Sling Complications

https://digitalscholarship.unlv.edu/wrin_briefs/1003/thumbnail.jp

Surgeon Volume

https://digitalscholarship.unlv.edu/wrin_briefs/1002/thumbnail.jp

Hoxb8 is required for normal grooming behavior in mice.

Journal ArticleRepertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Additionally, these mice excessively groom normal cagemates. We have been unable to detect any skin or PNS abnormalities in Hoxb8 mutants. These observations suggest that the excessive, pathological grooming exhibited by these mice results from CNS abnormalities. Consistent with this interpretation, we demonstrate Hoxb8 expression in regions of the adult mouse CNS previously implicated in the control of grooming. The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit

Radio Sources from a 31 GHz Sky Survey with the Sunyaev-Zel'dovich Array

We present the first sample of 31-GHz selected sources to flux levels of 1 mJy. From late 2005 to mid 2007, the Sunyaev-Zel'dovich Array (SZA) observed 7.7 square degrees of the sky at 31 GHz to a median rms of 0.18 mJy/beam. We identify 209 sources at greater than 5 sigma significance in the 31 GHz maps, ranging in flux from 0.7 mJy to ~200 mJy. Archival NVSS data at 1.4 GHz and observations at 5 GHz with the Very Large Array are used to characterize the sources. We determine the maximum-likelihood integrated source count to be N(>S) = (27.2 +- 2.5) deg^-2 x (S_mJy)^(-1.18 +- 0.12) over the flux range 0.7 - 15 mJy. This result is significantly higher than predictions based on 1.4-GHz selected samples, a discrepancy which can be explained by a small shift in the spectral index distribution for faint 1.4-GHz sources. From comparison with previous measurements of sources within the central arcminute of massive clusters, we derive an overdensity of 6.8 +- 4.4, relative to field sources.Comment: 13 pages, 5 figure

Application of a Self-Similar Pressure Profile to Sunyaev-Zel'dovich Effect Data from Galaxy Clusters

We investigate the utility of a new, self-similar pressure profile for fitting Sunyaev-Zel'dovich (SZ) effect observations of galaxy clusters. Current SZ imaging instruments - such as the Sunyaev-Zel'dovich Array (SZA) - are capable of probing clusters over a large range in physical scale. A model is therefore required that can accurately describe a cluster's pressure profile over a broad range of radii, from the core of the cluster out to a significant fraction of the virial radius. In the analysis presented here, we fit a radial pressure profile derived from simulations and detailed X-ray analysis of relaxed clusters to SZA observations of three clusters with exceptionally high quality X-ray data: A1835, A1914, and CL J1226.9+3332. From the joint analysis of the SZ and X-ray data, we derive physical properties such as gas mass, total mass, gas fraction and the intrinsic, integrated Compton y-parameter. We find that parameters derived from the joint fit to the SZ and X-ray data agree well with a detailed, independent X-ray-only analysis of the same clusters. In particular, we find that, when combined with X-ray imaging data, this new pressure profile yields an independent electron radial temperature profile that is in good agreement with spectroscopic X-ray measurements.Comment: 28 pages, 6 figures, accepted by ApJ for publication (probably April 2009

CARMA Measurements of the Sunyaev-Zel'dovich Effect in RXJ1347.5-1145

We demonstrate the Sunyaev-Zel'dovich (SZ) effect imaging capabilities of the Combined Array for Research in Millimeter-wave Astronomy (CARMA) by presenting an SZ map of the galaxy cluster RXJ1347.5-1145. By combining data from multiple CARMA bands and configurations, we are able to capture the structure of this cluster over a wide range of angular scales, from its bulk properties to its core morphology. We find that roughly 9% of this cluster's thermal energy is associated with sub-arcminute-scale structure imparted by a merger, illustrating the value of high-resolution SZ measurements for pursuing cluster astrophysics and for understanding the scatter in SZ scaling relations. We also find that the cluster's SZ signal is lower in amplitude than suggested by a spherically-symmetric model derived from X-ray data, consistent with compression along the line of sight relative to the plane of the sky. Finally, we discuss the impact of upgrades currently in progress that will further enhance CARMA's power as an SZ imaging instrument.Comment: 8 pages, 6 figure

Cosmological Constraints from a 31 GHz Sky Survey with the Sunyaev-Zel'dovich Array

