Assessing the ecological soundness of organic and conventional agriculture by means of life cycle assessment (LCA) - a case study of leek production

Purpose – Sustainable agriculture implies the ability of agro-ecosystems to remain productive in the long-term. It is not easy to point out unambiguously whether or not current production systems meet this sustainability demand. A priori thinking would suggest that organic crops are environmentally favourable, but may ignore the effect of reduced productivity, which shifts the potential impact to other parts of the food provision system. The purpose of this paper is to assess the ecological sustainability of conventional and organic leek production by means of life cycle assessment (LCA). Design/methodology/approach – A cradle-to-farm gate LCA is applied, based on real farm data from two research centres. For a consistent comparison, two functional units (FU) were defined: 1ha and 1?kg of leek production. Findings – Assessed on an area basis, organic farming shows a more favourable environmental profile. These overall benefits are strongly reduced when the lower yields are taken into account. Related to organic farming it is therefore important that solutions are found to substantially increase the yields without increasing the environmental burden. Related to conventional farming, important potential for environmental improvements are in optimising the farm nutrient flows, reducing pesticide use and increasing its self-supporting capacity. Research limitations/implications – The research is a cradle-to-farm gate LCA, future research can be expanded to comprise all phases from cradle-to-grave to get an idea of the total sustainability of our present food consumption patterns. The research is also limited to the case of leek production. Future research can apply the methodology to other crops. Originality/value – To date, there is still lack of clear evidence of the added value of organic farming compared to conventional farming on environmental basis. Few studies have compared organic and conventional food production by means of LCA. This paper addresses these issues

Adolescents’ perceptions of digital media’s potential to elicit jealousy, conflict and monitoring behaviors within romantic relationships

Understanding the role of digital media in adolescents’ romantic relationships is essential to the prevention of digital dating violence. This study focuses on adolescents’ perceptions of the impact of digital media on jealousy, conflict, and control within their romantic relationships. Twelve focus group interviews were conducted, among 55 secondary school students (ngirls = 28; 51% girls) between the ages of 15 and 18 years (Mage = 16.60 years; SD age = 1.21), in the Dutch-speaking community of Belgium. The respondents identified several sources of jealousy within their romantic relationships, such as online pictures of the romantic partner with others and online messaging with others. Adolescents identified several ways in which romantic partners would react when experiencing feelings of jealousy, such as contacting the person they saw as a threat or looking up the other person’s social media profiles. Along with feelings of jealousy, respondents described several monitoring behaviors, such as reading each other’s e-mails or accessing each other’s social media accounts. Adolescents also articulated several ways that they curated their social media to avoid conflict and jealousy within their romantic relationships. For instance, they adapted their social media behavior by avoiding the posting of certain pictures, or by ceasing to comment on certain content of others. The discussion section includes suggestions for future research and implications for practice, such as the need to incorporate information about e-safety into sexual and relational education and the need to have discussions with adolescents, about healthy boundaries for communication within their friendships and romantic relationships.</jats:p

Influence of sow dietary polyunsaturated fatty acid source on the immunoglobulin profile of piglets

To examine the effect of different n-3 polyunsaturated fatty acid (PUFA) sources in sow diets on piglets’ immunoglobulin (Ig) profile, two groups of twelve sows each were fed different diets from day 45 of pregnancy and during lactation on two commercial farms. On farm I, a palm oil diet (25 g/kg; PALM) and a linseed oil containing diet (20 g/kg; LIN) were fed. On farm II, the same PALM diet and a fish oil containing diet (20 g/kg; FISH) were fed. All diets contained equal amounts of C18:2n-6 (13 g/kg). One day before parturition, blood (for serum) was taken and shortly after parturition, colostrum was taken from the sows (not from sows on farm I) for determination of Ig levels. On day 5 post partum and the day before weaning, blood (for serum) was taken from 4 piglets of six sows per group (24 piglets in total per group; for 5-d old piglets on farm II, only 6 piglets of the FISH group were sampled). In all samples total IgG, IgA, IgM concentration and specific F4-IgG, -IgA and -IgM titer (Log2 titer) against E. coli were determined. On farm I, the sows of the LIN group showed a trend towards lower IgG titers compared to the PALM group around farrowing (P<0.1). On farm II, the sows on the FISH diet showed a significantly (P<0.05) lower F4-IgG titer compared to the sows fed PALM. The colostrum samples on farm II showed no differences between both groups. On farm I, the 5-d old piglets from the LIN group had significantly higher IgA and IgM concentrations and higher F4-IgA and F4-IgM titers (P<0.05). F4-IgA and F4-IgG titers were also significantly higher at weaning in the LIN group compared to the PALM group. On farm II, the piglets of the FISH group had a significantly higher IgG concentration and F4-IgA titer (P<0.05) and a trend towards a higher IgM concentration (P<0.1) around weaning compared to the PALM group. It seems that fish oil in the maternal diet increases total IgG concentration, while linseed oil reduces total IgG and increases total IgA compared to a palm fat containing diet. Both fish and linseed oil seem to have a positive effect on total IgM concentration compared to the palm diet

