Evaluation of the Nanodomain Structure in In-Zn-O Transparent Conductors

The optimization of novel transparent conductive oxides (TCOs) implies a better understanding of the role that the dopant plays on the optoelectronic properties of these materials. In this work, we perform a systematic study of the homologous series ZnkIn2Ok+3 (IZO) by characterizing the specific location of indium in the structure that leads to a nanodomain framework to release structural strain. Through a systematic study of different terms of the series, we have been able to observe the influence of the k value in the nano-structural features of this homologous series. The stabilization and visualization of the structural modulation as a function of k is discussed, even in the lowest term of the series (k = 3). The strain fields and atomic displacements in the wurtzite structure as a consequence of the introduction of In3+ are evaluated.Depto. de Química InorgánicaFac. de Ciencias QuímicasTRUEMinisterio de Ciencia, Innovación y Tecnología /Ministerio de EconomíaComunidad de Madridpu

The Role of Autophagy in Eye Diseases

This research was funded by the Ophthalmological Network OFTARED (Enfermedades oculares: Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares) (RD16/0008/0005 and RD16/0008/0026) of the Institute of Health of Carlos III of the Spanish Ministry of Economy and by the European programme FEDER; and Network RETiBRAIN (La retina un modelo para investigar Neuroprotección en patologías del Sistema Nervioso Central) (RED2018-102499-T) of Spanish Ministry of Science and Innovation. And J.A.F.-A. is currently funded by a Predoctoral Fellowship (FPU17/01023) from the Spanish Ministry of Science, Innovation, and Universities; and I.L.-C. is currently funded by a Predoctoral Fellowship (CT42/18-CT43/18) from the Complutense University of Madrid.Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.Depto. de Inmunología, Oftalmología y ORLFac. de MedicinaTRUEUnión EuropeaMinisterio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIUniversidad Complutense de Madridpu

Water-Gas Shift Reaction on K/Cu(111) and Cu/K/TiO2(110) Surfaces: Alkali Promotion of Water Dissociation and Production of H2

The addition of potassium atoms to Cu(111) and Cu/TiO2(110) surfaces substantially enhances the rate for water dissociation and the production of hydrogen through the water-gas shift reaction (WGS, CO + H2O → H2 + CO2). In the range of temperatures investigated, 550-625 K, Cu/K/TiO2(110) exhibits a WGS activity substantially higher than those of K/Cu(111), Cu(111), and Cu/ZnO(0001̄) systems used to model an industrial Cu/ZnO catalyst. The apparent activation energy for the WGS drops from 18 Kcal/mol on Cu(111) to 12 Kcal/mol on K/Cu(111) and 6 Kcal/mol on Cu/K/TiO2(110). The results of density functional calculations show that K adatoms favor the thermochemistry for water dissociation on Cu(111) and Cu/TiO2(110) with the cleavage of an O-H bond occurring at room temperature. Furthermore, at the Cu/K/TiO2 interface, there is a synergy, and this system has a unique ability to dissociate the water molecule and catalyze hydrogen production through the WGS process. Therefore, when optimizing a regular catalyst, it is essential to consider mainly the effects of an alkali promoter on the metal-oxide interface.US Department of Energy DE-SC0012704Ministerio de Economía y Competitividad CTQ2015-64669-

The definition of the European Almond Core collection

The European project 068 AGRI GEN RES 870/2004 has as an aim the definition of the European almond core collection. The methodology for creation of any core collection has to define how best to select entries using complex and incomplete accession data, as well as how and when to revise these decisions over time. The acquisition of data has been based on specific varietal descriptors, including morphological, physiological, phytopathological, genetic and chemical traits, following the descriptors defined by IBPGR/Bioversity, UPOV and the ECP/GR Prunus Working Group. Newly defined traits, not included in these descriptors, have also been considered because they are very important in defining the range of variability of the species. These traits include chilling and heat requirements for blooming, the molecular markers for genotype identification and the different chemical components of the kernel, as possible parameters for defining almond quality. As a result, a strategy to define the almond core collection was identified by highlighting the main steps to achieve in the near future.Peer ReviewedPrunus amygdalus Batschcore collectiongenetic resourcesgermplasmPublishe

