100 research outputs found

    Transplants in Brazil: where are we?

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    Clinical outcome of renal transplant patients after coronary stenting

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    OBJECTIVE: To assess the clinical outcome of renal transplant patients who developed coronary artery disease and were treated with coronary stenting (TCA-ST). METHODS: A total of 3,334 renal transplants were performed in our service - Hospital do Rim e Hipertensão - HRH (Kidney and Hypertension Hospital) from July, 1998 to November, 2004. During this period, 33 of the renal transplant patients underwent TCA-ST to treat 62 severe stenoses in 54 coronary arteries. A retrospective analysis was performed with renal transplant patients undergoing TCA-ST at HRH. The clinical events were registered using medical charts, medical visits and phone calls. RESULTS: During the 30-month clinical follow-up after TCA-ST, 67% of the patients remained asymptomatic, 18% presented stable angina, 6% presented acute coronary syndrome without ST-segment elevation (ACSWSTE), and 3% presented acute coronary syndrome with ST-segment elevation (ACSSTE). No strokes, CHF or cardiac deaths were observed. Three non-cardiac deaths occurred. A restenosis rate of 9% was observed, which is comparable to those found in studies on drug-eluting stents. CONCLUSION: In conclusion, renal transplant patients who developed CAD and were treated with coronary stenting had a low rate of in-stent restenosis, probably related to the immunosuppressive regimen given to prevent kidney rejection.OBJETIVO: Avaliar a evolução clínica de pacientes submetidos a transplante de rim, portadores de doença arterial coronariana, que foram tratados com implante de stent coronariano (ATC-ST). MÉTODOS: Entre julho de 1998 e novembro de 2004, foram realizados, no total, 3.334 transplantes de rim em nossa Instituição (Hospital do Rim e Hipertensão). Desse total, 33 pacientes previamente submetidos a transplante de rim fizeram ATC-ST para o tratamento de 62 estenoses graves em 54 artérias coronárias, nos quais foi realizada análise retrospectiva. O registro dos eventos clínicos foi feito por meio de análise do prontuário médico, consulta médica e ligações telefônicas. RESULTADOS: No seguimento clínico de 30 meses, após a ATC-ST, observou-se que 67% dos pacientes permaneceram assintomáticos, 18% dos pacientes apresentaram quadro de angina estável, 6% apresentaram síndrome coronariana aguda sem supra de ST e 3% apresentaram síndrome coronariana aguda com supra de ST. Não houve pacientes com acidente vascular cerebral, insuficiência cardíaca congestiva ou morte cardíaca. Houve três mortes não-cardíacas. Foi observado índice de reestenose de 9%, que é comparável ao dos estudos de stent farmacológico. CONCLUSÃO: Concluímos que pacientes submetidos a transplante de rim que desenvolveram doença arterial coronariana e que foram tratados com stent coronariano tiveram baixo porcentual de reestenose clínica, provavelmente relacionado ao regime de imunossupressão administrado para evitar rejeição renal.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital do Rim e HipertensãoUNIFESP, EPM, Hospital do Rim e HipertensãoSciEL

    Tridimensional rotational angiography (3D-RA) as a diagnostic tool for patients with transplant renal artery stenosis

