Map Task Corpus of Heritage BCMS spoken by second-generation speakers in Switzerland

In this paper, we present a corpus for heritage Bosnian/Croatian/Montenegrin/Serbian (BCMS) spoken in German-speaking Switzerland. The corpus consists of elicited conversations between 29 second-generation speakers originating from different regions of former Yugoslavia. In total, the corpus contains 30 turn-aligned transcripts with an average length of 6 min. It is enriched with extensive speakers’ metadata, annotations, and pre-calculated corpus counts. The corpus can be accessed through an interactive corpus platform that allows for browsing, querying, and filtering, but also for creating and sharing custom annotations. Principal user groups we address with this corpus are researchers of heritage BCMS, as well as students and teachers of BCMS living in diaspora. In addition to introducing the corpus platform and the workflows we adopted to create it, we also present a case study on BCMS spoken by a pair of siblings who participated in the map task, and discuss advantages and challenges of using this corpus platform for linguistic research

Analysis of Traffic and Design Elements of the Park Hrvatske mornarice Street in Zagreb with Proposal for Improvement

U završnom radu su analizirani postojeći prometno-oblikovni elementi ulice Park Hrvatske mornarice i dan je prijedlog rekonstrukcije ulice. Ustanovljeni su tlocrtni elementi ulice, te veličina i struktura prometnoga toka u karakterističnom danu. Analizirano je postojeće stanje sa stajališta sigurnosti svih sudionika u prometu te su predloţena rješenja kojima bi se povećala sigurnost i kvaliteta odvijanja prometa.The final paper analyses the current traffic and design elements of the Park Hrvatske mornarice Street and gives a proposal of street reconstruction. It establishes the layout street elements, as well as dimensions and structure of the traffic flow on a characteristic day. The current condition from the aspect of safety of all the traffic participants has been analysed and the solutions to enhance the safety and quality of traffic have been proposed

Papel del castigo parental en relación entre la adaptación económica y la inclusión escolar de niños

