Prospects of Semiconductor Terahertz Pulse Sources

Extremely high pump-to-terahertz (THz) conversion efficiencies up to 0.7% were demonstrated in recent experiments with ZnTe THz pulse sources. Such high efficiencies could be achieved by pumping at an infrared wavelength sufficiently long to suppress both two- and three-photon absorption and the associated free-carrier absorption at THz frequencies. Here, high-field high-energy THz pulse generation by optical rectification in semiconductor nonlinear materials is investigated by numerical simulations. Basic design aspects of infrared-pumped semiconductor THz sources are discussed. Optimal pumping and phase-matching conditions are given. Multicycle THz pulse generation for particle acceleration is discussed

Curriculum Development for Teaching Swimming in Hungary

Given the lack of publications describing changing curricular matters and the role of teaching and learning swimming in Hungary, the purpose of this study was to analyze the curricula of 1995, 2001, and 2003. It also was the authors’ goal to examine the role and place of swimming instruction in school education and provide discussion points to promote further review and the possible effects on teaching methodology and skill acquisition. The authors analyzed the Hungarian curricula for the years 1995, 2001, and 2003 based on records, official documents, administrative texts, and formal reports on curricular structures and applications. They concluded that the process of continuous curricular change has impeded the process of teaching and learning swimming in Hungary and recommend that teachers and local curriculum developers make an effort to integrate the best parts of each curriculum

Krpeljska fauna autohtone pramenke u Istočnoj Srbiji

Sheep production is an example of a sustainable production fully integrated within the local rural development. One of the main threats on the outdoor breeding of sheep is parasitism. Ticks are nuisances and vectors of several diseases agents. The distribution of ticks appears to be changing, with spread to previously unaffected areas. Tick and tick-borne disease control is one of the major components of animal health program protecting livestock in the developing countries, which reflects impact on the livelihood of resource-poor farming communities. Taking into consideration the negative impact on the health status of the livestock, also the direct and indirect economic losses, it is necessary to examine the tolerance and resistance of certain species against diseases. It is one of the most important elements of the strategy of selection and screening for resistant animals. The aim of this study was to determine the tick species persisting in 45 tested autochthonous Zackel sheep flocks, and examine their seasonal occurrence from March 2010 to January 2011, in the region of South Serbia. The result showed that Ixodes, Dermacentor, Ripicephalus and Haemaphysalis were the most abundant ticks found, affecting 50.40% tested sheep. The result of this study is a survey of tick species from autochthonous Zackel sheep in Serbia and implication of possible preventions measures for diseases caused and transmitted by ticks.Ovčarstvo predstavlja primer održive proizvodnje koja čini sastavni deo ruralnog razvoja. Jedan od glavnih zdravstvenih problema kod ekstenzivnog načina uzgoja ovaca predstavljaju parazitske infekcije. Krpelji su vektori za uzročnike mnogobrojnih oboljenja. Rasprostranjenost krpelja se menja i u novije vreme ih nalazimo i na novim arealima. U zemljama u razvoju, borba protiv krpelja i oboljenja prenosica krpeljima predstavljaju jedan od glavnih strateških tačaka zdravstvenog nadzora nad životinjama i ljudima. Uzimajući u obzir značaj direktnih i indirektnih ekonomskih gubitaka izazvanih krpeljima i oboljenjima čiji su oni uzročnici, posebna pažnja treba da se posveti ispitivanju tolerancije i otpornosti ka parazitskim bolestima pojedinih vrsta i rasa životinja. Potraga za otpornim jedinkama i njihova selekcija treba da bude deo strategije stočarstva. Cilj ovog rada je bio da prikaže rezultate ispitivanja o prisustvu krpeljske faune u 45 zapata ovaca autohtone pramenke. Ispitana je sezonalna distribucija pojave pojedinih krpelja u periodu između marta 2010. i januara 2011. godine, u regionu Istočne Srbije. Kod 50, 40% ispitanih ovaca ustanovljeno je prisustvo krpelja. Rezultati pokazuju da su krpelji iz rodova Ixodes, Dermacentor, Ripicephalus i Haemaphysalis najučestaliji u zapatima ovaca autohtone pramenke

The Very Young Type Ia Supernova 2012cg: Discovery and Early-Time Follow-Up Observations