VVVX-Gaia Discovery of a Low Luminosity Globular Cluster in the Milky Way Disk

© 2020 ESOMilky Way globular clusters (MW GCs) are difficult to identify at low Galactic latitudes because of high differential extinction and heavy star crowding. The new deep near-IR images and photometry from the VISTA Variables in the Via L\'actea Extended Survey (VVVX) allow us to chart previously unexplored regions. Our long term aim is to complete the census of MW GCs. The immediate goals are to estimate the astrophysical parameters, measuring their reddenings, extinctions, distances, total luminosities, proper motions, sizes, metallicities and ages. We use the near-IR VVVX survey database, in combination with Gaia DR2 optical photometry, and with the Two Micron All Sky Survey (2MASS) photometry. We report the detection of a heretofore unknown Galactic Globular Cluster at RA = 14:09:00.0; DEC=-65:37:12 (J2000). We calculate a reddening of E(J-K_s)=(0.3 +/- 0.03) mag and an extinction of A_Ks=(0.15 +/- 0.01) mag for this new GC. Its distance modulus and corresponding distance were measured as (m-M)=(15.93 +/- 0.03) mag and D=(15.5 +/- 1.0) kpc, respectively. We estimate the metallicity and age by comparison with known GCs and by fitting PARSEC and Dartmouth isochrones, finding $[Fe/H]=(-0.70\pm0.2)$ dex and t=(11.0 +/- 1.0) Gyr. The mean GC PMs from Gaia are mu_alpha^(star)=(-4.68 +/- 0.47) mas yr^(-1) and mu_delta=(-1.34 \pm 0.45) mas yr^(-1). The total luminosity of our cluster is estimated to be M_Ks=(-7.76 +/- 0.5) mag. We have found a new low-luminosity, old and metal-rich globular cluster, situated in the far side of the Galactic disk, at R_G=11.2 kpc from the Galactic centre, and at z=1.0 kpc below the plane. Interestingly, the location, metallicity and age of this globular cluster are coincident with the Monoceros Ring (MRi) structure.Peer reviewe

A deletion at Adamts9-magi1 Locus is associated with psoriatic arthritis risk

Objective: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. Methods: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ2 test. The most significant genomic CNV associations with PsA risk were independently tested in a validation sample of 1133 patients with PsA and 1831 healthy controls. In order to test for the specificity of the variants with PsA aetiology, we also analysed the association to a cohort of 822 patients with purely cutaneous psoriasis (PsC). Results: A total of 165 common CNVs were identified in the genome-wide analysis. We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014). Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032). Using next-generation sequencing, we characterised the 26 kb associated deletion. Finally, analysing the PsC cohort we found a lower frequency of the deletion compared with the PsA cohort (p=0.0088) and a similar frequency to that of healthy controls (p>0.3). Conclusions: The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk

Critical Exponents of the Fully Frustrated 2-D Xy Model

We present a detailed study of the critical properties of the 2-D XY model with maximal frustration in a square lattice. We use extensive Monte Carlo simulations to study the thermodynamics of the spin and chiral degrees of freedom, concentrating on their correlation functions. The gauge invariant spin-spin correlation functions are calculated close to the critical point for lattice sizes up to $240\times 240$; the chiral correlation functions are studied on lattices up to $96\times 96$. We find that the critical exponents of the spin phase transition are $\nu=0.3069$, and $\eta=0.1915$, which are to be compared with the unfrustrated XY model exponents $\nu=1/2$ and $\eta=0.25$. We also find that the critical exponents of the chiral transition are $\nu_{\chi}=0.875$, $2\beta=0.1936$, $2\gamma= 1.82$, and $2\gamma\>\prime=1.025$, which are different from the expected 2-D Ising critical exponents. The spin-phase transition occurs at $T_{U(1)}=0.446$ which is about 7\% above the estimated chiral critical temperature $T_{Z_{2}}= 0.4206$. However, because of the size of the statistical errors, it is difficult to decide with certainty whether the transitions occur at the same or at slightly different temperatures. Finally, the jump in the helicity modulus in the fully frustrated system is found to be about 23\% below the unfrustrated universal value. The most important consequence of these results is that the fully frustrated XY model appears to be in a novel universality class. Recent successful comparisons of some of these results with experimental data are also briefly discussed. (TO APPEAR IN PRB)Comment: 47 pages (PHYZZX

At the beginnings of the funerary Megalithism in Iberia at Campo de Hockey necropolis

