Laboratory Evaluation of Flurox, a Chitin Synthesis Inhibitor, on the Termite, Microcerotermes diversus

Microcerotermes diversus (Silvestri) (Isoptera: Termitidae) is the most economically destructive termite in structures in southwest Iran. One sustainable control strategy that usually helps to reduce subterranean termite damage in buildings, is the use of insect growth regualtors in a suitable bait matrix that are safe to the user and the environment. In the laboratory assays described here, the delayed toxicity of Flurox, a chitin synthesis inhibitor, to M. diversus was evaluated under force-feeding and choice trials. Flurox induced worker and nymph mortality and incomplete ecdysis in nymphs of M. diversus under no-choice and two-choice feeding tests. These adverse effects may cause disruption of the caste balance in M. diversus, leading to the collapse of the colony. These assays determined concentrations of Flurox that can be used in bait formulations

Geometric parameterisation of pelvic bone and cartilage in contact analysis of the natural hip: an initial study

Parameterised finite element models of the human hip have the potential to allow controlled analysis of the effect of individual geometric features on the contact mechanics of the joint. However, the challenge lies in defining a set of parameters which sufficiently capture the joint geometry in order to distinguish between individuals. In this study, a simple set of parameters to describe the geometries of acetabulum and cartilage in the hip were extracted from two segmentation-based models, which were then used to generate the parameterised finite element models for the two subjects. The contact pressure and contact area at the articular surface predicted from the parameterised finite element models were compared with the results from the segmentation-based models. The differences in the predicted results between the parameterised models and segmentation-based models were found to be within 11% across seven activities simulated. In addition, the parameterised models were able to replicate features of the contact pressure/area fluctuations over the loading cycle that differed between the two subjects. These results provide confidence that the parameterised approach could be used to generate representative finite element models of the human hip for contact analysis. Such a method has the potential to be used to systematically evaluate geometric features that can be captured from simple clinical measurements and provide a cost- and time-effective approach for stratification of the acetabular geometries in the patient population

Cooperative secretions facilitate host range expansion in bacteria

The majority of emergent human pathogens are zoonotic in origin, that is, they can transmit to humans from other animals. Understanding the factors underlying the evolution of pathogen host range is therefore of critical importance in protecting human health. There are two main evolutionary routes to generalism: organisms can tolerate multiple environments or they can modify their environments to forms to which they are adapted. Here we use a combination of theory and a phylogenetic comparative analysis of 191 pathogenic bacterial species to show that bacteria use cooperative secretions that modify their environment to extend their host range and infect multiple host species. Our results suggest that cooperative secretions are key determinants of host range in bacteria, and that monitoring for the acquisition of secreted proteins by horizontal gene transfer can help predict emerging zoonoses

Introduction to Khovanov Homologies. I. Unreduced Jones superpolynomial

An elementary introduction to Khovanov construction of superpolynomials. Despite its technical complexity, this method remains the only source of a definition of superpolynomials from the first principles and therefore is important for development and testing of alternative approaches. In this first part of the review series we concentrate on the most transparent and unambiguous part of the story: the unreduced Jones superpolynomials in the fundamental representation and consider the 2-strand braids as the main example. Already for the 5_1 knot the unreduced superpolynomial contains more items than the ordinary Jones.Comment: 33 page

HOMFLY and superpolynomials for figure eight knot in all symmetric and antisymmetric representations

Explicit answer is given for the HOMFLY polynomial of the figure eight knot $4_1$ in arbitrary symmetric representation R=[p]. It generalizes the old answers for p=1 and 2 and the recently derived results for p=3,4, which are fully consistent with the Ooguri-Vafa conjecture. The answer can be considered as a quantization of the \sigma_R = \sigma_{[1]}^{|R|} identity for the "special" polynomials (they define the leading asymptotics of HOMFLY at q=1), and arises in a form, convenient for comparison with the representation of the Jones polynomials as sums of dilogarithm ratios. In particular, we construct a difference equation ("non-commutative A-polynomial") in the representation variable p. Simple symmetry transformation provides also a formula for arbitrary antisymmetric (fundamental) representation R=[1^p], which also passes some obvious checks. Also straightforward is a deformation from HOMFLY to superpolynomials. Further generalizations seem possible to arbitrary Young diagrams R, but these expressions are harder to test because of the lack of alternative results, even partial.Comment: 14 page

Pulsational and evolutionary analysis of the double-mode RR Lyrae star BS Com

We derive the basic physical parameters of the field double-mode RR Lyrae star BS Com from its observed periods and the requirement of consistency between the pulsational and evolutionary constraints. By using the current solar-scaled horizontal branch evolutionary models of Pietrinferni et al. (2004) and our linear non-adiabatic purely radiative pulsational models, we get M/M(Sun) = 0.698 +/- 0.004, log(L/L(Sun)) = 1.712 +/- 0.005, T(eff) = 6840 +/- 14 K, [Fe/H] = -1.67 +/- 0.01, where the errors are standard deviations assuming uniform age distribution along the full range of uncertainty in age. The last two parameters are in a good agreement with the ones derived from the observed BVIc colours and the updated ATLAS9 stellar atmosphere models. We get T(eff) = 6842 +/- 10 K, [Fe/H] = -1.58 +/- 0.11, where the errors are purely statistical ones. It is remarkable that the derived parameters are nearly independent of stellar age at early evolutionary stages. Later stages, corresponding to the evolution toward the asymptotic giant branch are most probably excluded because the required high temperatures are less likely to satisfy the constraints posed by the colours. We also show that our conclusions are only weakly sensitive to nonlinear period shifts predicted by current hydrodynamical models.Comment: Accepted for publication by MNRAS on 2008 February 01. The paper contains 4 figures and 8 table

Enabling technology for human collaboration.

