3,756 research outputs found
Machines Versus Humans: The Counting and Recounting of Pre-Scored Punchcard Ballots
The counting of ballots, especially punchcard ballots, has received a great deal of attention in the years following the 2000 presidential election in Florida. Much of the research literature has focused on various measures of how accurately voting machines record voter intentions, with studies of the relative accuracy rates across voting machines (e.g., Caltech/MIT Voting Technology Project 2001), studies of voting accuracy across groups of the electorate (Alvarez and Sinclair 2003), and studies that examine the variability in voting machine accuracy across both machine types and voter types (Alvarez, Sinclair and Wilson 2002; Ansolabehere 2002; Tomz and Van Houweling 2003).Carnegie Corporation of New York; John S. and James L. Knight Foundation; John Randolph Haynes and Dora Haynes Foundatio
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Frequency of infant stroking reported by mothers moderates the effect of prenatal depression on infant behavioural and physiological outcomes
Animal studies find that prenatal stress is associated with increased physiological and emotional reactivity later in life, mediated via fetal programming of the HPA axis through decreased glucocorticoid receptor (GR) gene expression. Post-natal behaviours, notably licking and grooming in rats, cause decreased behavioural indices of fear and reduced HPA axis reactivity mediated via increased GR gene expression. Post-natal maternal behaviours may therefore be expected to modify prenatal effects, but this has not previously been examined in humans. We examined whether, according to self-report, maternal stroking over the first weeks of life modified associations between prenatal depression and physiological and behavioral outcomes in infancy, hence mimicking effects of rodent licking and grooming. From a general population sample of 1233 first time mothers recruited at 20 weeks gestation we drew a stratified random sample of 316 for assessment at 32 weeks based on reported inter-partner psychological abuse, a risk to child development. Of these 271 provided data at 5, 9 and 29 weeks post delivery. Mothers reported how often they stroked their babies at 5 and 9 weeks. At 29 weeks vagal withdrawal to a stressor, a measure of physiological adaptability, and maternal reported negative emotionality were assessed. There was a significant interaction between prenatal depression and maternal stroking in the prediction of vagal reactivity to a stressor (p = .01), and maternal reports of infant anger proneness (p = .007) and fear (p = .043). Increasing maternal depression was associated with decreasing physiological adaptability, and with increasing negative emotionality, only in the presence of low maternal stroking. These initial findings in humans indicate that maternal stroking in infancy, as reported by mothers, has effects strongly resembling the effects of observed maternal behaviours in animals, pointing to future studies of the epigenetic, physiological and behavioral effects of maternal stroking
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Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model
Abstract Background: Using data from the English & Romanian Adoptees (ERA) study we recently reported that early time-lmited exposure to severe institutional deprivation is
associated with early onset and persistent neurodevelopmental problems and later
onset emotional problems. Here we examine possible reasons for the late
emergence of emotional problems in this cohort. Our main focus is on testing a
developmental cascade mediated via the functional impact of early-appearing
neurodevelopmental problems on late adolescent functioning. We also explore a
second putative pathway via sensitization to stress. Methods: The ERA study includes 165 Romanian individuals who spent their early lives in grossly depriving institutions and were subsequently adopted into UK
families, along with 52 UK adoptees with no history of deprivation. Age six years
symptoms of neurodevelopmental problems and age 15 anxiety/depression
symptoms were assessed via parental reports. Young adult symptoms of depression
and anxiety were assessed by both parent and self-reports; young adults also
completed measures of stress reactivity , exposure to adverse life events and
functioning in work and interpersonal relationships. Results: The path between early institutional deprivation and adult emotional problems was mediated via the impact of early neurodevelopmental problems on
unemployment and poor friendship functioning during the transition to adulthood.
The findings with regard to early deprivation, later life stress reactivity and emotional
problems were inconclusive.
