Mindful Eating: Trait and State Mindfulness Predict Healthier Eating Behavior

Obesity and excess weight are significant societal problems. Mindfulness may encourage healthier weight and eating habits. Across four studies, we found a positive relation between mindfulness and healthier eating. Trait mindfulness was associated with less impulsive eating, reduced calorie consumption, and healthier snack choices. In addition, we found a causal effect of mindfulness on healthier eating. An experimental manipulation of state mindfulness led participants to consume fewer calories in a spontaneous eating task. We also found preliminary evidence that mindfulness affects eating behavior by encouraging attitudinal preferences for healthier foods. Taken together, these results provide strong evidence that mindfulness encourages healthier eating, even in the absence of specific instruction in mindful eating. These results suggest that generic mindfulness-based strategies could have ancillary benefits for encouraging healthier eating behavior

A Meta-Analysis of Procedures to Change Implicit Measures

Using a novel technique known as network meta-analysis, we synthesized evidence from 492 studies (87,418 participants) to investigate the effectiveness of procedures in changing implicit measures, which we define as response biases on implicit tasks. We also evaluated these procedures’ effects on explicit and behavioral measures. We found that implicit measures can be changed, but effects are often relatively weak (|ds| \u3c .30). Most studies focused on producing short-term changes with brief, single-session manipulations. Procedures that associate sets of concepts, invoke goals or motivations, or tax mental resources changed implicit measures the most, whereas procedures that induced threat, affirmation, or specific moods/emotions changed implicit measures the least. Bias tests suggested that implicit effects could be inflated relative to their true population values. Procedures changed explicit measures less consistently and to a smaller degree than implicit measures and generally produced trivial changes in behavior. Finally, changes in implicit measures did not mediate changes in explicit measures or behavior. Our findings suggest that changes in implicit measures are possible, but those changes do not necessarily translate into changes in explicit measures or behavior

Student-Athlete School Selection: A Family Systems Theory Approach

The primary focus of this study was to examine the role family members play in the college selection process for NCAA Division III student-athletes. The role of family members in the college selection process has been studied for nonathletes, NCAA Division I athletes, NCAA Division II athletes, and at a cross-divisional level for specific NCAA sports. In such research related to intercollegiate student-athletes, research has primarily been conducted quantitatively with the use of survey techniques. Little research exists specifically exploring the role of family members in the college selection process for NCAA Division III athletes. Based on the lack of research, the overarching Division III philosophy, the pure participation rates of NCAA Division III athletes (more than 180,000 current Division III athletes), and the ideal fit of Family Systems Theory to this selection process, this research study is fitting. In this project, sixty-nine student-athletes participated in semistructured interviews at eleven different NCAA Division III institutions. Five prompts directly related to potential family influence were asked. Data were analyzed using open coding based on a priori and emergent themes. Responses are collectively summarized and representative responses are presented verbatim. Results are also discussed through the framework of Family Systems Theory and related back to previous literature on the role of the family in the college selection process

On-Line Distributed Traffic Grooming

This paper addresses the problem of on-line traffic grooming in WDM paths. Each request consists of a source node, a destination node, and the desired bandwidth for the connection. Connections may be multi-hop, permitting the use of multiple lightpaths. We describe a new distributed on-line algorithm for this problem that is provably wide-sense non-blocking under cer- tain assumptions. Moreover, we use simulations to demonstrate that the algorithm is extremely effective even when some of these assumptions are relaxed

Analysis of the Relationship Between Diet and Exercise Beliefs and Actual Behaviors Among Breast Cancer Survivors in Northwest Ohio

Introduction: Studies have shown that a diet high in fruit and vegetable intake, as well as a routine including daily exercise or physical activity, can independently affect relapse rates and survivorship in breast cancer patients. Fruits and vegetables contain powerful anti-oxidant molecules, capable of preventing tumor formation and proliferation. Exercise can lower circulating levels of estrogen, the female hormone responsible for tumor proliferation in the estrogen-sensitive form of the disease. The most beneficial results have been shown in women who exercise and consume a diet rich in fruits and vegetables. We studied the attitudes towards and behaviors related to fruit and vegetable intake and exercise in a cohort of breast cancer survivors in northwest Ohio. Materials and Methods: Data were gathered from a survey sent out by the Northwest Ohio Branch of the Susan G. Komen For the Cure Foundation. We assessed and evaluated survivors’ self-reported beliefs, attitudes, and behaviors regarding exercise and fruit and vegetable intake. Results: Nearly half of the survivors (46.5%) reported being unsure or in disagreement with the statement “Eating at least 5 servings of fruits and/or vegetables per day will reduce the risk of breast cancer recurrence.” Only 46.8% of those in agreement with the previous statement actually report eating at least 5 fruits and/or vegetables per day. With respect to exercise, 32.9% reported being unsure or in disagreement with the statement “Engaging in regular physical activity will reduce the risk of breast cancer recurrence.” Only 68.5% of those in agreement with the previous statement report any physical activity in the past 30 days. Conclusions: Many breast cancer survivors do not appear to be aware of the benefits of diet and exercise. Further, a large proportion of those who are aware of the benefits do not adapt a healthy diet and exercise as part of their lifestyle. A majority of these survivors see a primary care physician, which we believe is the best venue to bridge this education gap. It is apparent by the pattern our data shows that more needs to be done to educate breast cancer survivors about the benefits of exercise and fruit and vegetable intake. Steps need to be taken to ensure that those who are educated also remain motivated to engage in a healthy lifestyle with the hopes of avoiding breast cancer recurrence

