500-Fold Amplification of Small Molecule Circularly Polarised Luminescence through Circularly Polarised FRET

Strongly dissymmetric circularly polarised (CP) luminescence from small organic molecules could transform a range of technologies, such as display devices. However, highly dissymmetric emission is usually not possible with small organic molecules, which typically give dissymmetric factors of photoluminescence (gPL) less than 10−2. Here we describe an almost 103-fold chiroptical amplification of a π-extended superhelicene when embedded in an achiral conjugated polymer matrix. This combination increases the |gPL| of the superhelicene from approximately 3×10−4 in solution to 0.15 in a blend film in the solid-state. We propose that the amplification arises not simply through a chiral environment effect, but instead due to electrodynamic coupling between the electric and magnetic transition dipoles of the polymer donor and superhelicene acceptor, and subsequent CP Förster resonance energy transfer. We show that this amplification effect holds across several achiral polymer hosts and thus represents a simple and versatile approach to enhance the g-factors of small organic molecules

Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3

Myofibrillary myopathies (MFM) are hereditary myopathies histologically characterized by degeneration of myofibrils and aggregation of proteins in striated muscle. Cardiomyopathy is common in MFM but the pathophysiological mechanisms are not well understood. The BAG3-Pro209Leu mutation is associated with early onset MFM and severe restrictive cardiomyopathy (RCM), often necessitating heart transplantation during childhood. We report on a young male patient with a BAG3-Pro209Leu mutation who underwent heart transplantation at eight years of age. Detailed morphological analyses of the explanted heart tissue showed intracytoplasmic inclusions, aggregation of BAG3 and desmin, disintegration of myofibers and Z-disk alterations. The presence of undegraded autophagosomes, seen by electron microscopy, as well as increased levels of p62, LC3-I and WIPI1, detected by immunohistochemistry and western blot analyses, indicated a dysregulation of autophagy. Parkin and PINK1, proteins involved in mitophagy, were slightly increased whereas mitochondrial OXPHOS activities were not altered. These findings indicate that altered autophagy plays a role in the pathogenesis and rapid progression of RCM in MFM caused by the BAG3-Pro209Leu mutation, which could have implications for future therapeutic strategies

Donor-acceptor nanoensembles of soluble carbon nanotubes

Donor-acceptor nanoensembles, prepared via electrostatic interactions of single wall carbon nanotubes and porphyrin salts, give rise to photoinduced intra-complex charge separation that lasts tens of microseconds.Peer reviewedChemistr