Conclusions: Our analysis suggests that the risk for adult depression and anxiety following extreme institutional deprivation is explained through the effects of early neurodevelopmental problems on later social and vocational functioning. Future research should more fully examine the role of stress susceptibility in this model
Re-analysis of ammonia spectra: Updating the HITRAN 14NH3 database
AbstractThe data incorporated in the HITRAN database for 14NH3 are analyzed using a comprehensive and consistent set of quantum numbers, empirical lower energy levels and the BYTe variationally calculated line list as reference points. Labelings are checked to ensure that they obey both the usual selection rules and the HITRAN labeling formalisms; the problems identified are corrected where possible. Further assignments are brought into question by combination difference (CD) checking of implied upper energy levels. The CD analysis yields an 89% complete 14NH3 energy level list up to 6610cmâ1 and J=21, self-consistent to 0.1cmâ1. In combination with the 1723 previously unassigned and unlabeled lines in HITRAN a total of 2529 problem lines were identified for re-analysis. The compiled energy level list was used to label and assign the set of problem transitions, resulting in a total of 249 new assignments and a further 368 new labelings. Assignment by comparison with the reference line list resulted in 111 further new line assignments and 14 new labelings. Intensities are checked against recent measurements and BYTe. New intensities are proposed for the ν2 band with new intensities and line positions for the 2ν2âν2 and new line lists are created for the ν2âν2, ν2âν4 and ν4âν4 bands. BYTe band intensities are analyzed to identify other regions of missing intensity
Mediators of Treatment Effect in the Back In Action Trial:Using Latent Growth Modeling to Take Change Over Time Into Account
Objectives: To test whether change in fear-avoidance beliefs was a mediator of the effect of treatment on disability outcome, and to test an analytical approach, latent growth modeling, not often applied to mediation analysis. Methods: Secondary analysis was carried out on a randomized controlled trial designed to compare an intervention addressing fear-avoidance beliefs (n=119) with treatment as usual (n=121) for patients with low back pain, which found the intervention to be effective. Latent growth modelling was used to perform a mediation analysis on the trial data to assess the role of change in fear-avoidance beliefs on disability outcome. The product of coefficients with bias-corrected bootstrapped confidence intervals was used to calculate the mediating effect. Results: A statistically significant mediating effect of fear-avoidance beliefs on the effect of treatment on disability outcome was found (standardized indirect effect â0.35; bias-corrected 95% CI, â0.47 to â0.24). Poor fit of the model to the data suggested that other factors not accounted for in this model are likely to be part of the same mediating pathway. Discussion: Fear-avoidance beliefs were found to mediate the effect of treatment on disability outcome. Measurement of all potential mediator variables in future studies would help to more strongly identify which factors explain observed treatment effects. Latent growth modelling was found to be a useful technique to apply to studies of treatment mediation, suggesting that future studies could use this approach
Lifelong reduction in complex IV induces tissueâspecific metabolic effects but does not reduce lifespan or healthspan in mice
A comparative study of WASP-67b and HAT-P-38b from WFC3 data
Atmospheric temperature and planetary gravity are thought to be the main
parameters affecting cloud formation in giant exoplanet atmospheres. Recent
attempts to understand cloud formation have explored wide regions of the
equilibrium temperature-gravity parameter space. In this study, we instead
compare the case of two giant planets with nearly identical equilibrium
temperature ( ) and gravity (. During Cycle 23, we collected WFC3/G141
observations of the two planets, WASP-67 b and HAT-P-38 b. HAT-P-38 b, with
mass 0.42 M and radius 1.4 , exhibits a relatively
clear atmosphere with a clear detection of water. We refine the orbital period
of this planet with new observations, obtaining . WASP-67 b, with mass 0.27 M and radius 0.83
, shows a more muted water absorption feature than that of
HAT-P-38 b, indicating either a higher cloud deck in the atmosphere or a more
metal-rich composition. The difference in the spectra supports the hypothesis
that giant exoplanet atmospheres carry traces of their formation history.
Future observations in the visible and mid-infrared are needed to probe the
aerosol properties and constrain the evolutionary scenario of these planets.Comment: 16 pages, 17 figures, 8 tables, accepted for publication in The
Astronomical Journa
Life expectancy in Duchenne Muscular Dystrophy : reproduced individual patient data meta-analysis
Objective: Duchenne Muscular Dystrophy (DMD) is a rare progressive disease, which is often diagnosed in early childhood, and leads to considerably reduced life-expectancy; due to its rarity, research literature and patient numbers are limited. To fully characterise the natural history, it is crucial to obtain appropriate estimates of the life-expectancy and mortality rates of patients with DMD.
Methods: A systematic review of the published literature on mortality in DMD up until July 2020 was undertaken, specifically focusing on publications in which Kaplan-Meier (KM) survival curves with age as a time-scale were presented. These were digitised and individual patient data (IPD) reconstructed. The pooled IPD were analysed using the Kaplan-Meier estimator and parametric survival analysis models. Estimates were also stratified by birth cohort.
Results: Of 1177 articles identified, 14 publications met the inclusion criteria and provided data on 2283 patients, of whom 1049 had died. Median life-expectancy was 22.0 years (95% CI: 21.2, 22.4). Analyses stratifying by three time-periods in which patients were born showed markedly increased life-expectancy in more recent patient populations; patients born after 1990 have a median life-expectancy of 28.1 years (95% CI 25.1, 30.3).
Conclusions: This paper presents a full overview of mortality across the lifetime of a patient with DMD, and highlights recent improvements in survival. In the absence of large-scale prospective cohort studies or trials reporting mortality data for patients with DMD, extraction of IPD from the literature provides a viable alternative to estimating life-expectancy for this patient population
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