6 research outputs found
A Simple and Reliable Strategy for BK Virus Subtyping and Subgrouping
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2017
- Field of study
International audiencevirus (BKV)-associated diseases in transplant recipients are an emerging issue. However, identification of the various BK virus subtypes/subgroups is a long and delicate process on the basis of currently available data. Therefore, we wanted to define a simple and effective one-step strategy for characterizing all BK virus strains from the VP1 gene sequence. Based on the analysis of 199 available complete DNA VP1 sequences, phylogenetic trees, alignments, and isolated polymorphisms were used to define an effective strategy for distinguishing the 12 different BK virus subtypes/subgroups. Based on the 12 subtypes identified from the 199 complete BKV VP1 sequences (1,089 bp), 60 mutations that can be used to differentiate these various subtypes/ subgroups were identified. Some genomic areas were more variable and comprised mutational hot spots. From a subregion of only 100 bp in the VP1 region (1977 through 2076), we therefore constructed an algorithm that enabled rapid determination of all BKV subtypes/subgroups with 99% agreement (197/ 199) relative to the complete VP1 sequence. We called this domain of the BK viral genome the BK typing and grouping region (BKTGR). Finally, we validated our viral subtype identification process in a population of 100 transplant recipients with 100% efficiency. The new simpler method of BKV subtyping/subgrouping reported here constitutes a useful tool for future studies that will help us to more clearly understand the impact of BKV subtypes/subgroups on diagnosis, infection, and BK virus-associated diseases
BK polyomavirus in the urine for follow-up of kidney transplant recipients
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
International audienceOBJECTIVES: After kidney transplantation, human BK polyomavirus (BKPyV) can induce a progressive disease, in three stages: viruria, viremia, and then nephropathy after a few months of viral replication. Therapeutic intervention is recommended when BKPyV is detected in the plasma. The objective of our study was to assess urinary BKPyV nucleic acid test as a predictor for developing viremia. METHODS: We first defined a viruria threshold based on 393 time-matched urine and plasma samples collected after kidney transplantation and then to validate this threshold, we followed-up a cohort of 236 kidney transplant patients. RESULTS: A BKPyV viruria threshold of 6.71 log10 copies/mL best discriminated between plasma-positive and plasma-negative patients (sensitivity: 90.9% (95%CI: 86.5-95); specificity: 90.3% (95%CI: 86.3-94.3); area under the curve: 0.953 (95%CI: 0.933-0.974). In the validation cohort, the risk of developing BKPyV viremia at one year was 16.5% (39/236) and rose to 90.7% (39/43) if BKPyV viruria remained above the threshold of 6.71 for more than one month. CONCLUSION: Sustained BKPyV viruria is a reliable, early marker of patients at high risk of developing BKPyV viremia. This marker should alert the clinician early, and thus allow timely therapeutic intervention
Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
International audienceBackground While malaria morbidity and mortality have declined since 2000, viral central nervous system infections appear to be an important, underestimated cause of coma in malaria-endemic Eastern Africa. We aimed to describe the etiology of non-traumatic comas in young children in Benin, as well as their management and early outcomes, and to identify factors associated with death.Methods From March to November 2018, we enrolled all HIV-negative children aged between 2 and 6 years, with a Blantyre Coma Score ≤ 2, in this prospective observational study. Children were screened for malaria severity signs and assessed using a systematic diagnostic protocol, including blood cultures, malaria diagnostics, and cerebrospinal fluid analysis using multiplex PCR. To determine factors associated with death, univariate and multivariate analyses were performed.Results From 3244 admissions, 84 children were included: malaria was diagnosed in 78, eight of whom had a viral or bacterial co-infection. Six children had a non-malarial infection or no identified cause. The mortality rate was 29.8% (25/84), with 20 children dying in the first 24 h. Co-infected children appeared to have a poorer prognosis. Of the 76 children who consulted a healthcare professional before admission, only 5 were prescribed adequate antimalarial oral therapy. Predictors of early death were jaundice or increased bilirubin [odd ratio ( OR )= 8.6; 95% confidential interval ( CI ): 2.03–36.1] and lactate > 5 mmol/L ( OR = 5.1; 95% CI : 1.49–17.30). Antibiotic use before admission ( OR = 0.1; 95% CI : 0.02–0.85) and vaccination against yellow fever ( OR = 0.2, 95% CI : 0.05–0.79) protected against mortality.Conclusions Infections were found in all children who died, and cerebral malaria was by far the most common cause of non-traumatic coma. Missed opportunities to receive early effective antimalarial treatment were common. Other central nervous system infections must be considered in their management. Some factors that proved to be protective against early death were unexpected
Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients
- Author
- Abbade Mohamed Adnan
- Abbassi Abdelhamid
- Abd El Fatah Mohamed Abo Bakr
- Abokasem Ayman
- Aboubekr Habib
- Abtahi Mahdi
- Acamer Sophie
- Achiche Jedjiga
- Adda Hassen
- Adem Arezki
- Adra Anne Laure
- Afiani Aida
- Agbonon Ekoue
- Aglae Violaine Emal
- Aguilera Didier
- Aizel Ali
- Akposso Kodso
- Al Morabiti Mustapha
- Aladib Mohamed
- Albadawy Mahen
- Albaret Julie
- Albert Catherine
- Aldigier Jean Claude
- Allal Asma
- Allal Radia
- Allot Vincent
- Almoubarak Imad
- Alouach Mahmoud
- Alphonse Jean Claude
- Alrifai Assem
- Amani Francois Roux
- Amaouche Amar
- Amara Brahim
- Amaria Rachid
- Amirou Mustapha
- Ammar Naji
- Ammor Mounia
- Amrandi Mokhtar
- Aneni Wided Tabbi
- Aoun Bilal
- Araujo Caroline
- Argiles Angel
- Arnautou Jean
- Atchia Hafsabhai
- Attias Julie Sohier
- Attias Philippe
- Aubertin Perrine
- Ayav Carole
- Azar Raymond
- Azoulay Eric
- Azzouz Lynda
- Babici Daniela
- Babinet Francois
- Bacchetta Justine
- Bacri Jean Louis
- Badid Cherif
- Badulescu Viorica
- Baillet Anabelle
- Balde Mamadou
- Baleynaud Juliette
- Balit Gabriel
- Ball Beatrice
- Baluta Simona
- Baranger Thierry
- Barbier Stephane
- Bargas Evelyne
- Baron Cecile Turc
- Baron Emmanuel
- Baron Maurice
- Barsumau Joseph
- Basse Francois
- Bassilios Nader
- Basteri Michel
- Bataille Pierre
- bataille stanislas
- Batho Jean Marie
- Bayer Florian
- Bazin Dorothee
- Beau S.