On 2012 May 17.2 UT, only 1.5 +/- 0.2 d after explosion, we discovered SN 2012cg, a Type Ia supernova (SN Ia) in NGC 4424 (d ~ 15 Mpc). As a result of the newly modified strategy employed by the Lick Observatory SN Search, a sequence of filtered images was obtained starting 161 s after discovery. Utilizing recent models describing the interaction of SN ejecta with a companion star, we rule out a ~1 M_Sun companion for half of all viewing angles and a red-giant companion for nearly all orientations. SN 2012cg reached a B-band maximum of 12.09 +/- 0.02 mag on 2012 June 2.0 and took ~17.3 d from explosion to reach this, typical for SNe Ia. Our pre-maximum brightness photometry shows a narrower-than-average B-band light curve for SN 2012cg, though slightly overluminous at maximum brightness and with normal color evolution (including some of the earliest SN Ia filtered photometry ever obtained). Spectral fits to SN 2012cg reveal ions typically found in SNe Ia at early times, with expansion velocities >14,000 km/s at 2.5 d past explosion. Absorption from C II is detected early, as well as high-velocity components of both Si II 6355 Ang. and Ca II. Our last spectrum (13.5 d past explosion) resembles that of the somewhat peculiar SN Ia 1999aa. This suggests that SN 2012cg will have a slower-than-average declining light curve, which may be surprising given the faster-than-average rising light curve.Comment: re-submitted to ApJL, 4 figures, 1 tabl

The Very Young Type Ia Supernova 2013dy: Discovery, and Strong Carbon Absorption in Early-Time Spectra

The Type Ia supernova (SN Ia) 2013dy in NGC 7250 (d ~ 13.7 Mpc) was discovered by the Lick Observatory Supernova Search. Combined with a prediscovery detection by the Italian Supernova Search Project, we are able to constrain the first-light time of SN 2013dy to be only 0.10 +/- 0.05 d (2.4 +/- 1.2 hr) before the first detection. This makes SN 2013dy the earliest known detection of an SN Ia. We infer an upper limit on the radius of the progenitor star of R_0 < 0.25 R_sun, consistent with that of a white dwarf. The light curve exhibits a broken power law with exponents of 0.88 and then 1.80. A spectrum taken 1.63 d after first light reveals a C II absorption line comparable in strength to Si II. This is the strongest C II feature ever detected in a normal SN Ia, suggesting that the progenitor star had significant unburned material. The C II line in SN 2013dy weakens rapidly and is undetected in a spectrum 7 days later, indicating that C II is detectable for only a very short time in some SNe Ia. SN 2013dy reached a B-band maximum of M_B = -18.72 +/- 0.03 mag ~17.7 d after first light.Comment: Accepted for Publication in ApJ Letter

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4

Three is the magic number -- distance measurement of NGC 3147 using SN 2021hpr and its siblings

The nearby spiral galaxy NGC 3147 hosted three Type Ia supernovae (SNe Ia) in the past decades, which have been subjects of intense follow-up observations. Simultaneous analysis of their data provides a unique opportunity for testing the different light curve fitting methods and distance estimations. The detailed optical follow-up of SN 2021hpr allows us to revise the previous distance estimations to NGC 3147, and compare the widely used light curve fitting algorithms to each other. After the combination of the available and newly published data of SN 2021hpr, its physical properties can be also estimated with higher accuracy. We present and analyse new BVgriz and Swift photometry of SN 2021hpr to constrain its general physical properties. Together with its siblings, SNe 1997bq and 2008fv, we cross-compare the individual distance estimates of these three SNe given by the SALT code, and also check their consistency with the results from the MLCS2k2 method. The early spectral series of SN 2021hpr are also fit with the radiative spectral code TARDIS in order to verify the explosion properties and constrain the chemical distribution of the outer ejecta. After combining the distance estimates for the three SNe, the mean distance to their host galaxy, NGC 3127, is 42.5 $\pm$ 1.0 Mpc, which matches with the distance inferred by the most up-to-date LC fitters, SALT3 and BayeSN. We confirm that SN~2021hpr is a Branch-normal Type Ia SN that ejected $\sim 1.12 \pm 0.28$ M$_\odot$ from its progenitor white dwarf, and synthesized $\sim 0.44 \pm 0.14$ M$_\odot$ of radioactive $^{56}$Ni.Comment: 16 pages, 17 figures, 11 tables; accepted for publication in A&

