Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment

In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid. Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator. The size of the polymer was manipulated by changing the mole percent of the crosslinker and evaluated for their morphology (TEM), particle size, zeta potential, loading efficiency, drug content and drug release. Furthermore, microgels were tagged with FITC, a fluorochrome which could be applied for cell imaging. Cytotoxicity studies revealed that the microgels were not toxic. These complex nanoparticles (Fe3O4/pNIPAM/FITC/5-Fu) appear to be a great promise to be used in controlled drug delivery and tumor targeting.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles

The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. Marine sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the Bengamides have showed an important biological profile, including antitumor, antibiotic and anthelmintic properties. Due to the interest of theses natural products, we describe a study directed towards the total synthesis of this class of compounds. Then we encapsulate Bengamides in temperature sensitive microgels with a magnetic core. Magnetic nanoparticles (Fe3O 4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid. Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Characteristics of Respiratory Syncytial Virus versus Influenza infection in hospitalized patients of Peru: a retrospective observational study

Respiratory syncytial virus (RSV) and influenza infections are important causes of respiratory illness associated with hospitalizations in children in Peru; however, comparisons of RSV and influenza hospitalization across all age groups are not available in Peru. Therefore, we conducted an observational, retrospective study between May 2015 and October 2021 using hospitalization from RSV and influenza infection data obtained from SUSALUD (open data) in Peru to compare the baseline characteristics of sex, age, region, and infection type. For the study, 2696 RSV-infected and 1563 influenza-infected hospitalized patients from different age groups were included. Most hospitalizations from RSV infection and the influenza virus occurred in children <5 years of age (86.1% vs. 32.2%, respectively). Compared with influenza infection, RSV infection was less likely to occur in individuals ≥5 years of age (adjusted odds ratio (aOR) = 0.07; 95% confidence interval (CI), 0.06–0.08; p < 0.0001; compared to <5 years of age), and more likely to occur in highlands (aOR = 1.75; 95% CI, 1.46–2.07; p < 0.0001, compared to coast region), and jungle region (aOR = 1.75; 95% CI, 1.27–2.41; p = 0.001, compared to coast region). Among the respiratory complications, RSV pneumonia was less likely to occur between different age groups (aOR = 0.29; 95% CI, 0.22–0.37; p < 0.0001, compared to <5 years of age), compared with influenza pneumonia. These findings on the RSV-hospitalization and its complications are helpful for health services planning and may increase awareness of the Peruvian population’s RSV and influenza disease burden.Campus Lima Centr

Relación familiar y logros de aprendizaje de los adolescentes beneficiarios del Programa San Lorenzo de Sicuani - Cusco 2019

La investigación denominada “Relación Familiar y Logros de Aprendizaje de los Adolescentes Beneficiarios del Programa San Lorenzo de Sicuani – Cusco 2019”. Tuvo como objetivo general determinar cómo las relaciones familiares influyen en los logros de aprendizaje de los adolescentes beneficiarios del Programa San Lorenzo de Sicuani. Para ello se planteó como hipótesis: Las relaciones familiares influyen directamente en los logros de aprendizaje de los adolescentes beneficiarios del Programa San Lorenzo de Sicuani. La investigación es básica teórica, corresponde al enfoque cuantitativo de tipo correlacional explicativo, con un diseño no experimental. El método utilizado fue el hipotético – deductivo. La población de estudio está constituida por 52 estudiantes, la muestra de estudio es no probabilística, se consideró el total de los estudiantes cuyas edades oscilan entre 11 a 17 años entre varones y mujeres inscritos en el nivel secundario pertenecientes al Programa San Lorenzo de Sicuani. La técnica utilizada fue la encuesta, como instrumento fue el cuestionario, el procesamiento de datos se efectuó en el paquete estadístico SPSS versión 25, y se validó por medio de la prueba estadística, Chi cuadrado, con un nivel de significancia al 95% con un margen de error al 5%. Los principales resultados arribados fueron, que el 21% de adolescentes obtienen sus logros esperados cuando la estructura familiar es de tipo nuclear, además que un 30% de los adolescentes obtuvieron sus logros esperados, ellos tienen una comunicación asertiva familiar, esto permite un buen desenvolvimiento, y la relación entre padres e hijos es un 23% activo, donde siempre los padres están en una participación constante con sus hijos y genera que obtengan sus logros esperados es así que los resultados obtenidos de esta investigación fue que existe un alto nivel de significancia entre las variables relación familiar y logros de aprendizaje donde el valor de significancia fue 0.025, y el nivel de confianza es 95%.Tesi

