Interview with Andrea Révész

Andrea Révész is a senior lecturer in applied linguistics and TESOL at Institute of Education, University College London. Her research interests lie in the areas of second language acquisition (SLA) and second language instruction. In particular, she has conducted research on the roles of tasks, implicit/explicit learning and teaching, and individual differences in instructed second language development

La escritura de estudiantes ESL escriben como una ventana a la competencia discursiva

This study explores the relationship between writing strategies and the cohesion of writing, and it compares how an ESL learner and a native speaker of English use strategies to organize their written narratives. A text analysis demonstrates that the ESL learner used fewer connectives than the native speaker of English, and produced a less cohesive narrative. Next, taking a qualitative approach, the study explores how the differences in their written products are related to the writers’ uses of different writing strategies and processes. The ESL learner used the strategy of translation from L1 to L2 and focused on grammar and vocabulary; the native English speaker drew on a mental template to organize her narrative. The conclusion discusses implications for L2 writing instruction.Este estudio explora la relación entre las estrategias de escritura de los alumnos de L2 y la cohesión en las narraciones. Emplea métodos de análisis cualitativos para investigar cómo un estudiante de ESL y un hablante nativo de inglés utilizaron estrategias similares o diferentes para organizar narraciones escritas. Los hallazgos demuestran que el estudiante de ESL usó menos conectivos que el hablante nativo de inglés, y la discusión explora cómo las diferencias se relacionan con los usos de los escritores de diferentes estrategias y procesos de escritura. Algunas de las influencias en sus estrategias de escritura incluyen, en el caso del estudiante de ESL, la traducción de L1 a L2 y un enfoque en la gramática y el vocabulario; y, en el caso del hablante nativo de inglés, la decisión de seguir una plantilla para organizar la narrativa. Los resultados tienen implicaciones educativas importantes para la instrucción de escritura L2

ESL learners’ writing as a window onto discourse competence

This study explores the relationship between writing strategies and the cohesion of writing, and it compares how an ESL learner and a native speaker of English use strategies to organize their written narratives. A text analysis demonstrates that the ESL learner used fewer connectives than the native speaker of English, and produced a less cohesive narrative. Next, taking a qualitative approach, the study explores how the differences in their written products are related to the writers’ uses of different writing strategies and processes. The ESL learner used the strategy of translation from L1 to L2 and focused on grammar and vocabulary; the native English speaker drew on a mental template to organize her narrative. The conclusion discusses implications for L2 writing instruction. Keywords: narrative, cohesion, discourse competence, writing strategiesEste estudio explora la relación entre las estrategias de escritura de los alumnos de L2 y la cohesión en las narraciones. Emplea métodos de análisis cualitativos para investigar cómo un estudiante de ESL y un hablante nativo de inglés utilizaron estrategias similares o diferentes para organizar narraciones escritas. Los hallazgos demuestran que el estudiante de ESL usó menos conectivos que el hablante nativo de inglés, y la discusión explora cómo las diferencias se relacionan con los usos de los escritores de diferentes estrategias y procesos de escritura. Algunas de las influencias en sus estrategias de escritura incluyen, en el caso del estudiante de ESL, la traducción de L1 a L2 y un enfoque en la gramática y el vocabulario; y, en el caso del hablante nativo de inglés, la decisión de seguir una plantilla para organizar la narrativa. Los resultados tienen implicaciones educativas importantes para la instrucción de escritura L2

Rare oncology therapeutics: review of clinical pharmacology package of drug approvals (2019-2023) by US FDA, best practices and recommendations.

There are many challenges with rare diseases drug development and rare oncology indications are not different. To understand the regulatory landscape as it relates to application of clinical pharmacology principles in rare oncology product development, we reviewed publicly available information of 39 approvals by US FDA between January 2019 and March 2023. The objective was to understand the expected clinical pharmacology studies and knowledge base in such approvals. Model informed drug development (MIDD) applications were also reviewed, as such approaches are expected to play a critical role in filling clinical pharmacology gaps in rare oncology, where number of clinical trials and size of these trials will perhaps continue to be small. The findings highlighted how clinical pharmacology contributed to the evidence of effectiveness, dose optimization and elucidation of intrinsic and extrinsic factors affecting drug's behavior. Clinical pharmacology studies were often integrated with modeling in many of the NDAs/BLAs. Of the post marketing requirements (PMR) received, 18% were for dose optimization, 49% for DDI, 8% for QTc, 49% for specific population, and 5% for food effect. Two post marketing commitments (PMC) were issued for immunogenicity of the 11 biologics submissions. 15% (6 of 39) of the submissions used maximum tolerated dose (MTD) to advance their molecule into Phase 2 studies. Of them 3 approvals received PMR for dose optimization. 3 + 3 was the most prevalent Phase 1 design with use in 74% of the New Drug Applications (NDA)/Biologic License Applications (BLA) reviewed. Rest used innovative approaches such as BLRM, BOIN or mTPi, with BLRM being the most common. Seamless clinical pharmacology and MIDD approaches are paramount for rare oncology drug development

Atmospheric Pressure Plasma Irradiation Facilitates Transdermal Permeability of Aniline Blue on Porcine Skin and the Cellular Permeability of Keratinocytes with the Production of Nitric Oxide

The transdermal delivery system of nutrients, cosmetics, and drugs is particularly attractive for painless, noninvasive delivery and sustainable release. Recently, atmospheric pressure plasma techniques have been of great interest to improve the drug absorption rate in transdermal delivery. Currently, plasma-mediated changes in the lipid composition of the stratum corneum are considered a possible mechanism to increase transdermal permeability. Nevertheless, its molecular and cellular mechanisms in transdermal delivery have been largely confined and still veiled. Herein, we present the effects of cold plasma on transdermal transmission on porcine skin and the cellular permeability of keratinocytes and further demonstrate the production of nitric oxide from keratinocytes. Consequently, argon plasma irradiation for 60 s resulted in 2.5-fold higher transdermal absorption of aniline blue dye on porcine skin compared to the nontreated control. In addition, the plasma-treated keratinocytes showed an increased transmission of high-molecular-weight molecules (70 and 150 kDa) with the production of nitric oxide. Therefore, these findings suggest a promoting effect of low-temperature plasma on transdermal absorption, even for high-molecular-weight molecules. Moreover, plasma-induced nitric oxide from keratinocytes is likely to regulate transdermal permeability in the epidermal layer

Antibacterial and deodorizing effects of cold atmospheric plasma-applied electronic deodorant

Abstract Axillary odor is a malodor produced by bacterial metabolism near the apocrine glands, which often causes discomfort in an individual's daily life and social interactions. A deodorant is a personal care product designed to alleviate or mask body odor. Currently, most deodorants contain antimicrobial chemicals and fragrances for odor management; however, direct application to the underarm skin can result in irritation or sensitivity. Therefore, there is a growing interest in technologies that enable disinfection and odor control without the antiperspirants or perfumes. The cold atmospheric plasma temporally generates reactive radicals that can eliminate bacteria and surrounding odors. In this study, cultured Staphylococcus hominis and Corynebacterium xerosis, the causative bacteria of axillary bromhidrosis, were killed after 90% plasma exposure for 3 min. Moreover, the electronic nose system indicated a significant reduction of approximately 51% in 3-hydroxy-3-methylhexanoic acid and approximately 34% in 3-methyl-3-sulfanylhexan-1-ol, the primary components of axillary odor, following a 5-min plasma exposure. These results support the dual function of our deodorant in eliminating bacteria and axillary odors without the chemical agents. Therefore, cold atmospheric plasma-applied deodorant devices have great potential for the treatment and management of axillary odors as a non-contact approach without chemical use in daily life

Biomolecule-Mediated Synthesis of Selenium Nanoparticles using Dried Vitis vinifera (Raisin) Extract

Biomolecule-mediated nanoparticle synthesis has recently gained the attention of researchers due to its ecofriendly and non-toxic nature. Metabolites from plant extracts represent a better alternative to chemical methods to fulfill the growing demand for non-hazardous nanoparticle synthesis routes. Selenium and its nanoparticles have an extensive range of applications. Thus, biofabrication of selenium nanoparticles can be potentially useful in various fields. This study reports a green approach to biosynthesize selenium nanoparticles (Se-np) using dried Vitis vinifera (raisin) extracts. The biosynthesized selenium nanoparticles were characterized using transmission electron microscope (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), energy dispersive X-ray (EDX) spectroscopy and Fourier transform infrared spectroscopy (FTIR). Transmission electron microscopic images revealed the spherical shape of biosynthesized selenium nanoparticles and a size range of 3–18 nm. Dynamic light scattering also confirmed the average particle size of 8.12 ± 2.5 nm with 0.212 PDI. The crystalline nature of selenium nanoparticles was confirmed by the X-ray diffraction study. Moreover, as inferred from the FTIR spectrum, the presence of highly stable lignin biopolymer on the surface of selenium nanoballs suggests a possible role as capping agent