Nasal T cell lymphoma: a rare entity

Nasal type of Natural Killer (NK)/T cell lymphoma manifests in the nasal cavity. Approximately 95% of them are associated with EBV(Ebstein Barr Virus) with a strong predilection for the Asian population. It has certain systemic and localized symptoms which aid in diagnosis of the condition. However, the histological criteria is pivotal in confirming the diagnosis as well as aiding in confirming the association of EBV. Nasal type of NK/T cell lymphoma has a guarded prognosis. Treatment plan include radiotherapy with concurrent chemotherapy. Despite all this, the 5-year survival rate ranges from 15-75%. A 35 years old male presented with an ulcerative nasal lesion. Diagnosed as nasal type of NK/T cell lymphoma via a tissue biopsy, it was managed by chemo-radiotherapy leading to complete resolution of symptoms and disease free on his follow-up 6 months later

Study of strange quark density fluctuations in Au+Au Collisions at sNN\sqrt{s_{NN}} = 7.7-200 GeV from AMPT Model

The strangeness production is an important observable to study the QCD phase diagram. The yield ratios of strange quark can be helpful to search for the QCD critical point and/or first order phase transition. In this work, we studied the production of $K^{\pm}$, $\Xi^-(\bar{\Xi}^{+})$, $\phi$ and $\Lambda (\bar \Lambda)$ in Au+Au collisions at $\sqrt{s_{NN}}$ = 7.7, 11.5, 14.5, 19.6, 27, 39, 54.4, 62.4 and 200 GeV from A Multi-Phase Transport model with string melting version (AMPT-SM). We calculated the invariant yield of these strange hadrons using a different set of parameters reported in earlier studies and also by varying the hadronic cascade time ($t_{max}$) in the AMPT-SM model. We also calculated the yield ratios, $\mathcal{O}_{K^{\pm}-\Xi^{-}(\bar \Xi^{+})-\phi-\Lambda (\bar \Lambda)}$ which are sensitive to the strange quark density fluctuations and found that the AMPT-SM model fails to describe the non-monotonic trend observed by the STAR experiment. The negative particle ratio are found to be higher than the ratio of positive particles which is consistent with the experimental data. A significant effect is also seen on these ratios by varying the $t_{max}$. This study based on the transport model can be helpful to provide possible constraints as well as reference for the search of CEP in future heavy-ion experiments. Our findings suggest that the ongoing Beam Energy Scan program at RHIC and the future heavy-ion experiments will be able to find/locate the possible CEP in the QCD phase diagram which results large quark density fluctuations.Comment: 7 pages, 2 figure

Use of integrated clinical scenarios in neuroanatomy laboratory sessions a strategy to foster students’ learning

Objective: Combinations of various teaching strategies have been employed to enhance neuroanatomy teaching, to little success. Herein, we describe the use of integrated clinical scenarios in anatomy laboratory sessions as an educational strategy to improve the learning process for students undertaking neuroscience course. Methods: We assessed the perception and performance of students who utilised the integrated clinical resources in the neuroanatomy labs. We also compared the performance of the students on their neuroscience course with the performance of the previous year\u27s students (who did not use the clinical scenarios). Results: A total of (130) 88% of the registered student both male and female participated by filling out a questionnaire. A majority (80%) of students supported introducing clinical cases at this early stage and agreed that cases covered learning objectives well. Students (81%) preferred a decreased faculty participation and 68% strongly agreed that cases were well integrated with other disciplines and assisted critical thinking and conceptual understanding. Most of them (90%) approved using plastic models and pictures as resource-material. The average mark obtained for all block together between the two cohorts did not differ significantly, while student performance was significantly improved in neuroscience block of the cohort which had access to the integrated clinical scenarios. Conclusions: Collectively, or specifically designed neuroanatomy lab sessions provided students with an empowering experience to help them apply critical thinking and use their basic neuroscience knowledge to solve clinical problems

Effect of hadronic cascade time on freeze-out properties of Identified Hadrons in Au+Au Collisions at sNN\sqrt{s_{NN}} = 7.7-39 GeV from AMPT Model