On the determining number and the metric dimension of graphs

This paper initiates a study on the problem of computing the difference between the metric dimension and the determining number of graphs. We provide new proofs and results on the determining number of trees and Cartesian products of graphs, and establish some lower bounds on the difference between the two parameters.Postprint (published version

Design and preliminarily validation of a tool to assess the impact of chronic non-cancer pain on people’s daily life in Spanish-language: PAIN_Integral Scale

Aim: To build and preliminarily validate a Spanish-language instrument to assess the impact that CNCP has on the daily lives of people who suffer from it. Background: The experience of pain is multifactorial and a correct assessment of it helps to control the intensity of pain. Although there are instruments that evaluate areas on which Chronic Non-Cancer Pain impacts, it would be necessary to include other aspects that scientific literature identifies as relevant. Design: Instrument and construct cross-sectional study for psychometric validation. Methods: A total of 157 items based on items from validated questionnaires were evaluated by a group of 21 chronic pain experts using Delphi methodology in three evaluation rounds. A final questionnaire of 55 items with a 5-point Likert-type scale was formed. This questionnaire was piloted on a total of 30 patients to assess their understanding of the items and the psychometric validation process was carried out (January to March 2020) on a subsequent sample of 395 people, all of whom attended Pain Units and Primary Care Centres of the Public Health System in Spain. Results: The PAIN_Integral Scale© showed acceptable internal consistency scores measured by Cronbach's alpha. Exploratory Factor Analysis indicated a structure of nine factors that explain 71.02% of the total variance, from 157 to a final total of 36 items. Confirmatory Factor Analysis showing adequate values confirmed this structure. The effect size was used to calculate the cut-off points for the overall scale, setting them at scores of 130 and 135. Conclusion: This instrument would allow to assess other constructs and dimensions not included in the instruments previously available such as treatment compliance, proactivity, resilience, hopelessness due to pain and pain catastrophizing. However, despite the fact that the preliminary analysis shows good results, it is necessary to continue with its validation process in subsequent studies

SABERES EN RE – CONOCIMIENTO

This own thinking article is the result of the first forthcoming to the doctorate in Artistic Studies. The research-creation question is supported by the possible approach to understand the tension between formal knowledge and the derived from transdisciplinar knowledge of the arts. The conceptual framework of reference is drawn from the praxis and slant of the Eurocentric formation in classical music with respect to that which emerges from the aisthetical practices for the artistic formation. Having shared, recently, with the Brazilian flutist Patápio, allows me to add one more actor to this text.El presente ensayo de reflexión es el resultado de las primeras aproximaciones al doctorado en Estudios Artísticos. La pregunta de investigación-creación se soporta en el posible acercamiento a la comprensión de la tensión entre el conocimiento formal y el derivado del saber transdisciplinar de las artes. El marco de referencia conceptual se traza desde la praxis y el sesgo de la formación eurocéntrica en música clásica respecto de la que emerge desde las prácticas aistheticas para formación artística. El compartir con el flautista brasilero Patápio, permite agregar un actor más a este ensayo

Desarrollo de herramientas on line para estudiar la inserción laboral de los graduados de la Universidad Complutense

Depto. de Biodiversidad, Ecología y EvoluciónFac. de Ciencias BiológicasFALSEsubmitte

A synopsis of the genus Malesherbia (Passifloraceae) in Peru

Se presentan 15 taxones de Malesherbia que ocurren en el Perú, incluyendo un nuevo registro, Malesherbia auristipulata. Se proporcionan datos actualizados de distribución departamental, rango altitudinal, además de una clave dicotómica para la determinación de las especies.We present 15 taxa of Malesherbia occurring in Peru, adding a new record, Malesherbia auristipulata. Updated data for departamental distribution, altitudinal range, and a species key are provided