Study of the Outcomes and Impacts of the Global Forum on Migration and Development and Civil Society Days

In November 2011, the Global Forum on Migration and Development (GFMD) and accompanying Civil Society Days (CSD) completed their fifth year of operation, with the aim of improving migration policy coherence and enhancing the benefits of migration to sending and receiving countries, and to migrants themselves. The John D. and Catherine T. MacArthur Foundation, the largest non-governmental donor to this process, commissioned this study to retrospectively assess the outcomes and impact of the CSD and GFMD on policies, practices, issue framing, and government-civil society cooperation; and to prospectively draw lessons learned for the future of the GFMD and CSD. The evaluation took place from November 2011 through September 2012, allowing the team to observe the CSD and GFMD in Geneva, conduct an in-depth case study in Mexico, distribute online surveys to participants, conduct interviews at the UN offices in New York, and conduct key informant interviews by phone. Using a mixed method approach, combining quantitative survey data with qualitative key informant interviews and an extensive document review, the team has worked to triangulate data and strengthen the validity of findings. This study is geared towards the main stakeholders of the GFMD and CSD, including governments, civil society representatives, and donors. It is hoped that the aforementioned stakeholders will be able to utilize the findings, conclusions, and recommendations within this report to better inform their work in migration and development moving forward -- both within and outside of the GFMD and CSD processes

Semi-Automated Nasal PAP Mask Sizing using Facial Photographs

We present a semi-automated system for sizing nasal Positive Airway Pressure (PAP) masks based upon a neural network model that was trained with facial photographs of both PAP mask users and non-users. It demonstrated an accuracy of 72% in correctly sizing a mask and 96% accuracy sizing to within 1 mask size group. The semi-automated system performed comparably to sizing from manual measurements taken from the same images which produced 89% and 100% accuracy respectively.Comment: 4 pages, 3 figures, 4 tables, IEEE Engineering Medicine and Biology Conference 201

Probing Pulsar Winds Using Inverse Compton Scattering

We investigate the effects of inverse Compton scattering by electrons and positrons in the unshocked winds of rotationally-powered binary pulsars. This process can scatter low energy target photons to produce gamma rays with energies from MeV to TeV. The binary radio pulsars PSR B1259-63 and PSR J0045-73 are both in close eccentric orbits around bright main sequence stars which provide a huge density of low energy target photons. The inverse Compton scattering process transfers momentum from the pulsar wind to the scattered photons, and therefore provides a drag which tends to decelerate the pulsar wind. We present detailed calculations of the dynamics of a pulsar wind which is undergoing inverse Compton scattering, showing that the deceleration of the wind of PSR B1259-63 due to `inverse Compton drag' is small, but that this process may confine the wind of PSR J0045-73 before it attains pressure balance with the outflow of its companion star. We calculate the spectra and light curves of the resulting inverse Compton emission from PSR B1259-63 and show that if the size of the pulsar wind nebula is comparable to the binary separation, then the gamma-ray emission from the unshocked wind may be detectable by atmospheric Cerenkov detectors or by the new generation of satellite-borne gamma-ray detectors such as INTEGRAL and GLAST. This mechanism may therefore provide a direct probe of the freely-expanding regions of pulsar winds, previously thought to be invisible.Comment: To be published in Astroparticle Physics. 27 pages, 5 figure

A Radio--Optical Reference Frame VIII. CCD observations from KPNO and CTIO: internal calibration and first results

In this pilot investigation, precise optical positions in the FK5 system are presented for a set of 16 compact extragalactic radio sources, which will be part of the future radio--optical reference frame. The 0.9 m KPNO and CTIO telescopes equipped with 2K CCD's have been used for this project. The astrometric properties of these instruments are investigated in detail. New techniques of using wide field CCD observations for astrometry in general are developed. An internal precision of 5 to 31 mas in position per single exposure is found, depending on the brightness of the object. The tie to the primary optical reference system is established by photographic astrometry using dedicated astrographs on both hemispheres. An accuracy of $\approx 30$ mas per source is estimated for the multi--step reduction procedure when based on the future Hipparcos catalog, while the FK5--based positions suffer from system errors of 100 to 200 mas as compared to the radio positions. This work provides a contribution to the international effort to link the Hipparcos instrumental coordinate system to the quasi--inertial VLBI radio reference frame. Precise radio and optical astrometry of a large sample of compact extragalactic sources will also contribute to the astrophysics of these objects by comparing the respective centers of emission at the optical and radio wavelengths.Comment: AAS v.4 LaTeX, 2 parts on 1 file (main text + deluxetable), accepted by AJ, Dec.95, fig. with reprint

RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch) : an experimental model uncoupling the growth hormone and nutritional signals regulating growth

Background Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (Gh) express Gh in multiple tissues which results in increased appetite and continuous high growth with satiation feeding. Restricting Gh-transgenics to the same lower ration (TR) as wild-type fish (WT) results in similar growth, but with the recruitment of fewer, larger diameter, muscle skeletal fibres to reach a given body size. In order to better understand the genetic mechanisms behind these different patterns of muscle growth and to investigate how the decoupling of Gh and nutritional signals affects gene regulation we used RNA-seq to compare the fast skeletal muscle transcriptome in TR and WT coho salmon. Results Illumina sequencing of individually barcoded libraries from 6 WT and 6 TR coho salmon yielded 704,550,985 paired end reads which were used to construct 323,115 contigs containing 19,093 unique genes of which >10,000 contained >90 % of the coding sequence. Transcripts coding for 31 genes required for myoblast fusion were identified with 22 significantly downregulated in TR relative to WT fish, including 10 (vaspa, cdh15, graf1, crk, crkl, dock1, trio, plekho1a, cdc42a and dock5) associated with signaling through the cell surface protein cadherin. Nineteen out of 44 (43 %) translation initiation factors and 14 of 47 (30 %) protein chaperones were upregulated in TR relative to WT fish. Conclusions TR coho salmon showed increased growth hormone transcripts and gene expression associated with protein synthesis and folding than WT fish even though net rates of protein accretion were similar. The uncoupling of Gh and amino acid signals likely results in additional costs of transcription associated with protein turnover in TR fish. The predicted reduction in the ionic costs of homeostasis in TR fish associated with increased fibre size were shown to involve multiple pathways regulating myotube fusion, particularly cadherin signaling.Publisher PDFPeer reviewe

Direct observation of a Fermi liquid-like normal state in an iron-pnictide superconductor

There are two prerequisites for understanding high-temperature (high-T$_c$) superconductivity: identifying the pairing interaction and a correct description of the normal state from which superconductivity emerges. The nature of the normal state of iron-pnictide superconductors, and the role played by correlations arising from partially screened interactions, are still under debate. Here we show that the normal state of carefully annealed electron-doped BaFe$_{2-x}$Co$_{x}$As$_2$ at low temperatures has all the hallmark properties of a local Fermi liquid, with a more incoherent state emerging at elevated temperatures, an identification made possible using bulk-sensitive optical spectroscopy with high frequency and temperature resolution. The frequency dependent scattering rate extracted from the optical conductivity deviates from the expected scaling $M_{2}(\omega,T)\propto(\hbar\omega)^{2}+(p\pi k_{B}T)^{2}$ with $p\approx$ 1.47 rather than $p$ = 2, indicative of the presence of residual elastic resonant scattering. Excellent agreement between the experimental results and theoretical modeling allows us to extract the characteristic Fermi liquid scale $T_{0}\approx$ 1700 K. Our results show that the electron-doped iron-pnictides should be regarded as weakly correlated Fermi liquids with a weak mass enhancement resulting from residual electron-electron scattering from thermally excited quasi-particles.Comment: 6+9pages, 3+9 figures To be published in Scientific Report

Inverse Compton Emission of TeV Gamma Rays from PSR B1259-63

We derive light curves for the hard gamma-ray emission, at energies up to several TeV, expected from the unique pulsar/Be-star binary system PSR B1259-63. This is the only known system in our galaxy in which a radio pulsar is orbiting a main sequence star. We show that inverse Compton emission from the electrons and positrons in the shocked pulsar wind, scattering target photons from the Be star, produces a flux of hard gamma-rays that should be above the sensitivity threshold of present day atmospheric Cerenkov detectors. Furthermore, we predict that the flux of hard gamma-rays produced via this mechanism has a characteristic variation with orbital phase that should be observable, and which is not expected from any other mechanism.Comment: To be published in Astroparticle Physics. 24 pages, 8 figure

Cardiac myoglobin deficit has evolved repeatedly in teleost fishes

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