7 research outputs found
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inková Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga María José Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-Lévi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- Bjørgo Kathrine
- Bjørnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
- Bonelli Raphael
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borowsky B.
- Bos Reineke
- Bos Reineke
- Bosca Maria E.
- Bosredon Cecile
- Bost Marie
- Boukbiza Ouhaid Lagha
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bürk Katrin
- C Jan Frich
- Caldentey Juan Garcia
- Callaghan J.
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Campbell C.
- Campbell C.
- Campbell M.
- Campos Anabel
- Capellari Sabina
- Capetian Philipp
- Carette Maryline Cabaret Anne-Sophie
- Carrillo Fátima
- Carruesco Gemma Tome
- Cash D. M.
- Castaldo Anna
- Catena Judit López
- Chu Carol
- Chu Carol
- Chu Carol
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman A.
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Hermoso Eva Pacheco
- Cortelli Pietro
- Coulthard Elizabeth
- Courtin Françoise
- Craufurd D.
- Craufurd David
- Crawford H.
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- Cáceres María Teresa
- D'Alessio Barbara
- da Silva Wildson Vieira
- Damas Fatima
- Davies Rhys
- De Bruycker Christelle
- De Michele Giuseppe
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- de Yébenes Justo García
- de Yébenes Justo García
- Debruxelles Sabrina
- Dec Malgorzata
- Decolongon J.
- Defebvre Eric Decorte Luc
- Dekker M.
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Descals Asunción Martínez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Maio Luigi
- Di Pietro Anna
- di Poggio Monica Bandettini
- Di Renzo Martina
- Diercks Gabriele
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas E. M.
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen
- Dupuit Michel
- Durr Alexandra
- Duru Cécile
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madeleine
- Fasquel Véronique
- Favellato Mariagrazia
- Fenollar María
- Ferrandes Giovanna
- Ferreira Joaquim
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fox N. C.
- Foy Kevin
- Frajman E.
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frontali Marina
- Frost C.
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Gago Miguel
- Galassi Roberto
- Gallantrae Deena
- Gallentrae Deena
- Ganos Christos
- Garcia Patrocinio Moreno
- García Rocío García-Ramos
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Gerrans Emily
- Gethin Louise
- Ghelli Elena
- Gibbard C.
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Godefroy Olivier
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gonzenbach Roman
- González González Sonia
- Goodman Anna
- Gorospe Aranzazú
- Gorzkowska Agnieszka
- Gorzolla Heike
- Grant Janet
- Griguoli Annamaria
- Gross Diana
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guerra Maria Rosália
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Gustafsson Lena
- Guzman Natalie Valle
- Guérid Marie-Anne
- Gørvell Per F.
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia
- Handley Olivia
- Handley Olivia J.
- Harding Alison
- Hare Marianne
- Harrison David
- Hauer Maria
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Moss Davina J.
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Durán
- Herrmann Lennard
- Hicks S.
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Ho Carrie
- Hobbs N.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hotter Anna
- Howard Liz
- Hughes Max
- Hughes Teresa
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago Jesús Miguel Ruiz
- Illmann Torsten
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Jasinska-Myga Barbara
- Johns Nicola
- Johnson H.
- Johnson Liz
- Jones Lesley
- Jones Lesley
- Jones Mary
- Jones R.
- Jones Una
- Julié Celine
- Jung Hans H.
- Jurgens C.
- Justo D.
- Kaelin Alain
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Keenan S.
- Kennard C.
- Kershaw Ann
- Kesse Andrea
- Khalil Hanan
- Klempír Jirí
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klöppel Stefan
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kotz Peter
- Kraus Alison
- Kraus Alison
- Kraus Alison
- Kraus P.
- Krawczyk Malgorzata
- Kremer B.
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Labuschagne I.
- Lafoucrière Danielle
- Lahiri N.
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer B.
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lang Christina
- Langbehn Douglas
- Lange Herwig
- Lange Herwig
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- Laurà Matilde
- Laver Fiona
- Leavitt Blair R.
- Lee S.
- Leenders K. L.
- Lehericy S.
- Lemaire Marie-Hélène
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewis Monica
- Lewis Monica
- Leythäuser Gabriele
- Lezius Franziska
- Liessens Dirk
- Lilek Sabine
- Linnsand Petra
- Lo Kitty
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Mónica Rodriguez
- Lorentzen Eirin
- Loutfi Ghada
- Lucena Carolina Mendez
- Löhle Matthias
- Maass Antonia
- Magnet Markus
- Maiwald Robert
- Majerová Veronika
- Malone I.
- Man A. Hoff
- Mandich Paola
- Manouvrier Sylvie
- Mantaux Béatrice
- Manzanares Salvadora
- Marchese Roberta
- Marcinkowski Jerzy
- Marelli C.
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Horta Saül
- Martinez-Jaurrieta Maria Dolores
- Martín Esther Suaréz San
- Martínez-Descals Asunción
- Mason Sarah
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- Mazzante Irene
- McGill Marie
- McKenzie Sue
- Mead Simon
- Mechi Claudia
- Mendes Tiago
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milchman C.
- Milkereit Eva
- Minet Cécile
- Minster Sara
- Minster Sara
- Mir Pablo
- Monaco W.
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Jose Manuel Garcia
- Moreno José Luis López-Sendón
- Mundler Laura
- Murch Ann
- Murphy Helen
- Musgrave Hannah
- Möller Jens Carsten
- Mühlau Mark
- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Mütze Lisanne
- Nanetti Lorenzo
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen Jørgen
- Nielsen Jørgen E.
