Más allá de las aulas : cuando el desierto se convierte en un oasis de esperanza

En este artículo se describe el viaje realizado por un grupo de alumnas y un alumno de la Facultad de Ciencias de la Educación de la Universidad de Huelva y Badajoz a los campamentos de refugiados Saharauis en Argelia. Con este relato pretenden poner de manifiesto tanto las necesidades educativas que viven niños y niñas en la escuela, como las costumbres y formas de vida de un pueblo en el exilio.__________________________________In this article it's described a study trip. We are university students of the Education Faculty of Huelva and Badajoz, and we visited fields of Sahara refugees in Argelia. We want to let be known the educative needs that these pupils are suffering and also, their way of lives in their exiled town

AVICENA, an ontology for the design of executable clinical practice guidelines

This is an electronic version of the paper presented at the Ninth International Protégé Conference, held in Stanford on 2006Clinical practice guidelines (CPG) are increasingly more demanded as a necessary tool in the supply of health care. In spite of their continuous evolution and spreading, their usage in the context of the new information technologies is still not enough developed. There is much work to be done in the area of execution of CPG, and, consequently, it is difficult to find repositories of formal and executable CPG. The project AVICENA is a new proposal of an ontology for the modelling of executable guidelines, that (1) creates new ways for the representation of clinical knowledge and (2) allows the management of the dynamics of health-related processes

A Mathcad‐based educational experience to address the design of nonisothermal plug flow reactors

Mathcad is a simple-to-use and intuitive mathematical software that helps students to minimize the mathematical difficulties involved in solving engineering problems. The design of nonisothermal plug flow reactors (PFR) is a fundamental issue within the field of chemical reaction engineering; however, its teaching–learning process is hindered by students' mathematical difficulties in solving ordinary differential equations. In this paper, the software Mathcad was conveniently integrated into an educational experience through the resolution of two real case studies. In the first one, a simple liquid-phase reaction is considered in a PFR working at different operating conditions, whereas the second case evaluates a PFR taking place multiple reactions (parallel reactions) with a heat exchanger attached. The assessment of this experience, which was held into two 5-h Mathcad workshops, revealed that Mathcad made the design of non-isothermal PFR more appealing, facilitated the understanding of the design process, and brought another dimension to the way the students perform complex calculations

ESTUDIO SOBRE INFECCIONES PERIAMIGDALINAS EN NUESTRO MEDIO.

RESUMEN Introducción: La infección periamigdalina es una de las complicaciones más frecuentes de las amigdalitis crónicas. Se produce como consecuencia de un proceso amigdalítico crónico, en el que la infección afecta tanto al estroma amigdalino como a la región de su cápsula, de tal manera que se colecciona pus entre la cápsula amigdalina y el músculo constrictor superior de la faringe. Objetivos: El objetivo principal del presente estudio es conocer datos epidemiológicos, diagnósticos y terapéuticos acerca de esta patología Material y métodos: Estudio descriptivo, de carácter retrospectivo y de corte transversal. Se recogieron todos los casos de infecciones periamigdalinas atendidos por el Servicio de Otorrinolaringología del Hospital Clínico Universitario Lozano Blesa de Zaragoza, entre Enero del año 2013 y Junio del año 2015 (ambos inclusive). Se han estudiado aspectos epidemiológicos, etiológicos, diagnósticos, evolutivos y terapéuticos. Resultados: Se recogieron datos de 111 pacientes, ingresados con diagnóstico de infección periamigdalina. La media de edad obtenida fue de 34,86 ± 15,35 años, algo mayor que en otras series registradas. En cuanto a la distribución por sexos el 61,62% de los casos correspondió al sexo masculino, y el 38,74% al sexo femenino. El verano es la estación del año en la que más episodios se produjeron. La estancia media hospitalaria fue de 5,85 ± 1,4 días, debido al régimen terapéutico establecido en nuestro servicio. Conclusión: Nuestra tasa de recidivas fue del 6,3% en los 3 meses siguientes al alta hospitalaria, lo que representa un dato sensiblemente menor al recogido en otras series publicadas, lo que justifica el tratamiento de este proceso en el Servicio de Otorrinolaringología del Hospital Clínico Lozano Blesa

