The Minimal Overlap Rule: Restrictions on Mergers for Creditors' Consensus

This paper proposes a notion of partial Additivity in bankruptcy, -Additivity. We show that this property, together with Anonymity and Continuity, identifies the Minimal Overlap rule, introduced by O'Neill (1982).Bankruptcy Problems; Additivity; Minimal Overlap Rule

Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging. A major advantage of human iPSC, compared to the pluripotent embryonic stem cells, is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human blastocysts. In addition, iPSC can be generated from somatic cells harvested from normal individuals or patients, and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible before. Besides these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells, these cells hold an immense potential for cell-based therapies, and for the discovery of new or personalized pharmacological treatments for many disorders. Here, we review some of the current challenges and concerns about iPSC technology. We introduce the potential held by iPSC for research and development of novel health-related applications. We briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation, characterization and long-term preservation. Finally, we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.info:eu-repo/semantics/publishedVersio

A methodological approach in order to support decision-makers when defining Mobility and Transportation Politics

Nowadays Portugal is under a large process of creation/revision of studies and plans related with land use and territorial planning, mainly due to the end of the lifetime period of the actual Municipal Master Plan, but also because of the creation of the new Metropolitan Authorities of Transportation, which will require Mobility Plans. Even though the Portuguese law doesn’t impose these Mobility Plans at the present moment, there is a general feeling about the importance of the mobility system for the society and economics in general. This is the case in highly density areas, where the need and complexity of the system requires these specific studies in order to obtain an efficient management; or in the case of low-density areas where the risk of loosing competitiveness is too high to ignore the importance of the transportation and mobility system, and the advantage of gaining local and regional competitiveness might increase the importance of the municipality in regional context. This paper intends to provide an innovative approach regarding the provision, at an early stage, of technical support to decision-makers in order to define Mobility and Transportation Policies. The opportunity provided by using adapted SWOT analysis (among others) to identify weakening or potential factors, and how to take advantage of the results, always using a cause and effect approach and a coherent policy in order to obtain high quality and effective studies and politics. The methodology relies on a two-stage process. In the first stage a summary diagnose is provided, using inputs which are supposed to well characterise the territory’s mobility patterns. Afterwards, in a second phase, these are inter-related and evaluated in order to build-up a table of options, where policies are proposed with a careful attention to its qualitative cross impact with the measures and objectives intended to be achieved. The proposed methodology was applied in the Alcobaça´s Municipality case study, which provided different lines of action in diverse subjects, such as, public and private transportation networks, parking policies and organisation, and territory competitiveness. This study was particularly relevant, since this Municipality is under great pressure of its neighbour municipalities, has a low level of regional importance and a low intra-municipal cohesion. Finally, the general opinion of the decision-makers about this technical approach is presented. Keywords: Mobility; Transportation; Land Planning and Policies; Decision-making Support

Analytical characterization of ancient mortars from the archaeological roman site of Pisões (Beja, Portugal)

The analytical characterization of mortar samples from the roman archaeological site of Pisões, located in Southern Portugal, were carried out by means of X-ray diffractometry (XRD), thermogravimetry (TGADTA), optical and electron scanning microscopy (SEM-EDS), potentiometry and combustion analysis. The Pisões archaeological complex includes a villa rustica, characterized by well-preserved mosaics and thermal baths, as well as a mill and a mausoleum. Countryside villae epitomized the Romanization of the Iberian Peninsula for over six centuries (2nd century BCE–4th century CE). Nevertheless, most of the Roman villae identified in Portugal have not yet been systematically explored and studied. This study provides valuable data on the construction materials and techniques used in Roman times in the Iberian Peninsula. The careful selection of raw materials and the use of natural and artificial pozzolanic materials can explain the favourable state of conservation, mechanical strength and long-term durability of these mortars

Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo

The TGF-beta-related molecule Nodal plays an essential and conserved role in left-right patterning of the vertebrate embryo. Previous reports have shown that the zebrafish and mouse Cerberus-related proteins Charon and Cerberus-like-2 (Cerl-2), respectively, act in the node region to prevent the Nodal signal from crossing to the right side, whereas chick Cerberus (cCer) has an unclear function in the left-side mesoderm. In this study, we investigate the transcriptional regulation and function of cCer in left-right development. By analyzing the enhancer activity of cCer 5' genomic sequences in electroporated chick embryos, we identified a cCer left-side enhancer that contains two FoxH1 and one SMAD binding site. We show that these Nodal-responsive elements are necessary and sufficient for the activation of transcription in the left-side mesoderm. In transgenic mouse embryos, cCer regulatory sequences behave as in chick embryos, suggesting that the cis-regulatory sequences of Cerberus-related genes have diverged during vertebrate evolution. Moreover, our findings from cCer overexpression and knockdown experiments indicate that cCer is a negative-feedback regulator of Nodal asymmetric signaling. We propose that cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.info:eu-repo/semantics/publishedVersio

