465 research outputs found

    Starting at the End: Measuring Learning Using Retrospective Pre-Post Evaluations

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    Blog post to AEA365, a blog sponsored by the American Evaluation Association (AEA) dedicated to highlighting Hot Tips, Cool Tricks, Rad Resources, and Lessons Learned for evaluators. The American Evaluation Association is an international professional association of evaluators devoted to the application and exploration of program evaluation, personnel evaluation, technology, and many other forms of evaluation. Evaluation involves assessing the strengths and weaknesses of programs, policies, personnel, products, and organizations to improve their effectiveness

    Environmental Correlates of Hermatypic Coral (Montastrea annularis) Growth on the East Flower Gardens Bank, Northwest Gulf of Mexico

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    Time series of annual linear growth increments from 12 Montastrea annularis (E. and S.) collected at the East Flower Gardens Bank reef in the northwestern Gulf of Mexico have a common pattern. This is best expressed in an index master chronology (average by year of the annual percentage deviations from the mean of each coral.) Comparisons with time series of environmental data indicate that coral extension rates vary positively with seasonal (February through May - 4 months) surface water temperature and negatively with annual discharge of the Atchafalaya River. We propose that secular variations of water temperature and other parameters are the major long term controls of coral growth in the area. Our data do not support the view that sinking of the Flower Gardens reef, caused by catastrophic collapse of the underlying substrate, has been a prime influence on the corals

    Biozonation of Deep-Water Lithoherms and Associated Hardgrounds in the Northeastern Straits of Florida

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    Elongated carbonate mounds ( lithoherms ) oriented parallel to prevailing northerly bottom currents at moderate depths (500-700 m) along the western margin of the Little Bahama Bank exhibit a consistent faunal zonation characterized by attached, suspension-feeding invertebrates. The four most abundant macroepibenthic groups (alcyonarians, crinoids, sponges and stylasterid hydrocorals) dominate all hard substrates examined except upcurrent ends and crests of lithoherms. We recognize three faunal zones on these mounds: a Coral Zone (Lophelia prolifera) restricted to the upcurrent end; a Zoanthid Zone (?Gerardia sp.) along upcurrent crests, and a Crinoid/Alcyonarian Zone along lithoherm flanks and downstream crests. Taxa characteristic of the latter also occur on surrounding, low-relief hardgrounds but are accompanied by additional taxa usually absent from mounds. Intervening unconsolidated sediment is largely barren. Biozonation appears chiefly dependent on current flow regime and secondarily on substrate. The observed zonation occurs over a much smaller areal scale than previously reported for deep-water (non-hydrothermal) hard bottoms. Abrupt, small-scale faunal zonation can no longer automatically be considered as evidence of a shallow-water environment in interpreting fossil assemblages

    Lessons Learned from Two Case Studies in Higher Education

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    As places where future citizens are educated, knowledge is (co-)produced and societal developments are critically reflected, higher education institutions (HEIs) can play a key role in addressing sustainability challenges. In order to accelerate mutual learning, shared problem understanding, and joint development of sustainable solutions, interinstitutional exchange and collaboration between HEIs is crucial. However, little research to date has focused on institutional HEI networks in the field of sustainability. More specifically, we still understand little about the concrete development, implementation, and adaptation of such networks. This article explores early-stage HEI networks for sustainability from a conceptual and empirical stance in order to develop a framework that facilitates structured descriptions of these networks, as well as to foster cross-HEI learning on their effective performance. It therefore combines insights from an explorative literature review, two case studies and an interactive workshop at the ISCN Conference 2018. As results, we first suggest an analytical framework to facilitate a systematic characterization of HEI networks. Second, by applying the framework to the two case studies, we present and discuss lessons learned on how a single HEI can contribute to establishing a network and how it can utilize its network membership effectively to strengthen its efforts for sustainability

    Sclerosponges: Primary framework constructors on the Jamaican deep fore-reef

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    Sclerosponges grow on hard substrates in areas protected from high rates of sediment accumulation to depths of about 200 m at Discovery Bay, Jamaica. Here they are primary framework builders on the deep fore-reef between 70 m and 105 m

    Vrana-See, Kroatien. Bauhistorische Untersuchungen zu den be­fes­tigten Höhensiedlungen in der kroatischen Vrana-See-Region (Zadar). Die Arbeiten des Jahres 2021

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    The architectural research on the ancient hilltop settlement of Zamina and other fortified gradines in its vicinity was supported by a research grant from the German Archaeological Institute (DAI). It is integrated into the ­German-Croatian research project of the Romano-Germanic Commission (RGK) »From the Karst Mountains to the Sea. Settlement forms, spatial de­velopment and use from the Iron Age to Late Antiquity at Lake Vrana«. In October 2021, a joint three-week building survey campaign was conducted by various project participants, ranging from hand measurements to 3D LiDAR scans. The construction research clearly shows how the interdependencies of the regional natural, anthropogenic, and economic conditions determined the settlement morphology

    Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4

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    The C-type lectin receptors (CLR) Mincle, Mcl and Dectin-2 bind mycobacterial and fungal cell wall glycolipids and carbohydrates. Recently, we described that expression of these CLR is down-regulated during differentiation of human monocytes to dendritic cells (DC) in the presence of GM-CSF and IL-4. Here, we demonstrate that the Th2 cytokine IL-4 specifically inhibits expression of Mincle, Mcl and Dectin-2in human APC. This inhibitory effect of IL-4 was observed across species, as murine macrophages and DC treated with IL-4 also down-regulated these receptors. IL-4 blocked up-regulation of Mincle and Mcl mRNA expression and cell surface protein by murine macrophages in response to the Mincle ligand Trehalose-6,6-dibehenate (TDB), whereas the TLR4 ligand LPS overcame inhibition by IL-4. Functionally, down-regulation of Mincle expression by IL-4 was accompanied by reduced cytokine production upon stimulation with TDB. These inhibitory effects of IL-4 were dependent on the transcription factor Stat6. Together, our results show that the key Th2 cytokine IL-4 exerts a negative effect on the expression of Mincle and other Dectin-2 cluster CLR in mouse and human macrophages and DC, which may render these sentinel cells less vigilant for sensing mycobacterial and fungal ligands

    Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature

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    A systematic review following PRISMA guidelines was conducted to answer the question: What epigenetic, telomeric and associated biological changes are associated with exposure to adverse childhood experiences (ACEs) in the under 12s? Using PRISMA guidelines, appropriate databases were searched. 190 papers were returned with 38 articles fully reviewed. Articles were each independently quality rated by two authors using the Crowe Critical Appraisal Tool and data were extracted. Of the 38 articles, 23 were rated as very high quality. Most study participants were adults (n = 7769) with n = 727 child participants. Only seven of the very/high-quality studies were prospective and involved children. Methylation was the most studied method of epigenetic modification. There is some evidence supporting epigenetic modification of certain markers in participants exposed to ACEs measured in adulthood. Research is lacking on non-coding aspects of the epigenome and on coding aspects other than DNA methylation. There is some evidence of a more powerful effect on telomere length if physical neglect was involved. Much further work is required to model biological and psychological effects of epigenetic changes during childhood using prospective study designs. The effect of ACEs on the cellular ageing process during childhood is inadequately investigated and relies solely on measure of telomere length. Future research suggestions are proposed
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