Laplacian-Steered Neural Style Transfer

Neural Style Transfer based on Convolutional Neural Networks (CNN) aims to synthesize a new image that retains the high-level structure of a content image, rendered in the low-level texture of a style image. This is achieved by constraining the new image to have high-level CNN features similar to the content image, and lower-level CNN features similar to the style image. However in the traditional optimization objective, low-level features of the content image are absent, and the low-level features of the style image dominate the low-level detail structures of the new image. Hence in the synthesized image, many details of the content image are lost, and a lot of inconsistent and unpleasing artifacts appear. As a remedy, we propose to steer image synthesis with a novel loss function: the Laplacian loss. The Laplacian matrix ("Laplacian" in short), produced by a Laplacian operator, is widely used in computer vision to detect edges and contours. The Laplacian loss measures the difference of the Laplacians, and correspondingly the difference of the detail structures, between the content image and a new image. It is flexible and compatible with the traditional style transfer constraints. By incorporating the Laplacian loss, we obtain a new optimization objective for neural style transfer named Lapstyle. Minimizing this objective will produce a stylized image that better preserves the detail structures of the content image and eliminates the artifacts. Experiments show that Lapstyle produces more appealing stylized images with less artifacts, without compromising their "stylishness".Comment: Accepted by the ACM Multimedia Conference (MM) 2017. 9 pages, 65 figure

A prospective study on evaluation of maternal and foetal outcomes of hypothyroidism with levothyroxine and prevalence of hypothyroidism in pregnancy in a tertiary care teaching hospital in Kerala

Background: Pregnancy influences a profound alteration in thyroid function and hypothyroidism has a massive impact on adverse pregnancy outcomes. An appropriate treatment with appropriate dose of levothyroxine is much essential during pregnancy. The present study evaluates the effect of levothyroxine dose in preventing maternal and foetal outcomes and the prevalence of hypothyroidism among pregnant women.Methods: 1500 antenatal women with singleton gestation attending outpatient of Obstetrics and Gynaecology Department, were analysed. Apart from routine obstetrical investigations, thyroid stimulating hormone (TSH) tests were done at the first antenatal visit. Patients were followed up till delivery after levothyroxine treatment. Their obstetrical and perinatal outcomes were noted. TSH estimation was done 3 days after delivery in new-borns to screen for neonatal thyroid disorders.Results: The prevalence of hypothyroidism was 10.54%. The common adverse maternal and foetal complications were preeclampsia (15.19%) and low birth weight babies (17.72%) respectively. The mean age of pregnant women was 26.66 years. As age advances there is an increased risk of developing hypothyroidism in pregnancy. Levothyroxine 25 μg daily was highly prescribed in 63.92% hypothyroid patients.Conclusions: Overall, the prevalence of hypothyroidism was high. Since maternal and foetal complications were higher in patients with hypothyroidism, levothyroxine treatment had decreased the risk of maternal and foetal outcome. Pre-pregnancy screening should be implemented at least in patients with high risk factors for thyroid dysfunction. Universal screening for new-borns is also recommended to detect hypothyroidism. Expert decisions and cost-effectiveness studies will promulgate the impact of universal screening

Spatially Resolved Images of Dust Belt(s) Around the Planet-hosting Subgiant Kappa CrB

We present Herschel spatially resolved images of the debris disc orbiting the subgiant Kappa CrB. Not only are these the first resolved images of a debris disc orbiting a subgiant, but Kappa CrB is a rare example of an intermediate mass star where a detailed study of the structure of the planetary system can be made, including both planets and planetesimal belt(s). The only way to discover planets around such stars using the radial velocity technique is to observe 'retired' A stars, which are cooler and slower rotators compared to their main-sequence counterparts. A planetary companion has already been detected orbiting the subgiant Kappa CrB, with revised parameters of m sin i = 2.1MJ and apl = 2.8AU (Johnson et al. 2008a). We present additional Keck I HIRES radial velocity measurements that provide evidence for a second planetary companion, alongside Keck II AO imaging that places an upper limit on the mass of this companion. Modelling of our Herschel images shows that the dust is broadly distributed, but cannot distinguish between a single wide belt (from 20 to 220AU) or two narrow dust belts (at around 40 and 165AU). Given the existence of a second planetary companion beyond approximately 3AU it is possible that the absence of dust within approximately 20AU is caused by dynamical depletion, although the observations are not inconsistent with depletion of these regions by collisional erosion, which occurs at higher rates closer to the star.Comment: Updated abstrac