- Beauchamp Christine
- Beaudoin Agnes Caillette
- Beaudreuil Severine
- Beaume Julie
- Becart Jacques
- Belhadj Ihssen
- Bellahsene Farid
- Bellenfant Xavier
- Bellhasene Farid
- Bellou Moufida
- Belmouaz Mohamed
- Ben Ahmed Adel
- Benabid Zaid
- Benalia Hadjira
- Benarbia Seddick
- Benbrahim Oussamah Fikri
- Bencheikh Larbi
- Bendini Jean Christophe
- Benhabib Tassadit
- Benmoussa Abdelatif
- Bennini Chaouki
- Bensalem Tayeb
- Bensman Albert
- Benyaghla Sidi Ali
- Benzakour Mountassir
- Berard Etienne
- Berge Franck
- Bernard Claude
- Bertaux Martine
- Bertrand Dominique
- Besnier Dominique
- Bessenay Lucie
- Bessin Catherine
- Besson Frederic
- Besson Virginie
- Bidault Caroline
- Bijak Krzysztof
- Billion Stephane
- Binaut Reynald
- Bindi Pascal
- Bittar Haiat
- Blanchier Dominique
- Bobrie Guillaume
- Bocquentin Frederique
- Boissinot Lucie
- Bonarek Herve
- Boncila Simona
- Bonnard Guillaume
- Bonne Jean Francois
- Bonniol Claude
- Borde Jean Sebastien
- Bosc Jean Yves
- Bouachi Khedidja
- Bouaka Christophe
- Boubenider Samir
- Boubia Toufik
- Boubia Veronique
- Bouchet Jean Louis
- Bouchoule Isabelle
- Boudemaghe Thierry
- Boudet Remi
- Boudi Wael
- Bougrida Hammouche
- Bouiller Marc
- Boukadida Amine
- Boukelmoune Maklouf
- Boukerroucha Zacharia
- Boukhalfa Zohra
- Boula Aime Remy
- Boulahia Ghada
- Boulahrouz Rehouni
- Boulanger Henri
- Boulechfar Hacene
- Boullenger Fanny
- Boumendjel Nourredine
- Bourdenx Jean Philippe
- Bourdon Franck
- Bourgeon Bruno
- Bourouma Rachid
- Boury Edouard
- Boustani Rafaat
- Bouvier Nicolas
- Bouzar Lilia Antri
- Bouzernidj Mouloud
- Brahim Mohamed
- Brahimi Mabrouk
- Brasseur Jose
- Bridoux Franck
- Briffa Dominique
- Brignon Pierre
- Brillet Georges
- Brocard Jean
- Broux Francoise
- Bruckmann Niels
- Brunak Yvan
- Brunet Philippe
- Bruno Danielle
- Bugnon Denis
- Bulte Francoise
- Burbach Maren
- Béchade Clémence
- Caillard Pauline
- Calonge Victorio Menoyo
- Caniot Elisabeth
- Canivet Eric
- Cantin Jean Francois
- Capdeville Arthur
- Cardon Gerard
- Cardozo Jorge
- Carolfi Jean
- Carre Assia Ferhat
- Carron Pierre Louis
- Cartou Charles
- Castellano Ines
- Castin Nelly
- Castrale Cindy
- Catoliquot Marie Noelle
- Caudwell Valerie
- Caux Dominique
- Cazajous Geraldine
- Cazin Marie Cecile
- Chabannier Marie Helene
- Chaghouri Baher
- Chaigne Virginie
- Chalabi Lotfi
- Chalmin Florence
- Chalopin Jean Marc
- Champion Gerard
- Champion Laure
- Chanas Monique
- Chantrel François
- Chapelet Arielle
- Charasse Christophe
- Chargui Soumaya
- Charles Jacques Ibsen
- Charlin Emmanuelle
- Chatelet T.
