Craven Basin and southern Pennines

Carboniferous rocks within this area occupy the region contiguous with the northern Pennines to the north (Chapter 12) and the Peak District to the south (Chapter 10). All of the stages of the Carboniferous are present at outcrop, with the exception of Stephanian strata, which are absent. The oldest Tournaisian strata crop out within the Craven Basin, and are represented by ramp carbonate rocks (Bowland High Group) deposited on the Bowland High and adjacent Lancaster Fells and Bowland sub-basins. These carbonate rocks are overlain by mainly Visean hemipelagic mudstone and carbonate turbidites (lower part of Craven Group). To the south of the Pendle Fault System (Fig. 11.1), further platform carbonate rocks are proved in the subsurface above the Central Lancashire High (Trawden Limestone Group) and the Holme High and Heywood High (Holme High Limestone Group). These carbonate rocks, which developed during the Tournaisian to late Visean, are known only from well records and geophysical information and are not divided into formations. During the Visean, the platform carbonate rocks pass laterally into more basinal successions in the Harrogate, Rossendale and Huddersfield sub-basins (Craven Group). The lithostratigraphical nomenclature for the Tournaisian and Visean strata is that of Waters et al. (2009), adapted from Riley (1990)

Global Entrepreneurship Monitor United Kingdom: 2007 Executive Report

This monitoring report compares Global Entrepreneurship Monitor (GEM) measures of entrepreneurial activity in the UK with participating G7 countries and the large industrialised or industrialising countries of Brazil, Russia, India and China ("BRIC"). It also summarises entrepreneurial activity within Government Office Regions of the UK

Shape memory alloy actuators for active disassembly using ‘smart’ materials of consumer electronic products

This paper reports the preliminary to current development of Shape Memory Alloy (SMA) actuators within their application in ‘Active Disassembly using Smart Materials’ (ADSM). This non-destructive self-dismantling process is to aid recycling of consumer electronic products. Actuators were placed in single and multi-stage hierarchical temperature regimes after being embedded into macro and sub-assemblies of electronic product assemblies. Findings include active disassembly and a hierarchical dismantling regime for product dismantling using developed SMA actuators embedded into candidate products

An Experimental Survey of the Cathodic Activation of Metals Including Mg, Sc, Gd, La, Al, Sn, Pb, and Ge in Dilute Chloride Solutions of Varying pH

The kinetics of the hydrogen evolution reaction (HER) have been reported to increase upon pure magnesium (Mg) surfaces, following prior anodic polarisation or corrosion. This phenomenon is termed anodically induced âÂÂcathodic activationâÂÂ, which is not necessarily an elementary concept. The tendencies of other metals to exhibit cathodic activation has not been systematically explored in the past. In this study, an experimental survey of cathodic activation was conducted for different metals on the basis of understanding the origin of the cathodic activation phenomenon on Mg; including the metals Sc, Gd, La, Al, Sn, Pb and Ge, in 0.1 M NaCl with pH ranging from 3-11. Sc, Gd, La and Mg showed cathodic activation in solutions of various pH, whereas Al showed cathodic activation only in an acidic solution. Sn, Pb and Ge did not show significant cathodic activation across the pH range tested. It is proposed on the basis of the results herein, metals that tend to directly react with water to form hydroxides in aqueous electrolytes have a higher tendency to demonstrate cathodic activation

Semi-supervised prediction of protein interaction sentences exploiting semantically encoded metrics

Protein-protein interaction (PPI) identification is an integral component of many biomedical research and database curation tools. Automation of this task through classification is one of the key goals of text mining (TM). However, labelled PPI corpora required to train classifiers are generally small. In order to overcome this sparsity in the training data, we propose a novel method of integrating corpora that do not contain relevance judgements. Our approach uses a semantic language model to gather word similarity from a large unlabelled corpus. This additional information is integrated into the sentence classification process using kernel transformations and has a re-weighting effect on the training features that leads to an 8% improvement in F-score over the baseline results. Furthermore, we discover that some words which are generally considered indicative of interactions are actually neutralised by this process

Direct and indirect orthotic management of medial compartment osteoarthritis of the knee

Osteoarthritis (OA) is a painful condition and affects approximately 80% of individuals by the age of 55 [1], with knee OA occurring two times more frequently than OA of the hand or hip [2].The condition is more prevalent in the medial compartment and restricts the daily lives of individuals due to pain and a lack of functional independence. Patients with medial compartment osteoarthritis often have a varus alignment, with the mechanical axis and load bearing passing through this compartment with a greater adduction moment leading to greater pain and progression of osteoarthritis [3]. Surgery for the condition is possible although in some cases, particularly younger patients or those not yet requiring surgery, clinical management remains a challenge. Before surgery is considered, however, conservative management is advocated, though no one treatment has been shown to be most effective, and there are few quality biomechanical or clinical studies. Of the conservative approaches the principal orthotic treatments are valgus knee braces and laterally wedged foot inlays. Studies of knee valgus bracing have consistently demonstrated an associated decreased pain and improved function [4], and greater confidence [5]. A laterally wedged foot inlay has a thicker lateral border and applies a valgus moment to the heel. It is theorised that by changing the position of the ankle and subtalar joints during weight-bearing [6] the lateral wedges may apply a valgus moment across the knee as well as the rearfoot, with the assumed reduction on load in the medial knee compartment [7]. However, there has been no study to directly compare these orthotic treatments in the same study. The aim of this research is to investigate the efficacy of valgus knee braces and laterally wedged foot inlays in reducing the varus knee moment

Myofibrillar Protein Turnover in Feed-Restricted and Realimented Beef Cattle

The objective of this study was to determine the effect of feed restriction and repletion on myofibrillar protein turnover in cattle. Crossbred steer calves (n = 12) about 310 d of age were assigned randomly to a diet of corn and silage that was 1) provided ad libitum for 146 d (ALC) or 2) restricted so steers gained .2 kg/d for 80 d but received ad libitum access to feed thereafter for 66 d (RFC). At 27, 55, 97, 118 and 146 d a 24-h urine sample and a blood sample were obtained. Urine was analyzed for Nτ-methylhistidine Nτ-MH), creatinine (C), urea nitrogen (UN) and total nitrogen (TN). Serum samples were analyzed for hydroxyproliine (HYF\u27), C and albumin (A). Body weights were lower (P \u3c .05) in RFC at 55, 97, 118 and 146 d. Excretion of Nτ-MH was lower (P \u3c .05) in the RFC at 27 and 55 d but higher at 118 d Urinary C excretion was higher in ALC at the last four sample times. Urinary UN and TN excretion were lower (P \u3c .05) in RFC at 55, 97 and 118 d; urinary UN also was lower (P \u3c .05) at d 146. Serum A was higher (P \u3c .05) in ALC at 55 and 118 d, respectively. Serum HYP was higher (P \u3c .05) in RFC at 27 and 55 d. Calculated myofibrillar protein breakdown rates (FBR) and fractional synthesis rates (FSR) were higher (P \u3c .05) in RFC at the last two sampling periods; FSR was lower for the RFC at the first sampling period. Realimentation after a period of feed restriction increased both synthesis and degradation of myofibrillar protein in beef cattle