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    BACKGROUND: Transplant renal artery stenosis (TRAS) is the major vascular complication associated to adverse events in patients with kidney grafts, whose incidence ranges from 1% to 23%. Angiography is the gold-standard for diagnosis, enabling immediate treatment; however, due to the variable anatomy and location of anastomosis, additional projections are often required, leading to greater exposure to contrast medium and radiation. Tridimensional rotational angiography (3D-RA) appears as a tool for diagnosis and treatment of TRAS. The aim of this paper was to evaluate the accuracy of measurements obtained by 3D-RA in comparison to conventional angiography. METHODS: From April, 2010 to January, 2011, 41 3D-RAs were performed in patients with clinical suspicion of TRAS. Images were analyzed by independent observers; conventional angiography measurements were obtained online and 3D-RA measurements were obtained offline with the Philips Allure 3D-RA software. RESULTS: Thirty-five 3D-RAs (84%) were considered adequate for angiographic measurements, and 20% provided additional and relevant information for the therapeutic strategy. There was no statistically significant difference between measurements obtained from the reference diameter and minimal luminal diameter of the artery using 3D-RA and conventional angiography. In addition, there was a strong correlation between them CONCLUSIONS: 3D-RA comes up as a useful tool for TRAS diagnosis, providing accurate measurements and complementary and relevant information for the diagnosis and treatment, in addition to potentially reducing procedure time and exposure to contrast and radiation.INTRODUÇÃO: A estenose da artéria do rim transplantado (EART) é a principal complicação vascular associada a eventos adversos em pacientes portadores de enxerto renal, cuja incidência varia de 1% a 23%. A arteriografia é o padrão de referência para o diagnóstico, possibilitando tratamento imediato; porém, em decorrência da anatomia variável e da localização da anastomose, muitas vezes são necessárias projeções adicionais, levando a maior exposição ao contraste e à radiação. A angiografia rotacional com reconstrução tridimensional (tridimensional rotational angiography - 3D-RA) surge como ferramenta para o diagnóstico e o tratamento da EART. O objetivo deste estudo foi avaliar a acurácia das medidas obtidas pela 3D-RA, comparativamente à obtida pela angiografia convencional. MÉTODOS: De abril de 2010 a janeiro de 2011, foram realizadas 41 3D-RA em pacientes com alta suspeita clínica de EART. As imagens foram analisadas por observadores independentes, sendo as medidas da arteriografia convencional obtidas no momento do procedimento e as da 3D-RA, após o processamento das imagens pelo software Philips Allure 3D-RA. RESULTADOS: Foram analisadas 35 3D-RA (84%) consideradas adequadas para a realização das medidas angiográficas, das quais 20% contribuíram com informações adicionais relevantes para a estratégia terapêutica. Não houve diferença estatisticamente significante entre as medidas dos diâmetros de referência e luminal mínimo da artéria obtidas pela 3D-RA e pela angiografia convencional, além de ter havido forte correlação entre elas. CONCLUSÕES: A 3D-RA surge como ferramenta útil para o diagnóstico da EART, ao obter medidas acuradas, oferecer informações complementares e relevantes para o diagnóstico e tratamento, além de potencialmente reduzir o tempo do procedimento e a exposição ao contraste e à radiação.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital São PauloUniversidade Federal de São Paulo (UNIFESP) Fundação Oswaldo Ramos Hospital do Rim e HipertensãoUNIFESP, EPM, Hospital São PauloUNIFESP, Fundação Oswaldo Ramos Hospital do Rim e HipertensãoSciEL

    The use of cyclosporine modifies the clinical and histopathological presentation of tuberculosis after renal transplantation

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    Tuberculosis is one of the most frequent opportunistic infections after renal transplantation and occurred in 30 of 1264 patients transplanted between 1976 and 1996 at Hospital São Paulo - UNIFESP and Hospital Dom Silvério, Brazil. The incidence of 2.4% is five times higher than the Brazilian general population. The disease occurred between 50 days to 18 years after the transplant, and had an earlier and worse development in patients receiving azathioprine, prednisone and cyclosporine, with 35% presenting as a disseminated disease, while all patients receiving azathioprine and prednisone had exclusively pulmonary disease. Ninety percent of those patients had fever as the major initial clinical manifestation. Diagnosis was made by biopsy of the lesion (50%), positivity to M. tuberculosis in the sputum (30%) and spinal cerebral fluid analysis (7%). Duration of treatment ranged from 6 to 13 months and hepatotoxicity occurred in 3 patients. The patients who died had a significant greater number of rejection episodes and received higher doses of corticosteroid. In conclusion, the administration of cyclosporine changed the clinical and histopathological pattern of tuberculosis occurring after renal transplantation.A tuberculose é uma das mais frequentes infecções oportunistas encontradas após o transplante renal. A tuberculose foi diagnosticada em 30 de 1.264 pacientes que foram transplantados entre 1976 e 1996 na unidade de Transplante Renal do Hospital São Paulo - UNIFESP e no Hospital Dom Silvério Gomes Pimenta em São Paulo. A incidência de 2,4%, é cinco vezes superior à estimada para população geral brasileira. O diagnóstico foi realizado entre 50 dias a 18 anos após o transplante. Nos pacientes com esquema duplo de imunossupressão (prednisona e azatioprina), a manifestação inicial foi mais tardia, sendo que em 11 dos 13 pacientes ocorreu após os primeiros 3 anos de transplante. Enquanto com esquema tríplice (prednisona, azatioprina e ciclosporina), em 14 de 17 pacientes a doença ocorreu dentro dos primeiros 3 anos. Com esquema duplo de imunossupressão não houve manifestação de doença extra-torácica, em contrapartida com esquema tríplice de imunossupressão a forma de apresentação disseminada ocorreu em 35% dos casos, sendo mais precoce e mais grave. A febre foi o sintoma clínico principal em 90% dos casos. O diagnóstico foi confirmado, em 50% (n=15) através da biópsia dos órgãos envolvidos, em 30% (n=9) através da pesquisa de bacilos álcool ácido resistentes (BAAR) no escarro, em 7% (n=2) no líquido céfalo-raquidiano e em 13% (n=4) através de necrópsia. O tempo de tratamento da tuberculose variou de 6 a 13 meses. A hepatotoxidade relacionada ao tratamento, ocorreu em três casos. O número de tratamentos prévios de episódios de rejeição e a dose administrada de corticóides foram maiores nos pacientes que morreram com este diagnóstico, quando comparados ao grupo que respondeu ao tratamento. Em conclusão a forma clínica e histopatológica de apresentação da tuberculose é diferente após o transplante em pacientes utilizando ciclosporina, sendo a resposta ao tratamento influenciada pela dose prévia de corticóide