This report summarizes the results of a five-month LDRD late start project which explored the potential of enabling technology to improve the performance of small groups. The purpose was to investigate and develop new methods to assist groups working in high consequence, high stress, ambiguous and time critical situations, especially those for which it is impractical to adequately train or prepare. A testbed was constructed for exploratory analysis of a small group engaged in tasks with high cognitive and communication performance requirements. The system consisted of five computer stations, four with special devices equipped to collect physiologic, somatic, audio and video data. Test subjects were recruited and engaged in a cooperative video game. Each team member was provided with a sensor array for physiologic and somatic data collection while playing the video game. We explored the potential for real-time signal analysis to provide information that enables emergent and desirable group behavior and improved task performance. The data collected in this study included audio, video, game scores, physiological, somatic, keystroke, and mouse movement data. The use of self-organizing maps (SOMs) was explored to search for emergent trends in the physiological data as it correlated with the video, audio and game scores. This exploration resulted in the development of two approaches for analysis, to be used concurrently, an individual SOM and a group SOM. The individual SOM was trained using the unique data of each person, and was used to monitor the effectiveness and stress level of each member of the group. The group SOM was trained using the data of the entire group, and was used to monitor the group effectiveness and dynamics. Results suggested that both types of SOMs were required to adequately track evolutions and shifts in group effectiveness. Four subjects were used in the data collection and development of these tools. This report documents a proof of concept study, and its observations are preliminary. Its main purpose is to demonstrate the potential for the tools developed here to improve the effectiveness of groups, and to suggest possible hypotheses for future exploration

Hazard Analysis of Critical Control Points Assessment as a Tool to Respond to Emerging Infectious Disease Outbreaks

Highly pathogenic avian influenza virus (HPAI) strain H5N1 has had direct and indirect economic impacts arising from direct mortality and control programmes in over 50 countries reporting poultry outbreaks. HPAI H5N1 is now reported as the most widespread and expensive zoonotic disease recorded and continues to pose a global health threat. The aim of this research was to assess the potential of utilising Hazard Analysis of Critical Control Points (HACCP) assessments in providing a framework for a rapid response to emerging infectious disease outbreaks. This novel approach applies a scientific process, widely used in food production systems, to assess risks related to a specific emerging health threat within a known zoonotic disease hotspot. We conducted a HACCP assessment for HPAI viruses within Vietnam’s domestic poultry trade and relate our findings to the existing literature. Our HACCP assessment identified poultry flock isolation, transportation, slaughter, preparation and consumption as critical control points for Vietnam’s domestic poultry trade. Introduction of the preventative measures highlighted through this HACCP evaluation would reduce the risks posed by HPAI viruses and pressure on the national economy. We conclude that this HACCP assessment provides compelling evidence for the future potential that HACCP analyses could play in initiating a rapid response to emerging infectious diseases

Superpolynomials for toric knots from evolution induced by cut-and-join operators

The colored HOMFLY polynomials, which describe Wilson loop averages in Chern-Simons theory, possess an especially simple representation for torus knots, which begins from quantum R-matrix and ends up with a trivially-looking split W representation familiar from character calculus applications to matrix models and Hurwitz theory. Substitution of MacDonald polynomials for characters in these formulas provides a very simple description of "superpolynomials", much simpler than the recently studied alternative which deforms relation to the WZNW theory and explicitly involves the Littlewood-Richardson coefficients. A lot of explicit expressions are presented for different representations (Young diagrams), many of them new. In particular, we provide the superpolynomial P_[1]^[m,km\pm 1] for arbitrary m and k. The procedure is not restricted to the fundamental (all antisymmetric) representations and the torus knots, still in these cases some subtleties persist.Comment: 23 pages + Tables (51 pages

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party

Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying 6-TG further on in IBD patients presented data on safety and efficacy of 6-TG. After thorough evaluation of its risk-benefit ratio, the group consented that 6-TG may still be considered as a rescue drug in stringently defined indications in IBD, albeit restricted to a clinical research setting. As a potential indication for administering 6-TG, we delineated the requirement for maintenance therapy as well as intolerance and/or resistance to aminosalicylates, azathioprine, 6-mercaptopurine, methotrexate and infliximab. Furthermore, indications are preferred in which surgery is thought to be inappropriate. The standard 6-TG dosage should not exceed 25 mg daily. Routine laboratory controls are mandatory in short intervals. Liver biopsies should be performed after 6-12 months, three years and then three-yearly accompanied by gastroduodenoscopy, to monitor for potential hepatotoxicity, including nodular regenerative hyperplasia (NRH) and veno-occlusive disease (VOD). Treatment with 6-TG must be discontinued in case of overt or histologically proven hepatotoxicity. Copyright (c) 2006 S. Karger AG, Basel