- Niess Anke
- Nigaud K.
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Regan A.
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Ordidge R.
- Ortega Paloma
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Owen G.
- Owen Michael
- Padieu Hélène
- Paganini Marco
- Painold Annamaria
- Pardiñas Antonio F.
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel A.
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Pepple T.
- Perea María Fuensanta Noguera
- Peter Mireille
- Petersen Jens
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Pica Emmanul
- Piedad John
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pourchot C.
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Probst Daniela
- Prundean Adriana
- Prüß Harald
- Päivärinta Markku
- Quarrell Oliver
- Queller S.
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria A.
- Ramos-Arroyo Maria A.
- Raymond Lucy
- Read J.
- Redondo Luis
- Reetz Kathrin
- REGISTRY investigators
- Reilmann R.
- Reilmann Ralf
- Reinante Gema
- Reisinger Karin
- Ret C. Jauff
- Retterstøl Lars
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo García
- Ribaï Pascale
- Ribbat Michael
- Richter Przemyslaw
- Rickards Hugh
- Rissling Ida
- Rivadeneyra Perez Jessica
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Rodríguez María José Torres
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos Raymund
- Roos Raymund A. C.
- Roos Raymund A. C.
- Rosas H. D.
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ruíz Pedro J. García
- Ryglewicz Danuta
- Røren Niini
- Sablonnière Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santhouse Alastair
- Santos R. Dar
- Sass Christian
- Say M.
- Scaglione Cesa
- Scahill R.
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián A. Rojo
- Sebastián Ana Rojo
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila A.
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Stattin Eva-Lena
- Stebler Yanik
- Stepniak Iwona
- Stokke Bodil
- Stompel Daniel
- Stopford C.
- Stopford Cheryl
- Storch Alexander
- Stout J.
- Stubbe Lars
- Sturrock A.
- Stárková Irena
- Städtler Michael
- Suarez María José Lama
- Sulek Anna
- Summers Fiona
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Sánchez Vicenta
- Süßmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres María Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- Valabrègue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-González Laura
- Vaughan Vivien
- Ventura Marta Fatás
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen Peiró
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
NMDA receptor gene variations as modifiers in Huntington disease: a replication study.
- Author
- Abbruzzese G
- Aguilar Barbera M
- Albanese A
- Alberti S
- Andrews T
- Andrews T
- Antczak J
- Arning Larissa
- Arran N
- Badenes Guia D
- Banaszkiewicz K
- Bandettini di Poggio Giovanna Ferrandes M
- Bandmann O
- Barker R
- Barrero F
- Barth K
- Bas J
- Bascuñana Garde M
- Bascuñana Garde M. Collaborators Barth K
- Bascuñana M
- Beister A
- Beister A
- Bentivoglio A
- Bertini E
- Bisson J
- Björnsson E
- Bjørgo K
- Bjørnevoll I
- Boczarska Jedynak M
- Bohlen S
- Bolwijn JJ
- Bonelli R
- Bos R
- Bos R
- Botne Sando S
- Bourne C
- Bradbury A
- Brugger F
- Bruno S
- Bryl A
- Burgunder JM
- Burrows L
- Busquets N
- Busse M
- Calopa M
- Carrillo F
- Casas Hernanz L
- Chu E
- Ciesielska A
- Clapton J
- Clayton C
- Codella V
- Coelho M
- Cormio C
- Craufurd D
- Craufurd David
- Cubo E
- De Gregorio F
- De Michele G
- De Nicola N
- De Sousa P
- de Souza J
- de Tommaso M
- DE TOMMASO Marina
- de Yebenes Justo Garcia
- de Yébenes JG
- Dekker M
- Di Donato S
- Di Maria E
- Difruscolo O
- Dipple H
- Doherty K
- Dose M
- Dose M
- Dose Matthias
- Dougherty A
- Dumas E
- Dunnett S
- Ecker D
- Ecker D
- Edwards M
- Ellison Rose L
- Epplen Null
- Eschenbach C
- Fannemel M
- Fasano A
- Fatàas M
- Ferreira J
- Fillingham K
- Fisher K
- Fletcher A
- Fortuna Alcaraz L
- Foustanos I
- Frontali M
- Fuensanta Noguera Perea M
- Fullam R
- Gago M
- García R
- García Ribas G
- García Ruíz P
- Garrett C
- Gellera C
- Golding C
- Gorospe A
- Goyder Goodman A
- Grant J
- Gross D
- Guerra M
- Guidubaldi A
- Gørvell P
- Hallam C
- Hammer K
- Hammer K
- Handley O
- Handley O
- Hasholt L
- Heiberg A
- Heinicke W
- Heinonen N
- Held C
- Hepperger C
- Herranhof B
- Hiivola H
- Hill S
- Hjermind L
- Hotter A
- Howard L
- Hughes T
- Hunt S
- Huson S
- Hödl A
- Ialongo T
- Jachinska K
- Jacopini G
- Jakobsen O
- Jamrozik Z
- Janik P
- Jasinska Myga B
- José Lama Suarez M
- José Saiz Artiga M
- José Torres Rodríguez M
- Jurgens C
- Kalbarczyk A
- Kapfhammer HP
- Kavalier F
- Kershaw A
- Klempíř J
- Klimberg A
- Koppitz M
- Kosinski C
- Krawczyk M
- Kremer B
- Kucharik M
- Kwiecinski H
- Lahiri N
- Lambeck J
- Lambord N
- Landwehrmeyer B
- Landwehrmeyer G. Bernhard
- Lange H
- Lange H
- Lashwood A
- Laurà M
- Laver F
- Leenders KL
- Legarda I
- Leythaeuser G
- Leythaeuser G
- Lezius F
- Longinus B
- Loria G
- Loutfi G
- Luigi D
- Luis López Moreno J
- López Catena J
- López Sendón Moreno J
- Löhle M
- Maglione V
- Magnet M
- Mahlknecht P
- Mandich P
- Marchese R
- Marcinkowski J
- Mariotti C
- Mariscal N
- Marit de Weert A
- Marquard R
- Marquard R
- Martikainen K
- Martino T
- Martirio Antequera Torres M
- Martínez Descals A
- Martínez Descals A
- Mason S
- McGill M
- Mechi C
- Mestre T
- Mestre T
- Middleton J
- Mir P
- Monza D
- Monza D
- Morales B
- Murch A
- Münchau A
- Naji J
- Naji J
- Nanetti L
- Navas Arques P
- Nemeth A
- Nielsen J
- Nocker M
- Novak M
- Nørremølle A
- Opala G
- Orobello S
- Orth M
- Orth M
- Otti D
- Padieu H
- Paganini M
- Painold A
- Partington Jones L
- Patel A
- Paterson N
- Patino D
- Patterson M
- Patton M
- Pearson P
- Peinemann A
- Piacentini S
- Piano C
- Pin Quiroga P
- Porteous M
- Price K
- Pro Koivisto S
- Probst D
- Pålhagen S
- Quarrell O.
