3,025 research outputs found
development of a radiographic scoring validating the presumption diagnosis
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Inhaltsverzeichnis
AbkĂŒrzungsverzeichnis
Einleitung
LiteraturĂŒbersicht
Material und Methoden
Ergebnisse
Diskussion
Zusammenfassung
Summary
Literaturverzeichnis
Anhang
Abbildungsverzeichnis
Tabellenverzeichnis
Danksagung
SelbstĂ€ndigkeitserklĂ€rungIn der Klinik und Poliklinik fĂŒr kleine Haustiere der FU Berlin wurden
zwischen 1997 und 2002 76 Satinmeerschweinchen wegen des Verdachts einer
Osteodystrophia fibrosa untersucht. 15 der 76 Satinmeerschweinchen wurden
pathologisch aufgearbeitet. 52 der Satinmeerschweinchen (25 â, 27 â) konnten
auch statistisch bearbeitet werden. Zur röntgenologischen Kontrolle wurden 25
skelettgesunde, normalfellige Meerschweinchen untersucht. Bei einer zweiten
Gruppe mit 36 gesunden, normalfelligen Meerschweinchen wurden Blut- und
Blutchemiewerte im Vergleich zum Patientenkollektiv analysiert. Die
Kontrolltiere waren zum allgemeinen Gesundheitscheck vorgestellt worden.
AuĂerdem wurden sieben SatintrĂ€germeerschweinchen (GentrĂ€ger, Normalfell; 6 â,
1 â) in die Untersuchungen mit einbezogen. 20 der 52 Satinmeerschweinchen
waren klinisch krank und 32 klinisch gesund. 15 der Tiere litten unter
Gewichtsverlust und zehn nahmen weniger oder selektiv Futter auf. Diese Tiere
hatten ein nasses Maul. Vier Satinmeerschweinchen waren exsikkotisch und bei
drei Tieren war die Zahnsubstanz weich und bröckelig. Zwei andere wiesen eine
BrĂŒckenbildung der PrĂ€molaren im Unterkiefer auf. Bei 12 Tieren waren
Unterkiefer und Kiefergelenk aufgetrieben. 15 Satinmeerschweinchen waren
bewegungsunfreudig, vier Tiere waren schmerzhaft in HĂŒft- und Kniegelenk, zwei
krĂŒmmten den RĂŒcken auf und 12 waren matt und apathisch. Bei elf der 15
pathologisch untersuchten Satinmeerschweinchen wurde die Diagnose
Osteodystrophia fibrosa gestellt. Von den SatintrÀgermeerschweinchen waren
sechs Tiere gesund, ein Tier wies einen blutigen Scheidenausfluss auf. Nach
dem Röntgenscoresystem wurde nach radiologischen VerÀnderungen einer
Osteodystrophia fibrosa an Scheitelbein, Stirnbein, Unterkieferast, Jochbogen,
LendenwirbelsĂ€ule, HĂŒftgelenk, Ober- und Unterschenkelknochen und Kniegelenk
gesucht. Neun bis maximal 27 Punkte konnten vergeben werden. Anhand der
Scoretestung durch sechs TierĂ€rzte wurde eine Grenze von †13 Punkten fĂŒr
radiologisch unauffĂ€llig und > 13 Punkten fĂŒr radiologisch auffĂ€llig
erarbeitet. Die Auswertung der 52 Satin-, sieben SatintrÀger- und 25
Kontrollmeerschweinchen mit dem Röntgenscore ergab, dass kein Kontroll- oder
SatintrĂ€germeerschweinchen mehr als 13 Punkte erhielt. Ăltere
Satinmeerschweinchen (> 25 Monate) erhielten einen signifikant höheren
Röntgenscore als jĂŒngere (†25 Monate) und klinisch kranke Tiere einen
signifikant höheren als gesunde. Satin-Glatthaartiere (22/52) erhielten einen
signifikant höheren Röntgenscore als Satin-Rex (12/52). Das Geschlecht erwies
sich als unbedeutend. Es wurden osteopenische VerÀnderungen an Unterkiefer,
Jochbogen, Wirbelkörpern, Becken und an langen Röhrenknochen sowie
osteosklerotische VerÀnderungen an SchÀdeldach, Endplatten der Wirbel und an
langen Röhrenknochen festgestellt. Bei Satinmeerschweinchen konnten
signifikant niedrigere Gesamtkalziumspiegel als bei Kontrollmeerschweinchen
gemessen werden. JĂŒngere Satinmeerschweinchen wiesen signifikant höhere
Phosphatwerte als Ă€ltere auf. JĂŒngere sowie Ă€ltere Satinmeerschweinchen hatten
signifikant höhere Alkalische-Phosphatase-Werte als die jeweilige
Kontrollgruppe. Bei klinisch kranken Satintieren waren die Alkalische-
Phosphatase-Werte signifikant höher als bei klinisch gesunden.