- Chatelet Valerie
- Chauveau Philippe
- Chauvet Sophie
- Chawki Mokhtar
- Chazot Charles
- Chedid Khalil
- Chenine Leila
- Cherif Mohamed Fodil
- Chlih Bouchra
- Chong Michel Fen
- Choukroun Gabriel
- Chuet Christian
- Ciobotaru Monica
- Citarda Salvatore
- Clabault Karine
- Clair Francois
- Claudeon Joelle
- Cledes Jacques
- Clement Guillaume
- Cloarec Sylvie
- Cluzel Pascal
- Coevoet Bruno
- Coindre Philippe
- Coldefy Olivier
- Colombo Alexandra
- Combarnous François
- Combe Christian
- Corne Benedicte Hodemon
- Coste Didier
- Coste Philippe
- Couchoud Cécile
- Coudert Krier Marie Jeanne
- Coulibaly Jean Marie
- Coulibaly Moussa
- Coulomb Francois
- Coupel Stephanie
- Cousin Maud
- Cremault Alain
- Creput Caroline
- Cristescu Diana Istrati
- Crougneau Valerie
- Croze Laure
- Cuny Melodie
- Cuvelier Rene
- D'ythurbide Geraldine
- Dabot Christian
- Dahmane Djamal
- Dahmoune Said
- Daniliuc Ioana
- Dardim Karim
- Dargelos Mathilde
- Darie Ioana
- Daroux Maite
- Daubresse Daniel
- Daugas Eric
- David Daniela
- De Cornelissen Francois
- De Fremont Jean Francois
- De Marion Gaja Catherine
- De Martin Alfio
- De Precigout Valerie
- De Preneuf Helene
- De Ste Foy Celia Lessore
- Debout Agnes Chapelet
- Debure Alain
- Dehay Julien
- Del Bello Arnaud
- Delattre Vincent
- Delaval Ronan
- Delavaud Guy
- Delbes Sebastien
- Delbet Jean Daniel
- Delclaux Caroline
- Deleaval Patrik
- Delezire Arnaud
- Delmas Yahsou
- Delvallez Luc
- Demontis Renato
- Depraetre Pascale
- Deprele Carole
- Deroure Benjamin
- Dervaux Thomas
- Deschenes Georges
- Deschodt Gerard
- Desport Estelle
- Dessassis Jean Francois
- Desvergnes Claude
- Desvergnes Gregoire Couvrat
- Deteix Patrice
- Detourne Cindy
- Devaux Jean Philippe
- Devriendt Isabelle
- Dhib Malek
- Diab Raji
- Diaconita Mirella
- Diant Marlene Beaubrun
- Diarrassouba Assetou
- Dickson Zara
- Diddaoui Ali Zineddine
- Diet Carine
- Dimitrov Yves
- Dimulescu Radu
- Dimulescu Theodora
- Dincu Daniela
- Diolez Jeremie
- Dion Jean Jacques
- Diouani Mohamed
- Dirhold Caroline Preissig
- Dita Camelia Ghiciuc
- Djeffal Rachid
- Djelaleddine Benyakoub
- Djema Assia
- Djiconkpode Irenee
- Donnadieu Patrick
- Doussy Yves
- Drouillat Valerie
- Drouineau Olivier
- du Halgouet Caroline
- Dubau Malina
- Dubosq Pascale
- Dubot Philippe
- Dubrasquet Astrid Godron
- Ducros Jacques
- Dufay Alexandre
- Duflot Laurent
- Dufresne Richard
- Dufresne Roger
- Duhem Alexandra
- Dumont Genevieve
- Dumoulin Alexandre
- Dumoulin Madeleine
- Dunand Olivier
- Duneau Gabrielle
- Dupont Philippe Martin
- Dupuis Clémentine
- Dupuis Emmanuel
- Duquennoy Simon
- Duquesne Alyette
- Durand Dominique
- Durand Pierre Yves
- Duval Sophie Rubens
- Duvic Christian
- Duvic Jacques
- Ebel Alexandre
- Ebikili Bertin
- El Ali Hamid
- El Amari Abderrahim
- El Esper Najeh
- El Haggan Wael
- El Kaeoui Khalil
- El Karoui Khalil
- El Nasser Khuzama
- Elmrabet Atman Haddj
- Emond Christian
- Enache Ioana
- Eprinchard Laure
- Erbilgin Dilaver
- Erina Torres Pablo Antonio
- Esposito Miguel
- Essi Marie
- Eugene Marc
- Fache Emilie
- Faller Anne Laure
- Falque Veronique
- Fat Maeva Wong
- Faucher Justine
- Faucon Jean Paul
- Favennec Caroline
- Fedorca Ana
- Ferrandini Corinne
- Ferrandiz Ines
- Fessi Hafed
- Fickl Rocsana
- Fievet Patrick
- Figueroa Enrique
- Fila Marc
- Filipozzi Pierre
- Finielz Paul
- Fleury Dominique
- Flodrops Hugues
- Fohrer Patrick
- Fontanier Pascal
- Formet Cedric
- Fort Magalie
- Fouque Denis
- Fourcade Jacques
- Fournier Alain
- FOURNIER Albert
- Fournier Philippe
- Fournier Veronique
- Francais Patrick
- Francois Clair
- Francois Maud
- Frangie Carlos
- Fraoui Rabah
- Frayssinet Raymond
- Freguin Caroline
- Freist Marine
- Frejate Fares
- Frimat Luc
- Fritz Olivier
- Fromentin Luc
- Fumeron Christine
- Gaboriau Elke
- Gabriel Jean Marc
- Galantine Valerie
- Galland Roula
- Gamberoni Joel
