A short proof that the Coulomb-gauge potentials yield the retarded fields

A short demonstration that the potentials in the Coulomb gauge yield the retarded electric and magnetic fields is presented. This demonstration is relatively simple and can be presented in an advanced undergraduate curse of electromagnetic theory

Geoportal proposal for the inventory of cultural heritage in Nabón (Ecuador)

[EN] Humanity is losing cultural heritage faster than it can be documented, preserved and disseminated. A combination of natural and human actions is heavily affecting heritage such as climate change, vandalism, looting and natural hazards such as floods, droughts, tsunamis and earthquakes. This paper presents a cooperation proposal for strengthening efforts to protect and safeguard the world¿s cultural and natural heritage through building a geoportal for the inventory of tangible and intangible cultural heritage in Cantón Nabón, province of Azuay, Ecuador. All the gathered information, historical records, old photographs, architectural and archaeological and geomorphological surveys, in combination with state-of-the-art photogrammetric documentation surveys, will integrate the new heritage geoportal. The initial implementation will be carried out by working together with local, regional and international experts, following the suggestions of the local inhabitants.The authors acknowledge the support by the Centro de Cooperación al Desarrollo, Universitat Politècnica de València (Research Programme ADSIDEO-COOPERACIÓN 2019).Lerma, JL.; Heras, V.; Mora Navarro, JG.; Rodas, P.; Matute, F. (2020). Geoportal proposal for the inventory of cultural heritage in Nabón (Ecuador). ISPRS. 1415-1418. https://doi.org/10.5194/isprs-archives-XLIII-B2-2020-1415-2020S1415141

Tumor expression of cyclin-dependent kinase 5 (Cdk5) is a prognostic biomarker and predicts outcome of oxaliplatin-treated metastatic colorectal cancer patients

In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines and in a large number of tumor samples in order to evaluate its relevance in this pathogenesis and possible use as a prognostic marker. We found that Cdk5 is highly expressed and activated in CRC cell lines and that silencing of the kinase decreases their migration ability. In tumor tissues, Cdk5 is overexpressed compared to normal tissues due to a copy number gain. In patients with localized disease, we found that high Cdk5 levels correlate with poor prognosis, while in the metastatic setting, this was only the case for patients receiving an oxaliplatin-based treatment. When exploring the Cdk5 levels in the consensus molecular subtypes (CMS), we found the lowest levels in subtype 1, where high Cdk5 again was associated with a poorer prognosis. In conclusion, we confirm that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease

Visor de escenarios de cambio climático de adapteCCa: consulta interactiva y acceso a escenarios-PNACC 2017

Ponencia presentada en: XI Congreso de la Asociación Española de Climatología celebrado en Cartagena entre el 17 y el 19 de octubre de 2018.[ES]Las proyecciones regionales de cambio climático son una información básica para realizar estudios de impacto y adaptación en distintos sectores socio-económicos. La recopilación y producción de estas proyecciones a nivel nacional es una tarea básica del Plan Nacional de Adaptación al Cambio Climático (PNACC), a través de Escenarios-PNACC. La primera versión (2012) se basó en la información del IPCCAR4 y en dos acciones estratégicas nacionales (ESCENA y ESTCENA). Recientemente, se ha llevado a cabo una actualización de estos escenarios regionales a partir de IPCC-AR5 y de los proyectos CORDEX y VALUE (con la participación de AEMET y CSIC-UC), que proporciona series diarias en rejilla y puntuales de distintas variables e índices para múltiples escenarios y modelos. En este trabajo se presenta la actualización Escenarios-PNACC 2017, así como el visor de escenarios de cambio climático desarrollado en el marco de la plataforma AdapteCCa para facilitar a los usuarios el análisis interactivo y el acceso a esta información (http://escenarios.adaptecca.es).[EN]Regional projections of climate change are key information to carry out impact and adaptation studies in different socio-economic sectors. The compilation and production of these projections at the national level is a basic task of the National Plan of Adaptation to Climate Change (PNACC), through Escenarios-PNACC. The first version (2012) was based on IPCC-AR3 information and two national strategic actions (ESCENA and ESTCENA). Recently, an update of these regional scenarios has been carried out from IPCC-AR5 and from the CORDEX and VALUE projects (with the participation of AEMET and CSIC-UC), providing daily gridded and point series of different variables and indices for multiple scenarios and models. This paper describes the update Escenarios-PNACC 2017, as well as the "viewer of climate change scenarios" developed within the framework of the AdapteCCa platform to provide users with interactive analysis and access to this information (http://escenarios.adaptecca.es)

How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?