Satinmeerschweinchen, die im Röntgenscore mehr als 13 Punkte aufwiesen, hatten
signifikant höhere Alkalische-Phosphatase-Werte als Tiere, die nur bis 13
Punkte erreichten. Die Kreatininwerte kranker Satinmeerschweinchen lagen
signifikant höher als die Werte gesunder. Gesunde SatintrÀger- sowie
Kontrollmeerschweinchen hatten signifikant höhere Werte als gesunde
Satinmeerschweinchen. Bei gesunden Satin- wurden auĂerdem signifikant
niedrigere Thrombozytenwerte als bei Kontrollmeerschweinchen gemessen. Das
Geschlecht der Tiere erwies sich fĂŒr alle Laborparameter als unbedeutend.
Aufgrund der Befunde wurde bei erkrankten Satinmeerschweinchen eine
Osteodystrophia fibrosa infolge eines sekundÀren Hyperparathyreoidismus
diagnostiziert. Die Ursache der Erkrankung konnte nicht definitiv geklÀrt
werden. Vermutet wird eine genetische Disposition, dies sollte in weiteren
Studien geklÀrt werden.Between 1997 and 2002 seventy-six satin type guinea pigs suspected to have
fibrous osteodystrophy were presented at the Clinic for Small Domestic
Animals, Freie UniversitÀt Berlin. 15 out of 76 satin guinea pigs were
examined pathologically. In the present study 52 satin type guinea pigs (sasa;
25 â, 27 â) were analysed statistically. Two control groups out of healthy,
non-satin, normal guinea pigs were established, one to compare radiological
results (n = 25) and one to compare blood chemistry and blood count values (n
= 36). In addition, seven carriers of the satin gene (sa-, normal fur; 6 â, 1
â) were examined. Twenty out of fifty-two satin type guinea pigs were
established to be clinically sick, in the other 32 there were no pathological
findings. Fifteen animals had lost weight, ten animals had not eaten and had
wet fur around their mouths. Four animals were dehydrated and the state of the
teeth in three had deteriorated. Two others had grown elongated cheek teeth
and twelve guinea pigs had misshapen mandibles. Fifteen satin type guinea pigs
were reluctant to walk, four had painful knees and a painful hip, two had
crooked backs. Twelve guinea pigs were weak and apathetic. Fibrous
osteodystrophy was diagnosed in eleven out of fifteen guinea pigs by
pathological examination. One out of seven carriers had vaginal discharge, the
others were healthy. A radiographic scoring out of nine parameters was
developed. Alterations in the course of fibrous osteodystrophy were assessed
at the os parietale, os frontale, ramus mandibulae, arcus zygomaticus,
vertebrae lumbales, articulatio coxae, os femoris, os tibiae and the
articulatio genus. Between 9 and 27 points were possible. Less than and equal
to 13 points were defined as being without pathological findings , more than
13 points as pathologic . None of the control group and none of the carriers
got more than 13 points. Scoring 52 satin guinea pigs showed that the younger
animals (†25 months) reached less points than the older animals (> 25 months;
p < 0.05; U-test). Sick animals reached more points than those without
pathological findings (p < 0.05). Sex was nonsignificant. We found osteopenia
in the os mandibulae, arcus zygomaticus, os femoris and os tibiae, vertebrae
lumbales and in the pelvic bone as well as osteosclerosis in bones like the os
parietale, os frontale, vertebrae lumbales and in long bones. Satin type
guinea pigs were hypocalcemic in comparison to control animals (p < 0.05;
U-test). Younger satin guinea pigs had a higher phosphorus level than older
ones (p < 0.05). Younger satin guinea pigs showed higher alkaline phosphatase
levels than younger control animals (p < 0.05). The same was true for older
animals. Sick satin guinea pigs had higher levels of the alkaline phosphatase
than satin guinea pigs without pathological findings (p < 0.05).