- Gansey Renaud
- Garnier Arnaud
- Garnier Fabrice
- Garrouste Cyril
- Gaudry Xavier Moreau
- Gaultier Jacques
- Gauthier Eric
- Gauthier Marion
- Gavard Marie Sophie
- Gbindoun Ubald Assogba
- Ged Etienne
- Genestier Sandrine
- Genin Robert
- Georgieva Lora
- Gerard Fabien
- Ghali Nasredine
- Ghazali Abderrahmane
- Gheerbrandt J. Dominique
- Ghemmour Amel
- Gilbert Olivia
- Gilson Brigitte
- Giorgita Ancuta Bouffandeau
- Giraud Patrick
- Girerd Sophie
- Glowacki Francois
- Godart Catherine
- Golea Gabriella
- Gouin Jean Baptiste
- Goumri Nabila
- Goupy Christophe
- Granolleras Celine
- Gruget Gabriel
- Guenifi Ismahane
- Guerard Arnaud
- Gueret Claudine
- Guergour Mounir
- Guerraoui Abdallah
- Guerrot Dominique
- Guery Bruno
- Gueuttin Victor
- Guiard Elsa
- Guibergia Corinne
- Guillodo Marie Paule
- Guillon Wen Qin
- Guincestre Thomas
- Guiraud Cecile
- Guiserix Jose
- Hachicha Mourad
- Hacini Sabria
- Hacq Bertrand
- Haddad Imad
- Hadj Abdelkader
- Hafi Ali
- Hafi Aline
- Haidar Fadi
- Halin Pascale
- Hallonet Patrick
- Hamani Abdelaziz
- Hamdini Nasser
- Hamel Didier
- Hammelin Jean Philippe
- Hanafi Latifa
- Hanf William
- Hannaert Marie Claude
- Hannedouche Thierry
- Hanoy Melanie
- HARAMBAT Jerome
- Harbouche Laid
- Hardin Jean Michel
- Harrami Elarbi
- Haskour Ibrahim
- Haultier Jean Jacques
- Haussaire Delphine
- Hazzan Marc
- Hebibi Hadia
- Hecht Michel
- Hecquet Emmanuelle
- Heibel Francoise
- Hemery Michele
- Henaoui Bachir
- Heng Anne Elisabeth
- Henri Patrick
- Hestin Dominique
- Heyani Alim
- Hiernaux Philippe
- Hitze Thibault Dolley
- Hoarau Monique
- Hoffmann Maxime
- Hogan Julien
- Hottelart Carine Achard
- Hourmant Maryvonne
- Housset Pierre
- Huchard Gabriel
- Hue Kheira
- Hue Patricia
- Hufnagel Gilles
- Hugot Valerie Granveau
- Hurot Jean Marc
- Ikonga Donatien
- Imhoff Olivier
- Imiela Jean Paul
- Indrieis Monica
- Ingwiller Maxime
- Islam Mohamed Sharifull
- Ismer Manfred
- Isnard Myriam
- Issad Belkassem
- Issautier Roland
- Izzedine Hassane
- Jaber Waddah
- Jablonski Mathieu
- Jacquet Antoine
- Jacquot Zohra
- Jalaby Al
- Jamali Mohamed
- Janbon Benedicte
- Jaubert Dominique
- Jaulin Jean Paul
- Jean Guillaume
- Jeanson Alain
- Jegado Audrey
- Jolimoy Cyrille
- Jolivot Anne
- Jolly Damien
- Joly Dominique
- Jonon Benoit
- Joseph Maan
- Josse Anne Gaelle
- Journet Julien
- Jousset Philippe
- Jouzel Charlotte
- Jurine Jacques
- Kahil Cynthia
- Kalbacher Emilie
- Karaaslan Huseyin
- Kareche Mimi
- Kassis Samuel
- Kazes Isabelle
- Keller Nicolas
- Kerkeni Nadia
- Kesler Gwenaelle Roussey
- Kesraoui Dalila
- Kessler Michele
- Khalili Mina
- Khayat Rateb
- Khoa Man Nguyen
- Khuzaie Usama
- Kihal Lilia
- Klein Alexandre
- Klisnick Arnaud
- Knefati Yannick
- Kofman Thomas
- Kofman Tomek
- Kohler Emmanuelle
- Kohn Wladimir
- Kolb Isabelle
- Kourilsky Olivier
- Kriaa Faycal
- Kribs Marc
- Krid Saoussen
- Krummel Thierry
- Kuentz François
- Kunz Kristian
- Labadens Anne Kolko
- Labatide Alanor Agnes
- Lacraz Adeline
- Ladriere Marc
- Lafage Lyliane
- Laforet Manon
- Lagarde Christian
- Lambrey Guy
- Lamotte Christian
- Lamouroux Elodie
- Lamriben Larbie
- Lanau Jean Marc
- Landru Isabelle
- Lang Philippe
- Laradi Achour
- Larue Jean Rene
- Laruelle Eric
- Lasseur Catherine
- Lataste Anne
- Latif Rezkallah
- Launay Emma Allain
- Laurain Emmanuelle
- Lavainne Frederic
- Lavaud Sylvie
- Lavelle Olivier
- Le Cacheux Philippe
- Le Chapois Didier
- Le Guen Eric
- Le Gurun Christine
- Le Maner Ophelie
- Le Mouellic Lionel
- Le Roy Frank
- Lebhour Fouad
- Lebleu Jacques
- Lebot Marc
- Lebourg Ludivine
- Lebrun Gaetan
- Leclerc Anne Laure
- Leduc Vincent
- Lefevre Jean Jacques
- Lefrancois Gaelle
- Lefrancois Nicole
- Legallicier Bruno
- Legrand Eric
- Legros Nicolas
- Lekhal Saliha
- Lemaire Marion
- Lemarchand Patricia
- Lemoine Corinne
- Lemoine Mathilde
- Leocardi Catherine
- Leon H.
