Constructing Human Dignity: An Investment Concept

This thesis explores the meaning of human dignity in law and its potential value as a legal concept. It claims that existing methods of analysis are predominantly caught up with seeking a fixed and conventional meaning, which has proven difficult and has invariably led to claims that the concept is vague or vacuous. In this light, the thesis proposes a fresh method of conceptual analysis that progresses the current debate on the meaning of the concept in a more fruitful and productive direction. It seeks to shift the focus of analysis away from the formal search for a clear concept that is simply there to be applied or repeated, in favour of constructing the concept to respond to the shifting problems that emerge in life, as well as unlocking new pathways to promote more dynamic, rich, active and joyful modes of living. In this respect, it is argued that a concept of dignity should be assessed not by how well it reflects the past, but how it can be constructed to produce change that unlocks new potentialities and creative tendencies in the present. In deploying this methodology, the author seeks to construct a theoretically informed concept of human dignity that progresses beyond the limited focus on dignity as autonomy to encompass a more holistic, dynamic and interdependent view of human personality. The author explores a notion of dignity that he terms an ‘investment concept’. On this account, the value of human life is situated in its creative potential that is inherent, which requires investment from the community and the individual in order to be nurtured. It depends on a relational view of humanity that sees the creative potentiality of an individual as always unfolding in relation to others in the community. This potential is promoted through increasing the power of acting and rest for both the body and mind that is joyful rather than sad. This establishes a multifaceted view of humanity that moves beyond the mainstream separation of mind-body, independence-dependence, emotion-reason, in favour of a more joined up and connected perspective on humanity that recognises that humans are vulnerable beings whose development depends upon the relationships and connections of which they are always a part. The thesis explores the implication of this construction for the law in England and Wales, considering how the concept can be connected to existing legal pathways, as well as extending or unlocking new legal paths to create a better future for the most vulnerable. The process of connecting the concept to the existing legal framework is also treated as an important foundation for refining and enriching the concept by drawing on the complexity of human experience. In this sense, connecting human dignity to law is treated as a basis for reflecting on the way in which dignity can be refined, adapted or modified to address the concrete problems or experiences faced in life. The final part of the thesis explores the potential transformative implications of investment dignity for concepts that have been connected to human dignity, such as the rule of law and democracy, which affect the relationship between the individual and the community

Slow Slip Triggers the 2018 Mw 6.9 Zakynthos Earthquake Within the Weakly Locked Hellenic Subduction System, Greece

Slow slip events (SSEs) at subduction zones can precede large-magnitude earthquakes and may serve as precursor indicators, but the triggering of earthquakes by slow slip remains insufficiently understood. Here, we combine geodetic, Coulomb wedge and Coulomb failure-stress models with seismological data to explore the potential causal relationship between two SSEs and the 2018 Mw 6.9 Zakynthos Earthquake within the Hellenic Subduction System. We show that both SSEs released up to 10 mm of aseismic slip on the plate-interface and were accompanied by an increase in upper-plate seismicity rate. While the first SSE in late 2014 generated only mild Coulomb failure stress changes (≤3 kPa), that were nevertheless sufficient to destabilize faults of various kinematics in the overriding plate, the second SSE in 2018 caused stress changes up to 25 kPa prior to the mainshock. Collectively, these stress changes affected a highly overpressured and mechanically weak forearc, whose state of stress fluctuated between horizontal deviatoric compression and tension during the years preceding the Zakynthos Earthquake. We conclude that this configuration facilitated episodes of aseismic and seismic deformation that ultimately triggered the Zakynthos Earthquake

Separating rapid relocking, afterslip, and viscoelastic relaxation: An application of the postseismic straightening method to the Maule 2010 cGPS

The postseismic deformation captured with continuous Global Positioning System (cGPS) monitoring following many recent mega-thrust events has been shown to be a signal composed of two dominant processes: afterslip on the plate interface and viscoelastic relaxation of the continental and oceanic mantles in response to the coseismic stress perturbation. Following the south-central Chile 2010 Maule Mw 8.8 earthquake, the time series from the regional cGPS network show a distinct curvature in the pathway of the horizontal motion that is not easily fit by a stationary decaying pattern of afterslip in combination with viscoelastic relaxation. Here we show that with realistic assumptions about the long-term decay of the afterslip signal, the postseismic signal can be decomposed into three first-order contributing processes: plate interface re-locking, plate interface afterslip, and mantle viscoelastic relaxation. From our analyses we conclude that the plate interface recovers its interseismic locking state rapidly (model space ranges between an instant recovery and a period of 1 year); a finding that supports laboratory experimental evidence as well as some recent studies of aftershocks and postseismic surface deformation. Furthermore, re-locking is the main cause of the curvature in the cGPS signal, and this study presents a plausible range of geodetic re-locking rates following a megathrust earthquake

Infant Neural Sensitivity to Dynamic Eye Gaze relates to quality of parent–infant interaction at 7-months in infants at risk for Autism

