Assessment of the evolution of the redox conditions in a low and intermediate level nuclear waste repository (SFR1, Sweden)

The evaluation of the redox conditions in an intermediate and low level radioactive waste repository such as SFR1 (Sweden) is of high relevance in the assessment of its future performance. The SFR1 repository contains heterogeneous types of wastes, of different activity levels and with very different materials, both in the waste itself and as immobilisation matrices and packaging. The level of complexity also applies to the different reactivity of the materials, so that an assessment of the uncertainties in the study of how the redox conditions would evolve must consider different processes, materials and parameters. This paper provides an assessment of the evolution of the redox conditions in the SFR1. The approach followed is based on the evaluation of the evolution of the redox conditions and the reducing capacity in 15 individual waste package types, selected as being representative of most of the different waste package types present or planned to be deposited in the SFR1. The model considers different geochemical processes of redox relevance in the system. The assessment of the redox evolution of the different vaults of the repository is obtained by combining the results of the modelled individual waste package types. According to the model results, corrosion of the steel-based material present in the repository keeps the system under reducing conditions for long time periods. The simulations have considered both the presence and the absence of microbial activity. In the initial step after the repository closure, the microbial mediated oxidation of organic matter rapidly causes the depletion of oxygen in the system. The system is afterwards kept under reducing conditions, and hydrogen is generated due to the anoxic corrosion of steel. The times for exhaustion of the steel contained in the vaults vary from 5 ky to more than 60 ky in the different vaults, depending on the amount and the surface area of steel. After the complete corrosion of steel, the system still keeps a high reducing capacity, due to the magnetite formed as steel corrosion product. The redox potential in the vaults is calculated to evolve from oxidising at very short times, due the initial oxygen content, to very reducing at times shorter than 5 years after repository closure. The redox potential imposed by the anoxic corrosion of steel and hydrogen production is on the order of -0.75 V at pH 12.5. In case of assuming that the system responds to the Fe(III)/Magnetite system, and considering the uncertainty in the pH due to the degradation of the concrete barriers, the redox potential would be in the range -0.7 to -0.01V. A Monte-Carlo probabilistic analysis on the rate of corrosion of steel shows that the reducing capacity of the system provided by magnetite is not exhausted at the end of the assessment period, even assuming the highest corrosion rates for steel. Simulations assuming presence of oxic water due to glacial melting, intruding the system 60 ky after repository closure, indicate that magnetite is progressively oxidised, forming Fe(III) oxides. The time at which magnetite is completely oxidised varies depending on the amount of steel initially present in the waste package. The behaviour of Np, Pu, Tc and Se under the conditions foreseen for this repository is discussed

Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice.

Macrophage migration inhibitory factor (MIF) has recently been forwarded as a critical regulator of inflammatory conditions, and it has been hypothesized that MIF may have a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Hence, we examined effects of MIF immunoneutralization on the development of allergen-induced eosinophilic inflammation as well as on lipopolysaccharide (LPS)-induced neutrophilic inflammation in lungs of mice. Anti-MIF serum validated with respect to MIF neutralizing capacity or normal rabbit serum (NRS) was administered i.p. repeatedly during allergen aerosol exposure of ovalbumin (OVA)-immunized mice in an established model of allergic asthma, or once before instillation of a minimal dose of LPS into the airways of mice, a tentative model of COPD. Anti-MIF treatment did not affect the induced lung tissue eosinophilia or the cellular composition of bronchoalveolar lavage fluid (BALF) in the asthma model. Likewise, anti-MIF treatment did not affect the LPS-induced neutrophilia in lung tissue, BALF, or blood, nor did it reduce BALF levels of tumor necrosis factor-alpha (TNF-alpha) and macrophage inflammatory protein-1alpha (MIP-1alpha). The present data suggest that MIF is not critically important for allergen-induced eosinophilic, and LPS-induced neutrophilic responses in lungs of mice. These findings do not support a role of MIF inhibition in the treatment of inflammatory respiratory diseases