- Leonetti Francoise
- Leou Sylvie
- Lepeytre Fanny
- Leray Helene
- Leroy Christine
- Leroy Fanny
- Leroy Valerie
- Levannier Martial
- Lionet Arnaud
- Llanas Brigitte
- Lloret Claudine
- Lobbedez Thierry
- Lohro Ronan
- Lokmane Hassan
- Lombart Dominique
- Lorcy Nolwenn
- Lorriaux Christie
- Lorthioir Aurelien
- Louvet Daniel
- Luang Nahn
- Lucats Florence
- Lumbroso Catherine
- Lyon Alain
- M'barga Roseline
- Maakaroun Ghassan
- Maaz Mehadji
- Macher Marie Alice
- Mackaya Leandre
- Maghlaoua Mohamed
- Magnol Roger
- Mahe Jean Luc
- Maheut Herve
- Mahmoud Diab Mohamed
- Mailliez Sebastien
- Maisin Anne
- Maisonneuve Nathalie
- Maiza Hakim
- Majbri Nabil
- Makdassi Raifat
- Maksour Edouard
- Malvezzi Paolo
- Mandart Lise
- Manescu Maria
- Mangenot Gerard
- Mann Youssef
- Mansour Janette
- Manucci Annie Lahoche
- Marc Jean Michel
- Marchal Francois
- Marcu Elena
- Mariot Agnes
- Maroun Nadine
- Marraoui Marcel
- Marroc Melanie
- Martin Alexandre
- Martin Stephane Jean
- Marty Luc
- Massad Michel
- Masselot Jean Paul
- Massoumi Afshin
- Maurice Francois
- Maurizi Jocelyne
- Maurouard Catherine Quere
- May Delia
- Mayor Brice
- Mazouz Hakim
- Meddeb Mohamed
- Meeus Frederique
- Mehama Hocine
- Mehdi Manolie
- Mehrenberger Marion
- Melander Catherine
- Menouer Soraya
- Merault Henri
- Mercadal Lucile
- Mertens Noel
- MESBAH Rafik
- Mesguen Caroline
- Messaoudene Fadhila Pech
- Messier Gilles
- Metivier Fabien
- Mezghani Mahmoud
- Michaut Patrick
- Michel Catherine
- Michel Ghylene Bourdat
- Michel Philippe
- Michel Pierre Alexandre
- Milcent Thierry
- Mingat Nadege
- Mirgaine Philippe
- Mocanu Alina
- Mohajer Mederick
- Moinat Adnan
- Molina Virginia
- Mondain Jean Rene
- Monge Matthieu
- Monjot Luc
- Monkam Regine
- Monnier Nicole
- Montagnac Richard
- Montoriol Jean
- Montseny Jean Jacques
- Moranne Olivier
- Moreau Karine
- Morel Bertrand
- Morin Denis
- Moriniere Philippe
- Mortelette Romain
- Motte Gerard
- Moumas Eric
- Mouneimne Alexandre
- Mourad Georges
- Mousson Christiane
- Muller Sandrine
- Muniz Blanca
- Muresan Carmina
- Mustel Jihad
- Mzoughi Sonia
- Nakhla Magued
- Namara Evelyne Mac
- Nankeu Nestor
- Nebbad Rachida
- Nefti Abdelhamid
- Nemmar Fazia
- Neyrat Nadine
- Nga Messi Liliane Ngango
- Nguyen Viet
- Niaudet Patrick
- Nicolet Laurence
- Nicoud Philippe
- Nistor Claudia
- Nobili Francois
- Noel Natacha
- Nogier Marie Beatrice
- Noguera Gonzalez Maria Eugenia
- Nolen Patrice
- Nony Alain
- Nony Sébastien
- Noordally Reschad
- Normand Michel
- Nour Derradji
- Novo Robert
- Nsembani Emerson
- Nzeyimana Hilaire
- Obama Caroline Ndomo
- Odry Leon
- Ohry Bernard
- Ollier Jacques
- Olmer Michel
- Onesta Tania
- Ortiz Jean Paul
- Ott Julien
- Ottavioli Jean Noel
- Ouziala Messaoud
- Ozenne Sophie
- Padilla Marc
- Pagniez Dominique
- Pain Christian
- Painchart Bernard
- Pajot Aurelie
- Palacin Pedro
- Palcoux Jean Bernard
- Pambrun Emilie
- Panescu Victor
- Papin Olivier
- Parahy Sophie
- Parasote Jennifer
- Parazols Fabien
- Pardon Agathe
- Parent Pierrot
- Paris Anne
- Paris Bruno
- Parvez Laura Braun
- Passeron Corinne
- Passos Elsa Martin
- Pastural Myriam
- Patrier Laure
- Pauly Patrick
- Pelle Gaelle
- Perez Lydie
- Pertuiset Nathalie
- Peters Nicolas
- Peyronnet Pierre
- Philippot Helene
- Piccoli Giorgina
- Pierre Dominique
- Pietrement Christine
- Pillet Adele
- Pincon Emilie
- Pinier Cedric
- Plasse Florent
- Poitou Anne Laure
- Poitou Caroline
- Poli Isabelle
- Pommereau Antoine
- Pongas Marios
- Postec Eric
- Potelune Natacha
- Potier Jacky
- Potier Jerome
- Pour Zoe Koochaki
- Pourreau Francois
- Poussard Gwenaelle
- Pouteau Lise Marie
- Poux Jean Michel
- Poyet Anais
- Pradier Vincent
- Preda Alina
- Prelipcean Camelia
- Presne Claire
- Prinz Eric
- Provot Francois
- Pruna Andre
- Prunescu Ionut
- Pujo Myriam
- Puslenghea Raluca
- Quang Doan Bui
- Queffeulou Guillaume
- Querard Anne Helene
- Queron Veronique
- Quirin Nicolas
- Rabate Clementine
- Rabec Marina
- Rachi Ahmed
- Ragab Eid Amr Ekhlas
- Raharivelina Claude
- Rakoff Lucien
- Ramanantsialonina Zana
- Ramdane Mohamed
- Ramperez Pierre
- Rance Nicole
- Ranchin Bruno
- Ranlin Alex
- Raphael Thomas
- Rasamimanantsoa Daniel
- Rasoloarijaona L.
