3,112 research outputs found
Bulk phase behaviour of binary hard platelet mixtures from density functional theory
We investigate isotropic-isotropic, isotropic-nematic and nematic-nematic
phase coexistence in binary mixtures of circular platelets with vanishing
thickness, continuous rotational degrees of freedom and radial size ratios
up to 5. A fundamental measure density functional theory, previously
used for the one-component model, is proposed and results are compared against
those from Onsager theory as a benchmark. For the system
displays isotropic-nematic phase coexistence with a widening of the biphasic
region for increasing values of . For size ratios , we
find demixing into two nematic states becomes stable and an
isotropic-nematic-nematic triple point can occur. Fundamental measure theory
gives a smaller isotropic-nematic biphasic region than Onsager theory and
locates the transition at lower densities. Furthermore, nematic-nematic
demixing occurs over a larger range of compositions at a given value of
than found in Onsager theory. Both theories predict the same
topologies of the phase diagrams. The partial nematic order parameters vary
strongly with composition and indicate that the larger particles are more
strongly ordered than the smaller particles
Report No. 29: The Mobility and Integration of People with Disabilities into the Labour Market
Report based on a study conducted for the European Parliament, Bonn 2010 (95 pages)
Toward a user-centered design of a weather forecasting decision-support tool
Hazard Services is a software toolkit that integrates information management, hazard alerting, and communication functions into a single user interface. When complete, National Weather Service forecasters across the United States will use Hazard Services for operational issuance of weather and hydrologic alerts, making the system an instrumental part of the threat management process. As a new decision-support tool, incorporating an understanding of user requirements and behavior is an important part of building a system that is usable, allowing users to perform work-related tasks efficiently and effectively. This paper discusses the Hazard Services system and findings from a usability evaluation with a sample of end users. Usability evaluations are frequently used to support software and website development and can provide feedback on a systemâs efficiency of use, effectiveness, and learnability. In the present study, a user-testing evaluation assessed task performance in terms of error rates, error types, response time, and subjective feedback from a questionnaire. A series of design recommendations was developed based on the evaluationâs findings. The recommendations not only further the design of Hazard Services, but they may also inform the designs of other decision-support tools used in weather and hydrologic forecasting.
Incorporating usability evaluation into the iterative design of decision-support tools, such as Hazard Services, can improve system efficiency, effectiveness, and user experience
Phase behaviour of binary mixtures of diamagnetic colloidal platelets in an external magnetic field
Using fundamental measure density functional theory we investigate
paranematic-nematic and nematic-nematic phase coexistence in binary mixtures of
circular platelets with vanishing thicknesses. An external magnetic field
induces uniaxial alignment and acts on the platelets with a strength that is
taken to scale with the platelet area. At particle diameter ratio lambda=1.5
the system displays paranematic-nematic coexistence. For lambda=2, demixing
into two nematic states with different compositions also occurs, between an
upper critical point and a paranematic-nematic-nematic triple point. Increasing
the field strength leads to shrinking of the coexistence regions. At high
enough field strength a closed loop of immiscibility is induced and phase
coexistence vanishes at a double critical point above which the system is
homogeneously nematic. For lambda=2.5, besides paranematic-nematic coexistence,
there is nematic-nematic coexistence which persists and hence does not end in a
critical point. The partial orientational order parameters along the binodals
vary strongly with composition and connect smoothly for each species when
closed loops of immiscibility are present in the corresponding phase diagram.Comment: 9 pages, to appear in J.Phys:Condensed Matte
Cryptococcal aortitis presenting as a ruptured mycotic abdominal aortic aneurysm
AbstractMycotic processes occasionally complicate atherosclerotic aortic disease and usually require aggressive surgical therapy to control sepsis and prevent arterial rupture. Rarely, fungal organisms are responsible for primary infection of the abdominal aorta. We report the first case of Cryptococcal aortitis presenting as a ruptured abdominal aortic aneurysm. The surgical, pathologic, and microbiologic aspects of fungal aortitis are discussed. (J Vasc Surg 1999;30:189-92.
Recommended from our members
Common DNA sequence variation influences 3-dimensional conformation of the human genome.
BACKGROUND:The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA sequence variation between individuals influences 3D chromatin conformation. RESULTS:To address these questions, we perform Hi-C on lymphoblastoid cell lines from 20 individuals. We identify thousands of regions across the genome where 3D chromatin conformation varies between individuals and find that this variation is often accompanied by variation in gene expression, histone modifications, and transcription factor binding. Moreover, we find that DNA sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality, and density of local cis contacts. We map hundreds of quantitative trait loci associated with 3D chromatin features and find evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. CONCLUSION:Our results demonstrate that common DNA sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized
Towards representing human behavior and decision making in Earth system models. An overview of techniques and approaches
Today, humans have a critical impact on the Earth system and vice versa, which can generate complex feedback processes between social and ecological dynamics. Integrating human behavior into formal Earth system models (ESMs), however, requires crucial modeling assumptions about actors and their goals, behavioral options, and decision rules, as well as modeling decisions regarding human social interactions and the aggregation of individualsâ behavior. Here, we review existing modeling approaches and techniques from various disciplines and schools of thought dealing with human behavior at different levels of decision making. We demonstrate modelersâ often vast degrees of freedom but also seek to make modelers aware of the often crucial consequences of seemingly innocent modeling assumptions. After discussing which socioeconomic units are potentially important for ESMs, we compare models of individual decision making that correspond to alternative behavioral theories and that make diverse modeling assumptions about individualsâ preferences, beliefs, decision rules, and foresight. We review approaches to model social interaction, covering game theoretic frameworks, models of social influence, and network models. Finally, we discuss approaches to studying how the behavior of individuals, groups, and organizations can aggregate to complex collective phenomena, discussing agent-based, statistical, and representative-agent modeling and economic macro-dynamics. We illustrate the main ingredients of modeling techniques with examples from land-use dynamics as one of the main drivers of environmental change bridging local to global scales
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep deprivation on dendritic structure. In mice, we find that five hours of sleep deprivation decreases dendritic spine numbers selectively in hippocampal area CA1 and increased activity of the filamentous actin severing protein cofilin. Recovery sleep normalizes these structural alterations. Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory caused by sleep deprivation. The elevated cofilin activity is caused by cAMP-degrading phosphodiesterase-4A5 (PDE4A5), which hampers cAMP-PKA-LIMK signaling. Attenuating PDE4A5 function prevents changes in cAMP-PKA-LIMK-cofilin signaling and cognitive deficits associated with sleep deprivation. Our work demonstrates the necessity of an intact cAMP-PDE4-PKA-LIMK-cofilin activation-signaling pathway for sleep deprivation-induced memory disruption and reduction in hippocampal spine density
- âŚ