Hybrid Encryption of Cloud Processing With IOT Devices Using DNA And RSA Cryptography

The research paper titled "Hybrid Data Encryption as well as Decryption Using Hybrid RSA and DNA" develops a hybrid cryptosystem by combining the usefulness of such an asymmetric-key (public-key) cryptosystem with the efficacy of a symmetric-key (private-key) cryptosystem. These two types of cryptosystems use different types of keys. The method addresses concerns regarding the users' right to privacy, authentication, and accuracy by utilizing a data encryption process that is secure in both directions. Both the process of encrypting data and the process of decrypting data, which are both utilized by the system, are two different encryption methods. It has been suggested that a hybrid encryption algorithm, which combines DNA and RSA, be used for file encryption in order to address the issues with efficiency and security. The results of the testing show that the RSA and DNA hybrid encryption algorithm is suitable for use. In this particular research project's hybrid encryption and decoding for cloud processing with IOT devices, the DNA and RSA algorithms were used

Smart Third Eye with Optimum and Safe Path Detection Based On Neural Networks for Blind Persons Using Raspberry-Pi

Blindness is the condition of lacking the visual sight due to physiological or neurological factors and partial blindness is due to lack of integration in the growth of the optic nerve or visual centre of the eye. In this proposed work, a simple, cheap, friendly user, virtual eye will be designed and implemented to improve the mobility of both blind and visually impaired people in a specific area. The proposed work includes a set of ultrasonic sensors for detection, raspberry-pi tool kit for programming and implementation,earphone for speech signal, hand stick(with sensors) using neural network. The main section of this project ultrasonic sensors which are used to scan a predetermined area around blind by emitting the waves.The rejected signals received from the barriers objects are used as inputs to raspberry-pi.Raspberry-pi carry out the issued commands and then communicate the status of a given appliances or device back to the earphone using raspberry-pi as speech. Also, this concept is cheap, fast and easy to use and an innovative a ordable solution to blind and visually impaired people

DEVELOPMENT OF HERB BASED PHARMACEUTICAL INDUSTRY IN UTTARAKHAND STATE

Uttarakhand has been known as a place for best medicinal plants since ancient times as referred in original Ayurvedic classics i.e. Charaka Samhita (1000 BC). In recent years the pharmaceutical industries have realized its potential medicinal flora because of diversified agro climatic zone as well as less environmental pollution as 63% of the land belongs to forest. Thus the state has immense potential area to cater the demand to produce best Ayurvedic products nutraceuticals, cosmoceuticals and Agro-chemical based industrial products. Herb based Pharmaceutical industry is having great potential and opportunities for development in future because of acetate demand of the medicinal plants & their value added products are well accepted in Domestic & International Market as Ayurvedic, Unani and Siddha, Homoeopathic medicines, Herbal Nutraceuticals, Herbal Cosmoceutical, Herbal Health drinks, Dietary Health Supplements, Medicinal Plants / Crude Drugs, Herbal Extracts / Concentrates, Veterinary Medicines, Health Foods. Various issues & challenges of Herbal Pharmaceutical Industries in Uttarakhand need proper attention of policy makers in favour of small industries. If, the challenges & issues related to development of Herbal sector in Uttarakhand is addressed the State could be the capital of Herbs in India

How Prevalent Are Autistic Traits Among Children With Attention-Deficit/Hyperactivity Disorder? A Qualitative Review of the Literature

Twin, family, and linkage studies have indicated that attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) share a portion of their heritable etiology. This suggests that individuals with ADHD may manifest different forms of ASDs that may range from fully developed syndromic forms of the disorder to milder manifestations of ASD symptomatology, which will henceforth be referred to as autistic traits.The main purpose of this study was to conduct a literature search to examine the current body of knowledge regarding the prevalence of autistic traits (operationalized as the presence of autistic symptoms in the absence of a diagnosis of ASD) among children with ADHD and the associated morbidity of such traits.A systematic literature search in PubMed was conducted to discover all controlled studies published in the English language that systematically assessed the presence of autistic traits in children with ADHD who did not meet the criteria for ASDs. Three articles met our inclusion and exclusion criteria and were included in this qualitative review.Only three scientific papers that met our a priori inclusion and exclusion criteria were identified. These articles described findings obtained from clinical samples and identified a prevalence of autistic traits among children with ADHD that ranged from 7% to 60%. As compared with children with ADHD without these traits, the presence of autistic traits in children with ADHD was associated with more severe dysfunction in a wide range of non-overlapping domains and in the social and communication domains in particular.Although this study was limited by the small amount of available literature about this subject, these findings suggest that a sizeable subset of children with ADHD manifest autistic traits and that the presence of these traits is associated with increased dysfunction and social and communication deficits