- Ratsimbazafy Anderson
- Raynal Nathalie
- Reade Richard
- Reberolle Matthieu
- Rebibou Jean Michel
- Reboux Anne Helene
- Renaud Henri
- Renaudineau Eric
- Revenco Mariana
- Rey Isabelle
- Reynaud Franck
- Ribal Sonia
- Richer Christine
- Richter Sarah
- Ridel Christophe
- Rieu Philippe
- Rifaat Mohamed
- Rifard Mohamad Khair
- Rivory Jean Pierre
- Robert Alain
- Robin Etienne
- Roccabianca Arnaud
- Roger Tiphaine Guyon
- Rogol Joffrey
- Roques Olivier
- Rosati Clelia
- Rosier Emmanuelle
- Rostoker Guy
- Rouannet Catherine
- Roubicek Christa
- Roubiou Caroline
- Roueff Stephane
- Roura Raoul
- Rousseau Philippe
- Sacquepee Mathieu
- Sadreux Thomas
- Sahar Adel
- Saidani Farid
- Saingra Yannick
- Saksi Salima
- Sakso Salima Ahriz
- Salandre Aurelie Davourie
- Saltiel Claudine
- Sampol Jerome
- Sandor Alex Vido
- Sarraj Ayman
- Sartorius Albane Brodin
- Savenkoff Benjamin
- Sawadogo Theophile
- Sayegh Johnny
- Scheidt Elise
- Schillinger Francis
- Schmitt Renee
- Schohn Dominique
- Schortgen Gerard
- Schott Francoise Moussion
- Schweitzer Camoin Marie Christine
- Sebahoun Pascale
- Sechet Anne
- Sedrati Nadia
- Segalen Isabelle
- Seidowsky Alexandre
- Seigneuric Bruno
- Sekhri Hacene
- Selcer Isabelle
- Semjen Elisabeth
- Seniuta Piotr
- Sens Florence
- Seret Guillaume
- Serrato Tomas
- Serveaux Mf.
- Servel Marie France
- Shahapuni Irina
- Shenouda Milad
- Simon Amelie
- Siohan Pascale
- Sirajedine Khaled
- Skalli Amina
- Slingeneyer Alain
- Smati Mustafa
- SOLTANI Nadia
- Soltani Zaara
- Souid Marc
- Soulis Fabien
- Spataru Luciana
- Sporer Philippe
- Stamatakis Georges
- Stancu Alexandra
- Stanescu Corina
- Stolz Arnaud
- Stroumza Paul
- Strullu Bernard
- Subra Jean Francois
- Sury Aurore
- Sutra Estelle Ricard
- Taddei Catherine
- Tafelin Cecile
- Takla Zafer
- Talaszka Aline
- Tamain Mathilde
- Tamiji Lili Taghipour
- Tanter Yves
- Taque Sophie
- Teboulle Dan
- Temperville Bernard
- Terki Nazim
- Terrasse Marianne
- Terzic Joelle
- Testa Angelo
- Testevuide Pascale
- Testou Didier
- Tetaz Rachel
- Thibaudin Damien
- Thierry Antoine
- Thomas Aurelia Bertholet
- Thomas Kedna
- Thomas Patrick
- Thorel Philippe
- Thouret Marie Christine
- Tiple Aurelien
- Tirolien Yannick
- Tivollier Jean Michel
- Tolani Michel
- Toledano Daniel
- Tollis Frederic
- Tomeh Monzer
- Tomkiewicz Elisabeth
- Torner Stephane
- Touam Malik
- Toure Fatouma
- Touzot Maxime
- Trivin Claire
- Tsimaratos Michel
- Tubail Zead
- Tudorache Elena
- Ulinski Tim
- Urena Torres Pablo Antonio
- Vairon Codaccioni Marie Xaviere
- Valentin Jean Francois
- Van Der Pijl Hans
- Van Der Straaten Menno
- Van Cyril Vo
- Vandooren Ann Karolien
- Vanhille Philippe
- Vautrin Pierre
- Vecina Frederique
- Veillon Sebastien
- Vela Carlos
- Vendrely Benoit
- Venot Marion
- Vercel Caroline Gourraud
- Verdier Jean Francois
- Verhille Sandra
- Vernier Isabelle
- Vernin Guillaume
- Verove Cathy
- Verrier Christelle
- Vetromile Fernando
- Viaud Christel
- Vidil Marie Jacques
- Vigeral Philippe
- Vilaine Eve
- Villar Emmanuel
- Villemain Florence
- Viprey Delphine Henriet
- Viron Beatrice
- Virot Jean Simon
- Visanica Dorina
- Vitanova Lorita
- Vittoz Nathalie
- Viviani Veronique
- Von Ey Friederike
- Von Kotze Clarissa
- Vrigneaud Laurence
- Vrillon Isabelle
- Wajsbrot Lucie
- Wauquier Jean Pierre
- Weclawiak Hugo
- Wehbe Bassem
- Weis Lise
- Westeel Pierre Francois
- Wheatley Pascal
- Wiart Geraldine Robitaille
- Wong Tony
- Wuillai Anne
- Yazbeck Fatima
- Yazji Jamal
- Yousfi Kamel
- Yue Wah Philippe Lan
- Yverneau Paule Hardy
- Zaidi Hocine
- Zanetta Gilbert
- Zannier Alfredo
- Zaoui Philippe
- Ziane Abdelaziz
- Zins Brigitte
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2020
- Field of study
International audienceThe aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed
A highly virulent variant of HIV-1 circulating in the Netherlands
- Author
- Aarsman K
- Abel Sylvie
- Abeler-Dörner Lucie
- Abgrall Sophie
- Abgueguen Pierre
- Abraham Bruno
- Ackens R P
- Adam Axel
- Adams A
- Agher Nouara
- Ahmad S
- Ainsworth J
- Aissi Emmanuelle
- Ajana Faïza
- Al Moujahid A
- Alagna Laura
- Albers M
- Albert Jan
- Alberto A
- Alcaraz Isabelle
- Allavena Clotilde
- Allegre Thierry
- Allen S
- Allienne Christophe
- Alvarez Muriel
- Alvarez-Huve Sandrine
- Amirat Naouel
- Ammerlaan H S M
- Anderson J
- Andrady U
- Andre Marie
- Ang C W
- Antoniotti Odile
- Antonucci S
- Aquilina Christian
- Arastéh Keikawus
- Arbter Peter
- Arends J E
- Arumainayyagam J
- Arvieux Cédric
- Aslan Alexandre
- Assi Assi
- Atoui Nadine
- Aubert V
- Audebert Franz
- Aumaitre Hugues
- Autar R S
- Avettand Fenoel Véronique
- Baas S
- Babiker Abdel
- Back N K T
- Baclet Véronique
- Baillat Vincent
- Bakker M
- Bakker Margreet
- Bakker Y
- Balausine Stéphanie
- Balsarin Florence
- Bannert Norbert
- Bannert Norbert
- Bansaal D
- Bantsimba Jonas
- Barbe Frédérique
- Barbuat Claudine
- Barin Francis
- Barth R E
- Bassant N
- Bastides Frédéric
- Batala Anne-Sophie
- Batard Marie-Laure
- Batisse Dominique
- Battegay M
- Baudry Thomas
- Baumgarten Axel
- Bax H I
- Bazin Christine
- Beck Charles
- Beck-Wirth Geneviève
- Belan Alix Greder
- Belarbi Linda
- Bellenger Katharine
- Ben Abdallah Saadia
- Benomar Meryem
- Berger Jean-Luc