We report the transverse momentum $p_T$ spectra of identified hadrons ($\pi^\pm$, $K^\pm$ and $p(\bar p)$) in Au+Au collisions at $\sqrt{s_{NN}}$ = 7.7 - 39 GeV from A Multi Phase Transport Model with string melting effect (AMPT-SM). During this study, a new set of parameters are explored to study the effect of hadronic cascade by varying hadronic cascade time $t_{max}$ = 30 $f$m/$c$ and 0.4 $f$m/$c$. No significant effect of this change is observed in the $p_T$ spectra of light hadrons and the AMPT-SM model reasonably reproduces the experimental data. To investigate the kinetic freeze-out properties the blast wave fit is performed to the $p_T$ spectra and it is found that the blast wave model describes the AMPT-SM simulations well. We additionally observe that the kinetic freeze-out temperature ($T_{kin}$) increases from central to peripheral collisions, which is consistent with the argument of short-lived fireball in peripheral collisions. Whereas the transverse flow velocity, shows a decreasing trend from central to peripheral collisions indicating a more rapid expansion in the central collisions. Both, $T_{kin}$ and show a weak dependence on the collision energy at most energies. We also observe a strong anti-correlation between $T_{kin}$ and $$. The extracted freeze-out parameters from the AMPT-SM simulations agree with the experimental data as opposed to earlier studies that reported some discrepancies. Whereas, no significant effect is found on the freeze-out parameters by varying the $t_{max}$. We also report the $p_T$ spectra of light hadrons and their freeze-out parameters by AMPT-SM simulations at $\sqrt{s_{NN}}$ = 14.5 GeV, where no experimental data is available for comparison. Overall, the set of parameters used in this study well describes the experimental data at BES energies.Comment: 12 pages, 7 figures, 2 table

Study of Baryon number transport using model simulations in pppp collisions at LHC Energies

We report on the excitation function of anti-baryon to baryon ratios ($\overline{p}/p$, {\alam /\lam} and {\axi / \xim}) in $pp$ collisions at {\sqrts} = 0.9, 2.76, 7 TeV from DPMJET-III, Pythia~8, EPOS~1.99, and EPOS-LHC model simulations. To study the predictions of these models at {\sqrts} = 13.6 TeV. The anti-baryon to baryon ratios are extremely important for the study of baryon number transport mechanisms. These ratios help determine the carriers of the baryon number and in the extraction of baryon structure information. Even though all models show a good agreement between model simulations and data, the ratios extracted from DPMJET-III model closely describes data at all energies. It is observed that these ratios converge to unity for various model predictions. This convergence also indicates that the anti-baryon to baryon ratios follow the mass hierarchy, such that the hyperon specie containing more strange quarks ({\alam /\lam} and {\axi / \xim}) approaches unity faster than specie containing fewer strange quarks ($\overline{p}/p$). It is also observed that the $\overline{B}/B$ ratio approaches unity more rapidly with the increase in {\sqrts} energy. At lower energies we observe an excess production of baryons over anti-baryons. However, this effect vanishes at higher energies due to the baryon-anti-baryon pair production and the baryon-anti-baryon yield becomes equal. Using model simulations, we additionally compute the asymmetry, (A\equiv\frac{N_{p}-N_{\bar{p}}}N_{p}+N_{\bar{p}}}) for protons. The asymmetry shows a decreasing trend with increase in energy from 0.9 to 7 TeV for all energies. This asymmetry trend is confirmed by model predictions at {\sqrts} = 13.6 TeV which will help to put possible constraints on model calculations at {\sqrts} = 13.6 TeV once the Run-III data for LHC becomes available.Comment: 14 pages, 8 figures, 2 table

Sentinel node localisation using pre-operative lymphoscintigraphy and intraoperative gamma probe in early oral cavity cancer

Objectives: To assess the diagnostic value of sentinel lymph node localisation using pre-operative lymphoscintigraphy and intra-operative gamma probe radio localisation in Pakistani patients suffering from early stage squamous cell carcinoma of the oral cavity.Methods: The prospective case series was conducted between September 2007 and April 2010 at the Aga Khan University Hospital, Karachi. It comprised patients with T1and T2 oral cavity cancer with clinically and radiologically negative neck. Pre-operative lymphoscintigraphy was performed one day before surgery and intra-operative gamma probe was used to detect sentinel node. Final histo-pathological evaluation was taken as the gold standard.Results: The study comprised 42 patients: 32(76%) males and 10(24%) females. The primary tumour site was buccal mucosa in 25 (60%) patients, and tongue in 17 (40%). Sentinel lymph node was detected in 38 (90%) patients.On final histopathological identification, 7 (17%) patients had cancer in the neck nodes. In all patients with metastasis, sentinel lymph node technique correctly identified the involved neck level. None of the patients revealed metastasis in non-sentinel lymph nodes.Conclusion: Evidence suggested the use of sentinel node biopsy in patients with head and neck squamous cell carcinoma

Toluidine blue: Yet another low cost method for screening oral cavity tumour margins in Third World countries

Objective: To use toluidine blue intra-operatively to identify tumour involved margins after the removal of oral cavity squamous cell carcinoma, and to compare the findings with those of final histopathology.Methods: The study was conducted at the Aga Khan University Hospital from December 1, 2009, to March 14, 2010, and comprised 56 consecutive patients with biopsy-proven squamous cell carcinoma of oral cavity regardless of grade and stage of tumour. Intra-operatively toluidine blue was used on the resected tumour margins and the staining patterns were assessed. Results were then compared with the final histopathology report.Results: A total of 11(19.64%) margins were positive with toluidine blue staining out of which 8 (14.28%) were false positive. Sensitivity and specificity was found to be 100% and 84.9% respectively with a positive predictive value of 27.2%; a negative predictive value of 100%; and diagnostic accuracy of 85.71%.Conclusion: Toluidine blue costs only Rs25 (USD 0.30) and takes only 5 minutes for application and interpretation. It can be used with significant confidence in smaller lesions (T-I and T-II) as an alternative to frozen sections in developing countries where facilities are unavailable. Its use in larger lesions (T-III and TIV) remains the topic of controversy and awaits a multi centre trial with a larger cohort

Advanced Carbon Materials: Base of 21st Century Scientific Innovations in Chemical, Polymer, Sensing and Energy Engineering

Advance carbon material that includes graphene, fullerenes, hierarchical carbon, and CNTs are referred to as strength of revolution and advancement in the era of material science and technology. In general, 20th century corresponds to plastic meanwhile 21st century will be named as “Century of Graphene” owing to its exceptional physical properties. Graphene is now well-known and prominent 2D carbon allotrope that is considered as multipurpose material in comparison with any material discovered on earth. One of the interesting properties of graphene is strongest and lightest material that enables it to conduct electricity and heat as compared to any other material. Such features permit it to utilize in numerous applications including biosensors, electronic industry, environmental remediation, drug delivery, energy storage, and production as well. Owing to these capabilities, it can be stated that graphene can be utilized to improve effectiveness and performance of existing substances and materials. In the future, conjugation of graphene with other 2D material will be devolved to produce further remarkable compounds that make it appropriate for an extensive variety of applications. This chapter grants the utilization and applications of advanced carbons materials in chemical, polymer, sensing and energy enegineering

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties. This study aimed to evaluate the catalytic and bactericidal potential of undoped and Sr-doped Cr2O3 nanostructures (NSs) synthesized through the co-precipitation method. In addition, the morphological, optical, and structural properties of the resultant NSs were also examined. The optical bandgap energy of Cr2O3 has been substantially reduced by Sr doping, as confirmed through extracted values from absorption spectra recorded by UV-Vis studies. The field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) micrographs illustrate that the composition of Cr2O3 primarily consisted of agglomerated, irregularly shaped NSs with a morphology resembling nanoflakes. Moreover, the presence of Sr in the lattice of Cr2O3 increased the roughness of the resulting NSs. The catalytic activity of synthesized NSs was analyzed by their reduction ability of Rhodamine B (RhB) dye in the dark under different pH conditions. Their antibacterial activity was evaluated against MDR Escherichia coli (E. coli). Sr doping increased antibacterial efficiency against MDR E. coli, as indicated by inhibition zone measurements of 10.15 and 11.75 mm at low and high doses, respectively. Furthermore, a molecular docking analysis was conducted to determine the binding interaction pattern between NSs and active sites in the target cell protein. The findings corroborated antimicrobial test results indicating that Sr-Cr2O3 is the most effective inhibitor of FabH and DHFR enzymes

Carbon Nanotubes

Carbon nanotubes (CNTs) are referred to as carbon nano-architecture allotropes, with wrapped graphene sheets forming a cylindrical structure. CNTs are either developed by metals or narrow-band semiconductors with rolling graphene sheets in various ways. Researchers have dedicated a great deal of attention to understanding the fascinating properties of CNTs over the years, and possess certain peculiar properties, such as a high degree of stiffness, a wide ratio of length to diameter, and remarkable toughness, and are employed in a number of applications. These properties can be enhanced by scheming the diameter, nature of walls, chirality, length of CNTs which is rolled up, and depending on the synthesis process. This chapter extensively covers the various properties of CNTs and how it influences to desired applications and also explains numerous methods of synthesis and processing of CNTs with advantages and some drawbacks