5,300 research outputs found
Boltzmann Generators: Sampling Equilibrium States of Many-Body Systems with Deep Learning
Computing equilibrium states in condensed-matter many-body systems, such as solvated proteins, is a long-standing challenge. Lacking methods for generating statistically independent equilibrium samples directly, vast computational effort is invested for simulating these system in small steps, e.g., using Molecular Dynamics. Combining deep learning and statistical mechanics, we here develop Boltzmann Generators, that are shown to generate statistically independent samples of equilibrium states of representative condensed matter systems and complex polymers. Boltzmann Generators use neural networks to learn a coordinate transformation of the complex configurational equilibrium distribution to a distribution that can be easily sampled. Accurate computation of free energy differences, and discovery of new system states are demonstrated, providing a new statistical mechanics tool that performs orders of magnitude faster than standard simulation methods
Boltzmann Generators: Sampling Equilibrium States of Many-Body Systems with Deep Learning
Computing equilibrium states in condensed-matter many-body systems, such as solvated proteins, is a long-standing challenge. Lacking methods for generating statistically independent equilibrium samples directly, vast computational effort is invested for simulating these system in small steps, e.g., using Molecular Dynamics. Combining deep learning and statistical mechanics, we here develop Boltzmann Generators, that are shown to generate statistically independent samples of equilibrium states of representative condensed matter systems and complex polymers. Boltzmann Generators use neural networks to learn a coordinate transformation of the complex configurational equilibrium distribution to a distribution that can be easily sampled. Accurate computation of free energy differences, and discovery of new system states are demonstrated, providing a new statistical mechanics tool that performs orders of magnitude faster than standard simulation methods
Extraction of the electron mass from factor measurements on light hydrogenlike ions
The determination of the electron mass from Penning-trap measurements with
C ions and from theoretical results for the bound-electron
factor is described in detail. Some recently calculated contributions slightly
shift the extracted mass value. Prospects of a further improvement of the
electron mass are discussed both from the experimental and from the theoretical
point of view. Measurements with He ions will enable a consistency
check of the electron mass value, and in future an improvement of the He
nuclear mass and a determination of the fine-structure constant
Towards a fully self-consistent spectral function of the nucleon in nuclear matter
We present a calculation of nuclear matter which goes beyond the usual
quasi-particle approximation in that it includes part of the off-shell
dependence of the self-energy in the self-consistent solution of the
single-particle spectrum. The spectral function is separated in contributions
for energies above and below the chemical potential. For holes we approximate
the spectral function for energies below the chemical potential by a
-function at the quasi-particle peak and retain the standard form for
energies above the chemical potential. For particles a similar procedure is
followed. The approximated spectral function is consistently used at all levels
of the calculation. Results for a model calculation are presented, the main
conclusion is that although several observables are affected by the inclusion
of the continuum contributions the physical consistency of the model does not
improve with the improved self-consistency of the solution method. This in
contrast to expectations based on the crucial role of self-consistency in the
proofs of conservation laws.Comment: 26 pages Revtex with 4 figures, submitted to Phys. Rev.
Design of a Microstructured System for Homogenization of Dairy Products with High Fat Content
High pressure homogenization of dairy products is today state of the art but limited by the fat content (max 17 vol.-%). This article describes the development of a novel simultaneous homogenization and mixing (SHM) valve which allows homogenization of dairy products with a fat content of up to 42 vol.-%. The challenging task of homogenizing dairy products with high fat content is to stabilize disrupted fat droplets especially against extensive aggregation. Aggregation and coalescence rates could be significantly reduced by a new microstructured valve allowing the emulsifier-containing phase to be injected directly into the zone of droplet disruption
The Nucleon Spectral Function at Finite Temperature and the Onset of Superfluidity in Nuclear Matter
Nucleon selfenergies and spectral functions are calculated at the saturation
density of symmetric nuclear matter at finite temperatures. In particular, the
behaviour of these quantities at temperatures above and close to the critical
temperature for the superfluid phase transition in nuclear matter is discussed.
It is shown how the singularity in the thermodynamic T-matrix at the critical
temperature for superfluidity (Thouless criterion) reflects in the selfenergy
and correspondingly in the spectral function. The real part of the on-shell
selfenergy (optical potential) shows an anomalous behaviour for momenta near
the Fermi momentum and temperatures close to the critical temperature related
to the pairing singularity in the imaginary part. For comparison the selfenergy
derived from the K-matrix of Brueckner theory is also calculated. It is found,
that there is no pairing singularity in the imaginary part of the selfenergy in
this case, which is due to the neglect of hole-hole scattering in the K-matrix.
From the selfenergy the spectral function and the occupation numbers for finite
temperatures are calculated.Comment: LaTex, 23 pages, 21 PostScript figures included (uuencoded), uses
prc.sty, aps.sty, revtex.sty, psfig.sty (last included
2-Amino-4-aryl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitriles with Microtubule-Disruptive, Centrosome-Declustering, and Antiangiogenic Effects in vitro and in vivo
A series of fifteen 2‐amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles (1 a–o) were synthesized via a three‐component reaction of 4‐hydroxycoumarin, malononitrile, and diversely substituted benzaldehydes or pyridine carbaldehydes. The compounds were tested for anticancer activities against a panel of eight human tumor cell lines. A few derivatives with high antiproliferative activities and different cancer cell specificity were identified and investigated for their modes of action. They led to microtubule disruption, centrosome de‐clustering and G2/M cell cycle arrest in 518 A2 melanoma cells. They also showed anti‐angiogenic effects in vitro and in vivo
Features of water chemical composition of oligotrophic and eutrophic bogs in the South of the Tomsk region
On the basis of the actual material the analysis of chemical composition of bog waters in the territory of the South of the Tomsk region is carried out. The data on average concentration of macro and trace components, organic matter, pH of bog waters are obtained. Significant distinctions in a chemical composition of surface water for different types of bogs are revealed. The composition and macrostructure of humic acids by the example of eutrophic bogs is studied
A High-Resolution Combined Scanning Laser- and Widefield Polarizing Microscope for Imaging at Temperatures from 4 K to 300 K
Polarized light microscopy, as a contrast-enhancing technique for optically
anisotropic materials, is a method well suited for the investigation of a wide
variety of effects in solid-state physics, as for example birefringence in
crystals or the magneto-optical Kerr effect (MOKE). We present a microscopy
setup that combines a widefield microscope and a confocal scanning laser
microscope with polarization-sensitive detectors. By using a high numerical
aperture objective, a spatial resolution of about 240 nm at a wavelength of 405
nm is achieved. The sample is mounted on a He continuous flow cryostat
providing a temperature range between 4 K and 300 K, and electromagnets are
used to apply magnetic fields of up to 800 mT with variable in-plane
orientation and 20 mT with out-of-plane orientation. Typical applications of
the polarizing microscope are the imaging of the in-plane and out-of-plane
magnetization via the longitudinal and polar MOKE, imaging of magnetic flux
structures in superconductors covered with a magneto-optical indicator film via
Faraday effect or imaging of structural features, such as twin-walls in
tetragonal SrTiO. The scanning laser microscope furthermore offers the
possibility to gain local information on electric transport properties of a
sample by detecting the beam-induced voltage change across a current-biased
sample. This combination of magnetic, structural and electric imaging
capabilities makes the microscope a viable tool for research in the fields of
oxide electronics, spintronics, magnetism and superconductivity.Comment: 14 pages, 11 figures. The following article has been accepted by
Review of Scientific Instruments. After it is published, it will be found at
http://aip.scitation.org/journal/rs
- …