Links between brain function measures and quality of parent–child interactions within the early developmental period have been investigated in typical and atypical development. We examined such links in a group of 104 infants with and without a family history for autism in the first year of life. Our findings suggest robust associations between event related potential responses to eye gaze and observed parent–infant interaction measures. In both groups, infants with more positive affect exhibit stronger differentiation to gaze stimuli. This association was observed with the earlier P100 waveform component in the control group but with the later P400 component in infants at-risk. These exploratory findings are critical in paving the way for a better understanding of how infant laboratory measures may relate to overt behavior and how both can be combined in the context of predicting risk or clinical diagnosis in toddlerhood

Understanding Quality of Life for People with Motor Neurone Disease Who Use Tracheostomy Ventilation and Family Members: A Scoping Review

Tracheostomy ventilation (TV) can increase survival time for people living with motor neurone disease (MND); however, the use of TV varies between countries. Concerns regarding anticipated quality of life (QoL) are among the reasons given by healthcare professionals for not recommending this intervention, yet little is known about QoL in this context. This scoping review was conducted to examine the evidence on QoL for those with MND who use TV and family members involved in their care. Using the methodological guidance of the Joanna Briggs Institute, 23 papers were identified for inclusion, and findings were inductively analysed to identify key themes. We found that people living with MND tend to rate QoL post TV more positively than anticipated by healthcare professionals or family members. QoL was found to be related to positive relationships and activities the person could maintain. Feeling able to make a choice and an adequate level of financial resources were also important factors. Family members tended to experience lower QoL, associated with the uncertainty surrounding an emergency procedure and the complexity of subsequently required care. More evidence on QoL from the perspectives of people with MND who use TV is needed to support decision making and inform guidance

Satellitengeodäsie und Erdbebendeformation in der nordchilenischen seismischen Lücke

Subduction earthquakes are the most powerful naturally occurring terrestrial processes often resulting in catastrophic fatality counts and decimation of human infrastructure. Over the past decades, great efforts have been undertaken to improve the understanding of the subduction earthquake physics. The Integrated Plate Boundary Observatory in Chile (IPOC) is a multi-instrument network installed in 2007 in the Northern Chile Seismic Gap, where a large magnitude earthquake was expected soon. On April 1st 2014, a portion of the IPOC-monitored region broke, producing the Mw 8.1 Iquique earthquake. In the year leading up to this event, IPOC’s instruments captured some unusual transient seismic and geodetic signals, resulting in a unique dataset recording the preparatory phase of a large earthquake. We combined IPOC data with satellite radar interferometry (InSAR) data to analyze not only the earthquake itself but also the interseismic phase and a detailed foreshock series before the main event. We found that the earthquake ruptured a zone on the plate interface that was highly locked before the earthquake. Additionally, we were able to characterize the aseismic (silent) slip that occurred in the two weeks leading up to the event by combining seismic and geodetic data. Application of these analyses in real-time might enable geoscientists to identify runaway processes that can precede large subduction earthquakes

Delivery of drinking, eating and mobilising (DrEaMing) and its association with length of hospital stay after major noncardiac surgery: observational cohort study

BACKGROUND: Enhanced recovery pathways are associated with improved postoperative outcomes. However, as enhanced recovery pathways have become more complex and varied, compliance has reduced. The ‘DrEaMing’ bundle re-prioritises early postoperative delivery of drinking, eating, and mobilising. We investigated relationships between DrEaMing compliance, postoperative hospital length of stay (LOS), and complications in a prospective multicentre major surgical cohort. METHODS: We interrogated the UK Perioperative Quality Improvement Programme dataset. Analyses were conducted in four stages. In an exploratory cohort, we identified independent predictors of DrEaMing. We quantified the association between delivery of DrEaMing (and its component variables) and prolonged LOS in a homogenous colorectal subgroup and assessed generalisability in multispecialty patients. Finally, LOS and complications were compared across hospitals, stratified by DrEaMing compliance. RESULTS: The exploratory cohort comprised 22 218 records, the colorectal subgroup 7230, and the multispecialty subgroup 5713. DrEaMing compliance was 59% (13 112 patients), 60% (4341 patients), and 60% (3421), respectively, but varied substantially between hospitals. Delivery of DrEaMing predicted reduced odds of prolonged LOS in colorectal (odds ratio 0.51 [0.43–0.59], P<0.001) and multispecialty cohorts (odds ratio 0.47 [0.41–0.53], P<0.001). At the hospital level, complications were not the primary determinant of LOS after colorectal surgery, but consistent delivery of DrEaMing was associated with significantly shorter LOS. CONCLUSIONS: Delivery of bundled and unbundled DrEaMing was associated with substantial reductions in postoperative LOS, independent of the effects of confounder variables. Consistency of process delivery, and not complications, predicted shorter hospital-level LOS. DrEaMing may be adopted by perioperative health systems as a quality metric to support improved patient outcomes and reduced LOS