The TRENDS High-Contrast Imaging Survey. V. Discovery of an Old and Cold Benchmark T-dwarf Orbiting the Nearby G-star HD 19467

The nearby Sun-like star HD 19467 shows a subtle radial velocity (RV) acceleration of -1.37+/-0.09 m/s/yr over an 16.9 year time baseline (an RV trend), hinting at the existence of a distant orbiting companion. We have obtained high-contrast adaptive optics images of the star using NIRC2 at Keck Observatory and report the direct detection of the body that causes the acceleration. The companion, HD 19467 B, is dK=12.57+/-0.09 mag fainter than its parent star (contrast ratio of 9.4e-6), has blue colors J-K_s=-0.36+/-0.14 (J-H=-0.29+/-0.15), and is separated by 1.653+/-0.004" (51.1+/-1.0 AU). Follow-up astrometric measurements obtained over an 1.1 year time baseline demonstrate physical association through common parallactic and proper motion. We calculate a firm lower-limit of m>51.9^{+3.6}_{-4.3}Mjup for the companion mass from orbital dynamics using a combination of Doppler observations and imaging. We estimate a model-dependent mass of m=56.7^{+4.6}_{-7.2}Mjup from a gyrochronological age of 4.3^{+1.0}_{-1.2} Gyr. Isochronal analysis suggests a much older age of $9\pm1$ Gyr, which corresponds to a mass of m=67.4^{+0.9}_{-1.5}Mjup. HD 19467 B's measured colors and absolute magnitude are consistent with a late T-dwarf [~T5-T7]. We may infer a low metallicity of [Fe/H]=-0.15+/-0.04 for the companion from its G3V parent star. HD 19467 B is the first directly imaged benchmark T-dwarf found orbiting a Sun-like star with a measured RV acceleration.Comment: Updated to reflect ApJ versio

A Systematic Review of Extended Reality (XR) for Understanding and Augmenting Vision Loss

Over the past decade, extended reality (XR) has emerged as an assistive technology not only to augment residual vision of people losing their sight but also to study the rudimentary vision restored to blind people by a visual neuroprosthesis. To make the best use of these emerging technologies, it is valuable and timely to understand the state of this research and identify any shortcomings that are present. Here we present a systematic literature review of 227 publications from 106 different venues assessing the potential of XR technology to further visual accessibility. In contrast to other reviews, we sample studies from multiple scientific disciplines, focus on augmentation of a person's residual vision, and require studies to feature a quantitative evaluation with appropriate end users. We summarize prominent findings from different XR research areas, show how the landscape has changed over the last decade, and identify scientific gaps in the literature. Specifically, we highlight the need for real-world validation, the broadening of end-user participation, and a more nuanced understanding of the suitability and usability of different XR-based accessibility aids. By broadening end-user participation to early stages of the design process and shifting the focus from behavioral performance to qualitative assessments of usability, future research has the potential to develop XR technologies that may not only allow for studying vision loss, but also enable novel visual accessibility aids with the potential to impact the lives of millions of people living with vision loss

Friends of Hot Jupiters II: No Correspondence Between Hot-Jupiter Spin-Orbit Misalignment and the Incidence of Directly Imaged Stellar Companions