GRASS UTILIZATION IN GROWING FINISHING BÍSARO PIGS (85-107 KG). PERFORMANCE AND CARCASS COMPOSITION

The use of different quantities of vegetables, forages or fresh grass as fodder for growing-finishing pigs is an important factor of the northern Portugal traditional system. The increasing development of swine production in outdoor systems, extensive and organic production, turns to upcoming natural diets, in which grass performs a significant part. With regard to this, some investigation has been made concerning the use of fibre-rich feed ingredients in pig nutrition. Metabolic effects of its ingestion are analysed concerning different sights (economical, social, environmental and physiological ones). The aim of this work was to study the effects of grass utilization in the diets on performances of finishing Bísaro pigs. A total of 22 pigs (16 castrated males and 6 females) was housed outdoor and fed ad libitum (37 – 85 kg live weight) with a growing diet and then transferred to an indoor system (with free access to an outdoor area) for 49 days, according to 3 different treatments: 100% concentrate (C), 75% concentrate + ad libitum grass (CE75), 50% concentrate + ad libitum grass (CE50). The grass was supplied and its intake registered on a daily basis. Every 14 days, the pigs were weighted and their back fat (P2 in vivo) measured. After slaughter (average weight of 107 kg LW), yield and ½ left carcass characteristics were controlled. During the outdoor growing phase, the ADG was 513 g/day. During the indoor finishing phase, the increase grass intake was proportional to the reduction of concentrate in the diet. The ADG (g) and the fat deposition (P2 cm) were significantly different (P<0,05) in the 3 treatments (ADG: C=641, CE75=467, CE50=356 and: C=11,4, CE75=+9,5, CE50=+6,2). The empty body weight (kg) was also proportional to the intake of concentrate (C=116,2; CE75=107,7; CE50=102,2). Comparatively to the weight of the body parts, pigs that had higher intake of grass and lower of concentrate showed a higher % of shoulder (P<0,05; C=20,4, CE75=21,7, CE50=22,2) and the pH45min of CE carcasses was significantly higher (P<0,05). As a conclusion, concentrate substitution for grass showed a slower growing rate, thinner carcasses and a high technological quality. Neverthelles variability (CV %) of the productive parameters at the end of this study were higher in the treatments that included grass: live weight (C= 10,5%; C75=10,7%; C50=14,3%), finishing ADG (C=24%; C75=37%, C50=42%), and final fat (C=37%; C75=32%, C50=52%). These values suggest that the utilization of fibrous feeds in growing-finishing swine may be one of the possible explanations of the more heterogeneous products and carcasses found in the traditional or extensive systems, common users of fibrous feeds in the carcass finishing phase

An analytical solution for the analysis of zero-length-column experiments with heat effects

An analytical solution for the analysis of zero-length-column (ZLC) experiments with heat effects is developed. The model is an extension of the original one developed by Eic and Ruthven with the inclusion of the energy balance. Two additional parameters are obtained, beta = (DeltaH/C-p) (partial derivativeq/partial derivativeT)\ (c0),(T0) and alpha = (ha/C-p)(r(c)(2)/D-c). A criterion for negligible heat effects, 3L beta/alpha < 0.1, is derived from the analytical solution based on ZLC operating parameters. ZLC desorption curves in nonisothermal operation are discussed. The model reduces to the original solution of isothermal operation developed by Eic and Ruthven when heat effects are negligible. ZLC experiments with heat effects are analyzed, and trends are in good agreement with theory. Because of its simplicity, the model is a valuable tool for the analysis of ZLC experiments with heat effects

Duration of Low Wage Employment: A Study Based on a Survival Model

This paper includes a survival analysis which attempts to explain the duration, as in the number of years a worker remains in a low wage situation. Explanatory variables take into account the characteristics of the employee, such as education, age, tenure with the company, gender and nationality, and the characteristics of the job and the company such as industry affiliation, number of employees, age of the company and location.low wage, survival, Portugal

Towards graphical user interface redefinition without source code access: System design and evaluation

Nowadays several interactive computing systems (ICSs) still have Graphical User Interfaces (GUIs) that are inadequate in terms of usability and user experience. Numerous improvements were made in the development of better GUIs however, little has been done to improve existing ones. This might be explained by the fact that most ICSs do not provide source code access. In most cases, this means that only persons with source code access can (easily) enhance the respective GUI. This paper presents a tool using computer vision (CV) algorithms to semi-automatically redefine existing GUIs without accessing their source code. The evaluation of a new GUI obtained from the redefinition of an existing GUI using the tool is described. Results show statistically significant improvements in usability (reduction of interaction mistakes), improved task completion success rate and improved user satisfaction.info:eu-repo/semantics/acceptedVersio