Background and Aims. To control the COVID-19 spread, in March 2020, a forced home lockdown was established in Spain. In the present study, we aimed to assess the effect of mobility and social COVID-19-established restrictions on depressive symptomatology in older adults with metabolic syndrome. We hypothesize that severe restrictions might have resulted in detrimental changes in depressive symptomatology. Methods. 2,312 PREDIMED-Plus study participants (men = 53:9%; mean age = 64:9±4:8 years) who completed a COVID-19 lockdown questionnaire to assess the severity of restrictions/lockdown and the validated Spanish version of the Beck Depression Inventory-II (BDI-II) during the three established phases concerning the COVID-19 lockdown in Spain (prelockdown, lockdown, and postlockdown) were included in this longitudinal analysis. Participants were categorized according to high or low lockdown severity. Analyses of covariance were performed to assess changes in depressive symptomatology across lockdown phases. Results. No significant differences in participant depression symptomatology changes were observed between lockdown severity categories (low/high) at the studied phases. During the lockdown phase, participants showed a decrease in BDI-II score compared to the prelockdown phase (mean (95% CI), -0.48 (-0.24, -0.72), P < 0:001); a nonsignificantly larger decrease was observed in participants allocated in the low-lockdown category (low: -0.59 (-0.95, -0.23), high: -0.43 (-0.67, -0.19)). Similar decreases in depression symptomatology were found for the physical environment dimension. The post- and prelockdown phase BDI-II scores were roughly similar. Conclusions. The COVID-19 pandemic lockdown was associated with a decrease in depressive symptomatology that returned to prelockdown levels after the lockdown. The degree of lockdown was not associated with depressive symptomatology. The potential preventive role of the physical environment and social interactions on mental disorders during forced home lockdown should be further studie

Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study

<p>Abstract</p> <p>Background</p> <p>In Spain, stroke is one of the major causes of death and the main cause of severe disability in people over 65 years. We analyzed the incidence of ischemic stroke, stroke subtypes, case fatality and disability at 90 days after the event in a Spanish population.</p> <p>Methods</p> <p>A prospective community-based register of ischemic strokes was established in Santa Coloma de Gramenet (Barcelona) [116,220 inhabitants of all ages, according to the municipal census of December 31,2001], from January 1 to December 31, 2003.</p> <p>Standard definitions and case finding methods were used to identify all cases in all age groups. Every patient underwent a complete clinical evaluation and systematic tests including neuroimaging (CT/MRI) and vascular studies (carotid duplex ultrasound intra and extracranial and MR angiography).</p> <p>Results</p> <p>Over a one year period, 196 ischemic strokes were registered [107 men; median age = 76 years (range 39–98)], being the first event in 159 patients (81.1%) and a recurrent stroke in 37 (18.9%). After age-adjustment to the European population, the incidence of ischemic stroke per 100,000 inhabitants was 172 (95% CI, 148–196); 219 (176–261) in men and 133 (105–160) in women, with an annual incidence for first ischemic stroke of 139 (118–161); 165 (128–201) in men and 115 (89–140) in women. The incidence of stroke increased with age.</p> <p>Stroke subtypes (TOAST classification criteria) were lacunar in 28.8%, atherothrombotic in 18.6%, cardioembolic in 26.6% and undetermined in 26.0% of patients. At 90 days, the case-fatality was 12%, and among survivors, moderate-to-severe disability was present in 45 % at 3 months.</p> <p>Conclusion</p> <p>This prospective community-based study shows one of the lowest incidences of stroke in Europe, as well as one of the lowest case fatality and disability rates at 90 days after stroke.</p