Risk Management of a Business Entity

Tato diplomová práce se zabývá řízením rizik společnosti Motortec s.r.o, podnikající v oblasti prodeje a servisu osobních a užitkových vozidel. Práce je rozdělena na část teoretickou, ve které jsou uvedeny všechny důležité pojmy, vztahující se k práci a část analytickou, ve které je aplikován proces řízení rizik. Proces obsahuje identifikaci, analýzu a následné ošetření zjištěných rizik. Identifikace rizik proběhla pomocí Porterovy analýzy pěti konkurenčních sil, SLEPT analýzy a 7S analýzy. Dále byla zpracována SWOT analýza. Definovaná rizika byla ohodnocena skórovací metodou a rozčleněna podle jejich závažnosti. V poslední části jsou navrhnuta opatření ke snížení hlavních rizik, ohrožujících sledovanou společnost.The thesis deals with the risk management in Motortec s.r.o., a company that operates in the field of sales and maintenance service of passenger and commercial vehicles. The thesis is divided into the theoretical part, in which all the essential terms are defined that relate to the thesis itself, and an analytical part that employs the process of risk management. The process includes identification, analysis and subsequent remedies to risks identified. The identification of risks has been carried out using Porter's five forces analysis, SLEPT analysis and McKinsey 7S Framework. SWOT analysis has been carried out subsequently. The risks defined have been assessed using a scoring method and grouped into categories based on their severity. The last part includes measures to reduce the major risks that threaten the examined company.

The metastasis promoting protein S100A4 is increased in idiopathic inflammatory myopathies

Objectives. The S100A4 protein is known as a metastasis promoting factor; however, its involvement in non-malignant diseases such as RA and psoriasis has been recently described. The aim of this study was to investigate the expression and possible role of S100A4 in idiopathic inflammatory myopathies. Methods. S100A4 protein expression was detected by immunohistochemistry in muscle tissue from control individuals (n = 11) and patients with PM and DM (n = 8/6). IF staining was used to co-localize S100A4 with selected cells. Cytokine expression and protein synthesis in S100A4-treated cells were analysed by RT-PCR and ELISA. Results. S100A4 protein was significantly up-regulated in muscle tissue of patients with inflammatory myopathies compared with control individuals and was associated particularly with the presence of mononuclear infiltrates. Only few regenerating muscle fibres in PM/DM expressed S100A4. Then we analysed the effect of S100A4 on human myocytes and peripheral blood mononuclear cells (PBMCs). Although S100A4 did not affect myocytes, stimulation of PBMCs with S100A4 significantly induced the expression and synthesis of TNF-α, IL-1β and IL-6, but not of IFN-α. We showed that S100A4 is not directly involved in perforin/granzyme B-induced apoptosis and that it does not modulate the expression of Bax and Bcl2 mRNA in myocytes and PBMCs. Conclusion. Increased expression of S100A4 in inflamed muscle tissue highlights its potential role in the pathogenesis of inflammatory myopathies. S100A4 may act as a cytokine-like factor indirectly promoting muscle fibre damage by stimulating mononuclear cells to increase the synthesis of pro-inflammatory cytokine

Increasing incidence of immune-mediated necrotizing myopathy:single-centre experience

OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in muscle biopsy and variable response to immunosuppressive treatment. The aims of this study were to analyse the temporal trend of IMNM incidence in our centre over the past 10 years and to explore the role of statins as possible causative agents.METHODS: A retrospective evaluation of muscle biopsy results, clinical and laboratory data, including antibody associations of all patients with idiopathic inflammatory myopathy newly diagnosed between 2004 and June 2014, was performed. Available sera were tested for the presence of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) autoantibodies.RESULTS: Of 357 biopsied patients, 233 fulfilled criteria for inflammatory/immune-mediated myopathy, including 27 (11.6%) classified as IMNM. There were no patients with IMNM diagnosed between 2004 and 2007; subsequently, two to three cases of IMNM per year were seen during the period 2008-11, with a substantial increase to 18 cases (66.6% of all IMNM biopsies) in 2012-14. Thirteen of 27 patients (48%) had a history of statin use, 11 (85%) of whom had positive anti-HMGCR antibodies. There was no IMNM patient without a history of statin use who was anti-HMGCR antibody positive.CONCLUSION: Our data show an increasing incidence of IMNM, which is mainly accounted for by anti-HMGCR-positive IMNM associated with the use of statins.</p

Hemodynamics in Ruptured Intracranial Aneurysms

Incidental detection of unruptured intracranial aneurysms (UIA) has increased in the recent years. There is a need in the clinical community to identify those that are prone to rupture and would require preventive treatment. Hemodynamics in cerebral blood vessels plays a key role in the lifetime cycle of intracranial aneurysms (IA). Understanding their initiation, growth, and rupture or stabilization may identify those hemodynamic features that lead to aneurysm instability and rupture. Modeling hemodynamics using computational fluid dynamics (CFD) could aid in understanding the processes in the development of IA. The neurosurgical approach during operation of IA allows direct visualization of the aneurysm sac and its sampling in many cases. Detailed analysis of the quality of the aneurysm wall under the microscope, together with histological assessment of the aneurysm wall and CFD modeling, can help in building complex knowledge on the relationship between the biology of the wall and hemodynamics. Detailed CFD analysis of the rupture point can further strengthen the association between hemodynamics and rupture. In this chapter we summarize current knowledge on CFD and intracranial aneurysms

Posouzení finanční situace podniku

Abstract Zámečník, J. Evaluation of the financial situation in a business company. Bachelor thesis. Brno, 2014. Aim of this bachelor thesis is to evaluate the financial situation and management of the company called AMB Finance s.r.o between the years 2008-2012. Methods of financial analysis were used to meet the objective. The input data are the financial statements balance sheets and the profit and loss statement. The thesis is divided into two parts. The literature retrieval and practical part. In the literature retrieval section the calculation methods used, substance and the application of the financial analysis are described. In the practical part theoretical knowledge is applied on the chosen company and its financial situation is evaluated using horizontal, vertical analysis, differential analysis, ratio indicators analysis and bankruptcy prediction models. The paper concludes with the overall evaluation of the financial situation of the company and proposed recommendations that would lead to the improvement in the financial situation of the company

Activism and the perception of the lives of LGBT individuals in the Czech Republic in the perspective of two generations of LGBT men

Katedra sociologieDepartment of SociologyFaculty of Social SciencesFakulta sociálních vě