We present the results of a 6.1 square degree survey for clusters of galaxies via their Sunyaev- Zel'dovich (SZ) effect at 31 GHz. From late 2005 to mid 2007 the Sunyaev-Zel'dovich Array (SZA) observed four fields of roughly 1.5 square degrees each. One of the fields shows evidence for significant diffuse Galactic emission, and we therefore restrict our analysis to the remaining 4.4 square degrees. We estimate the cluster detectability for the survey using mock observations of simulations of clusters of galaxies; and determine that, at intermediate redshifts (z ~ 0.8), the survey is 50% complete to a limiting mass (M200 rho mean) of ~ 6.0 x 10^14M_{solar}, with the mass limit decreasing at higher redshifts. We detect no clusters at a significance greater than 5 times the RMS noise level in the maps, and place an upper limit on \sigma_8, the amplitude of mass density fluctuations on a scale of 8h^-1 Mpc, of 0.84 + 0.07 at 95% confidence, where the uncertainty reflects calibration and systematic effects. This result is consistent with estimates from other cluster surveys and CMB anisotropy experiments.Comment: 10 pages, 7 figures, 3 table

LoCuSS: A Comparison of Sunyaev-Zel'dovich Effect and Gravitational Lensing Measurements of Galaxy Clusters

We present the first measurement of the relationship between the Sunyaev-Zel'dovich effect signal and the mass of galaxy clusters that uses gravitational lensing to measure cluster mass, based on 14 X-ray luminous clusters at z~0.2 from the Local Cluster Substructure Survey. We measure the integrated Compton y-parameter, Y, and total projected mass of the clusters (M_GL) within a projected clustercentric radius of 350 kpc, corresponding to mean overdensities of 4000-8000 relative to the critical density. We find self-similar scaling between M_GL and Y, with a scatter in mass at fixed Y of 32%. This scatter exceeds that predicted from numerical cluster simulations, however, it is smaller than comparable measurements of the scatter in mass at fixed T_X. We also find no evidence of segregation in Y between disturbed and undisturbed clusters, as had been seen with T_X on the same physical scales. We compare our scaling relation to the Bonamente et al. relation based on mass measurements that assume hydrostatic equilibrium, finding no evidence for a hydrostatic mass bias in cluster cores (M_GL = 0.98+/-0.13 M_HSE), consistent with both predictions from numerical simulations and lensing/X-ray-based measurements of mass-observable scaling relations at larger radii. Overall our results suggest that the Sunyaev-Zel'dovich effect may be less sensitive than X-ray observations to the details of cluster physics in cluster cores.Comment: Minor changes to match published version: 2009 ApJL 701:114-11

Observations of High-Redshift X-Ray Selected Clusters with the Sunyaev-Zel'dovich Array

We report measurements of the Sunyaev-Zel'dovich (SZ) effect in three high-redshift (0.89 ≤ z ≤ 1.03), X-ray selected galaxy clusters. The observations were obtained at 30 GHz during the commissioning period of a new, eight-element interferometer—the Sunyaev-Zel'dovich Array (SZA)—built for dedicated SZ effect observations. The SZA observations are sensitive to angular scales larger than those subtended by the virial radii of the clusters. Assuming isothermality and hydrostatic equilibrium for the intracluster medium and gas-mass fractions consistent with those for clusters at moderate redshift, we calculate electron temperatures, gas masses, and total cluster masses from the SZ data. The SZ-derived masses, integrated approximately to the virial radii, are 1.9^(+0.5)_(-0.4) × 10^(14) M_☉ for Cl J1415.1+3612, 3.4^(+0.6)_(-0.5) × 10^(14) M_☉ for Cl J1429.0+4241, and 7.2^(+1.3)_(-0.9) × 10^(14) M_☉ for Cl J1226.9+3332. The SZ-derived quantities are in good agreement with the cluster properties derived from X-ray measurements

Joint analysis of X-ray and Sunyaev Zel'dovich observations of galaxy clusters using an analytic model of the intra-cluster medium

We perform a joint analysis of X-ray and Sunyaev Zel'dovich (SZ) effect data using an analytic model that describes the gas properties of galaxy clusters. The joint analysis allows the measurement of the cluster gas mass fraction profile and Hubble constant independent of cosmological parameters. Weak cosmological priors are used to calculate the overdensity radius within which the gas mass fractions are reported. Such an analysis can provide direct constraints on the evolution of the cluster gas mass fraction with redshift. We validate the model and the joint analysis on high signal-to-noise data from the Chandra X-ray Observatory and the Sunyaev-Zel'dovich Array for two clusters, Abell 2631 and Abell 2204.Comment: ApJ in pres