Are Autistic Traits in Youth Meaningful? A Replication study in Non-referred Siblings of Youth with and without Attention-Deficit/Hyperactivity Disorder

Background: We previously described the high prevalence and burden of significant autistic traits (ATs) in youth with attention-deficit/hyperactivity disorder (ADHD). These traits are associated with significantly greater impairment in psychopathological, interpersonal, educational, and neuropsychological functioning. Because the sample consisted of referred ADHD youth, uncertainty remained regarding whether these findings are generalizable to non-referred populations of youths with and without ADHD. Objective: The aim of the current study was to assess the prevalence and implications of ATs in a non-referred population of siblings of probands with and without ADHD. Method: Participants were non-referred siblings of probands with ADHD (N = 257) and control probands (N = 234) of longitudinal, case-control family studies conducted at Massachusetts General Hospital. Assessments included measures of psychiatric, psychosocial, educational, and cognitive functioning. The presence of significant ATs was operationalized using the Child Behavior Checklist AT profile, which consists of combined aggregate T-scores of ≥ 195 on the Withdrawn, Social, and Thought Problems subscales. Results: ATs were significantly more prevalent among the siblings of probands with ADHD as compared with siblings of control probands (6% vs. 1%; P = .02). Siblings of probands with ADHD with a positive AT profile (N = 15) were significantly more impaired than those without an AT profile (N = 242) with regard to psychopathological, interpersonal, educational, and neuropsychological functioning. Conclusions: The current study reports a higher-than-expected prevalence of ATs in a non-referred sample of siblings of youth with ADHD, which is consistent with previous findings regarding ATs in a referred sample of youth with ADHD. The presence of ATs is associated with higher levels of morbidity and dysfunction

India

This article surveys significant legal developments in India during the year 2014

Histone Deacetylase Inhibitors Prevent Pulmonary Endothelial Hyperpermeability and Acute Lung Injury By Regulating Heat Shock Protein 90 Function

Transendothelial hyperpermeability caused by numerous agonists is dependent on heat shock protein 90 (Hsp90) and leads to endothelial barrier dysfunction (EBD). Inhibition of Hsp90 protects and restores transendothelial permeability. Hyperacetylation of Hsp90, as by inhibitors of histone deacetylase (HDAC), suppresses its chaperone function and mimics the effects of Hsp90 inhibitors. In this study we assessed the role of HDAC in mediating lipopolysaccharide (LPS)-induced transendothelial hyperpermeability and acute lung injury (ALI). We demonstrate that HDAC inhibition protects against LPS-mediated EBD. Inhibition of multiple HDAC by the general inhibitors panobinostat or trichostatin provided protection against LPS-induced transendothelial hyperpermeability, acetylated and suppressed Hsp90 chaperone function, and attenuated RhoA activity and signaling crucial to endothelial barrier function. Treatment with the HDAC3-selective inhibitor RGFP-966 or the HDAC6-selective inhibitor tubastatin A provided partial protection against LPS-mediated transendothelial hyperpermeability. Similarly, knock down of HDAC3 and HDAC6 by specific small-interfering RNAs provided significant protection against LPS-induced EBD. Furthermore, combined pharmacological inhibition of both HDAC3 and -6 attenuated the inflammation, capillary permeability, and structural abnormalities associated with LPS-induced ALI in mice. Together these data indicate that HDAC mediate increased transendothelial hyperpermeability caused by LPS and that inhibition of HDAC protects against LPS-mediated EBD and ALI by suppressing Hsp90-dependent RhoA activity and signaling

Novel Mechanism of Attenuation of LPS-Induced NF-Kappab Activation by the Heat Shock Protein 90 Inhibitor, 17-N-Allylamino-17-Demethoxygeldanamycin, in Human Lung Microvascular Endothelial Cells