    Myocardial Revascularization in Dyalitic Patients: In-Hospital Period Evaluation

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    Background:Coronary artery bypass grafting currently is the best treatment for dialytic patients with multivessel coronary disease, but hospital morbidity and mortality related to procedure is still high.Objective:Evaluate results and in-hospital outcomes of coronary artery bypass grafting in dialytic patients.Methods:Retrospective unicentric study including 50 consecutive and not selected dialytic patients, who underwent coronary artery bypass grafting in a tertiary university hospital from 2007 to 2012.Results:High prevalence of cardiovascular risk factors was observed (100% hypertensive, 68% diabetic and 40% dyslipidemic). There was no intra-operative death and 60% of the procedures were performed off-pump. There were seven (14%) in-hospital deaths. Postoperative infection, previous heart failure, cardiopulmonary bypass, abnormal ventricular function and surgical re-exploration were associated with increased mortality.Conclusion:Coronary artery bypass grafting is feasible to dialytic patients although high in-hospital morbidity and mortality. It is necessary better understanding about metabolic aspects to plan adequate interventions.Fundamentos:Atualmente, a revascularização cirúrgica do miocárdio é o melhor tratamento para o paciente dialítico com lesão coronariana multiarterial, contudo a mortalidade e a morbidade hospitalar do procedimento ainda permanecem altas.Objetivos:Avaliar os resultados e a evolução intra-hospitalar da revascularização cirúrgica do miocárdio isolada em pacientes dialíticos.Métodos:Estudo retrospectivo unicêntrico de 50 pacientes dialíticos consecutivos e não selecionados, submetidos à revascularização cirúrgica do miocárdio em um hospital terciário universitário no período de 2007 a 2012.Resultados:A casuística apresentou alta prevalência de fatores de risco cardiovasculares (100% hipertensos, 68% diabéticos e 40% dislipidêmicos). Não houve óbito intraoperatório, e 60% dos procedimentos foram feitos sem circulação extracorpórea. Houve sete (14%) óbitos intra-hospitalares. Infecção pós-operatória, insuficiência cardíaca prévia, uso de circulação extracorpórea, função ventricular anormal e reexploração cirúrgica foram os fatores associados a maior mortalidade.Conclusão:A revascularização cirúrgica do miocárdio é um procedimento factível para essa classe de pacientes, contudo com alta morbidade e mortalidade intra-hospitalar. É necessário melhor entendimento das particularidades metabólicas desses pacientes para o planejamento adequado das condutas.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade de Santo AmaroUNIFESP, EPMSciEL

    Cardiovascular risk in children and adolescents with end stage renal disease

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    OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD

    Risk factors of transplant renal artery stenosis in kidney transplant recipients

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    Background: Transplant Renal Artery Stenosis (TRAS) is a recognized vascular complication after kidney transplantation. The overall risk predictors of TRAS are poorly understood. Methods: Retrospective analysis of patients with suspected TRAS (Doppler ultrasound PSV > 200 cm/s) who underwent angiographic study in a single center between 2007 and 2014. All patients with stenosis > 50% were considered with TRAS. Stenosis restricted in the body of the artery was also analyzed in a subgroup. Results: 274 patients were submitted to a renal angiography and 166 confirmed TRAS. TRAS group featured an older population (46.3 ± 11.0 vs. 40.9 ±14.2 years; p = 0.001), more frequent hypertensive nephropathy (30.1% vs. 15.7%; p = 0.01), higher incidence of Delayed Graft Function (DGF) (52.0% vs. 25.6%; p < 0.001) and longer Cold Ischemia Time (CIT) (21.5 ± 10.6 vs. 15.7 ± 12.9h; p < 0.001). In multivariable analyses, DGF (OR = 3.31; 95% CI 1.78‒6.30; p < 0.0001) was independent risk factors for TRAS. DM and CIT showed a tendency towards TRAS. The compound discriminatory capacity of the multivariable model (AUC = 0.775; 95% CI 0.718‒0.831) is significantly higher than systolic blood pressure and creatinine alone (AUC = 0.62; 95% CI 0.558–0.661). In body artery stenosis subgroup, DGF (OR = 1.86; 95% CI 1.04‒3.36; p = 0.03) and Diabetes Mellitus (DM) (OR = 2.44; 95% CI 1.31‒4.60; p = 0.005) were independent risk factors for TRAS. Conclusion: In our transplant population, DGF increased more than 3-fold the risk of TRAS. In the subgroup analysis, both DGF and DM increases the risk of body artery stenosis. The addition of other factors to hypertension and renal dysfunction may increase diagnostic accuracy. TRAS Trial registred: clinicaltrials.gov (n° NCT04225338)
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