Radiologically suspected satin guinea pigs (> 13 points) had a higher alkaline
phosphatase level than those without radiological changes. Creatinine in sick
satin guinea pigs was higher than in animals that showed no clinical signs of
disease (p < 0.05; U-Test). Carriers and controls had higher levels of
creatinine than healthy satin type guinea pigs (p < 0.05). Clinicially
inconspicious satin guinea pigs had less platelets than controls (p < 0.05).
There were no significant differences in sex within all parameters. Fibrous
osteodystrophy caused by secondary hyperparathyroidism was diagnosed in sick
satin type guinea pigs. The cause of the disease is unknown. We suggest a
genetic disorder. This should be clarified in further studies
Raise Them Up- Part 1
In part one of this two-part series, the presenters will engage staff and address self-regulation in areas of mindfulness, healthy behaviors, tolerance and empathy, and digital/social consciousness. This workshop provides a brand-new approach to helping staff and students develop motivation, positive behavior, and resilience. They will provide team building and hands-on activities to implement in your organization as soon as tomorrow! SEL strategies are a powerful tool for helping young people and staff become culturally connected and allow them to have their own identities without judgment. This session provides myriad ways for staff to connect with each other as well as in the same ways as when they work with their students
Exploring Life Satisfaction with the kid-grit Holistic Wellness Wheel
If there was ever a time for self-careâit is now! This interactive session will help you examine your own health and wellness to find balance and energy to support youth. Using the kid-grit Holistic Wellness Wheel, the presenters will examine the CASEL framework and five additional strategies that will support you in and out of the workplace. You will walk away with an action plan that will support you and be used with your students
The English Language Learner Program at Burns Latino Studies Academy: Why Does it Fall Short in Servicing Students?
Burns Latino Studies Academy has been labeled an âat riskâ institution frequently reported on by the media. Inadequate funding for English Language Learners (ELL) is just one of the shortcomings cited, and has resulted in the school receiving extra support in the wake of a 2007 lawsuit filed by the Center for Childrenâs Advocacy. Since then, Burns has secured both additional ELL funding and a new ELL coach. However, a number of challenges remain. The current study asks the question: Why does Burns Latino Studies Academyâs bilingual program fall short of fully serving the needs of its ELL students? Employing a qualitative research approach, it provides a more comprehensive narrative of the many institutional barriers present at Burns. In-depth interviews with Principal Brase, three early childhood education teachers, and the recently hired ELL coach, along with classroom observations, point to two key factors, the state of Burnsâ bilingual classrooms and the quality of interactions with students identified as English Language Learners. Preliminary findings suggest both the need to provide greater individual attention to ânew arrivalâ students and the need to enhance ELL instructional technology in order to improve bilingual literacy. Based on these findings, the current study recommends that Burns Academy pair with family care centers in the community. It has also identified free online resources to assist in communication with ELL students and a potential private donor of new computers for the targeted student group at Burns Academy. Lastly, a donation from the company, Techroot, has been secured to replace the schoolâs recently destroyed ELL instructional equipment, and the research team is currently working with Trinity Collegeâs La Voz Latina student group to act as an outreach and mentoring resource for ELL students at Burns Academy
Impact of Immigrant Entrepreneurs and Workers in Leisure and Hospitality Businesses: Massachusetts and New England
This report examines the role and impact of immigrant entrepreneurs and workers on Leisure and Hospitality businesses in New England, particularly Massachusetts. A significant portion of state economies in New England, especially in Massachusetts, relies heavily on the employment of the foreign-born. As the native workforce ages and population growth declines, businesses are becoming increasingly dependent upon the availability of the foreign-born. This development has facilitated an increasingly significant presence and role of immigrant entrepreneurs in Leisure and Hospitality businesses that is documented for the first time in this report
Government Spending Across the World: How the United States Compares
In this brief, authors Michael Ettlinger, Jordan Hensley, and Julia Vieira analyze how much the governments of different countries spend, and on what, to illuminate the range of fiscal policy options available and provide a basis for determining which approaches work best. They report that the United States ranks twenty-fourth in government spending as a share of GDP out of twenty-nine countries for which recent comparable data are available. The key determinant of where countries rank in overall government spending is the amount spent on social protection. The United States ranks last in spending on social protection as a share of GDP and twenty-second in per capita spending. The United States ranks at or near the top in military, health care, education, and law enforcement spending. Measuring government spending by different methods and including tax expenditures does not appear to significantly alter the conclusion that the United States is a low-tax, low-spending country relative to the other countries examined, particularly when compared to its fellow higher-income countries
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'A Thingy World': Iris Murdoch's stuff
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