Infrared Absorption Investigations Confirm the Extraterrestrial Origin of Carbonado-Diamonds

The first complete infrared FTIR absorption spectra for carbonado-diamond confirm the interstellar origin for the most enigmatic diamonds known as carbonado. All previous attempts failed to measure the absorption of carbonado-diamond in the most important IR-range of 1000-1300 cm-1 (10.00-7.69 micro-m.) because of silica inclusions. In our investigation, KBr pellets were made from crushed silica-free carbonado-diamond and thin sections were also prepared. The 100 to 1000 times brighter synchrotron infrared radiation permits a greater spatial resolution. Inclusions and pore spaces were avoided and/or sources of chemical contamination were removed. The FTIR spectra of carbonado-diamond mostly depict the presence of single nitrogen impurities, and hydrogen. The lack of identifiable nitrogen aggregates in the infrared spectra, the presence of features related to hydrocarbon stretch bonds, and the resemblance of the spectra to CVD and presolar diamonds indicate that carbonado-diamonds formed in a hydrogen-rich interstellar environment. This is consistent with carbonado-diamond being sintered and porous, with extremely reduced metals, metal alloys, carbides and nitrides, light carbon isotopes, surfaces with glassy melt-like patinas, deformation lamellae, and a complete absence of primary, terrestrial mineral inclusions. The 2.6-3.8 billion year old fragmented body was of asteroidal proportions

500 days of SN 2013dy: Spectra and photometry from the ultraviolet to the infrared

SN 2013dy is a Type Ia supernova (SN Ia) for which we have compiled an extraordinary data set spanning from 0.1 to ~ 500 d after explosion. We present 10 epochs of ultraviolet (UV) through near-infrared (NIR) spectra with Hubble Space Telescope/Space Telescope Imaging Spectrograph, 47 epochs of optical spectra (15 of them having high resolution), and more than 500 photometric observations in the BVrRiIZYJH bands. SN 2013dy has a broad and slowly declining light curve (Δm15(B)=0.92 mag), shallow Si II λ6355 absorption, and a low velocity gradient. We detect strong C II in our earliest spectra, probing unburned progenitor material in the outermost layers of the SN ejecta, but this feature fades within a few days. The UV continuum of SN 2013dy, which is strongly affected by the metal abundance of the progenitor star, suggests that SN 2013dy had a relatively high-metallicity progenitor. Examining one of the largest single set of high-resolution spectra for an SN Ia, we find no evidence of variable absorption from circumstellar material. Combining our UV spectra, NIR photometry, and high-cadence optical photometry, we construct a bolometric light curve, showing that SN 2013dy had a maximum luminosity of 10.0+4.8 -3.8 × 1042 erg s-1. We compare the synthetic light curves and spectra of several models to SN 2013dy, finding that SN 2013dy is in good agreement with a solar-metallicity W7 model

mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression.

Schwann cell development is hallmarked by the induction of a lipogenic profile. Here we used amniotic fluid stem (AFS) cells and focused on the mechanisms occurring during early steps of differentiation along the Schwann cell lineage. Therefore, we initiated Schwann cell differentiation in AFS cells and monitored as well as modulated the activity of the mechanistic target of rapamycin (mTOR) pathway, the major regulator of anabolic processes. Our results show that mTOR complex 1 (mTORC1) activity is essential for glial marker expression and expression of Sterol Regulatory Element-Binding Protein (SREBP) target genes. Moreover, SREBP target gene activation by statin treatment promoted lipogenic gene expression, induced mTORC1 activation and stimulated Schwann cell differentiation. To investigate mTORC1 downstream signaling we expressed a mutant S6K1, which subsequently induced the expression of the Schwann cell marker S100b, but did not affect lipogenic gene expression. This suggests that S6K1 dependent and independent pathways downstream of mTORC1 drive AFS cells to early Schwann cell differentiation and lipogenic gene expression. In conclusion our results propose that future strategies for peripheral nervous system regeneration will depend on ways to efficiently induce the mTORC1 pathway