Una bibliografía para los estudios geográficos e históricos de la provincia de Huelva

Para la realización de un estudio histórico o geográfico es fundamental tener en cuenta tres tipos de fuentes de información: de carácter estadístico, cartográfico y bibliográfico. Nuestra atención en este artículo se centra en las fuentes de información bibliográfica. A pesar de la difusión, cada vez mayor, de los medios informáticos (consultas en bibliotecas e Internet), para muchos investigadores es muy útil la disponibilidad de sumarios que contengan un amplio repertorio de información bibliográfica. Así, el objetivo de este artículo es aportar y facilitar una bibliografía sobre temas geohistóricos de la provincia de Huelva.__________________________________In order to make a historical or geographical study, it is essential to keep in mind three types of sources of information: those of statistical, cartographic, and biographical characters. Our attention in this article is focused on sources of bibliographical information. In spite of the improving spreading of computer means (consults in libraries and Internet), in opinion of many investigators, the availability of summaries that contain a wide repertoire of bibliographical information is very useful. In this sense, the objective of this article is to provide and facilitate a bibliography on geo-historical themes of the province of Huelva

A New Approach to Social Entrepreneurship: A Systematic Review and Meta-Analysis

All social entrepreneurship experts state that the issue of definition is the main problem affecting research in this field. Although there is no single definition, this is clearly a new domain in the field of research on entrepreneurship. The main objective of this study is to further knowledge in this area by means of a systematic review of scientific literature to determine the conceptual development of social entrepreneurship and to identify the most interesting research trends. This study uses a research method, known as latent semantic analysis (LSA), which has been applied to a database of keywords collected from a rigorous selection of academic articles. The results show that this phenomenon has emerged from two parallel currents within the organization management field; on the one hand, the non-governmental organization (NGO) and voluntary tradition and, on the other, the world of business ethics and corporate social responsibility (CSR). The main lines of future research highlighted in the analysis include the measurement of social impact, venture philanthropy, and hybrid organizations

Influences of the solid load on the microstructure and compressive behavior of Fe2O3 scaffolds manufactured by freeze-casting using stearic acid as dispersant agent

Porous materials manufactured by freeze-casting are demonstrating potential application as oxygen carriers for the production and purification of hydrogen, or anode material for lithium-ion batteries. However, to obtain the required pore morphology and sufficient mechanical strength, the suspension processing parameters must be controlled. Fe2O3 nanoparticles/camphene suspensions were fabricated using stearic acid as the dispersant agent showing a low-viscosity (130 mPa⋅s) with a high solid volume fraction (0.3). Suspensions show a shear-thinning behavior according to the Sisko model and a maximum packing fraction of 0.569 estimated from a zero porosity sample. A modified Krieger and Dougherty model was introduced to incorporate the influence of the particleaspect ratio. The Fe2O3 scaffolds manufactured by freeze-casting shown a gradient pore size along the freezing direction, which was diminished with the solid volume fraction, the compression strength was improved with the pore size reduction and fitted according to the minimum solid area model.Universidad de Sevilla PIF II.2AAgencia Estatal de Investigación (AEI) MAT2016-76713-

Validación de la escala de engagement y efectos de la gamificación en el e-Commerce español

En este artículo presentamos la Escala de Engagement de Usuario (UES) como un instrumento válido y fiable para medir el engagement en el e-commerce español. Una vez confirmada su robustez, pretendemos comprobar si los elementos de Gamificación que se incluyen en la actualidad en sitios web de e-commerce influyen en el engagement del usuario. Se desarrollará un marco teórico sobre la escala del engagement y la Gamificación proponiendo un modelo de investigación. La UES será validada mediante el análisis exploratorio y confirmatorio, viéndose reducidos los factores que la componen. La influencia de la Gamificación sobre el engagement será comprobada mediante el empleo de modelos de ecuaciones estructurales.In this paper we present the User Engagement Scale (UES) as a valid and reliable instrument to measure engagement in Spanish e-commerce. Once confirmed its robustness, we try to verify if the elements of Gamification that are currently included in e-commerce websites influence the engagement of the user. A theoretical framework will be developed on the scale of engagement and Gamification proposing a research model. The UES will be validated through the exploratory and confirmatory analysis, reducing the factors that compose it. The influence of Gamification on engagement will be verified by the use of structural equation models

Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults

This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundacion Iberoamericana de Nutricion (FINUT), the Redes Tematicas de Investigacion Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigacion 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundacion Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012).Objective: Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results: Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress–derived 8,12-iso- iPF2α -VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion: Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.Spanish Government PI13/01393Retos de la Sociedad DEP2016-79512-REuropean Commission Spanish Government FPU16/02828 FPU19/01609Fundacion Iberoamericana de Nutricion (FINUT)Redes Tematicas de Investigacion Cooperativa RETIC Red SAMID RD16/0022AstraZenecaUniversity of Granada Plan Propio de Investigacion Excellence actions: Unit of Excellence on Exercise and Health (UCEES)Junta de Andalucia Consejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGR DOC 01151Fundacion Alfonso Martin EscuderoNetherlands CardioVascular Research Initiative: the Dutch Heart FoundationDutch Federation of University Medical CentersNetherlands Organization for Health Research and DevelopmentRoyal Netherlands Academy of Sciences CVON2017-20 GENIUS-2China Scholarship Council 201707060012 PTA-1226

Optimization of the therapeutic approach to patients with sarcoma: Delphi Consensus

Delphi consensus; Sarcoma treatment; Panel of expertsConsenso Delphi; Tratamiento del sarcoma; Panel de expertosConsens Delphi; Tractament del sarcoma; Panell d'expertsSoft tissue sarcomas (STS) constitute a heterogeneous group of rare solid tumors associated with significant morbidity and mortality. The evaluation and treatment of STS require a multidisciplinary team with extensive experience in the management of these types of tumors. National and international clinical practice guidelines for STS do not always provide answers to a great many situations that specialists have to contend with in their everyday practice. This consensus provides a series of specific recommendations based on available scientific evidence and the experience of a group of experts to assist in decision-making by all the specialists involved in the management of STS

Multiple Gestations and Assisted Reproductive Technologies: Qualitative Study of the Discourse of Health Professionals in Spain

Multiple gestations have become an increasing phenomenon that has impacted public health globally, largely due to the application of assisted reproductive technologies. The objective of this work was to find out the discourse that the health professionals involved in its follow-up have in our context. For this, a qualitative methodology was chosen, with semi-structured interviews recorded in audio, prior authorisation, and transcribed verbatim. It was based on a script designed for this purpose, with the following analysis categories: the current trend of multiple gestations, impact, and follow-up. The content analysis was based on the experiences, knowledge, and perceptions of the professionals interviewed. Professionals stated that the current socioeconomic and legal context hinders a single embryo transfer policy that decreases multiple gestation rates. They emphasised the importance of the psychic impact of such gestations on the couple, on the mother in particular, as well as the economic effect on families, health, and society in general. They expressed the need to create specific protocols to assist these gestations. Midwives, in particular, demanded that the health administration recognise and support the differentiated care they perform with this type of gestation. Work on specific models is needed to adequately size the impact of multiple gestations, as well as to generate social health policies that lead to co-responsible reconciliation measures that favour women having one pregnancy at a time

The nodD1 Gene of Sinorhizobium fredii HH103 Restores Nodulation Capacity on Bean in a Rhizobium tropici CIAT 899 nodD1/nodD2 Mutant, but the Secondary Symbiotic Regulators nolR, nodD2 or syrM Prevent HH103 to Nodulate with This Legume

Rhizobial NodD proteins and appropriate flavonoids induce rhizobial nodulation gene expression. In this study, we show that the nodD1 gene of Sinorhizobium fredii HH103, but not the nodD2 gene, can restore the nodulation capacity of a double nodD1/nodD2 mutant of Rhizobium tropici CIAT 899 in bean plants (Phaseolus vulgaris). S. fredii HH103 only induces pseudonodules in beans. We have also studied whether the mutation of different symbiotic regulatory genes may affect the symbiotic interaction of HH103 with beans: ttsI (the positive regulator of the symbiotic type 3 protein secretion system), and nodD2, nolR and syrM (all of them controlling the level of Nod factor production). Inactivation of either nodD2, nolR or syrM, but not that of ttsI, affected positively the symbiotic behavior of HH103 with beans, leading to the formation of colonized nodules. Acetylene reduction assays showed certain levels of nitrogenase activity that were higher in the case of the nodD2 and nolR mutants. Similar results have been previously obtained by our group with the model legume Lotus japonicus. Hence, the results obtained in the present work confirm that repression of Nod factor production, provided by either NodD2, NolR or SyrM, prevents HH103 to effectively nodulate several putative host plants.España Ministerio de Ciencia e Innovación y Universidades projects AGL2016-77163-R and PID2019-107634RB-I00España Ministerio de Ciencia e Innovación y Universidades FPU18/06248