Om illegal jakt i Fennoskandia

Ett ökat missnöje bland delar av landsbygdsbefolkningen och jägarsamhället gentemot bevarandepolitiken för stora rovdjur har påverkat den sociopolitiskt motiverade illegala jakten på dessa arter. Denna typ av jaktbrott har legat som grund för undersökningen i ett tvärvetenskapligt internationellt samarbetsprojekt lett av forskare vid Sveriges lantbruksuniversitet, vid Ultuna. Efter tre år av djupintervjuer med jägare, en enkätundersökning, jämförelser med andra delar av världen och nära samarbete med forskare i Fennoskandia avslutades projektet 2016. Föreliggande rapport fullbordar resultatförmedlingen och den avslutande diskussionen omkring forskningsresultaten från projektet och ger samtidigt uppslag för framtida forskning. För första gången presenterades hela projektet och dess medlemmar för en publik bestående av praktiker och intressegrupper runt jakt. Rapporten sammanfattar på detta sätt två dagars temadiskussioner i en workshop med 45 representanter från olika samhällssektorer, bland annat jägare- jordbruks- och naturskyddsorganisationer, länsstyrelser, Naturvårdsverket, polis och åklagare som de ser ut i länderna som utgör Fennoskandia: Sverige, Norge, Danmark och Finland. Diskussionerna handlade om social kontroll och illegal jakt, att flytta viltförvaltningen till domstolarna, EUs inflytande och olika plattformar för att förebygga illegal jakt, speciellt på stora rovdjur, som vargar. Rapporten riktar sig till både forskare och praktiker som möter problem med social accepterade, men hemliga och gömda, former av illegal jakt som i sin tur beror av statsapparatens legitimitetskris, misstro mot politik och politiker och som också är en manifestation för landsbygdens motstånd i ett modernt samhälle.The following report marks the dissemination and discussion of the research results and insights for future research produced by this project. Hence, it represents the first time the full research project and its members stand before the public and interest groups. The report synthesizes two days of workshop thematic discussions between 45 participants from societal sectors including hunting and nature conservation NGOs, county administrative boards, Environmental Protection Agencies, law enforcement, environmental attorneys and farming associations as they feature across the Fennoscandian countries: Sweden, Norway, Denmark and Finland. Its discussions center on social control in wildlife crime, the juridification of hunting issues, the influence of the EU and platforms for going forward to mitigate poaching, in particular of large carnivores like the wolf. The report is an essential read for both researchers and practitioners faced with the problem of socially accepted, but secretive and hidden, forms of illegal hunting in response to governmental legitimacy crises, distrust of policy and policy-makers, and as a manifestation of rural resistance in modernity

A network analysis of female sexual function: comparing symptom networks in women with decreased, increased, and stable sexual desire

Problems related to low sexual desire in women are common clinical complaints, and the aetiology is poorly understood. We investigated predictors of change in levels of sexual desire using a novel network approach, which assumes that mental disorders arise from direct interactions between symptoms. Using population-based data from 1,449 Finnish women, we compared between-subject networks of women whose sexual desire decreased, increased, or remained stable over time. Networks were estimated and analyzed at T1 (2006) and replicated at T2 (2013) using R. Domains included were, among others, sexual functions, sexual distress, anxiety, depression, body dissatisfaction, and relationship status. Overall, networks were fairly similar across groups. Sexual arousal, satisfaction, and relationship status were the most central variables, implying that they might play prominent roles in female sexual function; sexual distress mediated between general distress and sexual function; and sexual desire and arousal showed different patterns of relationships, suggesting that they represent unique sexual function aspects. Potential group-differences suggested that sex-related pain and body dissatisfaction might play roles in precipitating decreases of sexual desire. The general network structure and similarities between groups replicated well; however, the potential group-differences did not replicate. Our study sets the stage for future clinical and longitudinal network modelling of female sexual function

