4 research outputs found
Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma
- Author
- Ashton Garry
- Brognard John
- Carragher Neil
- Davies Lawrence
- Ejiama Sarah
- Fish Laura
- Frame Margaret
- Fusi Alberto
- Girotti Maria Romina
- Hohloch Juliane
- Johnson Louise
- Lopes Filipa
- Lorigan Paul
- Macleod Kenneth
- Marais Richard
- Marusiak Anna A.
- McLeary Robert
- Menard Delphine
- Niculescu-Duvaz Dan
- Pedersen Malin
- Preece Natasha
- Sanchez-Laorden Berta
- Saturno Grazia
- Springer Caroline
- Suijkerbuijk Bart M.J.M.
- Viros Amaya
- Whittaker Steven
- Zambon Alfonso
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
SummaryBRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs. Resistance is often mediated by pathway reactivation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which drive paradoxical reactivation of the pathway. We describe pan-RAF inhibitors (CCT196969, CCT241161) that also inhibit SFKs. These compounds do not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma. They inhibit melanoma cells and patient-derived xenografts that are resistant to BRAF and BRAF/MEK inhibitors. Thus, paradox-breaking pan-RAF inhibitors that also inhibit SFKs could provide first-line treatment for BRAF and NRAS mutant melanomas and second-line treatment for patients who develop resistance
LG-27DKFZ-BT66 - A NOVEL PILOCYTIC ASTROCYTOMA MODEL FOR PRECLINICAL DRUG TESTING
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Konsumentprisstatstik 1983, 1 kvartalet
- Author
- Ashton Garry
- Brognard John
- Carragher Neil
- Davies Lawrence
- Ejiama Sarah
- Fish Laura
- Frame Margaret
- Fusi Alberto
- Girotti Maria Romina
- Hohloch Juliane
- Johnson Louise
- Lopes Filipa
- Lorigan Paul
- Macleod Kenneth
- Marais Richard
- Marusiak Anna A.
- McLeary Robert
- Menard Delphine
- Niculescu-Duvaz Dan
- Pedersen Malin
- Preece Natasha
- Sanchez-Laorden Berta
- Saturno Grazia
- Springer Caroline
- Suijkerbuijk Bart M.J.M.
- Viros Amaya
- Whittaker Steven
- Zambon Alfonso
- Publication venue
- Tilastokeskus
- Publication date
- 15/04/1983
- Field of study
Suomen virallinen tilasto (SVT
Literaturverzeichnis
- Author
- Aufl Angelbachtal
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- Beichel-Benedetti
- Beitzke Günther
- Benedek Ferenc
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- Bilinski Andreas
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- Brosius-Gersdorf Frauke
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- Bundesministerium der Justiz
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- Hellners
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- Henkel Jörg
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- Hesse Konrad
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- Hierold Alfred E
- Hillgruber Christian
- Hillgruber Christian
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- Hobbes Thomas
- Hochwald Monika
- Hofmann Rainer
- Hohloch Gerhard
- Holböck Carl
- Holeschovsky Christine
- Hollsing Ingmar
- Holmbäck
- Holte Ragnar
- Hombach Stephanie
- Home Affairs Committee (UK)
- Homolka Walter
- Honecker Martin
- Honecker Martin
- Horn Werner
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- Huber Josef
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- Hufen Friedhelm
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- Häberle Peter
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- Iskander Sameh
- Janetzky Birgit
- Janson Jan
- Jarass Hans D
- Jarass Hans D
- Jarlert Anders
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- Jeand'Heur
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- Johansen Baber
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- Justizministerium Baden-Württemberg
- Jäggi Peter
- Jänterä-Jareborg Maarit
- Jänterä-Jareborg Maarit
- Jänterä-Jareborg Maarit
- Kallis Anastasios
- Kallis Anastasios
- Kaplan
- Karras
- Kaser
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- Kelek Necla
- Khazova Olga A
- Khoulap Vladimir
- Khoury Adel Theodor
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- Kindhäuser Urs
- Kindhäuser Urs
- Kirche Kompendium
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- Klefbeck Markus
- Klein Birgit E
- Klein Eckart
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- Knütel Rolf
- Koch Elisabeth
- Kotzur Hubert
- Krauss Günther
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- Kreuzer Karl
- Krings Günter
- Krishnaswami Arcot
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- Lichtenberg Georg
- Liermann Stephan
- Lindell
- Lindfelt
- Lindner
- Lindquist
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- Malhotra Ranjit
