19,574 research outputs found
Assessment worlds colliding? Negotiating between discourses of assessment on an online open course
Using the badged open course, Taking your first steps into Higher Education, this case study examines how assessment on online open courses draws on concepts of assessment used within formal and informal learning. Our experience was that assessment used within open courses, such as massive open online courses, is primarily determined by the requirements of quality assurance processes to award a digital badge or statement of participation as well as what is technologically possible. However, this disregards much recent work in universities that use assessment in support of learning. We suggest that designers of online open courses should pay greater attention to the relationship of assessment and learning to improve participant course completion
Migration as Adaptation? Exploring The Scope for Co-ordinating Environmental and Migration Policies in the European Union
Quantum Discord and Quantum Computing - An Appraisal
We discuss models of computing that are beyond classical. The primary
motivation is to unearth the cause of nonclassical advantages in computation.
Completeness results from computational complexity theory lead to the
identification of very disparate problems, and offer a kaleidoscopic view into
the realm of quantum enhancements in computation. Emphasis is placed on the
`power of one qubit' model, and the boundary between quantum and classical
correlations as delineated by quantum discord. A recent result by Eastin on the
role of this boundary in the efficient classical simulation of quantum
computation is discussed. Perceived drawbacks in the interpretation of quantum
discord as a relevant certificate of quantum enhancements are addressed.Comment: To be published in the Special Issue of the International Journal of
Quantum Information on "Quantum Correlations: entanglement and beyond." 11
pages, 4 figure
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Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene.
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. The overexpression induces genomic instability and blocks differentiation, likely mediated in part by enhanced expression of the stem cell gene SOX2. GLI2 also induces transforming growth factor (TGF)B1-dependent transdifferentiation of foreskin and tongue, but not gingival fibroblasts into myofibroblasts, creating an environment permissive for invasion by keratinocytes, which are in various stages of differentiation having downregulated GLI2. Thus, upregulated GLI2 expression is sufficient to induce a number of the acquired characteristics of tumor cells; however, the stroma, in a tissue-specific manner, determines whether certain GLI2 oncogenic traits are expressed
‘Collective intelligence’ is not necessarily present in virtual groups
When we communicate online, we miss an important element of group intelligence: social sensitivity, write Jordan B. Barlow and Alan R. Denni
A Novel Use of Light Guides and Wavelength Shifting Plates for the Detection of Scintillation Photons in Large Liquid Argon Detectors
Scintillation light generated as charged particles traverse large liquid
argon detectors adds valuable information to studies of weakly-interacting
particles. This paper uses both laboratory measurements and cosmic ray data
from the Blanche dewar facility at Fermilab to characterize the efficiency of
the photon detector technology developed at Indiana University for the single
phase far detector of DUNE. The efficiency of this technology was found to be
0.48% at the readout end when the detector components were characterized with
laboratory measurements. A second determination of the efficiency using cosmic
ray tracks is in reasonable agreement with the laboratory determination. The
agreement of these two efficiency determinations supports the result that
minimum ionizing muons generate photons/MeV as
they cross the LAr volume.Comment: Accepted version (without final editorial corrections
Electrostatics of ions inside the nanopores and trans-membrane channels
A model of a finite cylindrical ion channel through a phospholipid membrane
of width separating two electrolyte reservoirs is studied. Analytical
solution of the Poisson equation is obtained for an arbitrary distribution of
ions inside the trans-membrane pore. The solution is asymptotically exact in
the limit of large ionic strength of electrolyte on the two sides of membrane.
However, even for physiological concentrations of electrolyte, the
electrostatic barrier sizes found using the theory are in excellent agreement
with the numerical solution of the Poisson equation. The analytical solution is
used to calculate the electrostatic potential energy profiles for pores
containing charged protein residues. Availability of a semi-exact interionic
potential should greatly facilitate the study of ionic transport through
nanopores and ion channels
A non-associative quantum mechanics
A non-associative quantum mechanics is proposed in which the product of three
and more operators can be non-associative one. The multiplication rules of the
octonions define the multiplication rules of the corresponding operators with
quantum corrections. The self-consistency of the operator algebra is proved for
the product of three operators. Some properties of the non-associative quantum
mechanics are considered. It is proposed that some generalization of the
non-associative algebra of quantum operators can be helpful for understanding
of the algebra of field operators with a strong interaction.Comment: one typo in Eq. (23) is correcte
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