Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study

We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors.This study was sponsored by Takeda

The integration of knowledge about the Cantabrian Cordillera: towards an inter-regional observatory of global change

Ejemplar dedicado a: Paleoecología, analizando la cuarta dimensión de la biodiversidad[ES] La Cordillera Cantábrica (CC) presenta una serie de singularidades que le convierten en un excelente enclave para el seguimiento de los efectos del cambio global. Este estudio analiza la necesidad de generar un observatorio inter-autonómico del cambio global, que permitiría integrar el conocimiento actual sobre estas montañas y determinar las prioridades en la generación de nuevo conocimiento. Para cumplir este objetivo, se presentan dos aproximaciones complementarias. La primera consiste en la revisión de la literatura científica publicada sobre la CC y su comparación con otros enclaves geográficos de la Península Ibérica. La segunda consiste en la síntesis de información de un seminario titulado “La CC como Centinela de los Efectos del Cambio Global”, celebrado en Santander en agosto de 2015. El análisis bibliográfico muestra que el número de publicaciones científicas sobre la CC es similar al de otros enclaves geográficos de la Península Ibérica, pero con menor riqueza de disciplinas. La producción científica está dominada por los centros de investigación más próximos y tiene una alta participación internacional. Las conclusiones del seminario evidencian que este sistema es un candidato ideal para el seguimiento de los efectos del cambio global sobre multitud de elementos biofísicos. Se considera que la generación de un seminario permanente, junto con la consolidación de las redes de seguimiento actuales, la coordinación de nuevos trabajos, y la mejora de la comunicación entre administraciones y comunidad científico-técnica son elementos esenciales en la futura generación de un observatorio del cambio global en la CC[EN] The Cordillera Cantábrica (CC) presents a series of singularities that make this area an excellent place for monitoring the effects of global change. This study analyses the need to generate an interregional observatory of global change, which would integrate current knowledge about these mountains and help setting priorities in the generation of new knowledge. To achieve this goal, two complementary approaches are presented. The first is the review of the scientific literature published about the CC and its comparison with other mountain systems in the Iberian Peninsula. The second is the synthesis of information from a seminar entitled "The CC as a Sentinel of the Effects of Global Change" held in Santander in August 2015. The literature shows that the number of scientific publications about the CC is similar to other mountain systems in the Iberian Peninsula, but with a lower diversity of disciplines. Scientific production is dominated by the nearest research centres and has a large international participation. The conclusions of the seminar show that this system is an ideal candidate for monitoring the effects of global change on a multitude of biophysical elements. We consider that the generation of a permanent seminar, along with the consolidation of the actual monitoring networks, and the coordination of new studies and the improvement of communication between administrations and the scientific and technical communities are essential elements for the future generation of an observatory of global change in the CCS