Nonreciprocal Atomic Scattering: A saturable, quantum Yagi-Uda antenna

Recent theoretical studies of a pair of atoms in a 1D waveguide find that the system responds asymmetrically to incident fields from opposing directions at low powers. Since there is no explicit time-reversal symmetry breaking elements in the device, this has caused some debate. Here we show that the asymmetry arises from the formation of a quasi-dark-state of the two atoms, which saturates at extremely low power. In this case the nonlinear saturability explicitly breaks the assumptions of the Lorentz reciprocity theorem. Moreover, we show that the statistics of the output field from the driven system can be explained by a very simple stochastic mirror model and that at steady state, the two atoms and the local field are driven to an entangled, tripartite $\left| W \right\rangle$ state. Because of this, we argue that the device is better understood as a saturable Yagi-Uda antenna, a distributed system of differentially-tuned dipoles that couples asymmetrically to external fields.Comment: 12 pages, 5 Figure

Telemedicine use and satisfaction among Filipinos during the COVID-19 Pandemic

Introduction: There is limited knowledge on telemedicine use and patient satisfaction in the Philippines, especially during COVID-19. Aim: To examine visit-related characteristics of two years of video consultations conducted during the pandemic, patient satisfaction, and identified patient- and visit-related characteristics associated with video consultation satisfaction scores. Methods: A retrospective analysis was conducted of telemedicine use and satisfaction of patients aged ≥18y, who had a video consultation between 1 March 2020 to 31 March 2022, using the SeeYouDoc (SYD) platform. As part of SYD’s routine oversight, after each video consultation, SYD a 6-item feedback survey was automatically prompted which assessed the patient’s level of comfort during the encounter, their perception of the convenience of telemedicine, the acceptability of the lack of physical contact during the consult, presence of privacy-related concerns, overall satisfaction, and their intention to use teleconsultation again. Each item was evaluated on a 5-point Likert scale with 5 as the highest score. These scores were collected, and t-test and ANOVA were employed to measure the differences in mean telemedicine satisfaction scores. Results: 12,378 telemedicine visits were conducted from 1 March 2020 to 31 March 2022 and patient feedback was received from1,896 patients (15.3%). The mean age of the respondents was 34.7±12.3y. The majority were females (83.1%), new SYD telemedicine patients (69.1%), and in the 26-39y age group (57.0%). Satisfaction with telemedicine was expressed by 73.8%, 63.4% were highly satisfied while 26.2% reported dissatisfaction. Mean telemedicine satisfaction scores were significantly higher among patients who had their telemedicine visit in 2021 (x̄=4.7±0.92) compared to 2020 (x̄=3.4±1.75) and 2022 (x̄=4.3±1.32), p<0.001. Patients aged 60-79 years old had a higher mean satisfaction score compared to other age groups, p=0.014. Higher mean telemedicine satisfaction scores were observed among male patients, those with completed video consultations, and patients who paid for their consultation, p<0.001. Conclusion: We observed high patient satisfaction with telemedicine during COVID-19. Filipino patients and families consider telemedicine a viable medium to receive healthcare services

Nonreciprocity realized with quantum nonlinearity

Nonreciprocal devices are a key element for signal routing and noise isolation. Rapid development of quantum technologies has boosted the demand for a new generation of miniaturized and low-loss nonreciprocal components. Here we use a pair of tunable superconducting artificial atoms in a 1D waveguide to experimentally realize a minimal passive nonreciprocal device. Taking advantage of the quantum nonlinear behavior of artificial atoms, we achieve nonreciprocal transmission through the waveguide in a wide range of powers. Our results are consistent with theoretical modeling showing that nonreciprocity is associated with the population of the two-qubit nonlocal entangled quasi-dark state, which responds asymmetrically to incident fields from opposing directions. Our experiment highlights the role of quantum correlations in enabling nonreciprocal behavior and opens a path to building passive quantum nonreciprocal devices without magnetic fields

Coping Styles and Its Relationship to the Personality Traits of College Students

This study investigates the relationship between personality traits and coping styles among college students in private higher educational institution. Hence, employing correlational design to assess the relationship between coping styles and personality of 150 college students. The statistical analysis reveals that the r coefficient of 0.54 indicates a moderate positive correlation between the variables. The p-value of 0.00, which is less than 0.05, leads to the decision to reject the null hypothesis. Hence, a significant relationship exists between coping style and personality traits among fourth-year college students in a private state university

Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms

Comparison of pre- and post-treatment status revealed that the Cunningham Panel results correlated with changes in patient's neuropsychiatric symptoms. Based upon the change in the number of positive tests, the overall accuracy was 86%, the sensitivity and specificity were 88% and 83% respectively, and the Area Under the Curve (AUC) was 93.4%. When evaluated by changes in autoantibody levels, we observed an overall accuracy of 90%, a sensitivity of 88%, a specificity of 92% and an AUC of 95.7%. Assay reproducibility for the calcium/calmodulin-dependent protein kinase II (CaMKII) revealed a correlation coefficient of 0.90 (p < 1.67 × 10-6) and the ELISA assays demonstrated test-retest reproducibility comparable with other ELISA assays.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify PDGFRA(+)/SCA-1(+) bone marrow-derived mesenchymal stem cells (Pα(+)S MSCs) as KS spindle-cell progenitors and found that pro-angiogenic environmental conditions typical of KS are critical for KSHV sarcomagenesis. This is because growth in KS-like conditions generates a de-repressed KSHV epigenome allowing oncogenic KSHV gene expression in infected Pα(+)S MSCs. Furthermore, these growth conditions allow KSHV-infected Pα(+)S MSCs to overcome KSHV-driven oncogene-induced senescence and cell cycle arrest via a PDGFRA-signaling mechanism; thus identifying PDGFRA not only as a phenotypic determinant for KS-progenitors but also as a critical enabler for viral oncogenesis.Fil: Naipauer, Julian. Miami University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados UnidosFil: Rosario, Santas. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados UnidosFil: Gupta, Sachin. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados UnidosFil: Premer, Courtney. Miami University; Estados UnidosFil: Méndez Solís, Omayra. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados UnidosFil: Schlesinger, Mariana. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ponzinibbio, Maria Virginia. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jain, Vaibhav. University of Florida; Estados UnidosFil: Gay, Lauren. University of Florida; Estados UnidosFil: Renne, Rolf. University of Florida; Estados UnidosFil: Chan, Ho Lam. Miami University; Estados UnidosFil: Morey, Lluis. Miami University; Estados UnidosFil: Salyakina, Daria. Miami University; Estados Unidos. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados UnidosFil: Abba, Martín Carlos. Miami University; Estados Unidos. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Williams, Sion. Miami University; Estados UnidosFil: Hare, Joshua M.. Miami University; Estados UnidosFil: Goldschmidt Clermont, Pascal. Miami University; Estados UnidosFil: Mesri, Enrique Alfredo. Sylvester Comprehensive Cancer Center and Miami Center for AIDS Research; Estados Unidos. Miami University; Estados Unido

Lessons learned from organizing and teaching virtual phylogenetics workshops

No abstract available

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incompletely understood. Amino acids are essential nutrients for many cancer cells that can be obtained through the scavenging and catabolism of extracellular protein via macropinocytosis. In particular, macropinocytosis can be a nutrient source for pancreatic cancer cells, but it is not fully understood how the tumor environment influences metabolic phenotypes and whether macropinocytosis supports the maintenance of amino acid levels within pancreatic tumors. Here we utilize miniaturized plasma exchange to deliver labeled albumin to tissues in live mice, and we demonstrate that breakdown of albumin contributes to the supply of free amino acids in pancreatic tumors. We also deliver albumin directly into tumors using an implantable microdevice, which was adapted and modified from ref. 9. Following implantation, we directly observe protein catabolism and macropinocytosis in situ by pancreatic cancer cells, but not by adjacent, non-cancerous pancreatic tissue. In addition, we find that intratumoral inhibition of macropinocytosis decreases amino acid levels. Taken together, these data suggest that pancreatic cancer cells consume extracellular protein, including albumin, and that this consumption serves as an important source of amino acids for pancreatic cancer cells in vivo.National Science Foundation (U.S.) (Grant T32GM007287)National Cancer Institute (U.S.) (Grant F30CA183474)National Institute of General Medical Sciences (U.S.) (Award T32GM007753)National Institutes of Health (U.S.) (Grant P30CA1405141)National Institutes of Health (U.S.) (Grant R01CA168653