Multi-star systems are common, yet little is known about a stellar companion's influence on the formation and evolution of planetary systems. For instance, stellar companions may have facilitated the inward migration of hot Jupiters towards to their present day positions. Many observed short period gas giant planets also have orbits that are misaligned with respect to their star's spin axis, which has also been attributed to the presence of a massive outer companion on a non-coplanar orbit. We present the results of a multi-band direct imaging survey using Keck NIRC2 to measure the fraction of short period gas giant planets found in multi-star systems. Over three years, we completed a survey of 50 targets ("Friends of Hot Jupiters") with 27 targets showing some signature of multi-body interaction (misaligned or eccentric orbits) and 23 targets in a control sample (well-aligned and circular orbits). We report the masses, projected separations, and confirmed common proper motion for the 19 stellar companions found around 17 stars. Correcting for survey incompleteness, we report companion fractions of $48\%\pm9\%$, $47\%\pm12\%$, and $51\%\pm13\%$ in our total, misaligned/eccentric, and control samples, respectively. This total stellar companion fraction is $2.8\,\sigma$ larger than the fraction of field stars with companions approximately $50-2000\,$AU. We observe no correlation between misaligned/eccentric hot Jupiter systems and the incidence of stellar companions. Combining this result with our previous radial velocity survey, we determine that $72\% \pm 16\%$ of hot Jupiters are part of multi-planet and/or multi-star systems.Comment: typos and references updated; 25 pages, 7 figures and 10 tables, accepted for publication in Ap

Conceptual knowledge acquisition in biomedicine: A methodological review

AbstractThe use of conceptual knowledge collections or structures within the biomedical domain is pervasive, spanning a variety of applications including controlled terminologies, semantic networks, ontologies, and database schemas. A number of theoretical constructs and practical methods or techniques support the development and evaluation of conceptual knowledge collections. This review will provide an overview of the current state of knowledge concerning conceptual knowledge acquisition, drawing from multiple contributing academic disciplines such as biomedicine, computer science, cognitive science, education, linguistics, semiotics, and psychology. In addition, multiple taxonomic approaches to the description and selection of conceptual knowledge acquisition and evaluation techniques will be proposed in order to partially address the apparent fragmentation of the current literature concerning this domain

Spatial epidemiological patterns suggest mechanisms of land-sea transmission for Sarcocystis neurona in a coastal marine mammal.

Sarcocystis neurona was recognised as an important cause of mortality in southern sea otters (Enhydra lutris nereis) after an outbreak in April 2004 and has since been detected in many marine mammal species in the Northeast Pacific Ocean. Risk of S. neurona exposure in sea otters is associated with consumption of clams and soft-sediment prey and is temporally associated with runoff events. We examined the spatial distribution of S. neurona exposure risk based on serum antibody testing and assessed risk factors for exposure in animals from California, Washington, British Columbia and Alaska. Significant spatial clustering of seropositive animals was observed in California and Washington, compared with British Columbia and Alaska. Adult males were at greatest risk for exposure to S. neurona, and there were strong associations with terrestrial features (wetlands, cropland, high human housing-unit density). In California, habitats containing soft sediment exhibited greater risk than hard substrate or kelp beds. Consuming a diet rich in clams was also associated with increased exposure risk. These findings suggest a transmission pathway analogous to that described for Toxoplasma gondii, with infectious stages traveling in freshwater runoff and being concentrated in particular locations by marine habitat features, ocean physical processes, and invertebrate bioconcentration

Interaction between Microtubules and the Drosophila Formin Cappuccino and Its Effect on Actin Assembly

Formin family actin nucleators are potential coordinators of the actin and microtubule cytoskeletons, as they can both nucleate actin filaments and bind microtubules in vitro. To gain a more detailed mechanistic understanding of formin-microtubule interactions and formin-mediated actin-microtubule cross-talk, we studied microtubule binding by Cappuccino (Capu), a formin involved in regulating actin and microtubule organization during Drosophila oogenesis. We found that two distinct domains within Capu, FH2 and tail, work together to promote high-affinity microtubule binding. The tail domain appears to bind microtubules through nonspecific charge-based interactions. In contrast, distinct residues within the FH2 domain are important for microtubule binding. We also report the first visualization of a formin polymerizing actin filaments in the presence of microtubules. Interestingly, microtubules are potent inhibitors of the actin nucleation activity of Capu but appear to have little effect on Capu once it is bound to the barbed end of an elongating filament. Because Capu does not simultaneously bind microtubules and assemble actin filaments in vitro, its actin assembly and microtubule binding activities likely require spatial and/or temporal regulation within the Drosophila oocyte