Cilj je rada bio ispitati izravan i neizravanučinak ekonomske prilagodbe na emocionalnu i ponašajnu školsku uključenost djece. Pri tome su izravni i neizravni učinci, koji su rezultat roditeljskog kažnjavanja, provjeravani ovisno o spolu djeteta i roditelja te izvoru procjene istraživanih konstrukata. Na temelju teorijskih modela, odnosno modela odnosa obitelj – škola Adamsa i Ryana (2005), modela obiteljskog stresa Congera i suradnika (2010) te modela Yoshikawa i suradnika (2012), postavljena je hipoteza o postojanju značajnoga neizravnog, ali ne i izravnog učinka ekonomske prilagodbe na školsku uključenost dječaka i djevojčica. U radu su analizirani podatci prikupljeni od 285 djeteta školske dobi i njihova oba roditelja. Djeca su procjenjivala kažnjavanje posebno za oca i posebno za majku te svoju školsku uključenost, a roditelji su dali podatke o ekonomskoj prilagodbi. Koristeći Hayesovu (2013) medijacijsku procesnu analizu provjereno je osam modela s izravnim i neizravnim učincima ekonomske prilagodbe na školsku uključenost djece. Rezultati su dijelom potvrdili postavljenu hipotezu o postojanju značajnih neizravnih, a neznačajnih izravnih učinaka ekonomske prilagodbe na školsku uključenost djece. Dobiveni rezultati upućuju na to da je učinak ekonomske prilagodbe na školsku uključenost kod dječaka samo neizravan kroz roditeljsko kažnjavanje, dok je kod djevojčica ekonomska prilagodba i izravno i neizravno povezana sa školskom uključenosti. Kod dječaka se neizravan učinak ekonomske prilagodbe na školsku uključenost ostvaruje kroz povezanosti s ponašanjem i majke i oca, dok kod djevojčica samo s povezanosti koju ekonomska prilagodba ima s ponašanjem majke. Rezultati rada upućuju na značajan negativan učinak ekonomske prilagodbe na školsku uključenost djece.The aim of the paper was to examine the direct and indirect effect of economic adjustment on the emotional and behavioural school engagement of children, through parental punishment. The direct and indirect effects were examined depending on the gender of the child and the parent, and the source of the assessment of the examined constructs. Based on theoretical models, namely the Adams\u27s and Ryan Family–School Relationships Model (2005), the Conger\u27s and colleges Family Stress Model (2010), and the model of Yoshikawa and colleges (2012), hypothesis has been postulated about the existence of significant indirect but not the direct effect of the economic adjustment on the school engagement of boys and girls. In this paper, the data collected from 285 schoolchildren and their parents analysed. Children assessed punishment of the father and of the mother, and their school engagement and parents provided information on the economic adjustment. Using the Hayes\u27s (2013) mediation process analysis, eight models were tested with direct and indirect effects of the economic adjustment on school engagement of the children. The results partly supported the hypothesis of the existence of significant indirect but not direct effects of economic adjustment on school engagement. The obtained results indicate that the effect of economic adjustment on school engagement of boys is only indirect, namely through parental punishment, while in girls the economic adjustment is both directly and indirectly related to school engagement. In boys, the adverse effect of economic adjustment on school engagement is realized through the behaviour of both mothers and fathers, while in girls only with the relation to maternal behaviour. The results indicate the significant and negative impact of the economic adjustment on school engagement of children.El objetivo de este trabajo fue verificar el efecto directo e indirecto que a través del castigo parental tiene la adaptación económica sobre la inclusión escolar emocional y conductual de niños. Los efectos directos e indirectos fueron examinados dependiendo del sexo (tanto de niños, como padres) y de la fuente de evaluación de constructos investigados. A base de modelos teóricos, o sea, modelo de relación familia-escuela de Adams y Ryan (2005), modelo de estrés familiar de Conger y colaboradores (2010) y modelo de Yoshikawa y colaboradores (2012), se formuló la hipótesis sobre el efecto indirecto significativo (pero no también efecto directo) que tiene la adaptación económica sobre la inclusión escolar de niños y niñas. En el trabajo fueron analizados datos obtenidos de 285 niños de edad escolar y sus padres. Los niños evaluaron el castigo separadamente para el padre y para la madre. Evaluaron también su inclusión escolar, y los padres proporcionaron datos sobre la adaptación económica. Usando el análisis de mediación procesal de Hayes (2013) fueron verificados ocho modelos con efectos directos e indirectos de la adaptación económica sobre la inclusión escolar de niños. Los resultados confirmaron parcialmente la hipótesis formulada sobre la existencia de efectos indirectos significativos y efectos directos no significativos de la adaptación económica sobre la inclusión escolar de niños. Los resultados obtenidos indican que el efecto de la adaptación económica sobre la inclusión escolar de niños es solo indirecto a través del castigo parental, mientras que las niñas muestran la relación tanto directa, como indirecta, de la adaptación social con la inclusión escolar. En niños, el efecto indirecto de la adaptación económica sobre la inclusión escolar se realiza a través de la conexión con el comportamiento tanto de la madre como del padre, mientras que en niñas es así sólo con la conexión que la adaptación económica tiene con el comportamiento de la madre. Los resultados del trabajo indican un efecto negativo significativo que la adaptación económica tiene sobre la inclusión escolar de niños

Rhabdomyosarcoma with Bone Marrow Infiltration Mimicking Hematologic Neoplasia

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children younger than 15 years. According to the World Health Organization, there are embryonal, alveolar and pleomorphic types of RMS. Most RMS patients present with a tumor mass in the head and neck region, urogenital tract or lower extremities. Unusual clinical presentation of the disease with massive bone marrow infiltration at the disease onset and mimicking hematologic neoplasm is rarely seen. A case is presented of a 14-year-old, previously healthy girl hospitalized for outpatiently detected leukocyte elevation. For the last two weeks, she had complained of fatigue, myalgia and frequent bruising. On admission, clinical examination revealed numerous petechiae and hematomas, enlarged left inguinal lymph node and palpable spleen 2 cm below left costal arch. Laboratory findings showed leukocytosis, anemia and thrombocytopenia. Bone marrow fine needle aspiration (FNA) produced a hypercellular bone marrow sample with suppression of all three hemocytopoiesis lines and bone marrow infiltration with numerous undifferentiated tumor cells. Considering the morphological, cytochemical and phenotypic characteristics, the cytologic diagnosis was: bone marrow infiltration with RMS cells. Abdominal computerized tomography revealed a primary tumor occupying the entire retropeoritoneal space. Tumor biopsy confirmed alveolar subtype of RMS. In conclusion, in cases of bone marrow infiltration with primitive, immature cells, RMS should be considered as differential diagnostic possibility. Adjuvant technologies (cytochemistry, immunocytochemistry, cytogenetic analysis, flow cytometry, and molecular analysis) can be very helpful in diagnostic work-up, and may lead to definitive diagnosis in some cases