The Effect of Weekly Training Load across a Competitive Microcycle on Contextual Variables in Professional Soccer

10 p.Analysis of the key performance variables in soccer is one of the most continuous and attractive research topics. Using global positioning devices (GPS), the primary aim of this study was to highlight the physiological response of a professional soccer team across competitive microcycles in-season according to the most influential contextual performance variables. Determining the training load (TL), a work ratio was established between all recorded data within the training sessions and the competitive profile (CP). Each microcycle was classified in accordance with the contextual variables: opponent level (high, medium, low), match location (home and away) and score (win, draw, lose). Results revealed that the team were significantly more successful (games won) in competitive games against high-level opponents and when played at home. Cumulative microcycle/ weekly training load (WTL) was significantly lower when the team won. In addition to the opponent level and the match location, WTL could condition the athlete?s performance in the competition. Competitive performance responses are the main source of information for the planning of training programs. The results of this study could be used as a reference to structure TL and WTL according to contextual variables in the competition. This study, which is the first of its kind, revealed that WTL effects the performance of the players in the competition

miR-203 drives breast cancer cell differentiation

Breast cancer; Cell differentiationCáncer de mama; Diferenciación celularCàncer de mama; Diferenciació cel·lularA hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.This work has been in part financed by the crowdfunding project “Match point against breast cancer” (PRECIPITA PR242, 2019; FECYT; Spanish Ministry of Science and Innovation, MICINN, led by MS-R) and donations to Asociación Española contra el Cáncer (AECC). The work has been funded also by the Comunidad de Madrid (Y2020/BIO-6519 and S2022/BMD-7437) to MM, the Spanish Ministry of Science and Innovation through CNS2022-135364 to MS-R and PID2021-128726 to MM and the Spanish Ministry of Economy and Competitiveness by Instituto de Salud Carlos III (ISC III) through PI20/00590 to CS and co-funded by the European Union. MS-R was supported by AECC (AIOA120833SALA and INVES18005SALA), a Juan de la Cierva Incorporación and a Ramón y Cajal contract (RYC2020-028929-I, from the MICINN, FSE/ Agencia Estatal de Investigación). NGM-I was supported by AECC (PRDMA19003GARC)

Workloads of Different Soccer-Specific Drills in Professional Players

Soccer is a predominantly tactical sport and, therefore, tactical training has become the most widely used strategy to improve players&apos; performance. The objective of the present study was to assess the workload of soccer-specific drills in professional players over a two-season period in an established context. GPS technology was used to record the data. One hundred and thirty-two (n = 132) soccer-specific drills were studied and grouped by categories. The individual demands of each task were related to the individual competitive profile of each player. The level of physical demand was significantly different in relation to the specific soccer drills analysed. Total distance covered, high-speed running, and the total number of high accelerations and decelerations were significantly higher in competition than in drills used for training sessions (p < .001). The Large-Sided Games (LSG), Big-Position Games (BPG) and Position Games (PG) showed higher maximum running speed values than the rest of the exercises (p < .01). The sum of high accelerations and decelerations values was greater in the Small-Sided Games (SSG) than in BPG (p < .001), Small-Position Games (SPG) (p < .001) and Physical-Technical Circuits (PTC) (p < .001). Significant differences were observed in the exercises analysed according to the player?s position. The current findings provide a detailed description of conditional demands placed on soccer players in different soccer-specific drills during training sessions, in a professional soccer context and according to their playing position, which may be helpful in the development of individualized training programs in other contexts

Siete partidas

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-2013Sign. :[]2, A-Z4, 2A2Texto a dos col.Port. con grab. xil

Siete partidas

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-2013Sign.: []2, A-Q4, R2Texto a dos col.Port. con grab. xil

Siete partidas

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-2013Sign.: []2, A-M4, N2Texto a dos col.Port. con grab. xil