Galicia3D seismic volume: Connections between the western termination of the S reflector and eastern termination of the Peridotite Ridge

European Geosciences Union General Assembly 2015 (EGU2015), 12-17 April 2015, Vienna, Austria.-- 1 pageIn June thru September, 2013, a 3D reflection and a long offset seismic experiment were conducted at the Galicia rifted margin by investigators from the US, UK, Germany, and Spain. The 3D multichannel experiment covered 64 km by 20 km (1280 km2), using the RV Marcus Langseth. Four streamers 6 km long were deployed at 12.5 m hydrophone channel spacing. The streamers were 200 m apart. Two airgun arrays, each 3300 cu in, were fired alternately every 37.5 m, to collectively yield a 400 m wide sail line consisting of 8 CMP lines at 50 m spacing. We draw attention to the region from the Peridotite Ridge, PR, (on the west) and the western terminus of the S reflector (on the east). The S reflector is generally thought to separate continental crust and pre- and syn-rift sediment above, and serpentinized upper mantle below. In 2D and 3D seismic reflection data, the S reflector is very bright, generally horizontal, and is terminated very abruptly at the western end. The latter is particularly clear in the 3D volume. It is about 10-15 km wide between the end of the S reflector and the midpoint of the PR. In this interval, there appear to be fault bounded blocks that may be either continental crust or pre- or syn-rift sediments. The PR is a virtually straight, N-S ridge, without apparent fault offsets. The crest of the PR is at about 4800 mbsl at the S extent and is at 6070 mbsl at the N extent of the 3D volume. The crest is approximately linear in map view or N-S extent. Both sides, East and West of the PR, appear to show landslides and other mass wasting during the late stage of the syn-rifting interval. The PR rarely shows internal seismic structure in 2D and 3D. Most importantly, under the basin to the east of the PR there are substantially more recognizable structures connecting the S reflector and the PR. These were much less interpretable in previous 2D seismic profilesPeer Reviewe

Infectious alphavirus production from a simple plasmid transfection+

We have developed a new method for producing infectious double subgenomic alphaviruses from plasmids transfected into mammalian cells. A double subgenomic Sindbis virus (TE3'2J) was transcribed from a cytomegalovirus PolII promoter, which results in the production of infectious virus. Transfection of as little as 125 ng of plasmid is able to produce 1 × 108 plaque forming units/ml (PFU/ml) of infectious virus 48 hours post-transfection. This system represents a more efficient method for producing recombinant Sindbis viruses

Comparative Immunogenicity of Na-GST-1 Human Hookworm Vaccine with Synthetic Glucopyranosyl Lipid Adjuvant (GLA) in BALB/c Mice

More than 740 million people worldwide are infected with Hookworm. Hookworm infection is most prevalent in the poorest of the poor populations of the world, and has serious health effects. Hookworm infection causes blood loss leading to iron deficiency anemia and protein energy malnutrition, which results in a compromised immune response. Consequently, the target human population suffers from an increased susceptibility to infectious diseases including hookworm infection. We have developed recombinant adult hookworm vaccines against hookworm infection to break this vicious cycle. Toll-like receptor (TLR) 4 agonist are known to boost immune response in healthy and immunocompromised individuals. We believe that co-injecting Synthetic Glucopyranosyl Lipid Adjuvant (GLA) a novel TLR-4 agonist with adult hookworm Na-GST-1 + Alhydrogel® vaccine will produce a robust and sustainable immune response in this target human population. Here, we discuss the rationale of using GLA, study designs and the results of the pre-clinical immunogenicity studies of the Human Hookworm Na-GST-1 + Alhydrogel® Vaccine in BALB/c mice with and without GLA. We conclude that, GLA enhanced the immunogenicity of co-administered adult hookworm Na-GST-1 + Alhydrogel® vaccine, producing a strong anti-Na-GST-1 IgG response. These preclinical results lay the foundation of co-administrating GLA with adult hookworm Na-GST-1 + Alhydrogel® vaccine in Phase 1 clinical trial in Brazil

Potency Testing for NTD Vaccines: Determining Relative Potency for the Na-GST-1 Human Hookworm Vaccine

Over the next decade, a new generation of vaccines will target the neglected tropical diseases (NTDs) . The goal of most NTD vaccines will be to reduce the morbidity and decrease the chronic debilitating nature of these often-forgotten infections - outcomes that are hard to measure in the traditional potency-testing paradigm . The absence of measurable correlates of protection, a lack of permissive animal models for lethal infection, and a lack of clinical indications that do not include the induction of sterilizing immunity required us to reconsider the traditional bioassay methods for determining vaccine potency . Owing to these limitations, potency assay design for NTD vaccines will increasingly rely on a paradigm where potency testing is one among many tools to ensure that a manufacturing process yields a product of consistent quality . This potency test is a bioassay using BALB/c mice, which evaluates the immunogenicity of the vaccine at set time interval post manufacture . Herein, we discuss the results of 12 month potency testing of Necator americanus-glutathione-S- transferase-1 (Na-GST-1) vaccine . The Effective Dose 50 (ED50), with its 95% fiducial limits (FL) for each time point was determined along with the Relative Potency with its 95% FL for 3, 6, 9 and 12 months post manufacture . Potency testing has shown that storage at 4° C decreases the ED50 and increases the relative potency of Na-GST-1 vaccine . We proposed that the change in ED50 and relative potency coincide with higher affinity binding of the Na-GST-1 to the Alhydrogel® that occurred during storage at 4° C . These preclinical results lay the foundation for moving forward with Phase 1 clinical trial in Brazil