241 research outputs found

    Policing for Profit: A Constitutional Analysis of Washington State’s Civil Forfeiture Laws

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    The summer of 2020 reignited a conversation about the relationship between race and policing in the United States. While many have taken the opportunity to scrutinize the racially discriminate components of our criminal justice system, comparable aspects of civil law must be equally scrutinized. A particular area of concern pertains to racially biased policing and the concept of “policing for profits” with Black, Indigenous, and people of color communities (BIPOC), which is accomplished mainly through civil asset forfeiture at a state and federal level

    Pay-for-Performance in Five State Medicaid Programs: Lessons for the Nursing Home Sector

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    This project looks at the pay-for-performance program in five state Medicaid programs and lists the lessons that the Nursing Home Sector can learn from. They are: The federal government has traditionally sought to ensure quality outcomes through nursing home (NH) surveys conducted by state officials; Some states have begun to experiment with pay-for-performance (P4P) incentives, which provider higher Medicaid reimbursement to those facilities achieving desired outcomes; By 2007, there were 9 state P4P programs covering 20% of NHs and 16.7% of residents; Little is known about the use of P4P to promote quality and efficiency in the NH sector

    Vegetation Analysis of Urban Ethnic Markets Shows Supermarket Generalists and Chinatown Ethnic-specialist Vendors

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    researchThe growing cultural diversity in the United States calls attention to ethnobotanical studies of urban ethnic food markets. These venues illustrate dynamic interactions between people and plants. A market survey of the Chinatown markets in Honolulu, Hawai`i was conducted to collect empirical data on this culturally rich urban area. The objectives included: (1) To analyze the food plant richness of selected Chinatown markets in comparison to local mainstream supermarkets; and (2) To test the use of vegetation analysis to describe the structure of these markets (e.g., “ethnic markets”). Surveys and mapping of food plants at three market areas in Chinatown and three mainstream supermarkets were conducted between February and March 2006. Microsoft Excel and the Community Analysis Package programs were used to analyze and compare plant richness and the structure of vendors and markets. In all of the markets combined, 291 “fresh” food plant varieties were recorded, representing 42 plant families and a group of fungi. The mainstream supermarkets were more rich in varieties of food plants than the Chinatown market area (mean ± s, 144 ± 21 vs. 95 ± 23, p=0.05, Mann-Whitney U test). Allium cepa L. and Allium sativum L. were ubiquitous. The Mainstream market group contained significantly more sweet-fruits than the Chinatown market areas. Agglomerate cluster analyses revealed groupings of mainstream supermarkets, Chinatown market areas; further analysis of the Chinatown areas defined culturally identified “Filipino,” “Vietnamese,” and specialty fruits vendors. Mainstream supermarkets may be viewed as “generalists” while the Chinatown market areas and vendors may be viewed as “specialists” for an ethnic or cultural group or food plant commodity

    Perfect alignment and preferential orientation of nitrogen-vacancy centers during CVD growth of diamond on (111) surfaces

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    Synthetic diamond production is key to the development of quantum metrology and quantum information applications of diamond. The major quantum sensor and qubit candidate in diamond is the nitrogen-vacancy (NV) color center. This lattice defect comes in four different crystallographic orientations leading to an intrinsic inhomogeneity among NV centers that is undesirable in some applications. Here, we report a microwave plasma-assisted chemical vapor decomposition (MPCVD) diamond growth technique on (111)-oriented substrates that yields perfect alignment (94±294\pm2%) of as-grown NV centers along a single crystallographic direction. In addition, clear evidence is found that the majority (74±474\pm4%) of the aligned NV centers were formed by the nitrogen being first included in the (111) growth surface and then followed by the formation of a neighboring vacancy on top. The achieved homogeneity of the grown NV centers will tremendously benefit quantum information and metrology applications.Comment: 6 pages, 4 figures, changes to previous version: added acknowledgemen

    Development of gaze aversion: qualitiative changes over the early school years

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    Looking away from an interlocutors’ face during demanding cognitive activity can help adults and children answer challenging mental arithmetic and verbal-reasoning questions (Glenberg, Schroeder, & Robertson, 1998; Phelps, Doherty-Sneddon & Warnock, in press). Whilst such ‘gaze aversion’ (GA) is used far less by 5-year old school children, its use increases dramatically during the first years of primary education, reaching adult levels by 8-years of age (Doherty-Sneddon, Bruce, Bonner, Longbotham, & Doyle, 2002). The current study investigates whether developmental changes also occur in a qualitative aspect of GA - the direction of movement involved in GA shifts. Video data from 18 5-year-olds and 19 8-year-olds answering verbal and arithmetic questions were analysed for direction of GA. We found very different profiles of direction of GA across the two ages: whilst the 5-year-olds used predominantly rapid multi-directional ‘flicking’ movements and some sustained left lateral movements, the 8-year-olds used predominantly sustained rightward movements. It is concluded that, as well as quantitative increases in the use of GA across these age groups, there are concomitant qualitative changes in the nature of GA shifts. A model of human attention in face-to-face interaction is discussed as are implications for the assessment of children’s learning and development