- Raab T
- Raab T
- Rakowicz M
- Rankin J
- Raymond L
- Reilmann R
- Reisinge K
- Retterstøl L
- Rialland A
- Ribaï P
- Richter P
- Rickards H
- Rinaldi C
- Robertson D
- Rojo Sebastian A
- Romano S
- Romero I
- Romoli M
- Roos R
- Roos Raymund A. C.
- Rosa M
- Rosser A
- Roth J
- Ruddy D
- Rudzińska M
- Russo C
- Ryglewicz D
- Saft Carsten
- Salvatore E
- Sasinková P
- Sass C
- Schiefer J
- Schlangen C
- Schrenk C
- Schrenk C
- Schuierer M
- Schuierer M
- Schwarz C
- Schüpbach M
- Sciruicchio V
- Sempołowicz J
- Seppi K
- Serpino C
- Silva M
- Sitek E
- Siuda G
- Slawek J
- Smith P
- Snowden J
- Soleti F
- Soliveri P
- Sollom A
- Soltan W
- Sorbi S
- Spadaro M
- Squitieri F
- Stattin EL
- Stokholm J
- Stopford C
- Storch A
- Stubbe L
- Städtler M
- Suarez San Martin E
- Szczudlik A
- Sánchez J
- Sánchez V
- Sørensen S
- Tabrizi S
- Tabrizi Sarah J
- Taylor R
- Thompson J
- Thomson A
- Tidswell K
- Tomasello C
- Tome Carruesco G
- Trautmann S
- Trigo Cubillo P
- Trigo Cubillo P
- Tucci T
- Tuuha K
- Valadas A
- van den Bogaard SA
- van Hout M
- van Oostrom JC
- van Vugt J
- van Walsem M
- van Walsem M
- Verellen Dumoulin C
- Verstappen CC
- Verstraelen N
- Villanueva C
- Vivancos Moreau L
- Vives B
- Warner T
- Weber Zaugg S
- Weindl A
- Wenning G
- Werner C
- Westman L
- Westmoreland L
- Whaite A
- Wieczorek Stefan
- Wiedemann A
- Wiedemann A
- Wikström B
- Wild E
- Witjes Ané MN
- Witjes Ané MN
- Witkowski G
- Wolz A
- Wolz M
- Wright J
- Wójcik M
- Zaremba J
- Zdzienicka E
- Zeman A
- Zielonka D
- Zielonka D
- Zinzi P
- Zittel S
- Zucker B
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2011
- Field of study
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the “REGISTRY” cohort from the European Huntington Disease Network (EHDN). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD
Contributors
- Author
- Abe Takato
- Adams Harold P.
- Adeoye Opeolu
- Agarwal Sachin
- Aguilar Maria I.
- Al-Khoury Lama
- Arboix Adrià
- Auer Roland N.
- Awad Issam A.
- Baird Alison E.
- Baltan Selva
- Barnett Henry J.M.
- Batjer H. Hunt
- Benavente Oscar R.
- Bendok Bernard R.
- Bershad Eric M.
- Binder Jeffrey R.
- Boulos Alan S.
- Bousser Marie-Germaine
- Bova Frank J.
- Brainin Michael
- Brisman Jonathan L.
- Brown Wendy
- Brugge Karel ter
- Brust John C.M.
- Canhão Patrícia
- Caplan Louis R.
- Castellanos Mar
- Chabriat Hugues
- Chamorro Angel
- Choi Jae H.
- Chopp Michael
- Connolly E. Sander
- Coull Bruce M.
- Cucchiara Brett L.
- Dalkara Turgay
- Dani Krishna A.
- Dannenbaum Mark J.
- Dashti Shervin R.
- Davis Patricia H.
- Dawson Ted M.
- Dawson Valina L.
- Day Arthur L.
- De Leo Michael J.
- del Zoppo Gregory J.
- Di Tullio Marco R.
- Diedler Jennifer
- Diener Hans-Christoph
- Dobkin Bruce H.
- Drake Kendra
- Du Rose
- Ducros Anne
- Dzialowski Imanuel
- Eddleman Christopher S.