On illegal killings of wildlife in Fennoscandia

Rising levels of discontent among rural residents and parts of the hunting community toward large carnivore conservation policy has effected a phenomenon of socio-politically motivated illegal killing of these unpopular species. Such wildlife crime formed the investigation of an interdisciplinary and internationally collaborative research project headed by the Swedish University of Agricultural Sciences in Ultuna, Uppsala. Through 3 years of in-depth interview studies with hunters in Sweden, a quantitative survey to hunters, comparative studies in other parts of the world and close collaboration with Fennoscandian researchers and practitioners, this project ran to completion at the end of 2016. The following report marks the dissemination and discussion of the research results and insights for future research produced by this project. Hence, it represents the first time the full research project and its members stand before the public and interest groups. The report synthesizes two days of workshop thematic discussions between 45 participants from societal sectors including hunting and nature conservation NGOs, county administrative boards, Environmental Protection Agencies, law enforcement, environmental attorneys and farming associations as they feature across the Fennoscandian countries: Sweden, Norway, Denmark and Finland. Its discussions center on social control in wildlife crime, the juridification of hunting issues, the influence of the EU and platforms for going forward to mitigate poaching, in particular of large carnivores like the wolf. The report is an essential read for both researchers and practitioners faced with the problem of socially accepted, but secretive and hidden, forms of illegal hunting in response to governmental legitimacy crises, distrust of policy and policy-makers, and as a manifestation of rural resistance in modernity

A Practical Guide to Multi-Objective Reinforcement Learning and Planning

Real-world decision-making tasks are generally complex, requiring trade-offs between multiple, often conflicting, objectives. Despite this, the majority of research in reinforcement learning and decision-theoretic planning either assumes only a single objective, or that multiple objectives can be adequately handled via a simple linear combination. Such approaches may oversimplify the underlying problem and hence produce suboptimal results. This paper serves as a guide to the application of multi-objective methods to difficult problems, and is aimed at researchers who are already familiar with single-objective reinforcement learning and planning methods who wish to adopt a multi-objective perspective on their research, as well as practitioners who encounter multi-objective decision problems in practice. It identifies the factors that may influence the nature of the desired solution, and illustrates by example how these influence the design of multi-objective decision-making systems for complex problems

The integrated care pathway reduced the number of hospital days by half: a prospective comparative study of patients with acute hip fracture

BACKGROUND: The incidence of hip fracture is expected to increase during the coming years, demanding greater resources and improved effectiveness on this group of patients. The aim of the present study was to evaluate the effectiveness of an integrated care pathway (ICP) in patients with an acute fracture of the hip. METHODS: A nonrandomized prospective study comparing a consecutive series of patients treated by the conventional pathway to a newer intervention. 112 independently living patients aged 65 years or older admitted to the hospital with a hip fracture were consecutively selected. Exclusion criteria were pathological fracture and severe cognitive impairment. An ICP was developed with the intention of creating a care path with rapid pre-operative attention, increased continuity and an accelerated training programme based on the individual patient's prerequisites and was used as a guidance for each patient's tailored care in the intervention group (N = 56) The main outcome measure was the length of hospital stay. Secondary outcomes were the amount of time from the emergency room to the ward, to surgery and to first ambulation, as well as in-hospital complications and 30-day readmission rate. RESULTS: The intervention group had a significantly shorter length of hospital stay (12.2 vs. 26.3 days; p < 0.000), a shorter time to first ambulation (41 vs. 49 h; p = 0.01), fewer pressure wounds (8 vs. 19; p = 0.02) and medical complications (5 vs. 14; p = 0.003) than the comparison group. No readmissions occurred within 30 days post-intervention in either group. CONCLUSION: Implementing an ICP for patients with a hip fracture was found to significantly reduce the length of hospital stay and improve the quality of care

Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton

A series of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton, namely 3β-benzoyloxy-4,16-pregnadiene-6,20-dione and 3β-furoyloxy-4,16-pregnadiene- 6,20-dione, which may be good inhibitors for the 5α-reductase enzyme and show high antiandrogenic activity, were synthesized starting from diosgenin. The structures of the steroids were characterized by elemental analysis, 1H NMR, 13C NMR, IR and mass spectrum. Single crystal X-ray diffraction measurement on one of the new compounds, 3β-(p-methoxybenzoyloxy)-4,16-pregnadiene-6,20-dione revealed that the A, B, C, and D ring adopted half chair, distorted chair, distorted chair, and distorted envelope conformation, respectively. The molecules in the crystal were packed face-to-face at the normal van der Waals distances