The British in the Arctic, 1818-1829

This thesis will concern itself with British involvement in the Arctic during the period 1818 to 1829. This study seeks to determine and to explain why the British decided to go into the Arctic after the Napoleonic Wars, what happened in the various expeditions that were sent out, and what results were achieved from such an investigation. Various forces, motives and prominent figures are examined to establish the kind of rationale that induced government to sponsor not only one expedition but to embark upon a sustained and continuing series of exploration in the Arctic regions. A recurrent theme that presents itself throughout this quest - and a notion that had held the minds of men for centuries - was the road to Cathay. In order to achieve this dream, British policy was directed towards the discovery of a north-west passage or, failing that, a quicker route to the east via the North Pole. By 1829 the British had become disheartened in the quest. Again and again expeditions had returned without having achieved their goals. The most immediate and obvious success was, of course, the opening up of the North American continent bordering the Arctic Ocean. The other major achievements were the discoveries and additions given to science

Introduction to Human Geography (GGC)

This Grants Collection for Introduction to Human Geography was created under a Round Eight ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/geo-collections/1001/thumbnail.jp

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidities. It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females. Treatment interventions for fibromyalgia have limited success, leading to many patients seeking alternative forms of treatment, including modifications to their diet and lifestyle. The effectiveness of dietary changes in fibromyalgia has not been widely researched or evaluated. This systematic review identified twenty-two studies, including 18 randomised control trials (RCTs) and four cohort studies which were eligible for inclusion. In total these studies investigated 17 different nutritional interventions. Significant improvements in reported pain were observed for those following a vegan diet, as well as with the low fermentable oligo di-mono-saccharides and polyols (FODMAP) diets. Supplementation with Chlorella green algae, coenzyme Q10, acetyl-l-carnitine or a combination of vitamin C and E significantly improved measures of pain. Interpretation of these studies was limited due to the frequent poor quality of the study design, the wide heterogeneity between studies, the small sample size and a high degree of bias. Therefore, there is insufficient evidence to recommend any one particular nutritional intervention for the management of fibromyalgia and further research is needed

Quantifying Variation across 16S rRNA Gene Sequencing Runs in Human Microbiome Studies

Recent microbiome research has incorporated a higher number of samples through more participants in a study, longitudinal studies, and metanalysis between studies. Physical limitations in a sequencing machine can result in samples spread across sequencing runs. Here we present the results of sequencing nearly 1000 16S rRNA gene sequences in fecal (stabilized and swab) and oral (swab) samples from multiple human microbiome studies and positive controls that were conducted with identical standard operating procedures. Sequencing was performed in the same center across 18 different runs. The simplified mock community showed limitations in accuracy, while precision (e.g., technical variation) was robust for the mock community and actual human positive control samples. Technical variation was the lowest for stabilized fecal samples, followed by fecal swab samples, and then oral swab samples. The order of technical variation stability was inverse of DNA concentrations (e.g., highest in stabilized fecal samples), highlighting the importance of DNA concentration in reproducibility and urging caution when analyzing low biomass samples. Coefficients of variation at the genus level also followed the same trend for lower variation with higher DNA concentrations. Technical variation across both sample types and the two human sampling locations was significantly less than the observed biological variation. Overall, this research providing comparisons between technical and biological variation, highlights the importance of using positive controls, and provides semi-quantified data to better understand variation introduced by sequencing runs

Liver regeneration in dogs: Morphologic and chemical changes

Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later. Compensatory hypertrophy and hyperplasia ("regeneration") were evident within 1 day, reached a maximum in 3 days, and were almost complete by 6 days. Coincident with the histologic events of regeneration were decreases in responsiveness of receptor adenyl cyclase to glucagon stimulation, increases of cyclic AMP, inconsistent changes in plasma insulin, and increases in plasma glucagon. These studies have standardized hepatic resection in dogs and they have focused attention upon some possible mechanisms that will require further study. © 1978 Academic Press, Inc. All rights of reserved

Particle swarming of sensor correction filters

Reducing the impact of seismic activity on the motion of suspended optics is essential for the operation of ground-based gravitational wave detectors. During periods of increased seismic activity, low-frequency ground translation and tilt cause the Advanced LIGO observatories to lose 'lock', reducing their duty cycles. This paper applies modern global-optimisation algorithms to aid in the design of the 'sensor correction' filter, used in the control of the active platforms. It is shown that a particle swarm algorithm that minimises a cost-function approximating the differential root mean squared velocity between platforms can produce control filters that perform better across most frequencies in the control bandwidth than those currently installed. These tests were conducted using training data from the LIGO Hanford Observatory seismic instruments and simulations of the Horizontal Access Module Internal Seismic Isolation platforms. These results show that new methods of producing control filters are ready for use at LIGO. The filters were implemented at LIGO's Hanford Observatory, and use the resulting data to refine the cost function. © 2020 IOP Publishing Ltd Printed in the U

Methane emissions from oil and gas platforms in the North Sea

Since 1850 the concentration of atmospheric methane (CH4), a potent greenhouse gas, has more than doubled. Recent studies suggest that emission inventories may be missing sources and underestimating emissions. To investigate whether offshore oil and gas platforms leak CH4 during normal operation, we measured CH4 mole fractions around eight oil and gas production platforms in the North Sea which were neither flaring gas nor offloading oil. We use the measurements from summer 2017, along with meteorological data, in a Gaussian plume model to estimate CH4 emissions from each platform. We find CH4 mole fractions of between 11 and 370 ppb above background concentrations downwind of the platforms measured, corresponding to a median CH4 emission of 6.8 g CH4 s−1 for each platform, with a range of 2.9 to 22.3 g CH4 s−1. When matched to production records, during our measurements individual platforms lost between 0.04 % and 1.4 % of gas produced with a median loss of 0.23 %. When the measured platforms are considered collectively (i.e. the sum of platforms' emission fluxes weighted by the sum of the platforms' production), we estimate the CH4 loss to be 0.19 % of gas production. These estimates are substantially higher than the emissions most recently reported to the National Atmospheric Emission Inventory (NAEI) for total CH4 loss from United Kingdom platforms in the North Sea. The NAEI reports CH4 losses from the offshore oil and gas platforms we measured to be 0.13 % of gas production, with most of their emissions coming from gas flaring and offshore oil loading, neither of which was taking place at the time of our measurements. All oil and gas platforms we observed were found to leak CH4 during normal operation, and much of this leakage has not been included in UK emission inventories. Further research is required to accurately determine total CH4 leakage from all offshore oil and gas operations and to properly include the leakage in national and international emission inventories