Os cursos de ciências contábeis no Brasil e o conteúdo das disciplinas de sistemas de informação: a visão acadêmica versus a necessidade prática

The purpose of this study is to identify and quantify the perceived importance given to different topics from Information System field to be taught at accounting graduate Courses. A sample of 200 accounting practitioners from the Ribeirão Preto area (State of São Paulo ) and 71 professors in Accounting from the State of São Paulo Universities (Brazil ) were investigated for this purpose. The results shows that the differences in emphasis given to the 33 selected specific topics are very small. Since the content of Information System field being taught in Accounting graduate Courses is being considered inadequate for the practitioners, this might indicate the need for restructuring the Accounting graduate course to meet the practical needs of accountants and academics expectations. Implications and results will be presented here.O presente trabalho pesquisou um grupo de contadores profissionais (não acadêmicos) da Região de Ribeirão Preto - Estado de São Paulo /Brasil e os professores dos cursos de graduação em contabilidade do Estado de São Paulo /Brasil para identificar e quantificar a importância percebida referente a diversos tópicos da área de sistemas de Informação a se-rem ministrados nos cursos de Ciências Contábeis. Os resultados indicam que existem poucas divergências em relação à ênfase dada pelos acadêmicos e práticos em relação a 33 tópicos selecionados na área de Sistema de Informações. Uma vez que o conteúdo da área de Sistema de Informação está sendo considerado inadequado para os contadores profissionais (não acadêmicos), isto pode significar a necessidade de reestruturação dos cursos de graduação em Contabilidade para atender as necessidades práticas dos contadores, além de atender às expectativas dos acadêmicos

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Inquérito de toxoplasmose e de tripanossomíases realizado no Território do Amapá pela III Bandeira Científica do Centro Acadêmico "Oswaldo Cruz" da Faculdade de Medicina da Universidade de São Paulo

The survey was performed in three localities, in January 1962, and included inhabitants with 10 or more years of age and who had never left the Amazon Region.The Sabin-Feldman dye test was positive in 68.1 percent of 354 persons examined and the intradermal test with toxoplasmin in 46.4 percent of 366. The distribution of positive tests by locality, age, sex and race are presented.Through the complement fixation test for Chagas' disease (Guerreiro and Machado's test) performed in 353 persons and the xenodiagnosis in 116, no evidence of trypanosome infection was found.A severe malária outbreak which was occurring in the region is discussed.Descreve-se uma excursão realizada em janeiro de 1962 por estudantes da Faculdade de Medicina da Universidade de São Paulo ao Território do Amapá, onde realizaram inquéritos de toxoplasmose e tripanossomíase na cidade de Macapá e nas vilas de Paredão e Ferreira Gomes.A reação de Sabin-Feldman foi positiva em 68,1 % das 354 pessoas examinadas e a intradermorreação com toxoplasmina em 46,4% de 366. A distribuição das provas positivas é apresentada por localidade, sexo, idade e côr.A reação de fixação do complemento para doença de Chagas (prova de Guerreiro e Machado, técnica quantitativa), feita em 353 pessoas, não apresentou nenhum resultado seguramente positivo, sendo ainda negativos os 116 xenodiagnósticos efetuados com ninfas de triatomíneos (Rhodnius prolixus).Fazem-se ainda considerações sobre o intenso surto de malária que ocorria então na região