- Elhammady Mohamed Samy
- Elkind Mitchell S.V.
- Elliott J. Paul
- Ferro José M.
- Findlay J. Max
- Friedman William A.
- Furie Karen L.
- Furlan Anthony J.
- Geibprasert Sasikhan
- Gobin Y. Pierre
- Goldberg Mark P.
- Goldstein Larry B.
- Gonzales Nicole R.
- Gounis Matthew J.
- Greenberg Steven M.
- Greer David M.
- Grotta James C.
- Hacke Werner
- Hallenbeck John
- Hamann Gerhard F.
- Hartmann Andreas
- Hennerici Michael
- Heros Roberto C.
- Higashida Randall
- Homma Shunichi
- Hongo Kazuhiro
- Hopkins L. Nelson
- Horiuchi Tetsuyoshi
- Howard George
- Howard Virginia J.
- Huddle Daniel
- Iadecola Costantino
- Joutel Anne
- Jüttler Eric
- Kakarla Udaya K.
- Kalafut Mary A.
- Kannel William B.
- Kase Carlos S.
- Kasner Scott E.
- Kaste Markku
- Khaw Alexander
- Kidwell Chelsea S.
- Kim Helen
- Kim Louis J.
- Kim Stanley H.
- Klijn Catharina J.M.
- Kobayashi Shigeaki
- Komotar Ricardo J.
- Krings Timo
- Kunz Alexander
- Kurth Tobias
- Lamy Catherine
- Lazar Ronald M.
- Levy Elad I.
- Liebeskind David S.
- Lyden Patrick D.
- Markham Joanne
- Marshall Randolph S.
- Martí-Vilalta J.L.
- Mas Jean-Louis
- Mast Henning
- Masuda Junichi
- Mathers Colin D.
- Mayberg Marc R.
- Meairs Stephen
- Mendelow Alexander David
- Meschia James F.
- Miller Alyson A.
- Miyawaki Takahiro
- Mocco J
- Mohr J.P.
- Morcos Jacques J.
- Morgenstern Lewis B.
- Moskowitz Michael A.
- Nahed Brian V.
- Newell David W.
- Ofengeim Dimitry
- Ogata Jun
- Ogilvy Christopher S.
- Palesch Yuko Y.
- Pancioli Arthur
- Park Min S.
- Pawlikowska Ludmila
- Pile-Spellman John
- Powers William J.
- Puetz Volker
- Ransom Bruce R.
- Roine Risto O.
- Ruigrok Ynte M.
- Rundek Tatjana
- Sacco Ralph L.
- Sattenberg Ronald J.
- Saver Jeffrey L.
- Savitz Sean I.
- Seshadri Sudha
- Sharma Jitendra
- Silverboard Gerald
- Singhal Aneesh B.
- Sobey Christopher G.
- Spetzler Robert F.
- Stapf Christian
- Starke Robert M.
- Stiefel Michael F.
- Strong Kathleen
- Suarez José I.
- Sykora Marek
- Tafreshi Gilda
- Tilley Barbara C.
- Toni Danilo
- Tournier-Lasserve Elisabeth
- Vilela Marcelo D.
- von Kummer Rüdiger
- Wakhloo Ajay K.
- Warach Steven
- Weksler Babette B.
- Willey Joshua Z.
- Wintermark Max
- Wolf Philip A.
- Woo Daniel
- Yamaguchi Takenori
- Yasaka Masahiro
- Young William L.
- Zahuranec Darin B.
- Zazulia Allyson R.
- Zhang Zheng Gang
- Zukin R. Suzanne
- Zweifler Richard M.
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
Optimization of adsorptive removal of α-toluic acid by CaO2 nanoparticles using response surface methodology
- Author
- 't Hart Ellen P.
- Aaserud Olaf
- Abbruzzese Giovanni
- Aguilar Barbera Miquel
- Albanese Alberto
- Allain Philippe
- Alonso-Frech Fernando
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Antczak Jakub
- Antequera Torres María Martirio
- Arran Natalie
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-Lévi A. C.
- Badenes Guia Dolors
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barker Roger A.
- Barnes Kathy
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Bas Jordi
- Bascuñana Garde Mónica
- Bascuñana Garde Mónica
- Bastida Antonio Martín
- Bate Louise
- Bechtel Natalie
- Beckmann Heike
- Beister Antonie
- Bellonet Marcellin
- Bentivoglio A. R.
- Bentivoglio Anna Rita
- Bertini Elisabetta
- Bisson Jonathan
- Biunno I.
- Björn Yvonne
- Bjørgo Kathrine
- Bjørnevoll Inga
- Blinkenberg Ellen Økland
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J. J. W.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buongiorno Maria Teresa
- Buratti Lisa
- Burg Sabrina
- Burguera Juan Andrés
- Burgunder J. M.
- Burgunder Jean-Marc
- Burgunder Yvonne
- Burn John
- Burns Peter
- Burrows Liz
- Busquets Núria
- Busse Monica
- Bürk Kathrin
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Campos Garcia Anabel
- Cannella Milena
- Capellari Sabrina
- Carette Anne-Sophie
- Carrillo Fátima
- Casas Hernanz Laura
- Catalli Claudio
- Causley Aaron
- Cavaco Sara
- Chabot Christelle
- Chacón Peña José
- Cheriet Samia
- Chu Carol
- Chu Carol
- Chu Elvina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Codella Valentina
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia Guedes Leonor
- Correia Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Craufurd David
- Crooks Jenny
- Cubo Esther
- Curtis Adrienne
- Cáceres María Teresa
- Dalmau Elorza Marina
- Damásio Joana
- de Bruycker Christelle
- de Gregorio Francesca
- de Michele Giuseppe
- de Nicola Nunzia
- de Raedt Sylvie
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dekker M.