CD20 Positive Childhood B-non Hodgkin Lymphoma (B-NHL): Morphology, Immunophenotype and a Novel Treatment Approach: A Single Center Experience

Lymphomas represent the third most common group of cancers in childhood and adolescence, mature B non Hodgkin’s lymphoma (B-NHL) accounting for up to 60% of newly diagnosed patients. The diagnosis of specific entities of B-NHL is based on well-defined morphologic analysis, immunophenotyping, cytogenetics and molecular genetics, which determine the optimal treatment strategy. In adult population a major turning point in treatment of B-NHL has been achieved since rituximab, in combination with CHOP has improved the survival rate up to 19%. Rituximab is a chimeric monoclonal antibody that targets CD20, a transmembrane calcium channel expressed on normal and malignant B-cells that mediates cytotoxic, apoptotic and anti-proliferative effects. The effect of rituximab in pediatric population is still not well enough investigated. Based on morphology and immunophenotype of malignant cells, seven children with B-NHL in our institution were eligible for treatment with modified B-NHL-Berlin-Frankfurt-Münster (BFM)-95-based protocol with rituximab administered on day -5. The complete remission was achieved in all seven patients. Six patients are still in complete remission at least 12 months after having finished chemotherapy and one patient relapsed two months after the last cycle and subsequently died. Major adverse effects observed during treatment were prolonged B-cell depletion and myelosupression. Rituximab in combination with B-NHL-BFM-95 protocol was otherwise well tolerated and proved to be effective in children and adolescents with B-NHL. The number of our patients is too small and the follow-up of a larger group of patients will help in defining the role of rituximab in the treatment of childhood B-NHL

Immunoglobulin heavy/light chain analysis enhances the detection of residual disease and monitoring of multiple myeloma patients

Aim To evaluate the clinical utility of incorporating a novel heavy/light chain immunoassay (HLC) into the existing methods for the assessment of multiple myeloma (MM) patients. Methods Convenience sera samples from 90 previously treated IgG and IgA MM patients in different disease stages were analyzed. The study was conducted in Clinical Hospital Center Zagreb between 2011 and 2013. The collected sera were analyzed by standard laboratory techniques (serum protein electrophoresis, quantification of total immunoglobulins, serum immunofixation, serum free light chain [FLC] assay) and HLC assay. Results HLC ratios outside the normal range were found in 58 of 90 patients, including 28 out of 61 patients with total immunoglobulin measurements within the normal range and 5 out of 23 patients in complete response. Both elevated HLC isotype level and abnormal HLC ratio correlated with the parameters of tumor burden, including percentage of plasma cells in the bone marrow (P < 0.001 and P = 0.002, respectively) and an abnormal serum FLC ratio (for both P < 0.001). In addition, abnormal HLC isotype level correlated with serum beta-2-microglobulin level (P = 0.038). In terms of prognosis, abnormal HLC isotype level and abnormal HLC ratio were significantly associated with shorter overall survival (P < 0.001 and P = 0.002, respectively). Interestingly, suppression of the uninvolved (polyclonal) isotype pair, but not other non-myeloma immunoglobulin isotypes, was also associated with a shorter overall survival (P = 0.021). In a multivariate analysis, an abnormal HLC ratio and β2-microglobulin level >3.5mg/L were independent risk factors for survival. Conclusion The new HLC assay has greater sensitivity in detecting monoclonal protein, correlates with tumor burden markers, and affects patients’ outcome