Caracterización del ciclo menstrual en un grupo de mujeres con Cancer de mama del Centro Oncolologico ISSEMYM, Toluca, Estado de Mexico

Uno de los problemas de salud con mayor impacto económico y social es el cáncer de mama, es la principal neoplasia que presenta la población mexicana en edad reproductiva. Es importante destacar que hasta hoy en día, las estrategias para la detección oportuna y la prevención de esta enfermedad no han logrado definir la causa que propicia el desarrollo de esta enfermedad, sin embargo se han considerado factores ambientales, hereditarios, hormonales, estilos de vida y alimentación como predisponentes para manifestar el cáncer de mama. Por lo anterior, se decide realizar este proyecto de investigación tomando como población de estudio un grupo de mujeres con cáncer de mama del Centro Oncológico ISSEMYM, Toluca Estado de México. El proyecto tiene como objetivos: Describir características del ciclo menstrual en un grupo de mujeres con cáncer de mama. •Describir características Gineco-Obstétricas de las pacientes con cáncer de mama •Describir el ciclo menstrual de este grupo de mujeres •Conocer la relación del ciclo menstrual y cáncer de mama •Conocer si existe relación entre la ocupación y la exposición a ciertas sustancias que posibilitan la variación en el cáncer de mama. Para lograr los objetivos del proyecto, se adopta el diseño transversal con recolección retrospectiva de la información utilizando como instrumento un cuestionario, el cual se aplica a mujeres en edad reproductiva con cáncer de mama, que acepten participar voluntariamente y cumplan con el criterio de vivir en el Estado de México, al menos por seis meses, estar en condiciones de responder por sí misma

On the Use of the FuzzyARTMAP Neural Network for Pattern Recognition in Statistical Process Control using a Factorial Design

Time-series statistical pattern recognition is of prime importance in statistics, especially in quality control techniques for manufacturing processes. A frequent problem in this application is the complexity when trying to determine the behaviour (pattern) from sample data. There have been identified standard patterns which are commonly present when using the X chart; its detection depends on human judgement supported by norms and graphical criteria. In the last few years, it has been demonstrated that Artificial Neural Networks (ANN’s) are useful to predict the type of time-series pattern instead of the use of rules. However, the ANN control parameters have to be fixed to values that maximize its performance. This research proposes an experimental design methodology to determine the most appropriate values for the control parameters of the FuzzyARTMAP ANN such as: learning rate (β ) and network vigilance (ρa, ρb, ρab) in order to increment the neural network efficiency during unnatural pattern recognition

Press Coverage around the Problem Water in the Political Election

The press, by spreading the availability of resources, shortages linked with preservation. In this sense, the work explores nine briefings from 2002 to 2012 published in national newspapers regarding the lack of supply, quality, benefit, punishment and discomfort as a consequence of the water situation in a demarcation east of Mexico City.Index Framing the water situation (IESH) was used to weight the media bias in information note by content reaching a value of 102 points out of a total of 180. This finding was considered as evidence of a moderate degree of media coverage the press regarding the problems arising from water shortages. From the results discussed its implications with other studies conducted in the demarcation

Slanted Stixels: A way to represent steep streets

This work presents and evaluates a novel compact scene representation based on Stixels that infers geometric and semantic information. Our approach overcomes the previous rather restrictive geometric assumptions for Stixels by introducing a novel depth model to account for non-flat roads and slanted objects. Both semantic and depth cues are used jointly to infer the scene representation in a sound global energy minimization formulation. Furthermore, a novel approximation scheme is introduced in order to significantly reduce the computational complexity of the Stixel algorithm, and then achieve real-time computation capabilities. The idea is to first perform an over-segmentation of the image, discarding the unlikely Stixel cuts, and apply the algorithm only on the remaining Stixel cuts. This work presents a novel over-segmentation strategy based on a Fully Convolutional Network (FCN), which outperforms an approach based on using local extrema of the disparity map. We evaluate the proposed methods in terms of semantic and geometric accuracy as well as run-time on four publicly available benchmark datasets. Our approach maintains accuracy on flat road scene datasets while improving substantially on a novel non-flat road dataset.Comment: Journal preprint (published in IJCV 2019: https://link.springer.com/article/10.1007/s11263-019-01226-9). arXiv admin note: text overlap with arXiv:1707.0539

In vitro Evaluation of Phthalimide Derivatives Against Cancer Cell lines

Los cánceres de pulmón, próstata e hígado se encuentran entre los más prevalentes en los hombres. El cáncer de mama, de cuello uterino y de tiroides se encuentran entre los más prevalentes en mujeres (OMS, 2019). El tratamiento del cáncer generalmente incluye quimioterapia y radioterapia; sin embargo, los medicamentos contra el cáncer disponibles tienen una selectividad baja y causan efectos adversos graves, como nefrotoxicidad, neurotoxicidad y mielosupresión (Matsuo et al., 2010). Por tanto, el diseño y desarrollo de compuestos como nuevos agentes anticancerígenos frente a los tipos de cáncer de mayor incidencia son de vital importancia en el campo de la salud. Los derivados de ftalimida son compuestos prometedores para el desarrollo de nuevos agentes anticancerígenos (Li et al., 2011; Grigalius y Petrikaite, 2017; Kamal et al., 2002). Basado en lo anterior, Este trabajo tuvo como objetivo evaluar la actividad antiproliferativa de 43 derivados de ftalimida contra una línea celular de cáncer principal en hombres (HepG2) y dos líneas celulares de cáncer principales en mujeres (HeLa y 4T1). Además, se determinó la citotoxicidad de los compuestos contra una línea celular de fibroblasto murino normal (3T3). Los resultados mostraron que los compuestos C16, E11 y E16 presentaron la mejor actividad antiproliferativa contra las líneas celulares HeLa y 4T1. El compuesto H16 solo disminuyó la proliferación celular en un 32% contra la línea celular HepG2. Los compuestos H5, H16, E2, E16 y C1 no afectaron a la proliferación de la línea celular 3T3. Demostrando que sería importante continuar con el análisis de este tipo de compuestos frente a diferentes cánceres para encontrar nuevos compuestos con mejor actividad que los actualmente disponibles en el mercado