- Delliaux Marie
- Delphini Marie
- Delval Arnaud
- di Bella Daniela
- di Donato Stefano
- di Giacopo Raffaella
- di Maio Luigi
- di Maria Emilio
- di Pietro Anna
- Diercks Gabriele
- Difruscolo Olimpia
- Dinca Avarvarei Luminita
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dujardin Kathy
- Dumas Eve M.
- Dunnett S. B.
- Dunnett Stephen B.
- Duru Cécile
- Durán Herrera Carmen
- Durán-Sindreu Terol Santiago
- Démonet Jean-Francois
- Díez-Aja López Cristóbal
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Ellison-Rose Lynda
- Eschenbach Carolin
- Esmaeilzadeh Mona
- European Huntington's Disease Network
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madelein
- Fasano Alfonso
- Fatás Ventura Marta
- Fenollar María
- Fernández Recio Maria
- Ferrandes Giovanna
- Ferreira J. J.
- Ferreira Joaquim J.
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Floriach Robert Misericordia
- Foster Jillian
- Foustanos Isabella
- Fredlund Gunnel
- Frich Jan
- Friedrich Andrea
- Frontali Marina
- Fullam Ruth
- Gago Miguel
- Galitzky Monique
- Gallassi Roberto
- Ganos Christos
- Garcia Moreno José Manuel
- García de Yébenes Justo
- García Ribas Guillermo
- García Ruíz Pedro J.
- García-Ramos García Rocío
- Garrett Carolina
- Garzón Ruíz Belén
- Gaston Itziar
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Ghelli Elena
- Gill Paul
- Ginestroni Andrea
- Giuliano J.
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- González Casado Ana
- González González Sonia
- Goodman Anna
- Gorospe Aranzazú
- Gorzolla Heike
- Grant Janet
- Grosjean Hélène
- Gross Diana
- Guerra Maria Rosália
- Guidubaldi Arianna
- Guérid Marie-Anne
- Gøller Marie-Louise
- Gørvell Per
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Hammer Kathrin
- Handley Olivia J.
- Handley Olivia J.
- Handley Olivia J.
- Handley Olivia J.
- Harding Alison
- Haro Martínez Isabel
- Harrison David
- Harrower Timothy
- Hasholt Lis
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Henley Susie
- Hepperger Caroline
- Herranhof Brigitte
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Hotter Anna
- Howard Liz
- Howcroft Debbie
- Hughes Max
- Hughes Teresa
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Höglund Arja
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Ignatius Jaakko
- Illmann T.
- Illmann T.
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jakobsen Oda
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Januário Cristina
- Jasinska-Myga Barbara
- Johansson Anders
- Johns Nicola
- Jurgens Caroline K.
- Júlio Filipa
- Kaelin Alain
- Kalbarczyk Anna
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kershaw Ann
- Kieni Janina
- Klempí Jirí
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kraus Peter H.
- Krawczyk Malgorzata
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kucharík Martin
- Kwiecinski Hubert
- Kärppä Mikko
- Ladurner Gunther
- Lafoucrière Danielle
- Lahiri Nayana
- Lama Suarez María José
- Lambeck Johann
- Lambord Nicol
- Landwehrmeyer Bernhard Georg
- Landwehrmeyer G. Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Lange Herwig
- Lashwood Alison
- Laurà Mathilde
- Laver Fiona
- Leenders K. L.
- Legarda Inés
- Levey J.
- Lewerenz Jan
- Leythaeuser Gabriele
- Lezius Franziska
- Lilek Sabine
- Lilek Stefan
- Longinus Bernhard
- Lorenza Fortuna
- Loria Giovanna
- Loutfi Ghada
- López Catena Judit
- López del Val Javier
- López-Sendón Moreno José Luis
- Löhle Matthias
- Magalhães Marina
- Magnet Markus
- Mahlknecht Philipp
- Mair Katharina
- Majeed Tahir
- Mandich Paola
- Marchese Roberta
- Marcinkowski Jerzy T.
- Mareca Viladrich Celia
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martino Tiziana
- Martínez Martinez Laura
- Martínez-Descals Asunción
- Martínez-Descals Asunción
- Mason Sarah
- Massaro Francesca
- Matheson Kirsty
- McGill Marie
- McKenzie Sue
- McLean Tim
- Mechi Claudia
- Mendes Tiago
- Menéndez Guisasola Luis
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Milkereit Eva
- Miller Joanne
- Miller Julie
- Minster Sara
- Mir Pablo
- Modoni Anna
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreno Garcia Patrocinio
- Morez V.
- Mundler Laura
- Murch Ann
- Muth Sabine
- Muñoz Esteban
- Möller Jens Carsten
- Müller Nicole
- Münchau Alexander
- Nanetti Lorenzo
- Navas Arques Penelope
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen J. E.
- Nielsen Jørgen
- Niess Anke
- Nocker Michael
- Noguera Perea María Fuensanta
- Novak Marianne
- Nowak Marielle
- Nørremølle Anne
- O'Donovan Kirsty
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Orth Michael
- Orth Michael
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Overland Torborg
- Padieu Helene
- Paganini Marco
- Painold Annamaria
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Patino Dawn
- Patton Michael
- Paucar Martin
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peppa Nadia
- Peppa Nadia
- Peter Mireille
- Petersen Asa
- Peterson Maria
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pin Quiroga Purificacion
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Pons i Càrdenas Regina
- Porteous Mary
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Pro Koivisto Susana
- Pro Koivisto Susana
- Probst Daniela
- Prundean Adriana
- Prüss Harald
- Päivärinta M.
