Citizenship, Values, & Cultural Concerns: What Americans Want From Immigration Reform

In February 2013, Public Religion Research Institute (PRRI), in partnership with the Brookings Institution, conducted one of the largest surveys ever fielded on immigration policy, immigrants, and religious and cultural changes in the U.S. The survey of nearly 4,500 American adults explores the many divisions -- political, religious, ethnic, geographical, and generational -- within the nation over core values and their relationship to immigration. The new survey also tracks key questions from surveys conducted by PRRI in 2010-2011. This report presents the results of these surveys

Xenopus Meiotic Microtubule-Associated Interactome

In metazoan oocytes the assembly of a microtubule-based spindle depends on the activity of a large number of accessory non-tubulin proteins, many of which remain unknown. In this work we isolated the microtubule-bound proteins from Xenopus eggs. Using mass spectrometry we identified 318 proteins, only 43 of which are known to bind microtubules. To integrate our results, we compiled for the first time a network of the meiotic microtubule-related interactome. The map reveals numerous interactions between spindle microtubules and the newly identified non-tubulin spindle components and highlights proteins absent from the mitotic spindle proteome. To validate newly identified spindle components, we expressed as GFP-fusions nine proteins identified by us and for first time demonstrated that Mgc68500, Loc398535, Nif3l1bp1/THOC7, LSM14A/RAP55A, TSGA14/CEP41, Mgc80361 and Mgc81475 are associated with spindles in egg extracts or in somatic cells. Furthermore, we showed that transfection of HeLa cells with siRNAs, corresponding to the human orthologue of Mgc81475 dramatically perturbs spindle formation in HeLa cells. These results show that our approach to the identification of the Xenopus microtubule-associated proteome yielded bona fide factors with a role in spindle assembly

Governing immigrants and citizenship regimes: the case of France, 1950s–1990s

Does sustained and increasingly transnational immigration weaken the national character of citizenship regimes? This paper addresses this issue by examining French responses to immigration over a 40-year period. In spite of the changing character of immigration and changing state strategies, all governments throughout this period have sought to maintain the national character by making full access to rights contingent on one's conformity to national values and moralities. As the government made accessing rights dependent on conformity to national norms, the legitimacy of immigrant activists seeking to expand their rights has depended on their abilities to conform to the rules of the national political game. Resisting marginalization therefore requires the assimilation of the immigrants into nationally specific political cultures, which contributes to reinforcing the national character of citizenship regimes. By examining the particular case of France, the paper aims to show how top-down and bottom-up processes by states and activists work in different ways to keep the nation at the center of citizenship regimes in spite of the ongoing and very real challenges presented by transnationalism and globalization

How tumour-induced vascular changes alter angiogenesis: Insights from a computational model

International audienc

A Computational Framework to Assess the Efficacy of Cytotoxic Molecules and Vascular Disrupting Agents against Solid Tumours

A computational framework for testing the effects of cytotoxic molecules, specific to a given phase of the cell cycle, and vascular disrupting agents (VDAs) is presented. The model is based on a cellular automaton to describe tumour cell states transitions from proliferation to death. It is coupled with a model describing the tumour vasculature and its adaptation to the blood rheological constraints when alterations are induced by VDAs treatment. Several therapeutic protocols in two structurally different vascular networks were tested by varying the duration of cytotoxic drug perfusion and the periodicity of treatment cycles. The impact of VDAs were also tested both experimentally from intravital microscopy through a dorsal skinfold chamber on a mouse and numerically. Simulation results show that combining cytotoxic treatment with a post treatment of VDA through a judicious timing could favour the rapid eradication of the tumour. The computational framework thus gives some insights into the outcome of cytotoxic and VDAs treatments on a qualitative basis. Future validation from our experimental setup could open up new perspectives towards Computer-Assisted Therapeutic Strategies