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- Berkhout B
- Berkhout Ben
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- Bernard Louis
- Bernard Noëlle
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- Berrebi Valérie
- Berrevoets M A H
- Berthe Huguette
- Berzow Dirk
- Besnier Michel
- Bevan M
- Bevan Margaret-Ann
- Bezemer D O
- Bezemer Daniela
- Bezemer M
- Biekre Raphael
- Bieniek Bernhard
- Bierman W F W
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- Bodard Loïc
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- Bollens Diane
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- Bottero Julie
- Bouchaud Olivier
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- Brunet Cecile
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- Cerland Christophe
- Chabrol Amélie
- Chaigne de Lalande Severin
- Chaix Fabrice
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- Chambrin Véronique
- Champagne Hélène
- Chandramani S
- Chantalat Christelle
- Chapplain Jean-Marc
- Chardon Patricia
- Chas Julie
- Chavanet Pascal
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- Chennebault Jean Marie
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- Conort Guillaume
- Consigny Paul Henri
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- de Kroon I
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- de la Blanchardiere Arnaud
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- Schleehauf Dorothea
- Schlote Frank
- Schmalöer Dirk
- Schmid P
- Schmidt Daniel
- Schmidt Reinhold
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- Schnaitmann Eiko
- Schneider Luminita
- Schnörr P
- Schoorl M
- Schouten W E M
- Schranz Dietmar
- Schreiber Maria
- Schubert Franz
- Schulbin Hubert
- Schuler Christoph
- Schurink C A M
- Schuurman R
- Schölmerich Jürgen
- Schölvinck E H
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- Segeral Olivier
- Seghezzi Jean-Christophe
- Seng Rémonie
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- Sigaloff K C E
- Silbermann Benjamin
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- Simon Philippe
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- Stanley B
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- Stellbrink Hans-Jürgen
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- Valantin Marc Antoine
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- van Agtmael M A
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- van den Akker M
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- van den Berk G E L
- van den Bersselaar D N J
- van der Bliek G L
- van der Burg-van de Plas M
- van der Hut G
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- van der Meché I B
- van der Meer I
- van der Meulen P A
- van der Plas A
- van der Poll T
- van der Prijt L M M
- van der Reijden W A
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- van der Swaluw J
- van der Valk M
- van der Ven B
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- van der Vliet S
- van Duinen M
- van Eden J
- van Eeden A
- van Erve R
- Van Frankenhuijsen Maartje
- van Gorp E C M
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- van Hulzen A G W
- van Ijperen J M
- van Kampen J J A
- van Kasteren M E E
- van Leer-Buter C C
- van Lelyveld S F L
- van Loo I H M
- van Niekerk T
- van Nieuwkoop C
- van Nood E
- van Rooijen C S A M
- van Rossum A M C
- van Sighem A I
- van Sighem Ard
- van Truijen-Oud F A
- van Twillert G
- van Vonderen M G A
- van Vugt M
- van Welzen B J
- van Wijk M
- van Wolfswinkel M E
- van Zonneveld L M
- Vandenhende Marie-Anne
- Vareil Marc-Olivier
- Veenemans J
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- Veenstra J
- Verbon A
- Verdon Renaud
- Verduyn-Lunel F
- Verhage A R
- Verhagen D W M
- Vermont C L
- Vernazza P
- Viallard Jean-François
- Viard Jean-Paul
- Viget Nathalie
- Visser E
- Visser K M
- Vittecoq Daniel
- Voigt R
- Vriesde M
- Vrouenraets S M E
- Wagenvoort G H J
- Waldner Anne
- Wandolo Emily
- Wartel Guillaume
- Waters A
- Weber R
- Wegdam M C A
- Weijenberg-Maes B
- Weijsenfeld A M
- Weinberck Pierre
- Weiss Laurence
- Weitner Lutwin
- Wemmert Charlotte
- Wensing A M J
- Wesselmann Hans
- Wessels E
- White C
- White D
- Wicke Thomas
- Wiemer Dorothea
- Wiersinga W J
- Wijnands S
- Wildenbeest G S
- Wilding H
- Wilkins E
- Williams O
- Winter A
- Wintermans B
- Wirth Gaétane
- Wit F W M N
- Wither J
- Witte E C
- Wolfs T F W
- Wolthers K C
- Woodward R
- Woudstra T
- Wouthuyzen-Bakker M
- Wttewaal E
- Wymant Chris
- Yazdanpanah Yazdan
- Yerly S
- Young Carmel
- Young F
- Young S
- Youssef Elaney
- Zaaijer H L
- Zadeh Mahsa Mohseni
- Zaheri S
- Zak Dit Zbar Olivier
- Zeng Ai-Feng
- Zhao Lele
- Zucchetti Antonella
- Zucman David
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence
Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients
- Author
- Abdallah Guerraoui
- Abdelatif Benmoussa
- Abdelaziz Hamani
- Abdelaziz Ziane
- Abdelhamid Abbassi
- Abdelhamid Nefti
- Abdelkader Hadj
- Abderrahim El Amari
- Abderrahmane Ghazali
- Abo Bakr Abd El Fatah Mohamed
- Achour Laradi
- Adel Ben Ahmed
- Adel Sahar
- Adele Pillet
- Adeline Lacraz
- Adnan Moinat
- Afshin Massoumi
- Agathe Pardon
- Agnes Caillette Beaudoin
- Agnes Chapelet Debout