- Pålhagen Sven E.
- Quaranta Davide
- Quarrell Oliver
- Quiléz Ferrer Pilar
- Raab Tina
- Rabasa Perez Maria
- Rae Daniela
- Rakowicz Maria
- Raman Ashok
- Ramos-Arroyo Maria A.
- Rankin Julia
- Raymond Lucy
- Read Joy
- Redondo Vergé Luis
- Reilmann Ralf
- Reimer Jan
- Reinante Gema
- Reisinger Karin
- Retterstøl Lars
- Reza-Soltani Tina Walldén
- Rialland Amandine
- Ribaï Pascale
- Ribbat Michael
- Richter Przemyslaw
- Richter Sven
- Rickards Hugh
- Rinaldi Carlo
- Rissling Ida
- Ritchie Stuart
- Rizzo Giovanni
- Robertson Dene
- Roca Elvira
- Rohm Stefanie
- Roig Llesoy Joan
- Rojo Sebastián Ana
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos R. A.
- Roos Raymund A.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ruíz Idiago Jesús Miguel
- Ruíz Vergara Mar
- Ryglewicz Danuta
- Røren Ninni
- Saft Carsten
- Saiz Artiga María José
- Salmen Stephan
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sanchez Jesús
- Sando Sigrid Botne
- Sandström Britta
- Santala Maire
- Sasinková Pavla
- Sass Christian
- Say Miranda
- Scaglione Cesa
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse* Gagou, Clarisse Scherer-
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenke C.
- Schwenke Carsten
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián A. R.
- Selimbegovic-Turkovic Amina
- Sempolowicz Justyna
- Senkárová Zuzana
- Seppi Klaus
- Serpino Claudia
- Sieradzan Kasia
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila
- Sinadinosa Daniela
- Sipponen Marjatta
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Solis Pilar
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltani Riza
- Soltysiak Beverley
- Sorbi Sandro
- Soriano García Socorro
- Spadaro Maria
- Spruth Eike Jakob
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steiner Tanja
- Steinmetz Gisèle
- Stokholm Jette
- Stokke Bodil
- Stopford Cheryl
- Storch Alexander
- Strassburger Katrin
- Stubbe Lars
- Städtler Michael
- Suaréz San Martín Esther
- Sulek Anna
- Summers Fiona
- Svenningsson Per
- Szczudlik Andrzej
- Sánchez Sánchez Violeta
- Sánchez Vicenta
- Sørensen Sven Asger
- Süßmuth Sigurd
- Tabrizi S. J.
- Tabrizi Sarah
- Tabrizi Sarah
- Taylor Rachel
- Tedroff Joakim
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Thomson Jenny
- Tidswell Katherine
- Timóteo Angela
- Tomasello Chiara
- Tome Carruesco Gemma
- Torres Rodríguez María José
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhad Iris
- Trigo Cubillo Patricia
- Trigo Cubillo Patricia
- Tritsch Christine
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Uhrova T.
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Vale José
- van den Bogaard Simon J. A.
- van Hout Monique S.
- van Kammen D.
- van Oostrom J. C. H.
- van Reijen Dimphna
- van Vugt Jeroen P.
- van Walsem Marleen R.
- van Walsem Marlene R.
- Vandenberghe Wim
- Vandenberghe Wim
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Verstraelen Nichola
- Villa Riballo Antonio
- Villanueva Clara
- Vivancos Moreau Laura
- Vives Barbara
- Vázquez Rivera Susana
- Wagner Caroline
- Wahlström J.
- Wahlström Jan
- Walleczek Anna Maria
- Wallner M.
- Wannepain Sandrine
- Warner Thomas
- Weber Zaugg Sabine
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius Johannes
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hakan
- Wiedemann Alexandra
- Wiklund Leif
- Wikström Birgitta
- Wild E. J.
- Wild Edward
- Wild Sue
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wolf Elisabeth
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- Zangerl Anja
- Zaremba J.
- Zaremba Jacek
- Zdzienicka Elzbieta
- Zeman Adam
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Åman Jaana
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
The present work addresses the optimization of process parameters for adsorptive removal of α-toluic acid by calcium peroxide (CaO2) nanoparticles using response surface methodology (RSM). CaO2 nanoparticles were synthesized by chemical precipitation method and confirmed by Transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) analysis which shows the CaO2 nanoparticles size range of 5–15 nm. A series of batch adsorption experiments were performed using CaO2 nanoparticles to remove α-toluic acid from the aqueous solution. Further, an experimental based central composite design (CCD) was developed to study the interactive effect of CaO2 adsorbent dosage, initial concentration of α-toluic acid, and contact time on α-toluic acid removal efficiency (response) and optimization of the process. Analysis of variance (ANOVA) was performed to determine the significance of the individual and the interactive effects of variables on the response. The model predicted response showed a good agreement with the experimental response, and the coefficient of determination, (R2) was 0.92. Among the variables, the interactive effect of adsorbent dosage and the initial α-toluic acid concentration was found to have more influence on the response than the contact time. Numerical optimization of process by RSM showed the optimal adsorbent dosage, initial concentration of α-toluic acid, and contact time as 0.03 g, 7.06 g/L, and 34 min respectively. The predicted removal efficiency was 99.50%. The experiments performed under these conditions showed α-toluic acid removal efficiency up to 98.05%, which confirmed the adequacy of the model prediction
Suicidal ideation in a European Huntington's disease population.