Nutraceutic effect of free condensed tannins of lysiloma acapulcensis (kunth) benth on parasite infection and performance of pelibuey sheep

Abstract Forty-five Pelibuey sheep were experimentally infested with nematodes to evaluate the effect of three free condensed tannin (FCT) levels of Lysiloma acapulcensis on fecal egg counts (FECs), packed cell volumes (PCV), ocular mucosa colors (OMC), average daily gain (ADG), and adult nematode count. Five treatments were used: 12.5, 25.0, and 37.5 mg of FCT kg−1 of body weight (BW); sterile water (control); and ivermectine (0.22 mg kg−1 of BW) as chemical group. The data were processed through repeated measure- ment analysis. Even though the three FCT doses decreased (P < 0.05) the FEC, the highest reduction was obtained with 37.5 mg kg−1 of BW. No differences were observed in PCV and OMC. Higher ADG (P < 0.05) was observed with 37.5 mg kg−1 of BW of FCT. The count of adult nematodes (females and males) in the higher dose of FCT was similar to chemical treatment. Dose of 37.5 mg kg−1 of BW decreased the parasite infection and improved the lamb performance. Therefore, this dose could be used as a nutraceutic product in sheep production.This work was undertaken with funds from the Universidad Autónoma del Estado de México (Project UAEM 1026/2014RIFC). Our gratitude also goes to the Mexican National Council for Science and Technology (CONACYT) for the grant received by Cesar García Hernández

Modeling of The Determinants of The Image of The Destination As A Subsystem of The Peri-Urban Mobility Policies, The Transport of Zero Emissions of Carbon Dioxide To The Atmosphere And The Habitus of Transfer

The objective of the present work was to establish an exploratory factorial structure of the peri-urban mobility habitus. A non-experimental study was carried out with a non-probabilistic selection of 345 users of the metro public transportation system of Mexico City. The results show that the motivation of the trip is the determinant of the image of the destination, agreeing with the most recent findings, but complementary to the studies carried out around the habitus of peri-urban mobility

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents

Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. cruzi depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and triosephosphate isomerase (TIM) plays a key role in this metabolic pathway. This enzyme is an attractive target for the design of new trypanocidal drugs. In this study, a ligand-based virtual screening (LBVS) from the ZINC15 database using benzimidazole as a scaffold was accomplished. Later, a molecular docking on the interface of T. cruzi TIM (TcTIM) was performed and the compounds were grouped by interaction profiles. Subsequently, a selection of compounds was made based on cost and availability for in vitro evaluation against blood trypomastigotes. Finally, the compounds were analyzed by molecular dynamics simulation, and physicochemical and pharmacokinetic properties were determined using SwissADME software. A total of 1604 molecules were obtained as potential TcTIM inhibitors. BP2 and BP5 showed trypanocidal activity with half-maximal lytic concentration (LC50) values of 155.86 and 226.30 µM, respectively. Molecular docking and molecular dynamics simulation analyzes showed a favorable docking score of BP5 compound on TcTIM. Additionally, BP5 showed a low docking score (−5.9 Kcal/mol) on human TIM compared to the control ligand (−7.2 Kcal/mol). Both compounds BP2 and BP5 showed good physicochemical and pharmacokinetic properties as new anti-T. cruzi agents. View Full-Tex

Dignidad, Poder, Resistencia // Dignity, Power, Resistance

First To Go Abroad is a partnership between the Loyola Marymount University First To Go Program, LMU Study Abroad, and the Council on International Educational Exchange (CIEE), which seeks to increase study abroad opportunities for first-generation college students. In May 2017, fifteen first-gen students and two first-gen faculty mentors traveled together to Santiago, Dominican Republic, where they spent ten days exploring the country and learning about the local cultures, customs, and histories of the people who call the DR home. Travel is a privilege not all students have the same access to; for some students, this trip was the first time out of the United States. Like the first-generation college experience, the experience of international travel is marked by daily encounters with new spaces, people, and cultural practices that can be at once overwhelming and inspiring. This was a topic of exploration throughout the trip and the subject of the pages contained in this volume. The narratives published here are the product of a cross-institutional writing workshop, where students from LMU and the Pontificia Universidad Católica Madre y Maestra worked together to draft essays documenting their encounters with change that have pushed boundaries, broken down borders, and generated personal growth. We hope our readers around the world will appreciate these works, which showcase the transformative power of creative and collaborative global encounters