical modelling and imaging and focus particularly on the estimation of perfusion in the brain. In the forward model, the brain is treated as a porous medium and a two compartment model (arterial/venous) is used. Motivated by the similarity with techniques in reservoir modelling, we propose an ensemble Kalman filter to perform the parameter estimation and apply the method to a simple example as an illustrative example.acceptedVersio
Extranets of National Tourist Organisations: The Internet and planned Extranet Web-site of the Danish Tourist Board — compared with existing or planned Extranets of Australia, Austria and Norway
Attenuation of morphine-induced antinociception by L-glutamic acid at the spinal site in rats
Adjustment of Circadian Rhythms and EEG Sleep Functions to Day and Night Sleep Among Permanent Nightworkers and Rotating Shiftworkers
Value of information in closed-loop reservoir management
This paper proposes a new methodology to perform value of information (VOI) analysis within a closed-loop reservoir management (CLRM) framework. The workflow combines tools such as robust optimization and history matching in an environment of uncertainty characterization. The approach is illustrated with two simple examples: an analytical reservoir toy model based on decline curves and a water flooding problem in a two-dimensional five-spot reservoir. The results are compared with previous work on other measures of information valuation, and we show that our method is a more complete, although also more computationally intensive, approach to VOI analysis in a CLRM framework. We recommend it to be used as the reference for the development of more practical and less computationally demanding tools for VOI assessment in real fields.Geoscience & EngineeringCivil Engineering and Geoscience
Online group interaction and mental health: An analysis of three online discussion forums
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