848 research outputs found
Identification and prevention of the Lynch syndrome
Colorectal cancer is one of the
most common malignancies in the world. A family history of colon cancer
has been shown to increase an individual’s risk of developing the
disease. Approximately 2-3% of all colorectal cancers occur in the
setting of a well described autosomal dominant inherited syndrome: The
Lynch syndrome.
It is essential to identify individuals at increased risk to offer
adequate surveillance programs to prevent the development of tumors or
recognize them at an early stage. This thesis gives a laboratory workup
of suspected Lynch syndrome, including analysis of tumor tissue by
microsatellite instability analysis and immunohistochemistry, and
germline DNA analysis.
Several aspects of surveillance in Lynch syndrome are described. The
appropriate screening interval is discussed and the effect on mortality
because of surveillance is shown.
Further, we sought to establish whether individuals from dominant
families without mismatch repair deficiency are also at increased risk
by examining the incidence of advanced neoplasia during surveillance.
Finally, the prevalence of the frequency of a positive family history
for CRC, within a random cohort among the Dutch population is presented
and also the prevalence of adenomas among young individuals at average
risk for colorectal cancer is shown.LEI Universiteit LeidenThe Netherlands Organization for Health, Research and Development: ZonMW funded the research described in the thesis.Regulatieprocessen in de basale en klinische gastroenterologi
Ethnic background, socioeconomic status, and problem severity as dropout risk factors in psychotherapy with youth
Штанги для горизонтально направленного бурения
В статті наведено технічні дані про конструкцію та експлуатаційні вимоги до бурових
штанг горизонтально спрямованого буріння свердловин
Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study
In both men and women, circulating androgen levels decline with advancing
age. Until now, results of several small studies on the relationship
between endogenous androgen levels and atherosclerosis have been
inconsistent. In the population-based Rotterdam Study, we investigated the
association of levels of dehydroepiandrosterone sulfate (DHEAS) and total
and bioavailable testosterone with aortic atherosclerosis among 1,032
nonsmoking men and women aged 55 yr and over. Aortic atherosclerosis was
assessed by radiographic detection of calcified deposits in the abdominal
aorta, which have been shown to reflect intimal atherosclerosis. Relative
to men with levels of total and bioavailable testosterone in the lowest
tertile, men with levels of these hormones in the highest tertile had
age-adjusted relative risks of 0.4 [95% confidence interval (CI), 0.2-0.9]
and 0.2 (CI, 0.1-0.7), respectively, for the presence of severe aortic
atherosclerosis. The corresponding relative risks for women were 3.7 (CI,
1.2-11.6) and 2.3 (CI, 0.7-7.8). Additional adjustment for cardiovascular
disease risk factors did not materially affect the results in men, whereas
in women the associations diluted. Men with levels of total and
bioavailable testosterone in subsequent tertiles were also protected
against progression of aortic atherosclerosis measured after 6.5 yr (SD
+/- 0.5 yr) of follow-up (P for trend = 0.02). No clear association
between levels of DHEAS and presence of severe aortic atherosclerosis was
found, either in men or in women. In men, a protective effect of higher
levels of DHEAS against progression of aortic atherosclerosis was
suggested, but the corresponding test for trend did not reach statistical
significance. In conclusion, we found an independent inverse association
between levels of testosterone and aortic atherosclerosis in men. In
women, positive associations between levels of testosterone and aortic
atherosclerosis were largely due to adverse cardiovascular disease risk
factors
The Challenges of Managing Inflammatory Bowel Diseases in Older Patients
Pathophysiology, epidemiology and therapy of agein
A review of mental health treatment dropout by ethnic minority youth
New methods for child psychiatric diagnosis and treatment outcome evaluatio
Dirac gaugino as leptophilic dark matter
We investigate the leptophilic properties of Dirac gauginos in an
R--symmetric N=2 supersymmetric model with extended gauge and Higgs sectors.
The annihilation of Dirac gauginos to leptons requires no chirality flip in the
final states so that it is not suppressed as in the Majorana case. This implies
that it can be sizable enough to explain the positron excess observed by the
PAMELA experiment with moderate or no boost factors. When squark masses are
heavy, the annihilation of Dirac gauginos to hadrons is controlled by their
Higgsino fraction and is driven by the and final states.
Moreover, at variance with the Majorana case, Dirac gauginos with a
non-vanishing higgsino fraction can also have a vector coupling with the
gauge boson leading to a sizable spin--independent scattering cross section off
nuclei. Saturating the current antiproton limit, we show that Dirac gauginos
can leave a signal in direct detection experiments at the level of the
sensitivity of dark matter searches at present and in the near future.Comment: 24 pages, 10 figures, typos corrected, final version published on
JCA
Infant embodiment and interembodiment
This article brings together a range of research and scholarship from various disciplines which have investigated and theorised social and cultural aspects of infants’ bodies within the context of contemporary western societies. It begins with a theoretical overview of dominant concepts of infants’ bodies, including discussion of the concepts of the unfinished body, civility and the Self/Other binary opposition as well as that of interembodiment, drawn from the work of Merleau-Ponty. Then follows discussion of the pleasures and challenging aspects of interembodiment in relation to caregivers’ interactions with infants’ bodies, purity, danger and infant embodiment and lastly practices of surveilling the vulnerable, ‘at risk’ infant body
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