- Author
- 't Hart Ellen P
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- Albanese Alberto
- Alberti Silvia
- Alegre Javier
- Allain Philippe
- Alonso-Frech Fernando
- Amico Enrico
- Ammendola Sarah
- Andrade Carlos
- Andrews Thomasin
- Andrich Jürgen
- Antczak Jakub
- Armstrong Richard
- Arques Penelope Navas
- Arran Natalie
- Artiga María José Saiz
- Avarvarei Luminita Dinca
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-Lévi A-C
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A
- Barrero Francisco
- Barth Katrin
- Bas Jordi
- Bascuñana Mónica
- Bastida Antonio Martín
- Bek Judith
- Bellonet Marcellin
- Bentivoglio A R
- Bentivoglio Anna Rita
- Bernhard Landwehrmeyer G
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Bisson Jonathan
- Biunno I
- Bjørgo Kathrine
- Blaszcyk Magdalena
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J J W
- Bonelli R M
- Bonelli Raphael M
- Boogaerts Andrea
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Casterá
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder J-M
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Bürk Kathrin
- Cabaret Maryline
- Caldentey Juan Garcia
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Capellari Sabina
- Capetian Philipp
- Carette Anne-Sophie
- Carrillo Fátima
- Carruesco Gemma Tome
- Casado Ana González
- Catalli Claudio
- Catena Judit López
- Cavaco Sara
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia-Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Courtin Françoise
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- Càrdenas Regina Ponsi
- Cáceres María Teresa
- da Silva Wildson Vieira
- Damásio Joana
- Davidson Jill
- De Bruycker Christelle
- De Michele Giuseppe
- de Raedt Sylvie
- Debruxelles Sabrina
- Dec Małgorzata
- Decorte Eric
- Defebvre Luc
- Dekker M
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Descals Asunción Martínez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Pardo Alba
- Di Pietro Anna
- di Poggio Monica Bandettini
- Diercks Gabriele
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas Eve M
- Dunnett S B
- Dunnett Stephen
- Duru Cécile
- Dziadkiewicz Artur
- Démonet Jean-François
- Díez-AjaLópez Cristóbal
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Elorza Marina Dalmau
- Eschenbach Carolin
- Esmaeilzadeh Mona
- Eusebio Alexandre
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel Véronique
- Fenollar María
- Ferrandes Giovanna
- Ferreira J J
- Ferreira Joaquim J
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Fluchère Frédér- ique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frontali Marina
- Fullam Ruth
- Gago Miguel
- Gallantrae Deena
- Gallassi Roberto
- Ganos Christos
- Garcia Anabel Campos
- Garcia Patrocinio Moreno
- García Ruíz Pedro J
- García Rocío García-Ramos
- García Socorro Soriano
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Ghelli Elena
- Gill Paul
- Giltay Erik J
- Ginestroni Andrea
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- González Mónica
- González Sonia González
- Gorospe Aranzazú
- Gorzkowska Agnieszka
- Gorzolla Heike
- Griguoli Annamaria
- Guerra Maria Rosália
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Guzman [Unknown]
- Guérid Marie-Anne
- Göller Marie-Louise
- Gørvell Per
- Haider Salman
- Hamer Stephanie
- Hametner Eva-Maria
- Handley O J
- Handley Olivia
- Harding Alison
- Hare Marianne
- Harrison David
- Hartikainen Päivi
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg A
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Durán
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Horta Saul Martinez
- Hotter Anna
- Howard Liz
- Hubers Anna A M
- Hughes Alis
- Hughes Max
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Höglund Arja
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago Jesús Miguel Ruiz
- ielewska Anna Was
- Ignatius Jaakko
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Januário Cristina
- Jaremek Kamila Bojakowska
- Jasinska-Myga Barbara
- Johansson Anders
- Johns Nicola
- Johnson Liz
- Johnstone Catherine
- Jones Lesley
- Jones Mary
- Jones Una
- Júlio Filipa
- Kaelin Alain
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Khalil Hanan
- Klempíř Jiří
- Klimberg Aneta
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kraus Alison
- Krawczyk Malgorzata
- Kremer H P H
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Kärppä Mikko
- Kłodowska-Duda Gabriela
- Ladurner Gunther
- Lafoucrière Danielle
- Lahiri Nayana
- Laing Hana
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G B
- Lange Herwig
- Lashwood Alison
- Laurà Matilde
- Laver Fiona
- Leenders K L
- Legarda Inés
- Lemaire Marie-Hélène
- Levey J
- Lewerenz Jan
- Lewis Monica
- Leythaeuser Gabriele
- Lezius Franziska
- lhagen Sven E P
- Lilek Sabine
- Lilek Stefan
- Lima Joana
- Llesoy Joan Roig
- llmann T I
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lorentzen Eirin
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- López-Sendón Moreno José Luis
- Maass Antonia
- Magalhães Marina
- Maglione Vittorio
- Magnet Markus
- Majerová Veronika
- Mandich Paola
- Manouvrier Sylvie
- Mantaux Béatrice
- Manuel Jose
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Martirio María
- Martínez Isabel Haro
- Martínez Laura Martinez
- Martínez-Descals Asunción
- Mason Sarah
- Massano João
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- McGill Marie
- McKenzie Sue
- Mechi Claudia
- Meireles Joana
- Mendes Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Milkereit Eva
- Miller Joanne
- Minster Sara
- Mir Pablo
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Garcia
- Morez V
- Morgan Karen
- Mundler Laura
- Murphy Helen
- Musgrave Hannah
- Mustonen Aki
- Möller Jens Carsten
- Mühlau Mark
- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Mütze Lisanne
- Nanetti Lorenzo
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nielsen J E
- Nielsen Mette Gilling
- Niess Anke
- Noguera Perea María Fuensanta
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Orth Michael
- Otti Daniela
- Oughton Emma
- Overland Torborg
- Owen Michael
- Padieu Helene
- Paganini Marco
- Painold Annamaria
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Pearson Pauline
- Peinemann Alexander
- Peppa Nadia