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC activator cinaciguat are enhanced in apo-sGC mice, suggesting that the effects of NO on smooth muscle relaxation, blood pressure regulation and inhibition of platelet aggregation require sGC activation by NO. Tumour necrosis factor (TNF)-induced hypotension and mortality are preserved in apo-sGC mice, indicating that pathways other than sGC signalling mediate the cardiovascular collapse in shock. Apo-sGC mice allow for differentiation between sGC-dependent and -independent NO effects and between haem-dependent and -independent sGC effects. Apo-sGC mice represent a unique experimental platform to study the in vivo consequences of sGC oxidation and the therapeutic potential of sGC activators

Prediction of functional outcome after acute ischemic stroke : comparison of the CT-DRAGON score and a reduced features set

Background and Purpose:The CT-DRAGON score was developed to predict long-term functional outcome after acute stroke in the anterior circulation treated by thrombolysis. Its implementation in clinical practice may be hampered by its plethora of variables. The current study was designed to develop and evaluate an alternative score, as a reduced set of features, derived from the original CT-DRAGON score. Methods:This single-center retrospective study included 564 patients treated for stroke, in the anterior and the posterior circulation. At 90 days, favorable [modified Rankin Scale score (mRS) of 0-2] and miserable outcome (mRS of 5-6) were predicted by the CT-DRAGON in 427 patients. Bootstrap forests selected the most relevant parameters of the CT-DRAGON, in order to develop a reduced set of features. Discrimination, calibration and misclassification of both models were tested. Results:The area under the receiver operating characteristic curve (AUROC) for the CT-DRAGON was 0.78 (95% CI 0.74-0.81) for favorable and 0.78 (95% CI 0.72-0.83) for miserable outcome. Misclassification was 29% for favorable and 13.5% for miserable outcome, with a 100% specificity for the latter. National Institutes of Health Stroke Scale (NIHSS), pre-stroke mRS and age were identified as the strongest contributors to favorable and miserable outcome and named the reduced features set. While CT-DRAGON was only available in 323 patients (57%), the reduced features set could be calculated in 515 patients (91%) (p < 0.001). Misclassification was 25.8% for favorable and 14.4% for miserable outcome, with a 97% specificity for miserable outcome. The reduced features set had better discriminative power than CT-DRAGON for both outcomes (both p < 0.005), with an AUROC of 0.82 (95% CI 0.79-0.86) and 0.83 (95% CI 0.77-0.87) for favorable and miserable outcome, respectively. Conclusions:The CT-DRAGON score revealed acceptable discrimination in our cohort of both anterior and posterior circulation strokes, receiving all treatment modalities. The reduced features set could be measured in a larger cohort and with better discrimination. However, the reduced features set needs further validation in a prospective, multicentre study

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested to play important roles in the pathogenesis of MAFLD through their activation, although the exact roles played by these cells remain unclear. Here, we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin, a biomarker for patients with NASH, linked with the development of fibrosis. Fitting with this, LAMs were found in regions of the liver with reduced numbers of KCs, characterized by increased Desmin expression. Together, our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD

Archeologische opgraving van een midden-mesolithische tot midden-neolithische vindplaats te "Bazel-sluis 5" (gem. Kruibeke, prov. Oost-Vlaanderen)

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