    Measuring the defect structure orientation of a single NV- centre in diamond

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    The negatively charged nitrogen-vacancy (NV-) centre in diamond has many exciting applications in quantum nano-metrology, including magnetometry, electrometry, thermometry and piezometry. Indeed, it is possible for a single NV- centre to measure the complete three-dimensional vector of the local electric field or the position of a single fundamental charge in ambient conditions. However, in order to achieve such vector measurements, near complete knowledge of the orientation of the centres defect structure is required. Here, we demonstrate an optically detected magnetic resonance (ODMR) technique employing rotations of static electric and magnetic fields that precisely determines the orientation of the centres major and minor trigonal symmetry axes. Thus, our technique is an enabler of the centres existing vector sensing applications and also motivates new applications in multi-axis rotation sensing, NV growth characterization and diamond crystallography

    Clinical report : one year of treatment of Proteus syndrome with miransertib (ARQ 092)

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    A 20-yr-old man with Proteus syndrome (PS) and somatic mosaicism of the AKT1 c.49G > A p.(E17K) variant had asymmetric overgrowth of the right frontal and facial bones, asymmetric spinal overgrowth with thoracolumbar scoliosis, dilatation of the inferior vena cava, testicular cystadenoma, bilateral knee deformities, macrodactyly, and apparent intellectual disability. Miransertib (ARQ 092) is an oral, allosteric, selective pan-AKT inhibitor initially developed for cancer therapeutics, now being evaluated for the treatment of PS. After baseline evaluation, the patient started unblinded treatment of 10 mg oral miransertib daily (∌5 mg/m2/day), escalated to 30 mg daily (∌15 mg/m2/day), and then to 50 mg daily (∌25 mg/m2/day) after 3 mo of treatment. Adverse events included dry mouth, one episode of gingivostomatitis, and loose, painful dentition due to preexisting periodontal disease, all of which resolved spontaneously. After 11 mo of treatment, the patient reported improved general well-being, increased mobility of the ankle, spine, and hands, a subjective decrease in size of the right facial bone overgrowth, and reduced areas of cerebriform connective tissue nevi on the soles. Whole-body MRI findings were stable without apparent disease progression. We conclude that 1 yr of treatment with miransertib was beneficial in this case

    Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects

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    BACKGROUND: The consequences of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals remain unclear. This study aimed to assess the association between PVC burdens during submaximal exercise and major adverse cardiovascular events (MI/HF/LTVA: myocardial infarction [MI], heart failure [HF], and life-threatening ventricular arrhythmia [LTVA]), and all-cause mortality. Additional end points were MI, LTVA, HF, and cardiovascular mortality. METHODS: A neural network was developed to count PVCs from ECGs recorded during exercise (6 minutes) and recovery (1 minute) in 48 315 asymptomatic participants from UK Biobank. Associations were estimated using multivariable Cox proportional hazard models. Explorative studies were conducted in subgroups with cardiovascular magnetic resonance imaging data (n=6290) and NT-proBNP (N-terminal Pro-B-type natriuretic peptide) levels (n=4607) to examine whether PVC burden was associated with subclinical cardiomyopathy. RESULTS: Mean age was 56.8±8.2 years; 51.1% of the participants were female; and median follow-up was 12.6 years. Low PVC counts during exercise and recovery were both associated with MI/HF/LTVA risk, independently of clinical factors: adjusted hazard ratio (HR), 1.2 (1-5 exercise PVCs, P20 exercise PVCs, P5 recovery PVCs, P20 exercise PVCs, P5 recovery PVCs, P<0.001). Complex PVC rhythms were associated with higher risk compared with PVC count alone. PVCs were also associated with incident HF, LTVA, and cardiovascular mortality, but not MI. In the explorative studies, high PVC burden was associated with larger left ventricular volumes, lower ejection fraction, and higher levels of NT-proBNP compared with participants without PVCs. CONCLUSION: In this cohort of middle-aged and older adults, PVC count during submaximal exercise and recovery were both associated with MI/HF/LTVA, all-cause mortality, HF, LTVAs, and cardiovascular mortality, independent of clinical and exercise test factors, indicating an incremental increase in risk as PVC count rises. Complex PVC rhythms were associated with higher risk compared with PVC count alone. Underlying mechanisms may include the presence of subclinical cardiomyopathy
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