- Perez Maria Rabasa
- Peter Mireille
- Peterson Maria
- Petersén Asa
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Porteous Mary
- Pradella Silvia
- Price Kathleen
- Priller Josef
- Probst Daniela
- ProKoivisto S
- Prundean Adriana
- Prüß Harald
- Päivärinta M
- Pålhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Quiroga Purificacion Pin
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramos-Arroyo Maria A
- Recio Maria Fernández
- Reetz Kathrin
- Reilmann Ralf
- Reimer Jan
- Reinante Gema
- Reisinger Karin
- Retterstøl Lars
- Reza- Soltani Tina Walldén
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo García
- Richter Przemyslaw
- Rickards Hugh
- Rinaldi Carlo
- Rissling Ida
- Ritchie Stuart
- Rivera Susana Vázquez
- Riza-Soltani Tina Waldèn
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Roedig Verena
- Rogers Dawn
- Rojo Sebastián A
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos R A C
- Roos Raymund A C
- Rose Linda Ellison
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Rossi Fabiana
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzińska Monika
- Russo Cinzia Valeria
- Ruíz Belén Garzón
- Ryglewicz Danuta
- Røren Niini
- Sablonnière Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- San Martín Esther Suaréz
- Sando Botne
- Sandström Britta
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Scherer- Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenk Daniela
- Schöggl Helmut
- Schüpbach Michael
- Sciruicchio Vittorio
- Sebastián Ana Rojo
- Seliverstov Yury
- Sempołowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila
- Sinadinosa Daniela
- Singh Baldev
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Souza Jennyde
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gisèle
- Stenwak Agata
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Städtler Michael
- Stępniak Iwona
- Suarez María José Lama
- Summers Fiona
- Sundblom Jimmy
- Sułek Anna
- Svennigsson Per
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygieł Elżbieta
- Szinwelski Michal
- Sánchez Jesús
- Sánchez Vicenta
- Sánchez Violeta Sánchez
- Süßmuth Sigurd
- Tabrizi S J
- Tabrizi Sarah
- Tacik Pawel
- Taylor Catherine
- Taylor Rachel
- Tedr- off Joakim
- Terol Santiago Durán-Sindreu
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timóteo Ângela
- Tomasello Chiara
- Tommaso Marinade
- Torres Rodríguez María José
- Torres Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Tyvoll Hilde
- Uhrova T
- Ullah Jasmin
- Ure Alexandra
- Val Javier Lópezdel
- Valadas Anabela
- Valentine Ruth
- Valle Natalie
- van den Bogaard Simon J A
- van der Mast Rose C
- van Duijn Erik
- van Hout Monique S E
- van Reijen Dimphna
- van Vugt Jeroen P P
- Vandenberghe W
- Vandenberghe Wim
- Ventura Marta Fatás
- Verellen- Dumoulin C
- Vergara Mar Ruíz
- Vergé Luis Redondo
- Verny Christophe
- Verstraelen Nichola
- Viladrich Celia Mareca
- Villanueva Clara
- Vives Barbara
- Vuillaume Isabelle
- Wagner Caroline
- Wahlström J
- Wahlström Jan
- Walleczek Anna Maria
- Walsem Marleen Rvan
- Wannepain Sandrine
- Warner Thomas
- Weber Sabine
- Weert A Maritde
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius J
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hkan
- Wiklund Leif
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Winkelmann Juliane
- Winkler Jürgen
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
- Wolz Martin
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yarduiman Pam
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- Yébenes Justo Garcíade
- Zaremba J
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie- Agathe
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Åman Jaana
- Økland Ellen
- Šašinková Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2013
- Field of study
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
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- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
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- Etonyeaku Amarachukwu
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- Fairfield Cameron J
- Falato Armando
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- Figueiredo Ana Gabriela
- Finlay Ben
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- Forero-Torres Alexander
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- Wondoh Paul M.
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- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
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- Ashoushan Hana
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- Asif Ashar
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- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
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- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
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- Suresh Rishi
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- Suárez Sánchez Aida
- Svagzdys Saulius
- Syed Aamir Ali
- Syed Bilal
- Syllaios Athanasios
- Sylvester Kimutai
- Syminas Vilius
- Szabadhegyi Gabor
- Szabó Réka
- Szyszka Bartosz
- Sánchez Suárez Ramses
- Sánchez-García Jorge
- Sánchez-Guillén Luis
- Søreide Kjetil
- Tababa Osama
- Tabiri Stephen
- Tagliabue Fulvio
- Taglietti Lucio
- Taha Ehab
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- Tahboub Haya
- Tahir Abd al-Rahman
- Taiwo Agboola
- Taiwo Ogechukwu
- Takala Sini
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- Talavera Cherry
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- Tamini Nicolò
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- Tampo Mayou Martin
- Tan Ern Hwei Jeremy
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- Theodorou Dimitrios
- Theodosopoulos Theodosios
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- Trujillo Díaz Jeancarlos
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- Winoto Hadi
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- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
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- Wong Jane J
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- You Lucia
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- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit