Мотив протиставлення міста селу в українській літературі

У статті розглянуто мотив протиставлення міста селу в творах української літератури. Дослідження присвячено аналізу опозиції образів міста і села в творчості письменників. Простежено семантику лексем, їх стилістичне використання. Ключові слова: протиставлення образів, стилістика та семантика лексем.В статье рассматривается мотив противопоставления образа города и села в украинской литературе. В работе анализируется опозиция город – село в произведениях. Прослеживается семантика лексем, их стилистика. Ключевые слова: противопоставление образов, стилистика и семантика лексем.In the article reason of contrasting of city to the village is considered in works of Ukrainian literature. Research is devoted to the analysis of opposition of appearances of city and village in creation of writers. Semantics of lexemes is traced, them the stylistic use. Keywords: contrasting of appearances, stilistika and semantics of lexemes

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Rede, Wageningen 4 november 198

Does the chronically ill population in the Netherlands switch their health insurer as often as the general population? Empirical evidence from a nationwide survey study

BACKGROUND: Consumer mobility is an important aspect of a health insurance system based on managed competition. Both the general population and insured with a chronic illness should enjoy an equal opportunity to switch their insurer every year. We studied possible differences in the rates of switching between these two groups in the Netherlands. METHODS: A structured questionnaire was sent to 1500 members of Nivel's Dutch Health Care Consumer Panel (response rate: 47%) and to 1911 chronically ill members of the National Panel of the Chronically ill and Disabled (response rate: 84%) in February 2016. Associations between switching and background characteristics were estimated using logistic regression analyses with interaction effects. RESULTS: In general, we did not find significant differences in switching rates between the general population and chronically ill population. However, a combination of the population and background characteristics demonstrated that young insured with a chronic illness switched significantly less often than young insured from the general population (1% versus 17%). CONCLUSIONS: Our results demonstrated that the group of young people with a chronic illness is less inclined to switch insurer. This observation suggests that this group might either face difficulties or barriers which prevents them from switching, or that they experience a high level of satisfaction with their current insurer. Further research should therefore focus on unravelling the mechanisms which explain the differences in switching rates

The public's voice about healthcare quality regulation policies. A population-based survey

Background: In the wake of various high-profile incidents in a number of countries, regulators of healthcare quality have been criticised for their 'soft' approach. In politics, concerns were expressed about public confidence. It was claimed that there are discrepancies between public opinions related to values and the values guiding regulation policies. Although the general public are final clients of regulators' work, their opinion has only been discussed in research to a limited extent. The aim of this study is to explore possible discrepancies between public values and opinions and current healthcare quality regulation policies. Methods: A questionnaire was submitted to 1500 members of the Dutch Healthcare Consumer Panel. Questions were developed around central ideas underlying healthcare quality regulation policies. Results: The response rate was 58.3 %. The regulator was seen as being more responsible for quality of care than care providers. Patients were rated as having the least responsibility. Similar patterns were observed for the food service industry and the education sector. Complaints by patients' associations were seen as an important source of information for quality regulation, while fewer respondents trusted information delivered by care providers. However, respondents supported the regulator's imposition of lighter measures firstly. Conclusions: There are discrepancies and similarities between public opinion and regulation policies. The discrepancies correspond to fundamental concepts; decentralisation of responsibilities is not what the public wants. There is little confidence in the regulator's use of information obtained by care providers' internal monitoring, while a larger role is seen for complaints of patient organisations. This discrepancy seems not to exist regarding the regulator's approach of imposing measures. A gradual, and often soft approach, is favoured by the majority of the public in spite of the criticism that is voiced in the media regarding this approach. Our study contributes to the limited knowledge of public opinion on government regulation policies. This knowledge is needed in order to effectively assess different approaches to involve the public in regulation policies

Toxina botulínica para uso terapéutico

From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; ArgentinaFil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; ArgentinaFil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; ArgentinaFil: de Jong, L.I.T.. Universidad Nacional de Cuyo; ArgentinaFil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; ArgentinaFil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; Argentin

Missing data imputation of high-resolution temporal climate time series data

© 2020 The Authors. Meteorological Applications published by John Wiley & Sons Ltd on behalf of the Royal Meteorological Society. Analysis of high-resolution data offers greater opportunity to understand the nature of data variability, behaviours, trends and to detect small changes. Climate studies often require complete time series data which, in the presence of missing data, means imputation must be undertaken. Research on the imputation of high-resolution temporal climate time series data is still at an early phase. In this study, multiple approaches to the imputation of missing values were evaluated, including a structural time series model with Kalman smoothing, an autoregressive integrated moving average (ARIMA) model with Kalman smoothing and multiple linear regression. The methods were applied to complete subsets of data from 12 month time series of hourly temperature, humidity and wind speed data from four locations along the coast of Western Australia. Assuming that observations were missing at random, artificial gaps of missing observations were studied using a five-fold cross-validation methodology with the proportion of missing data set to 10%. The techniques were compared using the pooled mean absolute error, root mean square error and symmetric mean absolute percentage error. The multiple linear regression model was generally the best model based on the pooled performance indicators, followed by the ARIMA with Kalman smoothing. However, the low error values obtained from each of the approaches suggested that the models competed closely and imputed highly plausible values. To some extent, the performance of the models varied among locations. It can be concluded that the modelling approaches studied have demonstrated suitability in imputing missing data in hourly temperature, humidity and wind speed data and are therefore recommended for application in other fields where high-resolution data with missing values are common

Application of Circular Dichroism Spectroscopy in the Study of Mixed-Valence Asymmetric Ruthenium Polypyridyl Complexes

Circular dichroism (CD) spectroelectrochemistry is used to determine the extent of singly occupied molecular orbital delocalization in mixed-valence multinuclear complexes, specifically the mixed-valence RuIIRuIII states of the four diastereoisomers of [(Ru(bpy)2)2(bpt)]3+ [bpy = 2,2'-bipyridyl and bpt = 3,5-bis(pyrid-2'-yl)-1,2,4-triazolato anion]. The complex was found to be stable to thermal racemization in the three oxidation states, but photoracemization in the RuIIRuII state was observed.