- Agnes Mariot
- Ahmed Rachi
- Aida Afiani
- Aime Remy Boula
- Al Jalaby
- Alain Cremault
- Alain Debure
- Alain Fournier
- Alain Jeanson
- Alain Lyon
- Alain Nony
- Alain Robert
- Alain Slingeneyer
- Alanor Agnes Labatide
- Albane Brodin Sartorius
- Alberici
- Albert Bensman
- Albert Fournier
- Alex Ranlin
- Alex Vido Sandor
- Alexandra Colombo
- Alexandra Duhem
- Alexandra Stancu
- Alexandre Dufay
- Alexandre Dumoulin
- Alexandre Ebel
- Alexandre Klein
- Alexandre Martin
- Alexandre Mouneimne
- Alexandre Seidowsky
- Alfio De Martin
- Alfredo Zannier
- Ali Aizel
- Ali Hafi
- Ali Zineddine Diddaoui
- Alim Heyani
- Alina Mocanu
- Alina Preda
- Aline Hafi
- Aline Talaszka
- Alyette Duquesne
- Amar Amaouche
- Amel Ghemmour
- Amelie Simon
- Amina Skalli
- Amine Boukadida
- Amr Ekhlas Ragab Eid
- Ana Fedorca
- Anabelle Baillet
- Anais Poyet
- Ancuta Bouffandeau Giorgita
- Anderson Ratsimbazafy
- Andre Pruna
- Angel Argiles
- Angelo Testa
- Ann Karolien Vandooren
- Anne Elisabeth Heng
- Anne Gaelle Josse
- Anne Helene Querard
- Anne Helene Reboux
- Anne Jolivot
- Anne Kolko Labadens
- Anne Lataste
- Anne Laure Adra
- Anne Laure Faller
- Anne Laure Leclerc
- Anne Laure Poitou
- Anne Maisin
- Anne Paris
- Anne Sechet
- Anne Wuillai
- Annie Lahoche Manucci
- Antoine Jacquet
- Antoine Pommereau
- Antoine Thierry
- Arezki Adem
- Arielle Chapelet
- Arnaud Del Bello
- Arnaud Delezire
- Arnaud Garnier
- Arnaud Guerard
- Arnaud Klisnick
- Arnaud Lionet
- Arnaud Roccabianca
- Arnaud Stolz
- Arthur Capdeville
- Asma Allal
- Assem Alrifai
- Assetou Diarrassouba
- Assia Djema
- Assia Ferhat Carre
- Astrid Godron Dubrasquet
- Atman Haddj Elmrabet
- Audrey Jegado
- Aurelia Bertholet Thomas
- Aurelie Davourie Salandre
- Aurelie Pajot
- Aurelien Lorthioir
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- Aurore Sury
- Ayman Abokasem
- Ayman Sarraj
- Bachir Henaoui
- Baher Chaghouri
- Basile
- Basile
- Bassem Wehbe
- Beatrice Ball
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- Belkassem Issad
- Benedicte Hodemon Corne
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- Benjamin Deroure
- Benjamin Savenkoff
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- Bernard Ohry
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- Blanca Muniz
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- Burgner
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- Cho
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- Michele Kessler
- Miguel Esposito
- Milad Shenouda
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- Monica Ciobotaru
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- Monzer Tomeh
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- Mouloud Bouzernidj
- Mounia Ammor
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- Patrice Deteix
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- Patrick Michaut
- Patrick Niaudet
- Patrick Pauly
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- Paul Finielz
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- Paule Hardy Yverneau
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- Pedro Palacin
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- Philippe Attias
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- Sandra Verhille
- Sandrine Genestier
- Sandrine Muller
- Saoussen Krid
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- Sebastien Delbes
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- Seddick Benarbia
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- Shen
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- Su
- Sylvie Cloarec
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- Sylvie Leou
- Sébastien Nony
- T. Chatelet
- Tang
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- Theophile Sawadogo
- Thibault Dolley Hitze
- Thierry Baranger
- Thierry Boudemaghe
- Thierry Hannedouche
- Thierry Krummel
- Thierry Lobbedez
- Thierry Lobbedez
- Thierry Milcent
- Thomas Dervaux
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- Thomas Raphael
- Thomas Sadreux
- Tim Ulinski
- Tiphaine Guyon Roger
- Tomas Serrato
- Tomek Kofman
- Tony Wong
- Toufik Boubia
- Ubald Assogba Gbindoun
- Usama Khuzaie
- Valeri
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- Valerie De Precigout
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- Veronique Boubia
- Veronique Falque
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- Victor Gueuttin
- Victor Panescu
- Victorio Menoyo Calonge
- Viet Nguyen
- Vincent Allot
- Vincent Delattre
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- Violaine Emal Aglae
- Viorica Badulescu
- Virginia Molina
- Virginie Besson
- Virginie Chaigne
- Waddah Jaber
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- Wen Qin Guillon
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- William Hanf
- Williamson
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- Xavier Bellenfant
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- Yahsou Delmas
- Yannick Knefati
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- Youssef Mann
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- Zacharia Boukerroucha
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- Zaid Benabid
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