Heat shock protein (hsp) 90 inhibition attenuates NF-kappaB activation and blocks inflammation. However, the precise mechanism of NF-kappaB regulation by hsp90 in the endothelium is not clear. We investigated the mechanisms of hsp90 inhibition by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) on NF-kappaB activation by LPS in primary human lung microvascular endothelial cells. Transcriptional activation of NF-kappaB was measured by luciferase reporter assay, gene expression by real-time RT-PCR, DNA binding of transcription factors by chromatin immunoprecipitation assay, protein-protein interaction by coimmunoprecipitation/immunoblotting, histone deacetylase (HDAC)/histone acetyltransferase enzyme activity by fluorometry, and nucleosome eviction by partial microccocal DNase digestion. In human lung microvascular endothelial cells, 17-AAG-induced degradation of IKBalpha was accomplished regardless of the phosphorylation/ubiquitination state of the protein. Hence, 17-AAG did not block LPS-induced NF-kappaB nuclear translocation and DNA binding activity. Instead, 17-AAG blocked the recruitment of the coactivator, cAMP response element binding protein binding protein, and prevented the assembly of a transcriptionally competent RNA polymerase II complex at the kappaB elements of the IKBalpha (an NF-kappaB-responsive gene) promoter. The effect of LPS on IKBalpha mRNA expression was associated with rapid deacetylation of histone-H3(Lys9) and a dramatic down-regulation of core histone H3 binding. Even though treatment with an HDAC inhibitor produced the same effect as hsp90 inhibition, the effect of 17-AAG was independent of HDAC. We conclude that hsp90 inhibition attenuates NF-kappaB transcriptional activation by preventing coactivator recruitment and nucleosome eviction from the target promoter in human lung endothelial cells

Discriminant and Concurrent Validity of a Simplified DSM-Based Structured Diagnostic Instrument for the Assessment of Autism Spectrum Disorders in Youth and Young Adults

Background: To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs). Methods: To test concurrent validity, we assessed the structured interview's agreement in 123 youth with the expert clinician assessment and the Social Responsiveness Scale (SRS). Discriminant validity was examined using 1563 clinic-referred youth. Results: The structured diagnostic interview and SRS were highly sensitive indicators of the expert clinician assessment. Equally strong was the agreement between the structured interview and SRS. We found evidence for high specificity for the structured interview. Conclusions: A simplified DSM-based ASD structured diagnostic interview could serve as a useful diagnostic aid in the assessment of subjects with ASDs in clinical and research settings

Heat Shock Protein 90 Inhibitors Prevent LPS-Induced Endothelial Barrier Dysfunction by Disrupting Rhoa Signaling

Permeability of the endothelial monolayer is increased when exposed to the bacterial endotoxin LPS. Our previous studies have shown that heat shock protein (Hsp) 90 inhibitors protect and restore LPS-mediated hyperpermeability in bovine pulmonary arterial endothelial cells. In this study, we assessed the effect of Hsp90 inhibition against LPS-mediated hyperpermeability in cultured human lung microvascular endothelial cells (HLMVECs) and delineated the underlying molecular mechanisms. We demonstrate that Hsp90 inhibition is critical in the early phase, to prevent LPS-mediated hyperpermeability, and also in the later phase, to restore LPS-mediated hyperpermeability in HLMVECs. Because RhoA is a well known mediator of endothelial hyperpermeability, we investigated the effect of Hsp90 inhibition on LPS-mediated RhoA signaling. RhoA nitration and activity were increased by LPS in HLMVECs and suppressed when pretreated with the Hsp90 inhibitor, 17-allylamino-17 demethoxy-geldanamycin (17-AAG). In addition, inhibition of Rho kinase, a downstream effector of RhoA, protected HLMVECs from LPS-mediated hyperpermeability and abolished LPS-induced myosin light chain (MLC) phosphorylation, a target of Rho kinase. In agreement with these findings, 17-AAG or dominant-negative RhoA attenuated LPS-induced MLC phosphorylation. MLC phosphorylation induced by constitutively active RhoA was also suppressed by 17-AAG, suggesting a role for Hsp90 downstream of RhoA. Inhibition of Src family kinases also suppressed RhoA activity and MLC phosphorylation. Together, these data indicate that Hsp90 inhibition prevents and repairs LPS-induced lung endothelial barrier dysfunction by suppressing Src-mediated RhoA activity and signaling