[EN] The excavations undertaken at the Campo de Hockey site in 2008 led to the identification of a major Neolithic necropolis in the former Island of San Fernando (Bay of Cadiz). This work presents the results of the latest studies, which indicate that the site stands as one of the oldest megalithic necropolises in the Iberian Peninsula. The main aim of this work is to present with precision the chronology of this necropolis through a Bayesian statistical model that confirms that the necropolis was in use from c. 4300 to 3800 cal BC. The presence of prestige grave goods in the earliest and most monumental graves suggest that the Megalithism phenomenon emerged in relation to maritime routes linked to the distribution of exotic products. We also aim to examine funerary practices in these early megalithic communities, and especially their way of life and the social reproduction system. As such, in addition to the chronological information and the Bayesian statistics, we provide the results of a comprehensive interdisciplinary study, including anthropological, archaeometric and genetic data.We wish to express our gratitude to Antonio Saez Espligares (Historical Museum of San Fernando) and Lourdes Lorenzo (Figlina, s.l.) for their support during the archaeological excavation. This research was conducted in the framework of the following research projects: "Analysis of prehistoric societies from the Middle Palaeolithic to the Late Neolithic at both sides of the Strait of Gibraltar: relations and contacts", funded by the State Research Agency (SRA) and the European Regional Development Fund (ERDF). Ref.: HAR2017-87324-P. (2018-2021). "Analisis interdisciplinar para el conocimiento del poblamiento humano de la Bahia de Cadiz durante la Prehistoria Reciente (VI-II milenios a.n.e.)", funded by 2014-2020 ERDF Operational Programme and the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia. Ref.: FEDER-UCA18-106917 (2020-2023). "Analisis de los isotopos de oxigeno en conchas y de los isotopos estables de oxigeno y carbono en huesos humanos en el poblado neolitico insular de Campo de Hockey (San Fernando, Cadiz)", authorised and funded by CEIMAR. Ref.: CEIJ-015 (2018-2019). Eduardo Molina Piernas acknowledges co-funding from European Social Fund (D1113102E3) and Junta de Andalucia

Deep-sea habitat characterization using acoustic data and underwater imagery in Gazul mud volcano (Gulf of Cádiz, NE Atlantic)

Gazul is the shallowest mud volcano (MV) within the Shallow Field of Fluid Expulsion (SFFE) of the northeastern Gulf of Cádiz (NE Atlantic; 300–1200 m depth). The SFFE represents an important geo- and biodiversity area that was designated as a Site of Community Importance under the European Habitats Directive in 2014. In this study, geological features, habitats and associated biodiversity, as well as anthropogenic impacts, were characterized at Gazul MV from underwater imagery and multibeam bathymetry. Multivariate methods using the Bray-Curtis similarity index identified six main habitats, each of which harbored a characteristic faunal assemblage that included: (1) sandy ripple bottoms typified by the actiniarian Actinauge richardi; (2) sandy, muddy, coarse sand and bioclastic bottoms dominated by the solitary coral Flabellum chunii; (3) coarse sand and bioclastic bottoms, together with soft sediments covered by scattered methane-derived authigenic carbonates (MDACs) (mixed bottoms), characterized by the echinoid Cidaris cidaris; (4) hard bottoms comprising MDACs dominated by a wide variety of sponges and gorgonians; (5) coral-rubble bottoms typified by the presence of colonial scleractinian communities dominated by Madrepora oculata; and (6) mixed bottoms characterized by the presence of a styelid ascidian. Slope and water depth were the main factors explaining assemblages’ distribution, which was also supported by the presence of MDACs such as slabs, crusts and chimneys on the seafloor, as well as by the geomorphologic diversity of Gazul MV. The results highlight Gazul MV as an eco-biologically important area harboring different vulnerable marine ecosystem (VME) elements with indicator taxa such as scleractinians, sponges, gorgonians and black corals. ROV images revealed abandoned or lost fishing gears and marine debris on the seafloor, indicating anthropogenic impacts in Gazul MV and adjacent areas. Indeed trawling fisheries activities have also been detected in Vessel Monitoring System datasets. A fishery restricted area is recommended in Gazul MV due to the occurrence of diverse VMEs and species included in different conservation directives and conventions.Postprin

OBSERVATORIO TERRITORIAL Y AMBIENTAL ALENTEJO, EXTREMADURA, CENTRO (OTALEX C): DE GIS A IDE.

In the scope of the Spain-Portugal INTERREG projects and FEDER funded POCTEP program, OTALEX C (Territorial and Environmental Monitoring Alentejo Extremadura Center) project aims at studying of various territorial, socioeconomic and environmental indicators. It is the fundamental objective of this project, to develop a geo-portal accessible via internet, for anyone, so that the information will be useful in making decisions related to land use and therefore sustainable development of the environment. Under this general framework over the past fifteen years, we have developed different projects that have set the standardization of data between Portugal and Spain, also was designed GIS systems, and developed regional models and indicator systems, culminating in the current Spatial Data Infrastructure SDI-OTALEX C