- Malm Torbjörn
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- Mansel Heinz-Peter
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- Martiny Dieter
- Martling
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- Maurer Hartmut
- Maurer Hartmut
- Meier Norbert
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- Meyendorff John
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- Mugdan Benno
- Muscheler Karlheinz
- Möller Kai
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- Nebengesetzen
- Nebengesetzen
- Nebengesetzen
- Nelle Dietrich
- Nergelius Joakim
- Neuhaus
- Neuhaus
- Neuhaus Paul Heinrich
- Neuhaus Paul Heinrich
- Niebergall Alfred
- Nikolaou Theodor
- Nilsson Gerd
- Notz
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- Pauly Walter
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- Pintens Walter
- Pintens Walter
- Pirson Dietrich
- Pirson Dietrich
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- Potz
- Prader
- Prader Joseph
- Prader Joseph
- Prader Joseph
- Prader Joseph
- Putzer Max
- Puza
- Puza Richard
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- Puza Richard
- Pålsson Lennart
- Rasquin Klaus
- Rauch Isabel
- Rauscher Thomas
- Rauscher Thomas
- Rauscher Thomas
- Rehman Javaid
- Reicke Siegfried
- Renck Ludwig
- Reuter Hans-Richard
- Reuterskiöld
- Reynolds
- Richter Klemens
- Riedel Johannes
- Rietschel
- Rimša
- Ritzer Korbinian
- Rixe Georg
- Robbers Gerhard
- Robinson Nehemiah
- Rohe Mathias
- Rohe Mathias
- Roos Lena
- Rotter Hans
- Rubenson Samuel
- Rude-Antoine Edwige
- Rupp Marina
- Russo Carl
- Sachs Michael
- Sachs Michael
- Sayed Mosa
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- Scharffs Brett G
- Scheftelowitz
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- Schilling Heinz
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- Schiratzki Johanna
- Schlief
- Schlüter Wilfried
- Schmidt Folke
- Schmidt Kurt Dietrich
- Schmidt-Bleibtreu
- Schmidt-Volkmar Erich
- Schmitz Heribert
- Schmitz-Justen Christian
- Scholz Peter
- Scholz Peter
- Scholz-Löhnig Cordula
- Scholz-Löhnig Cordula
- Schott Clausdieter
- Schröter Michael
- Schubert Karin
- Schubert Werner
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- Schulz Wolfgang
- Schulze Ulrich W
- Schulze Ulrich W
- Schumann Friedrich Karl
- Schumann Kay
- Schwab Dieter
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- Schwab Dieter
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- Schwendendenwein Hugo
- Schwenzer Ingeborg
- Schwenzer Ingeborg
- Schönke Begr
- Schüller Heribert
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- Societas Goerresiana
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- Sonnenberger Hans Jürgen
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- Spernat Thomas
- Starck Christian
- Stavros Stephanos
- Steding Ulrich
- Stern
- Stern Klaus
- Stone
- Strauch Dieter
- Strätz
- Strätz Hans-Wolfgang
- Strömberg Håkan
- Strömberg Håkan
- Stupperich Robert
- Sturm Fritz
- Sturm Fritz
- Sundberg
- Sundberg
- Sundberg
- Sundberg
- Sundberg Lars-Göran
- Sundby Olof
- Svenska Kyrkan
- Svenska Kyrkan
- Szeibert-Erdös Orsolya
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- Söderberg Staffan
- Sörgjerd Caroline
- SütÅü Feliz
- Taussi Sjöberg Marja
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- Thesing
- Thomson Arthur
- Thöle Reinhard
- Thüsing Gregor
- Tietz Gerold
- Tillmanns Reiner
- Tilly Heinz Peter
- Tottie
- Tottie Lars
- Towfigh
- Treggiari Susan
- Tröger Elisabeth
- Ulbrich Claudia
- Unicef
- Usarski Frank
- Valerius Brian
- van Bijsterveld Sophie C
- van Dijk Pieter
- VELKD
- Verlinden Ann
- Vermeulen Ben
- von Bar Christian
- von Campenhausen
- von Campenhausen Axel
- von Campenhausen Axel
- von Campenhausen Axel
- von Campenhausen Axel
- von Heintschel-Heinegg Bernd
- von Münch Begr
- von Oppen Alexandra
- von Ungern-Sternberg Antje
- Vorgrimler Herbert
- Vosman
- Voßkuhle Andreas
- Wachsmann Monika
- Wacke Andreas
- Wagenitz
- Wagenitz Thomas
- Wagner Wolfgang
- Wahl Rainer
- Waldhoff Christian
- Waldhoff Christian
- Waldhoff Christian
- Waldstein Wolfgang
- Wardle Lynn D
- Ware Kallistos
- Weber Edmund
- Weber Hermann
- Wellenhofer Marina
- Wenz Gunther
- Wesel Uwe
- Westman
- Wick Lukas
- Wielandt Rotraud
- Wiemann Rebecca
- Willutzki Siegfried
- Winroth
- Winter Jörg
- Witte John Jr
- Wolf Alfred
- Wolff Christian
- Wolff Heinrich Amadeus
- Wolfrum Rüdiger
- Zacharias Diana
- Zapp Hartmut
- Zick Andreas
- Zippelius Reinhold
- Zuleeg Manfred
- Zweigert
- äktenskap
- ür Familie Senioren
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study