Upward Influence in Organizations: Test of A Model

A causal model of upward influence in organizations was proposed and tested on a sample of staff nurses and their supervisors in a hospital setting. LISREL results demonstrated that the proposed model fit the data well, and reflected a better fit than several alternative models that were estimated. The contributions and limitations of the present study are discussed, in addition to challenges and directions for future research

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and associated biological processes regulated by FoxO during cancer cachexia are unknown. We hypothesize that FoxO is a central upstream regulator of diverse gene networks in skeletal muscle during cancer that may act coordinately to promote the wasting phenotype. METHODS: To inhibit endogenous FoxO DNA-binding, we transduced limb and diaphragm muscles of mice with AAV9 containing the cDNA for a dominant negative (d.n.) FoxO protein (or GFP control). The d.n.FoxO construct consists of only the FoxO3a DNA-binding domain that is highly homologous to that of FoxO1 and FoxO4, and which outcompetes and blocks endogenous FoxO DNA binding. Mice were subsequently inoculated with Colon-26 (C26) cells and muscles harvested 26 days later. RESULTS: Blocking FoxO prevented C26-induced muscle fiber atrophy of both locomotor muscles and the diaphragm and significantly spared force deficits. This sparing of muscle size and function was associated with the differential regulation of 543 transcripts (out of 2,093) which changed in response to C26. Bioinformatics analysis of upregulated gene transcripts that required FoxO revealed enrichment of the proteasome, AP-1 and IL-6 pathways, and included several atrophy-related transcription factors, including Stat3, Fos, and Cebpb. FoxO was also necessary for the cancer-induced downregulation of several gene transcripts that were enriched for extracellular matrix and sarcomere protein-encoding genes. We validated these findings in limb muscles and the diaphragm through qRT-PCR, and further demonstrate that FoxO1 and/or FoxO3a are sufficient to increase Stat3, Fos, Cebpb, and the C/EBPβ target gene, Ubr2. Analysis of the Cebpb proximal promoter revealed two bona fide FoxO binding elements, which we further establish are necessary for Cebpb promoter activation in response to IL-6, a predominant cytokine in the C26 cancer model. CONCLUSIONS: These findings provide new evidence that FoxO-dependent transcription is a central node controlling diverse gene networks in skeletal muscle during cancer cachexia, and identifies novel candidate genes and networks for further investigation as causative factors in cancer-induced wasting.R01 AR060217 - NIAMS NIH HHS; R01 AR060209 - NIAMS NIH HHS; T32 HD043730 - NICHD NIH HHS; R00 HL098453 - NHLBI NIH HHS; R00HL098453 - NHLBI NIH HHS; R01AR060209 - NIAMS NIH HHS; R01AR060217 - NIAMS NIH HH

Development of electrical test procedures for qualification of spacecraft against EID. Volume 1: The CAN test and other relevant data

A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. The data on the response of a simple satellite model, called CAN, to electron-induced discharges is presented. The experimental results were compared to predicted behavior and to the response of the CAN to electrical injection techniques simulating blowoff and arc discharges. Also included is a review of significant results from other ground tests and the P78-2 program to form a data base from which is specified those test procedures which optimally simulate the response of spacecraft to EID. The electrical and electron spraying test data were evaluated to provide a first-cut determination of the best methods for performance of electrical excitation qualification tests from the point of view of simulation fidelity

From Forbidden Coronal Lines to Meaningful Coronal Magnetic Fields

We review methods to measure magnetic fields within the corona using the polarized light in magnetic-dipole (M1) lines. We are particularly interested in both the global magnetic-field evolution over a solar cycle, and the local storage of magnetic free energy within coronal plasmas. We address commonly held skepticisms concerning angular ambiguities and line-of-sight confusion. We argue that ambiguities are in principle no worse than more familiar remotely sensed photospheric vector-fields, and that the diagnosis of M1 line data would benefit from simultaneous observations of EUV lines. Based on calculations and data from eclipses, we discuss the most promising lines and different approaches that might be used. We point to the S-like [Fe {\sc XI}] line (J=2 to J=1) at 789.2nm as a prime target line (for ATST for example) to augment the hotter 1074.7 and 1079.8 nm Si-like lines of [Fe {\sc XIII}] currently observed by the Coronal Multi-channel Polarimeter (CoMP). Significant breakthroughs will be made possible with the new generation of coronagraphs, in three distinct ways: (i) through single point inversions (which encompasses also the analysis of MHD wave modes), (ii) using direct comparisons of synthetic MHD or force-free models with polarization data, and (iii) using tomographic techniques.Comment: Accepted by Solar Physics, April 201

Uncertainty in the numerical modelling of masonry triplet tests under dynamic loading

Masonry structures have been broadly used worldwide for centuries. These structures are likely to be subjected to seismic movements, malicious or accidental blast and/or impact loading. Expanding the current body of knowledge of how masonry structures perform under such conditions and developing reliable and robust modelling techniques is essential to improve both the efficiency and safety of the design and retrofitting of such structures. A great deal of research is currently ongoing to understand the behaviour of masonry under shock and impact loading, and this is proving to be a challenging endeavour. Masonry construction on the whole is surrounded by a high degree of variability ranging from the heterogeneity of the materials used, the degree of workmanship during construction and the uncertainty regarding the physical and mechanical properties of the brick-to-mortar interface. Masonry is known to experience a dynamic enhancement of its strength properties when subjected to impact loading and dynamic increase factors (DIFs) have been used to adjust static masonry properties accordingly when subjected to this type of loading. These DIFs are derived from sparse experimental tests and their use can be severely limited to the conditions of the tests performed, and the results obtained can carry a high degree of uncertainty. This paper considers the uncertainty present at the brick-to-mortar interface, by using Monte Carlo simulations, when subjected to dynamic loading in a standard triplet test using LS-DYNA. The results of the modelling have been compared, contrasted and discussed for use in a larger research project on the robust characterisation of masonry structures when subjected to blast and seismic loadin

'This is what democracy looks like' : New Labour's blind spot and peripheral vision

New Labour in government since 1997 has been roundly criticized for not possessing a clear, coherent and consistent democratic vision. The absence of such a grand vision has resulted, from this critical perspective, in an absence of 'joined-up' thinking about democracy in an evolving multi-level state. Tensions have been all too apparent between the government's desire to exert central direction - manifested in its most pathological form as 'control freakery' - and its democratising initiatives derived from 'third-way' obsessions with 'decentralising', 'empowering' and 'enabling'. The purpose of this article is to examine why New Labour displayed such apparently impaired democratic vision and why it appeared incapable of conceiving of democratic reform 'in the round'. This article seeks to explain these apparent paradoxes, however, through utilising the notion of 'macular degeneration'. In this analysis, the perceived democratic blind spot of New Labour at Westminster is connected to a democratic peripheral vision, which has envisaged innovative participatory and decentred initiatives in governance beyond Westminster

Minimum-Uncertainty Angular Wave Packets and Quantized Mean Values

Uncertainty relations between a bounded coordinate operator and a conjugate momentum operator frequently appear in quantum mechanics. We prove that physically reasonable minimum-uncertainty solutions to such relations have quantized expectation values of the conjugate momentum. This implies, for example, that the mean angular momentum is quantized for any minimum-uncertainty state obtained from any uncertainty relation involving the angular-momentum operator and a conjugate coordinate. Experiments specifically seeking to create minimum-uncertainty states localized in angular coordinates therefore must produce packets with integer angular momentum.Comment: accepted for publication in Physical Review