4,651 research outputs found

    Synchronisation of time--delay systems

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    We present the linear-stability analysis of synchronised states in coupled time-delay systems. There exists a synchronisation threshold, for which we derive upper bounds, which does not depend on the delay time. We prove that at least for scalar time-delay systems synchronisation is achieved by transmitting a single scalar signal, even if the synchronised solution is given by a high-dimensional chaotic state with a large number of positive Lyapunov-exponents. The analytical results are compared with numerical simulations of two coupled Mackey-Glass equations

    The C242T polymorphism of the NAD(P)H oxidase p22(phox) subunit is associated with an enhanced risk for cerebrovascular disease at a young age

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    Background and Purpose: Oxidative stress has been proposed as a major contributing factor for vascular disease, that acts independently from its participation in predisposing disorders such as diabetes and arterial hypertension. A functionally relevant C242T polymorphism of the CYBA gene encoding the NAD(P)H oxidase p22(phox) subunit, is supposed to lead to an abnormal reduction in the generation of reactive oxygen species in vascular smooth-muscle and endothelial cells. Methods: We investigated the p22(phox) C242T single-nucleotide polymorphism by polymerase chain reaction in consecutive patients with ischemic stroke or transient ischemic attack under the age of 50 (n = 161) and in population-based control subjects (n = 136). Results: Homozygosity for the T variant was associated with an enhanced risk for cerebral ischemia (odds ratio 3.85, confidence interval 1.39-10.64) after adjusting for classical risk factors. Risk for cerebral ischemia was not increased in heterozygous subjects. Conclusion: The p22(phox) C242T single-nucleotide polymorphism is associated with stroke risk. This finding supports the hypothesis that oxidative stress may contribute to stroke pathogenesis. Copyright (C) 2008 S. Karger AG, Basel

    Data report: evaluation of shipboard magnetostratigraphy by alternating field demagnetization of discrete samples, Expedition 361, Site U1475

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    The paleomagnetic shipboard data of International Ocean Discovery Program Site U1475, with a record reaching back to approximately 7 Ma, allowed for the identification of major magnetic polarity chrons and subchrons back to ~3.5 Ma. However, the natural remanent magnetization (NRM) was very weak, and transitional intervals with unclear polarity were as thick as several meters. The midpoints of these transitional intervals were reported in the shipboard results without decimal places because of the poor data quality. To evaluate and possibly refine the shipboard magnetostratigraphy, subsampling was performed across the polarity transitions. Detailed alternating field (AF) demagnetization experiments were conducted on these discrete samples and were complemented by anhysteretic remanent magnetization acquisition measurements and subsequent demagnetization. AF demagnetization data of NRM were analyzed using anchored principal component analysis (PCA) to obtain the characteristic remanent magnetization. These PCA results generally confirm the smoothed signal across polarity transitions at Site U1475. However, the midpoint depths of the top of the Keana Subchron, the Gauss-Matuyama and Matuyama-Brunhes boundaries, and the base of the Olduvai Subchron were adjuste

    The combinatorics of open covers (II)

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    We continue to investigate various diagonalization properties for sequences of open covers of separable metrizable spaces introduced in Part I. These properties generalize classical ones of Rothberger, Menger, Hurewicz, and Gerlits-Nagy. In particular, we show that most of the properties introduced in Part I are indeed distinct. We characterize two of the new properties by showing that they are equivalent to saying all finite powers have one of the classical properties above (Hurewicz property in one case and in the Menger property in other). We consider for each property the smallest cardinality of metric space which fails to have that property. In each case this cardinal turns out to equal another well-known cardinal less than the continuum. We also disprove (in ZFC) a conjecture of Hurewicz which is analogous to the Borel conjecture. Finally, we answer several questions from Part I concerning partition properties of covers

    Ring Expansion Of Alkylidenecarbenes Derived From Lactams, Lactones, And Thiolactones Into Strained Heterocyclic Alkynes: A Theoretical Study

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    Strained cycloalkynes are of considerable interest to theoreticians and experimentalists, and possess much synthetic value as well. Herein, a series of cyclic alkylidenecarbenes—formally obtained by replacing the carbonyl oxygen of four-, five-, and six-membered lactams, lactones, and thiolactones with a divalent carbon—were modeled at the CCSD(T)/cc-pVTZ//B3LYP/6-311+G** and CCSD(T)/cc-pVTZ//CCSD/6-311+G** levels of theory. The singlet carbenes were found to be more stable than the triplets. The strained heterocyclic alkynes formed by ring expansion of these singlet carbenes were also modeled. Interestingly, the C≡C bonds in the five-membered heterocycles, obtained from the rearrangement of β-lactam- and β-lactone-derived alkylidenecarbenes, displayed lengths intermediate between formal double and triple bonds. Furthermore, 2-(1-azacyclobutylidene)carbene was found to be nearly isoenergetic with its ring-expanded isomer, and 1-oxacyclopent-2-yne was notably higher in energy than its precursor carbene. In all other cases, the cycloalkynes were lower in energy than the corresponding carbenes. The transition states for ring-expansion were always lower for the 1,2-carbon shifts than for 1,2-nitrogen or oxygen shifts, but higher than for the 1,2-sulfur shifts. These predictions should be verifiable using carbenes bearing appropriate isotopic labels. Computed vibrational spectra for the carbenes, and their ring-expanded isomers, are presented and could be of value to matrix isolation experiments

    Sensitivity of Vertebrate Embryos to Heavy Metals as a Criterion of Water Quality

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    Embryonic and/or larval stages of the leopard frog (Rana pipiens), domestic fowl (Gallus domesticus) and the goldfish (Carassiua auratus) were treated with cadmium chloride, mercuric chloride, lead chloride, zinc chloride and sodium arsenite. The principal objectives were (1) to determine the sensitivity of vertebrate embryos to certain metals which are of consequence in water pollution, and (2) to ascertain the suitalility of vertebrate embryos as bioassay organisms for monitoring metallic pollutants within water resources. Vertebrate embryos are found to be highly sensitive to the toxic effects of all the metals studied. Concentrations of mercury as low as 10 ppb, with continuous treatment, produced a 100% kill of frog embryos and a significant degree of lethality in chick embryos. Cadmium and lead also produced detectable levels of lethality and/or anomalous development when administered to chick embryos at concentrations of 10 ppb. At 0.5 ppm mercury and cadmium produced 100% lethality in populations of goldfish embryos treated for four days. Lead and zinc were less toxic to the latter, producing approximately 80% lethality under simitar conditions. These results indicate that vertebrate embryos are substantially more sensitive to metallic pollutants than are adult forms, and that they may constitute a valuable tool for monitoring the quality of water resources
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